Jing Xu

Technology for Planar Power Semiconductor Devices Package with Improved Voltage Rating (2009)

Xu, Jing

The high-voltage SiC power semiconductor devices have been developed in recent years. They cause an urgent in the need for the power semiconductor packaging to have not only low interconnect...

Technology for Planar Power Semiconductor Devices Package with Improved Voltage Rating (2009)

Xu, Jing

The high-voltage SiC power semiconductor devices have been developed in recent years. They cause an urgent in the need for the power semiconductor packaging to have not only low interconnect...

2,2-Bis(1H-indol-3-yl)indolin-3-one (2009)

Zhao-Hao Li, Jing Xu, Wen-Liang Wu, Wei-Ping Su

In the title molecule, C24H17N3O, the mean plane of the indolone ring forms dihedral angles of 112.0 (1) and 103.1 (1)° with the planes of the two indole rings. The dihedral angle...

Ethyl 5-cyano-4-[2-(2,4-dichlorophenoxy)acetamido]-1-phenyl-1H-pyrrole-3-carboxylate (2009)

Jing Xu, Hui Sheng, Mei He, Ping He

In the title compound, C22H17Cl2N3O4, the pyrrole ring and the 2,4-dichlorophenyl group form a dihedral angle of 8.14 (13)°; the phenyl ring is twisted with respect to the pyrrole ring,...

Community-based study on CKD subjects and the associated risk factors (2009)

Chen, Nan, Wang, Weiming, Huang, Yanping, Shen, Pingyan, Pei, Daoling, Yu, Haijin, ...

Background. The study was performed to investigate the prevalence, awareness and the risk factors of chronic kidney disease (CKD) in the community population in Shanghai, China. Methods. A total of...

Ethyl 5-methyl-4-oxo-3-phenyl-2-propylamino-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylate (2009)

Ai-Hua Zheng, Yan-Mei Ren, Jing Xu

The title compound, C19H21N3O3S, was synthesized via the aza-Wittig reaction of functionalized iminophosphorane with phenyl isocyanate under mild conditions. In the molecule, the fused...

Identification of a Benzamide Derivative that Inhibits Stress-Induced Adrenal Corticosteroid Synthesis (2009)

Jing Xu, Laurent Lecanu, Matthew Tan, Janet Greeson, Vassilios Papadopoulos

Elevated serum glucocorticoid levels contribute to the progression of many diseases, including depression, Alzheimer’s disease, hypertension, and acquired immunodeficiency syndrome. Here we show...

Chromones from the endophytic fungus Pestalotiopsis sp. isolated from the Chinese mangrove plant Rhizophora mucronata (2009)

Xu, Jing, Kjer, Julia, Sendker, Jandirk, Wray, Victor, Guan, Huashi, Edrada-Ebel, Ru Angelie, ...

Six new chromones, named pestalotiopsones A−F (1−6), and the known derivative 7-hydroxy-2-(2-hydroxypropyl)-5-methylchromone (7) were obtained from the mycelia and culture filtrate of the...

3-Isopropyl-2-(4-methoxyphenoxy)-1-benzofuro[3,2-d]pyrimidin-4(3H)-one (2009)

Xiao-Bao Chen, Jing Xu, Ai-Hua Zheng, Jia-Hua Tian, Hong Luo

In the title compound, C20H18N2O4, all non-H atoms of the three fused rings of the benzofuro[3,2-d]pyrimidine system are almost coplanar (r.m.s. deviation 0.021 Å). The dihedral angle...

1-{1-[(2-Chlorothiazol-5-yl)methyl]-5-methyl-1H-1,2,3-triazol-4-yl}ethanone (2009)

Xiao-Bao Chen, Jia-Hua Tian, Jing Xu, Yong Yu, Qun Wang

In the title compound, C9H9ClN4OS, the two rings enclose a dihedral angle of 84.67 (11)°. Intermolecular C—H...O and C—H...N hydrogen bonds stabilize the crystal packing.

On the Use of Fuzzy Modeling in Virtualized Data Center Management (2008)

Jing Xu, Ming Zhao, José Fortes, Robert Carpenter, Mazin Yousif

One of the most important goals of data-center management is to reduce cost through efficient use of resources. Virtualization techniques provide the opportunity of carving individual physical...

Abstract: Approaches to Anomaly Detection using Host Network-Traffic Traces (2008)

John Mark Agosta, Jaideep Ch, Frédéric Giroire, Carl Livadas, Jing Xu

As part of a larger project on distributed anomaly detection using local host traffic, (See Agosta et al. [2005], Dash et al. [2006]) we review some current analysis and modeling of enterprise...

