Jiri Neuzil

a-Tocopheryl succinate induces cytostasis and apoptosis in osteosarcoma cells: the role of E2F1 (2005)

Yes

Alleva, Renata, Benassi, Maria Serena, Tomasetti, Marco, Gellert, Nina, Ponticelli, Francesca, Borgha, Battista, ...

Yes

a-Lipoic acid supplementation inhibits oxidative damage accelerating chronic wound healing in patients undergoing hyperbaric oxygen therapy (2005)

Alleva, Renata, Nasole, Emmanuele, Donato, Ferruccio Di, Borghi, Battista, Neuzil, Jiri, Tomasetti, Marco

Yes

a-Tocopheryl succinate inhibits malignant mesothelioma by disrupting the Fibroblast Growth Factor Autocrine Loop: Mechanism and the role of oxidative stress (2005)

Stapelberg, Michael, Gellert, Nina, Swettenham, Emma Angela, Tomasetti, Marco, Witting, Paul K., Procopio, Antonio, ...

Yes

a-Tocopheryl succinate selectively induces apoptosis in neuroblastoma cells: Potential therapy of malignancies of the nervous system? (2005)

Swettenham, Emma Angela, Whiting, Paul K., Salvatore, Brian A., Neuzil, Jiri

Vitamin E (VE) analogues, epitomized by ±-tocopheryl succinate (±-TOS), are potent inducers of apoptosis and anti-cancer agents. Here, we tested their effect on the highly malignant N-type...

Vitamin E amides, a new class of vitamin E analogues with enhanced pro-apoptotic activity. (2005)

Tomic-Vatic, Adisa, EyTina, John, Chapman, James, Mahdavian, Elahe, Neuzil, Jiri, Salvatore, Brian A.

Yes

Oxidative stress in myocardial ischemia reperfusion injury: a renewed focus on a long-standing area of research. (2005)

Neuzil, Jiri, Rayner, Benjamin S., Lowe, Harry C., Witting, Paul K.

Yes

Vitamin E analogs trigger apoptosis in HER2/erbB2-overexpressing breast cancer cells by signaling via the mitochondrial pathway (2005)

Wang, Xiu-Fang, Whiting, Paul K., Salvatore, Brian A., Neuzil, Jiri

α-Tocopheryl succinate (α-TOS) is a redox-silent vitamin E (VE) analog with high pro-apoptotic and anti-neoplastic activity. Here we investigated whether α-TOS and several novel VE analogs kill...

Hepatic processing determines dual activity of α-tocopheryl succinate: a novel paradigm for a shift in biological activity due to pro-vitamin-to-vitamin conversion (2005)

α-Tocopheryl succinate induces cytostasis and apoptosis in osteosarcoma cells: the role of E2F1 (2005)

Yes

Alleva, Renata, Benassi, Maria Serena, Tomasetti, Marco, Gellert, Nina, Ponticelli, Francesca, Borgha, Battista, ...

Yes

α-Lipoic acid supplementation inhibits oxidative damage accelerating chronic wound healing in patients undergoing hyperbaric oxygen therapy (2005)

Alleva, Renata, Nasole, Emmanuele, Donato, Ferruccio Di, Borghi, Battista, Neuzil, Jiri, Tomasetti, Marco

Hyperbaric oxygen (HBO) therapy is successfully used for the treatment of a variety of conditions. However, prolonged exposure to high concentrations of oxygen induces production of reactive oxygen...

α-Tocopheryl succinate inhibits malignant mesothelioma by disrupting the Fibroblast Growth Factor Autocrine Loop: Mechanism and the role of oxidative stress (2005)

Stapelberg, Michael, Gellert, Nina, Cowie, Emma Angela, Tomasetti, Marco, Witting, Paul K., Procopio, Antonio, ...

We have studied the potential effect against human malignant mesotheliomas (MM) of α-tocopheryl succinate (α-TOS), a redox-silent vitamin E analog with strong pro-apoptotic and anti-cancer...

α-Tocopheryl succinate selectively induces apoptosis in neuroblastoma cells: Potential therapy of malignancies of the nervous system? (2005)

Cowie, Emma Angela, Witting, Paul K., Salvatore, Brian A., Neuzil, Jiri

Vitamin E (VE) analogues, epitomized by α-tocopheryl succinate (α-TOS), are potent inducers of apoptosis and anti-cancer agents. Here, we tested their effect on the highly malignant N-type...

Vitamin E amides, a new class of vitamin E analogues with enhanced pro-apoptotic activity. (2005)

Tomic-Vatic, Adisa, EyTina, John, Chapman, James, Mahdavian, Elahe, Neuzil, Jiri, Salvatore, Brian A.

Vitamin E (VE) analogues, epitomized by -tocopheryl succinate (-TOS), are proapoptotic agents with selective antineoplastic activity. The molecule of -TOS comprises several structurally and...

Oxidative stress in myocardial ischemia reperfusion injury: a renewed focus on a long-standing area of research. (2005)

Neuzil, Jiri, Rayner, Benjamin S., Lowe, Harry C., Witting, Paul K.

Advances in the treatment of coronary artery disease have seen a significant drop in mortality and morbidity particularly amongst patients with acute myocardial infarction (MI). In particular,...