Towards Autonomic Grid Data Management with Virtualized Distributed File Systems (2008)

Ming Zhao, Jing Xu, Renato J. Figueiredo

Grid data management is a challenging task because of the heterogeneous, dynamic and largescale nature of Grid environments. This paper proposes an autonomic Grid data management architecture based...

Elevation of circulating big endothelin-1: an independent prognostic factor for tumor recurrence and survival in patients with esophageal squamous cell carcinoma (2008)

Jiao, Wenjie, Xu, Jing, Zheng, Jinsheng, Shen, Yi, Lin, Lesheng, Li, Jian

Abstract Background Endothelin(ET) axis plays a key role in many tumor progression and metastasis via various mechanisms such as angiogenesis, mediating extracellular matrix degradation and...

On elusive permutation groups of squarefree degree (2008)

Jing Xu

An elusive permutation group is a transitive permutation group with no fixed point free elements of prime orders. In this paper we proved that each minimal normal subgroup of an elusive permutation...

Mechanistic Evaluation of Granular Base Stabilization Systems in Saskatchewan (2008)

Xu, Jing

Saskatchewan Ministry of Highways and Infrastructure (MHI) is responsible for maintaining approximately 26,100 km of two lane equivalent highways network. Most highways in Saskatchewan are...

Mechanistic Evaluation of Granular Base Stabilization Systems in Saskatchewan (2008)

Xu, Jing

Saskatchewan Ministry of Highways and Infrastructure (MHI) is responsible for maintaining approximately 26,100 km of two lane equivalent highways network. Most highways in Saskatchewan are...

GRID Highly reliable (2008)

Ming Zhao, Jing Xu, Renato Figueiredo

� Grid data provisioning • Wide-area latency/bandwidth, dynamism of resources … • How to provide data with application-tailored optimizations? job job job Compute server job job job Compute...

Mechanistic Evaluation of Granular Base Stabilization Systems in Saskatchewan (2008)

Xu, Jing

Saskatchewan Ministry of Highways and Infrastructure (MHI) is responsible for maintaining approximately 26,100 km of two lane equivalent highways network. Most highways in Saskatchewan are...

EFFECT OF SN CONCENTRATION ON THE CORROSION RESISTANCE OF PB-SN ALLOYS IN H2SO4 SOLUTION (2008)

Jing Xu, Xingbo Liu, Xiaogang Li, Ever Barbero, Chaofang Dong

The effect of Sn concentration on the corrosion resistance of Pb-Sn alloy in H2SO4 electrolyte was investigated by potentiodynamic polarization. A new approach to calculate the exchange current...

Liquid Metal Corrosion of 316L Stainless Steel, 410 Stainless Steel, and 1015 Carbon Steel in a Molten Zinc Bath (2008)

Jing Xu, Mark A. Bright, Xingbo Liu, Ever Barbero

Corrosion tests of 1015 low-carbon steel and two stainless steels (410 and 316L) were conducted in a pure zinc bath (99.98 wt pct Zn) in order to better understand the reaction mechanisms that occur...

Antiinflammatory Constituents from the Roots of Smilax bockii warb. (2008)

Xu, Jing, Li, Xian, Zhang, Peng, Li, Zhan-Lin, Wang, Yi

From $70\%$ ethanol extract of the roots of Smilax bockii warb., seven flavonoids, kaempferol (1), $kaempferol-7-O-\beta-D-glucopyranoside$ (2), quercetin (3), isorhamnetin (4),...

Antibacterial Constituents from Fruit Bodies of Ascomyce Bulgaria inquinans (2008)

Zhang, Peng, Li, Xian, Li, Ning, Xu, Jing, Li, Zhan-Lin, Wang, Yi, ...

Two ergosterins and two triterpenoids were isolated from the dried fruit bodies of Ascomyce Bulgaria inquinans. By means of chemical (hydrolysis) and spectroscopic methods (NMR, EIMS), their...

Antimicrobial Constituents from Fruits of Ailanthus Altissima SWINGLE (2008)

Zhao, Chun-Chao, Shao, Jian-Hua, Li, Xian, Xu, Jing, Zhang, Peng

A new naturally occurring sterol, compound 5, and six known stigmasterols were isolated from fruits of Ailanthus altissima Swingle by repeated column chromatography and RP-HPLC. Their structures were...