Vitamin E analogs trigger apoptosis in HER2/erbB2-overexpressing breast cancer cells by signaling via the mitochondrial pathway (2005)

Wang, Xiu-Fang, Whiting, Paul K., Salvatore, Brian A., Neuzil, Jiri

α-Tocopheryl succinate (α-TOS) is a redox-silent vitamin E (VE) analog with high pro-apoptotic and anti-neoplastic activity. Here we investigated whether α-TOS and several novel VE analogs kill...

Hepatic processing determines dual activity of α-tocopheryl succinate: a novel paradigm for a shift in biological activity due to pro-vitamin-to-vitamin conversion (2005)

α-Tocopheryl succinate induces cytostasis and apoptosis in osteosarcoma cells: the role of E2F1 (2005)

Alleva, Renata, Benassi, Maria Serena, Tomasetti, Marco, Gellert, Nina, Ponticelli, Francesca, Borgha, Battista, ...

α-Lipoic acid supplementation inhibits oxidative damage accelerating chronic wound healing in patients undergoing hyperbaric oxygen therapy (2005)

Alleva, Renata, Nasole, Emmanuele, Donato, Ferruccio Di, Borghi, Battista, Neuzil, Jiri, Tomasetti, Marco

Hyperbaric oxygen (HBO) therapy is successfully used for the treatment of a variety of conditions. However, prolonged exposure to high concentrations of oxygen induces production of reactive oxygen...

α-Tocopheryl succinate inhibits malignant mesothelioma by disrupting the Fibroblast Growth Factor Autocrine Loop: Mechanism and the role of oxidative stress (2005)

Stapelberg, Michael, Gellert, Nina, Cowie, Emma Angela, Tomasetti, Marco, Witting, Paul K., Procopio, Antonio, ...

We have studied the potential effect against human malignant mesotheliomas (MM) of α-tocopheryl succinate (α-TOS), a redox-silent vitamin E analog with strong pro-apoptotic and anti-cancer...

α-Tocopheryl succinate selectively induces apoptosis in neuroblastoma cells: Potential therapy of malignancies of the nervous system? (2005)

Cowie, Emma Angela, Witting, Paul K., Salvatore, Brian A., Neuzil, Jiri

Vitamin E (VE) analogues, epitomized by α-tocopheryl succinate (α-TOS), are potent inducers of apoptosis and anti-cancer agents. Here, we tested their effect on the highly malignant N-type...

Vitamin E amides, a new class of vitamin E analogues with enhanced pro-apoptotic activity. (2005)

Tomic-Vatic, Adisa, EyTina, John, Chapman, James, Mahdavian, Elahe, Neuzil, Jiri, Salvatore, Brian A.

Vitamin E (VE) analogues, epitomized by -tocopheryl succinate (-TOS), are proapoptotic agents with selective antineoplastic activity. The molecule of -TOS comprises several structurally and...

Oxidative stress in myocardial ischemia reperfusion injury: a renewed focus on a long-standing area of research. (2005)

Neuzil, Jiri, Rayner, Benjamin S., Lowe, Harry C., Witting, Paul K.

Advances in the treatment of coronary artery disease have seen a significant drop in mortality and morbidity particularly amongst patients with acute myocardial infarction (MI). In particular,...

Vitamin E analogs trigger apoptosis in HER2/erbB2-overexpressing breast cancer cells by signaling via the mitochondrial pathway (2005)

Wang, Xiu-Fang, Whiting, Paul K., Salvatore, Brian A., Neuzil, Jiri

α-Tocopheryl succinate (α-TOS) is a redox-silent vitamin E (VE) analog with high pro-apoptotic and anti-neoplastic activity. Here we investigated whether α-TOS and several novel VE analogs kill...

Hepatic processing determines dual activity of α-tocopheryl succinate: a novel paradigm for a shift in biological activity due to pro-vitamin-to-vitamin conversion (2005)

α-Tocopheryl succinate induces cytostasis and apoptosis in osteosarcoma cells: the role of E2F1 (2005)

Redox-silent vitamin E analogues, represented by α-tocopheryl succinate, are potent anti-cancer drugs with potential secondary bioactivity due to their processing in vivo. Here we verified the...

Alleva, Renata, Benassi, Maria Serena, Tomasetti, Marco, Gellert, Nina, Ponticelli, Francesca, Borgha, Battista, ...

α-Tocopheryl succinate (α-TOS), a redox-inactive analog of vitamin E, induces cell cycle arrest, differentiation, and triggers apoptosis. We examined the ability of α-TOS to induce cytostasis...

α-Lipoic acid supplementation inhibits oxidative damage accelerating chronic wound healing in patients undergoing hyperbaric oxygen therapy (2005)

Alleva, Renata, Nasole, Emmanuele, Donato, Ferruccio Di, Borghi, Battista, Neuzil, Jiri, Tomasetti, Marco

Hyperbaric oxygen (HBO) therapy is successfully used for the treatment of a variety of conditions. However, prolonged exposure to high concentrations of oxygen induces production of reactive oxygen...

α-Tocopheryl succinate inhibits malignant mesothelioma by disrupting the Fibroblast Growth Factor Autocrine Loop: Mechanism and the role of oxidative stress (2005)

Stapelberg, Michael, Gellert, Nina, Cowie, Emma Angela, Tomasetti, Marco, Witting, Paul K., Procopio, Antonio, ...

We have studied the potential effect against human malignant mesotheliomas (MM) of α-tocopheryl succinate (α-TOS), a redox-silent vitamin E analog with strong pro-apoptotic and anti-cancer...

α-Tocopheryl succinate selectively induces apoptosis in neuroblastoma cells: Potential therapy of malignancies of the nervous system? (2005)

Cowie, Emma Angela, Witting, Paul K., Salvatore, Brian A., Neuzil, Jiri

Vitamin E (VE) analogues, epitomized by α-tocopheryl succinate (α-TOS), are potent inducers of apoptosis and anti-cancer agents. Here, we tested their effect on the highly malignant N-type...

Vitamin E amides, a new class of vitamin E analogues with enhanced pro-apoptotic activity. (2005)

Tomic-Vatic, Adisa, EyTina, John, Chapman, James, Mahdavian, Elahe, Neuzil, Jiri, Salvatore, Brian A.

Vitamin E (VE) analogues, epitomized by -tocopheryl succinate (-TOS), are proapoptotic agents with selective antineoplastic activity. The molecule of -TOS comprises several structurally and...

Oxidative stress in myocardial ischemia reperfusion injury: a renewed focus on a long-standing area of research. (2005)

Neuzil, Jiri, Rayner, Benjamin S., Lowe, Harry C., Witting, Paul K.

Advances in the treatment of coronary artery disease have seen a significant drop in mortality and morbidity particularly amongst patients with acute myocardial infarction (MI). In particular,...

alpha-Tocopheryl succinate and TRAIL selectively synergise in induction of apoptosis in human malignant mesothelioma cells (2004)

Tomasetti, M, Rippo, MR, Alleva, R, Moretti, S, Andera, L, Neuzil, Jiri, ...

Yes

Enzymatically modified low-density lipoprotein upregulates CD36 in low-differentiated monocytic cells in a peroxisome proliferator-activated receptor-gamma-dependent way (2004)

Jostarndt, K., Rubic, T., Kuhn, H., Anthonsen, M.W., Andera, L., Gellert, Nina, ...

Peroxisome proliferator-activated receptor-³ (PPAR³) has been suggested to upregulate CD36. Since free oxidized polyunsaturated fatty acids are PPAR³ ligands, we studied the effects of LDL...

A vitamin E analogue suppresses malignant mesothelioma in a preclinical model: a future drug against a fatal neoplastic disease? (2004)

Tomasetti, Marco, Gellert, Nina, Procopio, Antonio, Neuzil, Jiri

Yes

alpha-Tocopheryl succinate inhibits proliferation of mesothelioma cells by differential down-regulation of fibroblast growth factor receptors (2004)

Stapelberg, Michael, Tomasetti, Marco, Alleva, Renata, Gellert, Nina, Procopio, Antonio, Neuzil, Jiri, ...

Yes

Vitamin E analogues: a new class of inducers of apoptosis with selective anti-cancer effects (2004)

Neuzil, Jiri, Tomasetti, Marco, Mellick, Albert, Alleva, Renata, Salvatore, Brian A., Birringer, Marc, ...

Yes

Aging of cardiac myocytes in culture oxidative stress, lipofuscin accumulation, and mitochondrial turnover (2004)

Terman, Alexei, Dalen, Helge, Eaton, John W., Neuzil, Jiri, Brunk, Ulf T.

Yes

Sensitization of mesothelioma to TRAIL apoptosis by inhibition of histone deacetylase: role of Bcl-xL down-regulation (2004)

Neuzil, Jiri, Swettenham, Emma Angela, Gellert, Nina, W. Baumeister

Yes

Oxidative stress mediates toxicity of pyridoxal isonicotinoyl hydrozone analogs (2004)

Cyclopentanone prostaglandins induce endothelial cell apoptosis independent of peroxisome proliferator activated receptor-gamma (2004)

Yes

Erl, Wolfgang, Weber, Christian, Zernecke, Alma, Neuzil, Jiri, Vosseler, Claudia A., Kim, Hyo Jung, ...

Yes

α-Tocopheryl succinate and TRAIL selectively synergise in induction of apoptosis in human malignant mesothelioma cells (2004)

Tomasetti, M, Rippo, MR, Alleva, R, Moretti, S, Andera, L, Neuzil, Jiri, ...

Yes

Enzymatically modified low-density lipoprotein upregulates CD36 in low-differentiated monocytic cells in a peroxisome proliferator-activated receptor-gamma-dependent way (2004)

Jostarndt, K., Rubic, T., Kuhn, H., Anthonsen, M.W., Andera, L., Gellert, Nina, ...

Peroxisome proliferator-activated receptor-γ (PPARγ) has been suggested to upregulate CD36. Since free oxidized polyunsaturated fatty acids are PPARγ ligands, we studied the effects of LDL...

A vitamin E analogue suppresses malignant mesothelioma in a preclinical model: a future drug against a fatal neoplastic disease? (2004)

Tomasetti, Marco, Gellert, Nina, Procopio, Antonio, Neuzil, Jiri

Yes

α-Tocopheryl succinate inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors (2004)

Stapelberg, Michael, Tomasetti, Marco, Alleva, Renata, Gellert, Nina, Procopio, Antonio, Neuzil, Jiri

α-Tocopheryl succinate (α-TOS), a redox-silent analogue of vitamin E, inhibits malignant mesotheliomas (MM) in a pre-clinical model. Here we investigated the underlying mechanism. Exposure of MM...