2-(4,6-Dimethylpyrimidin-2-ylsulfanyl)-N-(4-methylpyridin-2-yl)acetamide (2008)

Dong Liang, Li-Xing Gao, Yan Gao, Jing Xu, Wei Wang

The non-H atoms of the title molecule, C14H16N4OS, are coplanar, with an r.m.s. deviation of 0.039 Å. The dihedral angle between the two aromatic rings is 2.4 (2)°. An...

Ethyl 1-(6-chloro-3-pyridylmethyl)-5-ethoxymethyleneamino-1H-1,2,3-triazole-4-carboxylate (2008)

Xiao-Bao Chen, Feng-Mei Sun, Hai-Tao Gao, Jing Xu, Ai-Hua Zheng

In the title compound, C14H16ClN5O3, there is evidence for significant electron delocalization in the triazolyl system. Intramolecular C—H...O and intermolecular C—H...O and C—H...N...

Ethyl 1-[(2-chloro-1,3-thiazol-5-yl)methyl]-5-methyl-1H-1,2,3-triazole-4-carboxylate (2008)

Xiao-Bao Chen, Feng-Mei Sun, Jing Xu, Zuan Ma, Ai-Hua Zheng

In the title compound, C10H11ClN4O2S, the triazole ring carries methyl and ethoxycarbonyl groups and is bound via a methylene bridge to a chlorothiazole unit. There is also evidence for significant...

The Laplacian Spread of a Tree (2008)

Yi-Zheng Fan, Jing Xu, Yi Wang, Dong Liang

The Laplacian spread of a graph is defined to be the difference between the largest eigenvalue and the second smallest eigenvalue of the Laplacian matrix of the graph. In this paper, we show that the...

VEGF Trap induces antiglioma effect at different stages of disease (2008)

Gomez-Manzano, Candelaria, Holash, Jocelyn, Fueyo, Juan, Xu, Jing, Conrad, Charles A., Aldape, Kenneth D., ...

Pathological angiogenesis is a hallmark of cancer, specifically of glioblastomas, the most malignant and common primary brain tumor. Vascular endothelial growth factor (VEGF) is the key protein in...

Non-ohmic spin transport in n-type doped silicon (2007)

Jang, Hyuk-Jae, Xu, Jing, Li, Jing, Huang, Biqin, Appelbaum, Ian

We demonstrate the injection and transport of spin-polarized electrons through n-type doped silicon with in-plane spin-valve and perpendicular magnetic field spin precession and dephasing ("Hanle...

Acknowledgments (2007)

Jing Xu, Supervisors Sorour Falahati, Bartosz Mielczarek

In this report, the throughput and the delay performance of the Rate Compatible Punctured Turbo (RCPT) codes on Rayleigh fading channels are evaluated through simulations and compared with the...

Identity Based Threshold Proxy Signature. Cryptology ePrint Archive (2007)

Jing Xu, Zhenfeng Zhang, Dengguo Feng

Abstract. Identity-based (ID-based) public key cryptosystem can be a good alternative for certificate-based public key setting, especially when efficient key management and moderate security are...

Examination of the Therapeutic Potential of Delta-24-RGD in Brain Tumor Stem Cells: Role of Autophagic Cell Death (2007)

Jiang, Hong, Gomez-Manzano, Candelaria, Aoki, Hiroshi, Alonso, Marta M., Kondo, Seiji, McCormick, Frank, ...

The eradication of brain tumor stem cells is essential for long-term brain tumor remission after treatment. In this study, we examined the therapeutic potential of an oncolytic adenovirus,...

A transcriptome anatomy of human colorectal cancers (2006)

Lü, Bingjian, Xu, Jing, Lai, Maode, Zhang, Hao, Chen, Jian

Abstract Background Accumulating databases in human genome research have enabled integrated genome-wide study on complicated diseases such as cancers. A practical approach is to mine a global...

On closures of finite permutation groups (2006)

Xu, Jing

[Formulae and special characters in this field can only be approximated. See PDF version for accurate reproduction] In this thesis we investigate the properties of k-closures of certain finite...

On closures of finite permutation groups (2006)

Xu, Jing

[Formulae and special characters in this field can only be approximated. See PDF version for accurate reproduction] In this thesis we investigate the properties of k-closures of certain finite...

On closures of finite permutation groups (2006)

Xu, Jing

[Formulae and special characters in this field can only be approximated. See PDF version for accurate reproduction] In this thesis we investigate the properties of k-closures of certain finite...

On closures of finite permutation groups (2006)

Xu, Jing

[Formulae and special characters in this field can only be approximated. See PDF version for accurate reproduction] In this thesis we investigate the properties of k-closures of certain finite...