Vitamin E analogues: a new class of inducers of apoptosis with selective anti-cancer effects (2004)

Neuzil, Jiri, Tomasetti, Marco, Mellick, Albert Sleiman, Alleva, Renata, Salvatore, Brian A., Birringer, Marc, ...

Yes

Aging of cardiac myocytes in culture: oxidative stress, lipofuscin accumulation, and mitochondrial turnover (2004)

Terman, Alexei, Dalen, Helge, Eaton, John W., Neuzil, Jiri, Brunk, Ulf T.

Oxidative stress is believed to be an important contributor to aging, mainly affecting long-lived postmitotic cells such as cardiac myocytes and neurons. Aging cells accumulate functionally effete,...

Sensitization of mesothelioma to TRAIL apoptosis by inhibition of histone deacetylase: role of Bcl-xL down-regulation (2004)

Neuzil, Jiri, Cowie, Emma Angela, Gellert, Nina

The TNF-related apoptosis-inducing ligand (TRAIL) is an immunological inducer of apoptosis selectively killing many, but not all, cancer cells. Malignant mesothelioma (MM) is fatal neoplasia with no...

Oxidative stress mediates toxicity of pyridoxal isonicotinoyl hydrazone analogs (2004)

Cyclopentanone prostaglandins induce endothelial cell apoptosis independent of peroxisome proliferator activated receptor-γ (2004)

Pyridoxal isonicotinoyl hydrazone (PIH) and many of its analogs are effective iron chelators in vivo and in vitro, and are of interest for the treatment of secondary iron overload. Because previous...

Erl, Wolfgang, Weber, Christian, Zernecke, Alma, Neuzil, Jiri, Vosseler, Claudia A., Kim, Hyo Jung, ...

Yes

α-Tocopheryl succinate and TRAIL selectively synergise in induction of apoptosis in human malignant mesothelioma cells (2004)

Tomasetti, M, Rippo, MR, Alleva, R, Moretti, S, Andera, L, Neuzil, Jiri, ...

Enzymatically modified low-density lipoprotein upregulates CD36 in low-differentiated monocytic cells in a peroxisome proliferator-activated receptor-gamma-dependent way (2004)

Jostarndt, K., Rubic, T., Kuhn, H., Anthonsen, M.W., Andera, L., Gellert, Nina, ...

Peroxisome proliferator-activated receptor-γ (PPARγ) has been suggested to upregulate CD36. Since free oxidized polyunsaturated fatty acids are PPARγ ligands, we studied the effects of LDL...

A vitamin E analogue suppresses malignant mesothelioma in a preclinical model: a future drug against a fatal neoplastic disease? (2004)

Tomasetti, Marco, Gellert, Nina, Procopio, Antonio, Neuzil, Jiri

α-Tocopheryl succinate inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors (2004)

Stapelberg, Michael, Tomasetti, Marco, Alleva, Renata, Gellert, Nina, Procopio, Antonio, Neuzil, Jiri

α-Tocopheryl succinate (α-TOS), a redox-silent analogue of vitamin E, inhibits malignant mesotheliomas (MM) in a pre-clinical model. Here we investigated the underlying mechanism. Exposure of MM...

Vitamin E analogues: a new class of inducers of apoptosis with selective anti-cancer effects (2004)

Neuzil, Jiri, Tomasetti, Marco, Mellick, Albert Sleiman, Alleva, Renata, Salvatore, Brian A., Birringer, Marc, ...

Aging of cardiac myocytes in culture: oxidative stress, lipofuscin accumulation, and mitochondrial turnover (2004)

Terman, Alexei, Dalen, Helge, Eaton, John W., Neuzil, Jiri, Brunk, Ulf T.

Oxidative stress is believed to be an important contributor to aging, mainly affecting long-lived postmitotic cells such as cardiac myocytes and neurons. Aging cells accumulate functionally effete,...

Sensitization of mesothelioma to TRAIL apoptosis by inhibition of histone deacetylase: role of Bcl-xL down-regulation (2004)

Neuzil, Jiri, Cowie, Emma Angela, Gellert, Nina

The TNF-related apoptosis-inducing ligand (TRAIL) is an immunological inducer of apoptosis selectively killing many, but not all, cancer cells. Malignant mesothelioma (MM) is fatal neoplasia with no...

Oxidative stress mediates toxicity of pyridoxal isonicotinoyl hydrazone analogs (2004)

Cyclopentanone prostaglandins induce endothelial cell apoptosis independent of peroxisome proliferator activated receptor-γ (2004)

Pyridoxal isonicotinoyl hydrazone (PIH) and many of its analogs are effective iron chelators in vivo and in vitro, and are of interest for the treatment of secondary iron overload. Because previous...

Erl, Wolfgang, Weber, Christian, Zernecke, Alma, Neuzil, Jiri, Vosseler, Claudia A., Kim, Hyo Jung, ...

α-Tocopheryl succinate and TRAIL selectively synergise in induction of apoptosis in human malignant mesothelioma cells (2004)

Tomasetti, M, Rippo, MR, Alleva, R, Moretti, S, Andera, L, Neuzil, Jiri, ...

Malignant mesothelioma (MM) is a fatal type of neoplasia with poor therapeutic prognosis, largely due to resistance to apoptosis. We investigated the apoptotic effect of alpha-tocopheryl succinate...

Enzymatically modified low-density lipoprotein upregulates CD36 in low-differentiated monocytic cells in a peroxisome proliferator-activated receptor-gamma-dependent way (2004)

Jostarndt, K., Rubic, T., Kuhn, H., Anthonsen, M.W., Andera, L., Gellert, Nina, ...

Peroxisome proliferator-activated receptor-γ (PPARγ) has been suggested to upregulate CD36. Since free oxidized polyunsaturated fatty acids are PPARγ ligands, we studied the effects of LDL...

A vitamin E analogue suppresses malignant mesothelioma in a preclinical model: a future drug against a fatal neoplastic disease? (2004)

Tomasetti, Marco, Gellert, Nina, Procopio, Antonio, Neuzil, Jiri

α-Tocopheryl succinate inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors (2004)

Stapelberg, Michael, Tomasetti, Marco, Alleva, Renata, Gellert, Nina, Procopio, Antonio, Neuzil, Jiri

α-Tocopheryl succinate (α-TOS), a redox-silent analogue of vitamin E, inhibits malignant mesotheliomas (MM) in a pre-clinical model. Here we investigated the underlying mechanism. Exposure of MM...

Vitamin E analogues: a new class of inducers of apoptosis with selective anti-cancer effects (2004)

Neuzil, Jiri, Tomasetti, Marco, Mellick, Albert Sleiman, Alleva, Renata, Salvatore, Brian A., Birringer, Marc, ...

In spite of unrelenting effort, the net incidence of neoplastic diseases appears not to have been curbed. While some types of cancer have been suppressed significantly, others are either stagnating...

Aging of cardiac myocytes in culture: oxidative stress, lipofuscin accumulation, and mitochondrial turnover (2004)

Terman, Alexei, Dalen, Helge, Eaton, John W., Neuzil, Jiri, Brunk, Ulf T.

Oxidative stress is believed to be an important contributor to aging, mainly affecting long-lived postmitotic cells such as cardiac myocytes and neurons. Aging cells accumulate functionally effete,...

Sensitization of mesothelioma to TRAIL apoptosis by inhibition of histone deacetylase: role of Bcl-xL down-regulation (2004)

Neuzil, Jiri, Cowie, Emma Angela, Gellert, Nina

The TNF-related apoptosis-inducing ligand (TRAIL) is an immunological inducer of apoptosis selectively killing many, but not all, cancer cells. Malignant mesothelioma (MM) is fatal neoplasia with no...

Oxidative stress mediates toxicity of pyridoxal isonicotinoyl hydrazone analogs (2004)

Cyclopentanone prostaglandins induce endothelial cell apoptosis independent of peroxisome proliferator activated receptor-γ (2004)

Pyridoxal isonicotinoyl hydrazone (PIH) and many of its analogs are effective iron chelators in vivo and in vitro, and are of interest for the treatment of secondary iron overload. Because previous...

Erl, Wolfgang, Weber, Christian, Zernecke, Alma, Neuzil, Jiri, Vosseler, Claudia A., Kim, Hyo Jung, ...

Cyclopentenone prostaglandins (CP-PG), such as prostaglandin A1 (PGA1) or 15-deoxy-12,14-prostaglandin J2 (PGJ2), induce apoptosis in different cell types. PGJ2 is also a potent activator of the...

Vitamin E succinate and cancer treatment: a vitamin E prototype for selective antitumour activity (2003)

Vitamin E analogues as inducers of apoptosis: structure-function relation (2003)

Yes

Birringer, M, EyTina, J H, Salvatore, B A, Neuzil, Jiri

Yes

Pyridoxal isonicotinoyl hydrazone analogs induce apoptosis in hematopoietic cells due to their iron-chelating properties (2003)

Buss, Joan L., Neuzil, Jiri, Gellert, Nina, Weber, Christian, Ponka, Prem

Analogs of pyridoxal isonicotinoyl hydrazone (PIH) are of interest as iron chelators for the treatment of secondary iron overload and cancer. PIH, salicylaldehyde isonicotinoyl hydrazone (SIH), and...

Mitochondrial recycling and aging of cardiac myocytes: the role of autophagocytosis (2003)

Terman, Alexei, Dalen, Helge, Eaton, John W., Neuzil, Jiri, Brunk, Ulf T.

The mechanisms of mitochondrial alterations in aged post-mitotic cells, including formation of so-called giant' mitochondria, are poorly understood. To test whether these large mitochondria might...

Mitochondria play a cerntral role in apoptosis induced by a-Tocopheryl succinate, an agent with antineoplastic activity: Comparison with receptor-mediated pro-apoptotic signaling (2003)

Weber, Tobias, Dalen, Helge, Andera, Ladislav, Negre-Salvayre, Anne, Auge, Nathalie, Sticha, Martin, ...