On closures of finite permutation groups (2006)

Xu, Jing

[Formulae and special characters in this field can only be approximated. See PDF version for accurate reproduction] In this thesis we investigate the properties of k-closures of certain finite...

On closures of finite permutation groups (2006)

Xu, Jing

[Formulae and special characters in this field can only be approximated. See PDF version for accurate reproduction] In this thesis we investigate the properties of k-closures of certain finite...

On closures of finite permutation groups (2006)

Xu, Jing

[Formulae and special characters in this field can only be approximated. See PDF version for accurate reproduction] In this thesis we investigate the properties of k-closures of certain finite...

On closures of finite permutation groups (2006)

Xu, Jing

[Formulae and special characters in this field can only be approximated. See PDF version for accurate reproduction] In this thesis we investigate the properties of k-closures of certain finite...

Probing the collective vibrational dynamics of a protein in liquid water by terahertz absorption spectroscopy (2006)

Xu, Jing, Plaxco, Kevin W., Allen, S. James

Biological polymers are expected to exhibit functionally relevant, global, and subglobal collective modes in the terahertz (THz) frequency range (i.e., picosecond timescale). In an effort to monitor...

On closures of finite permutation groups (2006)

Xu, Jing

[Formulae and special characters in this field can only be approximated. See PDF version for accurate reproduction] In this thesis we investigate the properties of k-closures of certain finite...

L.: Performance Modeling and Prediction of Enterprise JavaBeans with Layered Queuing Network Templates (2005)

Jing Xu, Re Oufimtsev, Murray Woodside, Liam Murphy

Component technologies, such as Enterprise Java Beans (EJB) and.NET, are used in enterprise servers with requirements for high performance and scalability. This work considers performance prediction...

Modeling the effects of repetitions, study time, and similarity on associative recognition of verbal and nonverbal stimuli / (2005)

Xu, Jing.

To examine the effects of repetition, study time, and similarity on associative recognition (AR), two experiments were conducted and a new model of associative recognition that accounts for both...

Expression of Transcription Factor E2F1 and Telomerase in Glioblastomas: Mechanistic Linkage and Prognostic Significance (2005)

Alonso, Marta M., Fueyo, Juan, Shay, Jerry W., Aldape, Kenneth D., Jiang, Hong, Lee, Ok-Hee, ...

Background: Several tumor suppressor pathways have been identified as modulators of telomerase function. We examined the functional role of the retinoblastoma-E2F1 pathway in regulating telomerase...

Ethnic identity, socialization factors, and culture-specific consumption behavior (2004)

Xu, Jing, Shim, Soyeon, Lotz, Sherry, Almeida, David

This study is designed to discover the degree to which ethnic identity and socialization factors influence the culture-specific consumption behaviors of Asian American young adults, in general as...

Parallel Multistage Decision Feedback Equalizer for Single-Carrier Layered Space-Time Systems in Frequency-Selective Channels (2004)

Jing Xu, Haifeng Wang, Shixin Cheng, Ming Chen

Space-time transmission techniques can greatly increase the spectral efficiency. In this paper, a parallel multistage decision feedback equalizer (PMDFE) is proposed for single-carrier layered...

Id-based proxy signature using bilinear pairings. Cryptology ePrint Archive, Report 2004/206 (2004)

Jing Xu, Zhenfeng Zhang, Dengguo Feng

Abstract. Identity-based (ID-based) public key cryptosystem can be a good alternative for certificate-based public key setting, especially when efficient key management and moderate security are...

Parallel Multistage Decision Feedback Equalizer for Single-Carrier Layered Space-Time Systems in Frequency-Selective Channels (2004)

Ming Chen, Shixin Cheng, Haifeng Wang, Jing Xu

Space-time transmission techniques can greatly increase the spectral efficiency. In this paper, a parallel multistage decision feedback equalizer (PMDFE) is proposed for single-carrier layered...

Parallel Multistage Decision Feedback Equalizer for Single-Carrier Layered Space-Time Systems in Frequency-Selective Channels (2004)

Jing Xu, Haifeng Wang, Shixin Cheng, Ming Chen

Space-time transmission techniques can greatly increase the spectral efficiency. In this paper, a parallel multistage decision feedback equalizer (PMDFE) is proposed for single-carrier layered...

Attack on an Identification Scheme Based on Gap Die-Hellman Problem (2003)

Jing Xu, Deng-guo Feng

In [KK], a new identification scheme based on the Gap Di#e-Hellman problem was proposed at SCIS 2002, and it is shown that the scheme is secure against active attacks under the Gap Di#e-Hellman...

Performance Analysis of a Software Design Using the UML Profile for Schedulability, Performance and Time (2003)

Jing Xu, Murray Woodside, Dorina Petriu

As software development cycles become shorter, it is more important to evaluate non-functional properties of a design, such as its performance (in the sense of response times, capacity and...

Effective generation of transgenic pigs and mice by linker based sperm-mediated gene transfer. (2002)

Chang, Keejong, Qian, Jin, Jiang, MeiSheng, Liu, Yi-Hsin, Wu, Ming-Che, Chen, Chi-Dar, ...

Abstract Background Transgenic animals have become valuable tools for both research and applied purposes. The current method of gene transfer, microinjection, which is widely used in transgenic mouse...

Communicating technical information to the Chinese: A cultural analysis with guidelines (1996)

Xu, Jing

As China's immensity and rapidly growing economy attract more and more international investors, manufacturers, and other business people, the need to study how to communicate technical information to...

A study of the starting characteristics of an unlubricated journal bearing / (1995)

Xu, Jing.

Thesis (M.S.)--State University of New York at Binghamton, Watson School of Engineering and Applied Science, 1995.

Stereochemistry-dependent bending in oligonucleotide duplexes induced by site-specific covalent benzo[a]pyrene diol epoxide-guanine lesions (1995)

Xu, Rong, Mao, Bing, Xu, Jing, Li, Bin, Birke, Sheryl, Swenberg, Charles E., ...

The apparent persistence length of enzymatically linearized plBI30 plasmid DNA molecules {small tilde}2300 bp long, as measured by a hydrodynamic linear flow dlchroism method, Is markedly decreased...

Synthesis and characterization of covalent adducts derived from the binding of benzo[a]pyrene diol epoxide to a -GGG- sequence in a deoxyoligonucleotide (1995)

Mao, Bing, Xu, Jing, Li, Bin, Margulis, Leonid A., Smirnov, Sergey, Ya, Nai-Qi, ...

Direct synthesis and purification procedures are described for the preparation of adducts derived from the covalent binding of 7R,8S-dihydroxy-9S,10R-epoxy-7,8,9,10-tetrahydro-benzo[a]pyrene...

Phosphoenolpyruvate-Insensitive Phosphofructokinase Isozyme from Thermus thermophilus HB8 (1991)

Xu, Jing, Oshima, Tairo, Yoshida, Masasuke

In the previous paper [Xu, J., Oshima, T., & Yoshida, M. (1990) J. Mol Biol 215, 697–606], we reported that phosphofructokinase from Thermus thermophilus is allosterically inhibited by...

Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor β signaling by targeting Smads to the ubiquitin–proteasome pathway

Xu, Jing, Attisano, Liliana

Biological signals for transforming growth factor β (TGF-β) are transduced through transmembrane serine/threonine kinase receptors that signal to a family of intracellular mediators known as Smads....

A Role for Tlg1p in the Transport of Proteins within the Golgi Apparatus of Saccharomyces cerevisiae

Coe, John G. S., Lim, Anthony C. B., Xu, Jing, Hong, Wanjin

Members of the syntaxin protein family participate in the docking–fusion step of several intracellular vesicular transport events. Tlg1p has been identified as a nonessential protein required for...

Pan1p, End3p, and Sla1p, Three Yeast Proteins Required for Normal Cortical Actin Cytoskeleton Organization, Associate with Each Other and Play Essential Roles in Cell Wall Morphogenesis

Tang, Hsin-Yao, Xu, Jing, Cai, Mingjie

The EH domain proteins Pan1p and End3p of budding yeast have been known to form a complex in vivo and play important roles in organization of the actin cytoskeleton and endocytosis. In this report,...

Pharmacokinetics of Azithromycin Administered Alone and with Atovaquone in Human Immunodeficiency Virus-Infected Children

Ngo, Leock Y., Yogev, Ram, Dankner, Wayne M., Hughes, Walter T., Burchett, Sandra, Xu, Jing, ...

To evaluate if atovaquone (ATQ) interacts pharmacokinetically with azithromycin (AZ) in human immunodeficiency virus-infected children, 10 subjects (ages, 4 to 13 years) were randomized in a...

Pharmacokinetics of Dapsone Administered Daily and Weekly in Human Immunodeficiency Virus-Infected Children

Mirochnick, Mark, Cooper, Ellen, McIntosh, Ken, Xu, Jing, Lindsey, Jane, Jacobus, David, ...