Yes

a-Tocopheryl succinate sensitises a T lymphoma cell line to TRAIL-induced apoptosis by suppressing NF-kB activation (2003)

Vitamin E succinate and cancer treatment: a vitamin E prototype for selective antitumour activity (2003)

Yes

Vitamin E analogues as inducers of apoptosis: structure-function relation (2003)

Great hope has been given to micronutrients as anticancer agents, since they present natural compounds with beneficial effects for normal cells and tissues. One of these is vitamin E (VE), an...

Birringer, M, EyTina, J H, Salvatore, B A, Neuzil, Jiri

Yes

Pyridoxal isonicotinoyl hydrazone analogs induce apoptosis in hematopoietic cells due to their iron-chelating properties (2003)

Buss, Joan L., Neuzil, Jiri, Gellert, Nina, Weber, Christian, Ponka, Prem

Analogs of pyridoxal isonicotinoyl hydrazone (PIH) are of interest as iron chelators for the treatment of secondary iron overload and cancer. PIH, salicylaldehyde isonicotinoyl hydrazone (SIH), and...

Mitochondrial recycling and aging of cardiac myocytes: the role of autophagocytosis (2003)

Terman, Alexei, Dalen, Helge, Eaton, John W., Neuzil, Jiri, Brunk, Ulf T.

The mechanisms of mitochondrial alterations in aged post-mitotic cells, including formation of so-called 'giant' mitochondria, are poorly understood. To test whether these large mitochondria might...

Mitochondria play a central role in apoptosis induced by α-Tocopheryl succinate, an agent with antineoplastic activity: Comparison with receptor-mediated pro-apoptotic signaling (2003)

Weber, Tobias, Dalen, Helge, Andera, Ladislav, Negre-Salvayre, Anne, Auge, Nathalie, Sticha, Martin, ...

Yes

α-Tocopheryl succinate sensitises a T lymphoma cell line to TRAIL-induced apoptosis by suppressing NF-kB activation (2003)

Vitamin E succinate and cancer treatment: a vitamin E prototype for selective antitumour activity (2003)

Yes

Vitamin E analogues as inducers of apoptosis: structure-function relation (2003)

Great hope has been given to micronutrients as anticancer agents, since they present natural compounds with beneficial effects for normal cells and tissues. One of these is vitamin E (VE), an...

Birringer, M, EyTina, J H, Salvatore, B A, Neuzil, Jiri

Pyridoxal isonicotinoyl hydrazone analogs induce apoptosis in hematopoietic cells due to their iron-chelating properties (2003)

Buss, Joan L., Neuzil, Jiri, Gellert, Nina, Weber, Christian, Ponka, Prem

Analogs of pyridoxal isonicotinoyl hydrazone (PIH) are of interest as iron chelators for the treatment of secondary iron overload and cancer. PIH, salicylaldehyde isonicotinoyl hydrazone (SIH), and...

Mitochondrial recycling and aging of cardiac myocytes: the role of autophagocytosis (2003)

Terman, Alexei, Dalen, Helge, Eaton, John W., Neuzil, Jiri, Brunk, Ulf T.

The mechanisms of mitochondrial alterations in aged post-mitotic cells, including formation of so-called 'giant' mitochondria, are poorly understood. To test whether these large mitochondria might...

Mitochondria play a central role in apoptosis induced by α-Tocopheryl succinate, an agent with antineoplastic activity: Comparison with receptor-mediated pro-apoptotic signaling (2003)

Weber, Tobias, Dalen, Helge, Andera, Ladislav, Negre-Salvayre, Anne, Auge, Nathalie, Sticha, Martin, ...

α-Tocopheryl succinate sensitises a T lymphoma cell line to TRAIL-induced apoptosis by suppressing NF-kB activation (2003)

Vitamin E succinate and cancer treatment: a vitamin E prototype for selective antitumour activity (2003)

Vitamin E analogues as inducers of apoptosis: structure-function relation (2003)

Great hope has been given to micronutrients as anticancer agents, since they present natural compounds with beneficial effects for normal cells and tissues. One of these is vitamin E (VE), an...

Birringer, M, EyTina, J H, Salvatore, B A, Neuzil, Jiri

Recent results show that alpha-tocopheryl succinate (alpha-TOS) is a proapoptotic agent with antineoplastic activity. As modifications of the vitamin E (VE) molecule may affect its apoptogenic...

Pyridoxal isonicotinoyl hydrazone analogs induce apoptosis in hematopoietic cells due to their iron-chelating properties (2003)

Buss, Joan L., Neuzil, Jiri, Gellert, Nina, Weber, Christian, Ponka, Prem

Analogs of pyridoxal isonicotinoyl hydrazone (PIH) are of interest as iron chelators for the treatment of secondary iron overload and cancer. PIH, salicylaldehyde isonicotinoyl hydrazone (SIH), and...

Mitochondrial recycling and aging of cardiac myocytes: the role of autophagocytosis (2003)

Terman, Alexei, Dalen, Helge, Eaton, John W., Neuzil, Jiri, Brunk, Ulf T.

The mechanisms of mitochondrial alterations in aged post-mitotic cells, including formation of so-called 'giant' mitochondria, are poorly understood. To test whether these large mitochondria might...