Although dapsone is a commonly used alternative agent for prophylaxis against Pneumocystis carinii pneumonia in children intolerant to trimethoprim-sulfamethoxazole, there are few data that describe...

Phase I Safety and Pharmacokinetics Study of Micronized Atovaquone in Human Immunodeficiency Virus-Infected Infants and Children

Hughes, Walter, Dorenbaum, Alejandro, Yogev, Ram, Beauchamp, Belinda, Xu, Jing, McNamara, James, ...

A phase I dose-escalating safety and pharmacokinetic study evaluated an oral suspension of micronized atovaquone (m-atovaquone) in infants and children stratified into age groups from 1 month to 12...

G protein-coupled receptor kinase 4 gene variants in human essential hypertension

Felder, Robin A., Sanada, Hironobu, Xu, Jing, Yu, Pei-Ying, Wang, Zheng, Watanabe, Hidetsuna, ...

Essential hypertension has a heritability as high as 30–50%, but its genetic cause(s) has not been determined despite intensive investigation. The renal dopaminergic system exerts a pivotal role in...

Molecular Epidemiology of Vibrio cholerae O139 in China: Polymorphism of Ribotypes and CTX Elements

Qu, Mei, Xu, Jing, Ding, Yanpeng, Wang, Ruibai, Liu, Peng, Kan, Biao, ...

Vibrio cholerae O139, the second etiological serogroup of cholera, triggered the first outbreak of O139 cholera in China in 1993. To analyze the clone polymorphism of O139 isolates in China, 117...

Foxo1 mediates insulin action on apoC-III and triglyceride metabolism

Altomonte, Jennifer, Cong, Lin, Harbaran, Sonal, Richter, Anja, Xu, Jing, Meseck, Marcia, ...

The apolipoprotein apoC-III plays an important role in plasma triglyceride metabolism. It is predominantly produced in liver, and its hepatic expression is inhibited by insulin. To elucidate the...

Identification of Novel Subgenomic RNAs and Noncanonical Transcription Initiation Signals of Severe Acute Respiratory Syndrome Coronavirus

Hussain, Snawar, Pan, Ji'an, Chen, Yu, Yang, Yalin, Xu, Jing, Peng, Yu, ...

The expression of the genomic information of severe acute respiratory syndrome coronavirus (SARS CoV) involves synthesis of a nested set of subgenomic RNAs (sgRNAs) by discontinuous transcription. In...

Taxation and Economic Performance: A Cross-Country Comparison and Model Sensitivity Analysis

Jing Xu

This paper is a companion to the two-sector, computable endogenous growth model of government spending and taxation developed by Xu (1997). This paper studies the sensitivity of the results to the...

Sustained Angiopoietin-2 Expression Disrupts Vessel Formation and Inhibits Glioma Growth1

Lee, Ok-Hee, Fueyo, Juan, Xu, Jing, Yung, W K Alfred, Lemoine, Michael G, Lang, Frederick F, ...

Systematic analyses of the expression of angiogenic regulators in cancer models should yield useful information for the development of novel therapies for malignant gliomas. In this study, we...

Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor β signaling by targeting Smads to the ubiquitin–proteasome pathway

Xu, Jing, Attisano, Liliana

Biological signals for transforming growth factor β (TGF-β) are transduced through transmembrane serine/threonine kinase receptors that signal to a family of intracellular mediators known as Smads....

A Role for Tlg1p in the Transport of Proteins within the Golgi Apparatus of Saccharomyces cerevisiae

Coe, John G. S., Lim, Anthony C. B., Xu, Jing, Hong, Wanjin

Members of the syntaxin protein family participate in the docking–fusion step of several intracellular vesicular transport events. Tlg1p has been identified as a nonessential protein required for...

Pan1p, End3p, and Sla1p, Three Yeast Proteins Required for Normal Cortical Actin Cytoskeleton Organization, Associate with Each Other and Play Essential Roles in Cell Wall Morphogenesis

Tang, Hsin-Yao, Xu, Jing, Cai, Mingjie

The EH domain proteins Pan1p and End3p of budding yeast have been known to form a complex in vivo and play important roles in organization of the actin cytoskeleton and endocytosis. In this report,...

Pharmacokinetics of Azithromycin Administered Alone and with Atovaquone in Human Immunodeficiency Virus-Infected Children

Ngo, Leock Y., Yogev, Ram, Dankner, Wayne M., Hughes, Walter T., Burchett, Sandra, Xu, Jing, ...

To evaluate if atovaquone (ATQ) interacts pharmacokinetically with azithromycin (AZ) in human immunodeficiency virus-infected children, 10 subjects (ages, 4 to 13 years) were randomized in a...

Pharmacokinetics of Dapsone Administered Daily and Weekly in Human Immunodeficiency Virus-Infected Children

Mirochnick, Mark, Cooper, Ellen, McIntosh, Ken, Xu, Jing, Lindsey, Jane, Jacobus, David, ...

Although dapsone is a commonly used alternative agent for prophylaxis against Pneumocystis carinii pneumonia in children intolerant to trimethoprim-sulfamethoxazole, there are few data that describe...

Phase I Safety and Pharmacokinetics Study of Micronized Atovaquone in Human Immunodeficiency Virus-Infected Infants and Children

Hughes, Walter, Dorenbaum, Alejandro, Yogev, Ram, Beauchamp, Belinda, Xu, Jing, McNamara, James, ...

A phase I dose-escalating safety and pharmacokinetic study evaluated an oral suspension of micronized atovaquone (m-atovaquone) in infants and children stratified into age groups from 1 month to 12...

G protein-coupled receptor kinase 4 gene variants in human essential hypertension

Felder, Robin A., Sanada, Hironobu, Xu, Jing, Yu, Pei-Ying, Wang, Zheng, Watanabe, Hidetsuna, ...

Essential hypertension has a heritability as high as 30–50%, but its genetic cause(s) has not been determined despite intensive investigation. The renal dopaminergic system exerts a pivotal role in...

Molecular Epidemiology of Vibrio cholerae O139 in China: Polymorphism of Ribotypes and CTX Elements

Qu, Mei, Xu, Jing, Ding, Yanpeng, Wang, Ruibai, Liu, Peng, Kan, Biao, ...

Vibrio cholerae O139, the second etiological serogroup of cholera, triggered the first outbreak of O139 cholera in China in 1993. To analyze the clone polymorphism of O139 isolates in China, 117...

Foxo1 mediates insulin action on apoC-III and triglyceride metabolism

Altomonte, Jennifer, Cong, Lin, Harbaran, Sonal, Richter, Anja, Xu, Jing, Meseck, Marcia, ...

The apolipoprotein apoC-III plays an important role in plasma triglyceride metabolism. It is predominantly produced in liver, and its hepatic expression is inhibited by insulin. To elucidate the...

Identification of Novel Subgenomic RNAs and Noncanonical Transcription Initiation Signals of Severe Acute Respiratory Syndrome Coronavirus

Hussain, Snawar, Pan, Ji'an, Chen, Yu, Yang, Yalin, Xu, Jing, Peng, Yu, ...

The expression of the genomic information of severe acute respiratory syndrome coronavirus (SARS CoV) involves synthesis of a nested set of subgenomic RNAs (sgRNAs) by discontinuous transcription. In...

Sustained Angiopoietin-2 Expression Disrupts Vessel Formation and Inhibits Glioma Growth1

Lee, Ok-Hee, Fueyo, Juan, Xu, Jing, Yung, W K Alfred, Lemoine, Michael G, Lang, Frederick F, ...

Systematic analyses of the expression of angiogenic regulators in cancer models should yield useful information for the development of novel therapies for malignant gliomas. In this study, we...

Vector-Virus Mutualism Accelerates Population Increase of an Invasive Whitefly

Jiu, Min, Zhou, Xue-Ping, Tong, Lin, Xu, Jing, Yang, Xiao, Wan, Fang-Hao, ...

The relationships between plant viruses, their herbivore vectors and host plants can be beneficial, neutral, or antagonistic, depending on the species involved. This variation in relationships may...

Maternal exposure to polycyclic aromatic hydrocarbons diminishes murine ovarian reserve via induction of Harakiri

Jurisicova, Andrea, Taniuchi, Asako, Li, Han, Shang, Yuan, Antenos, Monica, Detmar, Jacqui, ...

Maternal smoking during pregnancy is associated with a variety of adverse neonatal outcomes including altered reproductive performance. Herein we provide molecular evidence for a pathway involved in...

Probing the collective vibrational dynamics of a protein in liquid water by terahertz absorption spectroscopy

Xu, Jing, Plaxco, Kevin W., Allen, S. James

Biological polymers are expected to exhibit functionally relevant, global, and subglobal collective modes in the terahertz (THz) frequency range (i.e., picosecond timescale). In an effort to monitor...

MIF Signal Transduction Initiated by Binding to CD74

Leng, Lin, Metz, Christine N., Fang, Yan, Xu, Jing, Donnelly, Seamas, Baugh, John, ...