Mitochondria play a central role in apoptosis induced by α-Tocopheryl succinate, an agent with antineoplastic activity: Comparison with receptor-mediated pro-apoptotic signaling (2003)

Weber, Tobias, Dalen, Helge, Andera, Ladislav, Negre-Salvayre, Anne, Auge, Nathalie, Sticha, Martin, ...

α-Tocopheryl succinate (α-TOS) is a semisynthetic vitamin E analogue with high pro-apoptotic and anti-neoplastic activity [Weber, T et al. (2002) Clin. Cancer Res. 8, 863−869]. Previous studies...

α-Tocopheryl succinate sensitises a T lymphoma cell line to TRAIL-induced apoptosis by suppressing NF-kB activation (2003)

Vitamin E analogs: a new class of multiple action agents with anti-neoplastic and anti-atherogenic acitivity (2002)

Activation of nuclear factor-kappaB (NF-kappaB) can interfere with induction of apoptosis triggered by the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL; Apo2L). Therefore, agents...

Neuzil, Jiri, Kagedal, K., Andera, L., Weber, C., Brunk, U. T., Dr. Mels Sluyser

Yes

Decreased apoptotic response of inclusion-cell disease fibroblasts: a consequence of lysosomal enzyme missorting? (2002)

Terman, Alexei, Neuzil, Jiri, Kagedal, Katarina, Ollinger, Karin, Brunk, Ulf T., U. Lendahl

Yes

Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 Ligand) in vivo (2002)

Weber, Tobias, Lu, Min, Andera, Ladislav, Lahm, Harald, Gellert, Nina, Fariss, Marc W., ...

Yes

alpha Tocopheryl succinate, an agent with in vivo anti-tumour activity, induces apoptosis by causing lysosomal instability (2002)

Neuzil, Jiri, Zhao, Ming, Ostermann, Georg, Sticha, Martin, Gellert, Nina, Weber, Christian, ...

Yes

alpha Tocopheryl succinate epitomizes a compound with a shift in biological activity due to pro-vitamin-to vitamin conversion (2002)

Neuzil, Jiri, W. Baumeister

Yes

The European perspective on vitamin E: current knowledge and future research (2002)

Brigelius-Flohe, Regina, Kelly, Frank J, Salonen, Jukka T, Neuzil, Jiri, Zingg, Jean-Marc, Azzi, Angelo

Yes

The role of oxidative stress in the toxicity of pyridoxal isonicotinoyl hydrazone (PIH) analogues (2002)

Buss, J. L., Neuzil, Jiri, Ponka, P., John Wrigglesworth

Yes

Vitamin E analogs: a new class of multiple action agents with anti-neoplastic and anti-atherogenic acitivity (2002)

Neuzil, Jiri, Kagedal, K., Andera, L., Weber, C., Brunk, U. T.

The incidence of cancer and atherosclerosis, two most common causes of death in developed countries, has been stagnating or, even, increasing. Drugs effective against such conditions are needed and,...

Decreased apoptotic response of inclusion-cell disease fibroblasts: a consequence of lysosomal enzyme missorting? (2002)

Terman, Alexei, Neuzil, Jiri, Kagedal, Katarina, Ollinger, Karin, Brunk, Ulf T.

To better understand the role of lysosomes in apoptosis, we compared the responses to apoptotic stimuli of normal fibroblasts with those of inclusion cells (I-cells), i.e., fibroblasts with impaired...

Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 Ligand) in vivo (2002)

Weber, Tobias, Lu, Min, Andera, Ladislav, Lahm, Harald, Gellert, Nina, Fariss, Marc W., ...

α -Tocopheryl succinate (α -TOS), a redox-inactive analogue of vitamin E, is a strong inducer of apoptosis, whereas -tocopherol (α -TOH) lacks apoptogenic activity (J. Neuzil et al., FASEB J., 15:...

α-tocopheryl succinate, an agent with in vivo anti-tumour activity, induces apoptosis by causing lysosomal instability (2002)

Neuzil, Jiri, Zhao, Ming, Ostermann, Georg, Sticha, Martin, Gellert, Nina, Weber, Christian, ...

Certain vitamin E analogues, such as a-tocopheryl succinate (a-TOS), exhibit in vivo anti-tumour activity and, in vitro , induce apoptosis of cultured tumour cells. In the present study we report...

α -tocopheryl succinate epitomizes a compound with a shift in biological activity due to pro-vitamin-to vitamin conversion (2002)

The European perspective on vitamin E: current knowledge and future research (2002)

With the advent of the third millennium, a number of pathologies have been eradicated or taken under control. However, the incidences, of cancer and atherosclerosis, the two most common causes of...

Brigelius-Flohe, Regina, Kelly, Frank J, Salonen, Jukka T, Neuzil, Jiri, Zingg, Jean-Marc, Azzi, Angelo

Yes

The role of oxidative stress in the toxicity of pyridoxal isonicotinoyl hydrazone (PIH) analogues (2002)

Buss, J. L., Neuzil, Jiri, Ponka, P.

Pyridoxal isonicotinoyl hydrazone (PIH) analogues are effective iron chelators in vivo and in vitro, and may be of value for the treatment of secondary iron overload. The sensitivity of Jurkat cells...

Vitamin E analogs: a new class of multiple action agents with anti-neoplastic and anti-atherogenic acitivity (2002)

Neuzil, Jiri, Kagedal, K., Andera, L., Weber, C., Brunk, U. T.