Macrophage migration inhibitory factor (MIF) accounts for one of the first cytokine activities to have been described, and it has emerged recently to be an important regulator of innate and adaptive...

Severe Intrauterine Growth Restriction Pregnancies Have Increased Placental Endoglin Levels : Hypoxic Regulation via Transforming Growth Factor-β3

Yinon, Yoav, Nevo, Ori, Xu, Jing, Many, Ariel, Rolfo, Alessandro, Todros, Tullia, ...

Endoglin, a co-receptor for transforming growth factor (TGF)-β1 and -β3 is expressed in the human placenta and plays an important role in the pathogenesis of preeclampsia. Because preeclampsia is...

Ribosomal Proteins and Colorectal Cancer

Lai, Mao-De, Xu, Jing

The ribosome is essential for protein synthesis. The composition and structure of ribosomes from several organisms have been determined, and it is well documented that ribosomal RNAs (rRNAs) and...

Hybrids of the bHLH and bZIP Protein Motifs Display Different DNA-Binding Activities In Vivo vs. In Vitro

Chow, Hiu-Kwan, Xu, Jing, Shahravan, S. Hesam, De Jong, Antonia T., Chen, Gang, Shin, Jumi A.

Minimalist hybrids comprising the DNA-binding domain of bHLH/PAS (basic-helix-loop-helix/Per-Arnt-Sim) protein Arnt fused to the leucine zipper (LZ) dimerization domain from bZIP (basic...

Clofazimine Inhibits Human Kv1.3 Potassium Channel by Perturbing Calcium Oscillation in T Lymphocytes

Ren, Yunzhao R., Pan, Fan, Parvez, Suhel, Fleig, Andrea, Chong, Curtis R., Xu, Jing, ...

The Kv1.3 potassium channel plays an essential role in effector memory T cells and has been implicated in several important autoimmune diseases including multiple sclerosis, psoriasis and type 1...

Differential RhoA Dynamics in Migratory and Stationary Cells Measured by FRET and Automated Image Analysis

Eichorst, John Paul, Lu, Shaoying, Xu, Jing, Wang, Yingxiao

Genetically-encoded biosensors based on fluorescence resonance energy transfer (FRET) have been widely applied to study the spatiotemporal regulation of molecular activity in live cells with high...

Serum Activity of Platelet-Activating Factor Acetylhydrolase Is a Potential Clinical Marker for Leptospirosis Pulmonary Hemorrhage

Yang, Junwei, Zhang, Yixuan, Xu, Jing, Geng, Yan, Chen, Xiaoying, Yang, Hongliang, ...

Pulmonary hemorrhage has been recognized as a major, often lethal, manifestation of severe leptospirosis albeit the pathogenesis remains unclear. The Leptospira interrogans virulent serogroup...

Lysosome Biogenesis Mediated by vps-18 Affects Apoptotic Cell Degradation in Caenorhabditis elegans

Xiao, Hui, Chen, Didi, Fang, Zhou, Xu, Jing, Sun, Xiaojuan, Song, Song, ...

Appropriate clearance of apoptotic cells (cell corpses) is an important step of programmed cell death. Although genetic and biochemical studies have identified several genes that regulate the...

Visualization of Polarized Membrane Type 1 Matrix Metalloproteinase Activity in Live Cells by Fluorescence Resonance Energy Transfer Imaging*S⃞

Ouyang, Mingxing, Lu, Shaoying, Li, Xiao-Yan, Xu, Jing, Seong, Jihye, Giepmans, Ben N. G., ...

Membrane type 1 matrix metalloproteinase (MT1-MMP) plays a critical role in cancer cell biology by proteolytically remodeling the extracellular matrix. Utilizing fluorescence resonance energy...

Community-based study on CKD subjects and the associated risk factors

Chen, Nan, Wang, Weiming, Huang, Yanping, Shen, Pingyan, Pei, Daoling, Yu, Haijin, ...

Background. The study was performed to investigate the prevalence, awareness and the risk factors of chronic kidney disease (CKD) in the community population in Shanghai, China.

Port site and distant metastases of gallbladder cancer after laparoscopic cholecystectomy diagnosed by positron emission tomography

Hu, Jian-Bin, Sun, Xiao-Nan, Xu, Jing, He, Chao

We report port site and distant metastases of unsuspected gallbladder cancer after laparoscopic cholecystectomy diagnosed by positron emission tomography (PET) in two patients. Patient 1, a...