The incidence of cancer and atherosclerosis, two most common causes of death in developed countries, has been stagnating or, even, increasing. Drugs effective against such conditions are needed and,...

Decreased apoptotic response of inclusion-cell disease fibroblasts: a consequence of lysosomal enzyme missorting? (2002)

Terman, Alexei, Neuzil, Jiri, Kagedal, Katarina, Ollinger, Karin, Brunk, Ulf T.

To better understand the role of lysosomes in apoptosis, we compared the responses to apoptotic stimuli of normal fibroblasts with those of inclusion cells (I-cells), i.e., fibroblasts with impaired...

Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 Ligand) in vivo (2002)

Weber, Tobias, Lu, Min, Andera, Ladislav, Lahm, Harald, Gellert, Nina, Fariss, Marc W., ...

α -Tocopheryl succinate (α -TOS), a redox-inactive analogue of vitamin E, is a strong inducer of apoptosis, whereas -tocopherol (α -TOH) lacks apoptogenic activity (J. Neuzil et al., FASEB J., 15:...

α-tocopheryl succinate, an agent with in vivo anti-tumour activity, induces apoptosis by causing lysosomal instability (2002)

Neuzil, Jiri, Zhao, Ming, Ostermann, Georg, Sticha, Martin, Gellert, Nina, Weber, Christian, ...

Certain vitamin E analogues, such as a-tocopheryl succinate (a-TOS), exhibit in vivo anti-tumour activity and, in vitro , induce apoptosis of cultured tumour cells. In the present study we report...

α -tocopheryl succinate epitomizes a compound with a shift in biological activity due to pro-vitamin-to vitamin conversion (2002)

The European perspective on vitamin E: current knowledge and future research (2002)

With the advent of the third millennium, a number of pathologies have been eradicated or taken under control. However, the incidences, of cancer and atherosclerosis, the two most common causes of...

Brigelius-Flohe, Regina, Kelly, Frank J, Salonen, Jukka T, Neuzil, Jiri, Zingg, Jean-Marc, Azzi, Angelo

The role of oxidative stress in the toxicity of pyridoxal isonicotinoyl hydrazone (PIH) analogues (2002)

Buss, J. L., Neuzil, Jiri, Ponka, P.

Pyridoxal isonicotinoyl hydrazone (PIH) analogues are effective iron chelators in vivo and in vitro, and may be of value for the treatment of secondary iron overload. The sensitivity of Jurkat cells...

Dissociation of apoptosis induction and CD36 upregulation by enzymatically modified low-density lipoprotein in monocytic cells (2002)

Jostarndt, Kristina, Gellert, Nina, Rubic, Tina, Weber, Christian, Kuhn, Hartmut, Johansen, Berit, ...

Modified low-density lipoprotein (LDL) has been implicated as an initiating or amplifying factor in atherogenesis. Some of its biological activities, such as apoptosis induction and upregulation of...

Dissociation of apoptosis induction and CD36 upregulation by enzymatically modified low-density lipoprotein in monocytic cells (2002)

Jostarndt, Kristina, Gellert, Nina, Rubic, Tina, Weber, Christian, Kuhn, Hartmut, Johansen, Berit, ...

Modified low-density lipoprotein (LDL) has been implicated as an initiating or amplifying factor in atherogenesis. Some of its biological activities, such as apoptosis induction and upregulation of...

Vitamin E analogs: a new class of multiple action agents with anti-neoplastic and anti-atherogenic acitivity (2002)

Neuzil, Jiri, Kagedal, K., Andera, L., Weber, C., Brunk, U. T.

The incidence of cancer and atherosclerosis, two most common causes of death in developed countries, has been stagnating or, even, increasing. Drugs effective against such conditions are needed and,...

Decreased apoptotic response of inclusion-cell disease fibroblasts: a consequence of lysosomal enzyme missorting? (2002)

Terman, Alexei, Neuzil, Jiri, Kagedal, Katarina, Ollinger, Karin, Brunk, Ulf T.

To better understand the role of lysosomes in apoptosis, we compared the responses to apoptotic stimuli of normal fibroblasts with those of inclusion cells (I-cells), i.e., fibroblasts with impaired...

Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 Ligand) in vivo (2002)

Weber, Tobias, Lu, Min, Andera, Ladislav, Lahm, Harald, Gellert, Nina, Fariss, Marc W., ...

α -Tocopheryl succinate (α -TOS), a redox-inactive analogue of vitamin E, is a strong inducer of apoptosis, whereas -tocopherol (α -TOH) lacks apoptogenic activity (J. Neuzil et al., FASEB J., 15:...

α-tocopheryl succinate, an agent with in vivo anti-tumour activity, induces apoptosis by causing lysosomal instability (2002)

Neuzil, Jiri, Zhao, Ming, Ostermann, Georg, Sticha, Martin, Gellert, Nina, Weber, Christian, ...

Certain vitamin E analogues, such as a-tocopheryl succinate (a-TOS), exhibit in vivo anti-tumour activity and, in vitro , induce apoptosis of cultured tumour cells. In the present study we report...

α -tocopheryl succinate epitomizes a compound with a shift in biological activity due to pro-vitamin-to vitamin conversion (2002)