Joakim Dillner

Efficacy of HPV DNA Testing With Cytology Triage and/or Repeat HPV DNA Testing in Primary Cervical Cancer Screening (2009)

Naucler, Pontus, Ryd, Walter, Törnberg, Sven, Strand, Anders, Wadell, Göran, Elfgren, Kristina, ...

Background Primary cervical screening with both human papillomavirus (HPV) DNA testing and cytological examination of cervical cells with a Pap test (cytology) has been evaluated in randomized...

Is Smoking an Independent Risk Factor for Invasive Cervical Cancer? A Nested Case-Control Study Within Nordic Biobanks (2009)

Kapeu, Aline Simen, Luostarinen, Tapio, Jellum, Egil, Dillner, Joakim, Hakama, Matti, Koskela, Pentti, ...

The strong correlation between smoking and exposure to oncogenic human papillomaviruses (HPVs) has made it difficult to verify the independent role of smoking in cervical carcinogenesis. Thus, the...

Screening-Preventable Cervical Cancer Risks: Evidence From a Nationwide Audit in Sweden (2008)

Andrae, Bengt, Kemetli, Levent, Sparén, Pär, Silfverdal, Lena, Strander, Björn, Ryd, Walter, ...

Background The effectiveness of cervical cancer screening programs differs widely in different populations. The reasons for these differences are unclear. Routine and comprehensive audits have been...

Activation of Maternal Epstein-Barr Virus Infection and Risk of Acute Leukemia in the Offspring (2007)

Tedeschi, Rosamaria, Bloigu, Aini, Ögmundsdottir, Helga M., Marus, Alessia, Dillner, Joakim, DePaoli, Paolo, ...

After identifying an association between maternal Epstein-Barr virus (EBV) reactivation and acute lymphoblastic leukemia (ALL), the authors analyzed a nested case-control study within Finnish and...

Heparin-based ELISA reduces background reactivity in virus-like particle-based papillomavirus serology. (2005)

Wang, Xiaohong, Sapp, Martin, Christensen, Neil D, Dillner, Joakim

The interaction between human papillomavirus (HPV) particles and cell surface heparan sulfate requires intact conformation of the HPV particles. Type-specific HPV serology is currently based on...

Virologic versus cytologic triage of women with equivocal Pap smears: a meta-analysis of the accuracy to detect high-grade intraepithelial neoplasia (2004)

Paraskevaidis, Evangelos, Martin-Hirsch, Pierre, Dillner, Joakim

BACKGROUND: The appropriate management of women with minor cytologic lesions in their cervix is unclear. We performed a meta-analysis to assess the accuracy of human papillomavirus (HPV) DNA testing...

Can genital-tract human papillomavirus infection and cervical cancer be prevented with a vaccine? (2004)

Dillner, Joakim, Brown, Darron R

Human papillomavirus (HPV) infection is the cause of squamous cell carcinoma of the uterine cervix. This causative relationship has provided the rationale and incentive for development of a...

Human papillomavirus genotypes in cervical cancers in Mozambique. (2004)

Naucler, Pontus, Da Costa, Flora Mabota, Ljungberg, Otto, Bugalho, Antonio, Dillner, Joakim

The distribution of human papillomavirus (HPV) types in cervical cancers is essential for design and evaluation of HPV type-specific vaccines. To follow up on a previous report that HPV types 35 and...

Virologic Versus Cytologic Triage of Women With Equivocal Pap Smears: A Meta-analysis of the Accuracy To Detect High-Grade Intraepithelial Neoplasia (2004)

Arbyn, Marc, Buntinx, Frank, Ranst, Marc Van, Paraskevaidis, Evangelos, Martin-Hirsch, Pierre, Dillner, Joakim

Background: The appropriate management of women with minor cytologic lesions in their cervix is unclear. We performed a meta-analysis to assess the accuracy of human papillomavirus (HPV) DNA testing...

Seroepidemiology of the human polyomaviruses. (2003)

Stolt, Annika, Sasnauskas, Kestutis, Koskela, Pentti, Lehtinen, Matti, Dillner, Joakim

To assess the stability of polyomavirus antibodies in serial samples over time and the incidence and age-specific prevalence of polyomavirus infections, we established enzyme immunoassays (EIAs)...

Time trends in incidence and prevalence of human papillomavirus type 6, 11 and 16 infections in Finland. (2003)

Laukkanen, Päivi, Koskela, Pentti, Pukkala, Eero, Dillner, Joakim, Läärä, Esa, Knekt, Paul, ...

Human papillomavirus (HPV) type 16 is the major cause of cervical carcinoma, the incidence of which is decreasing in western countries. In Finland the incidence is, however, increasing in women aged

Maternal Herpesvirus Infections and Risk of Acute Lymphoblastic Leukemia in the Offspring (2003)

Lehtinen, Matti, Koskela, Pentti, Ögmundsdottir, Helga M., Bloigu, Aini, Dillner, Joakim, Gudnadottir, Margret, ...

A critical role for infection in the etiology of childhood leukemia has repeatedly been suggested. The authors undertook a case-control study nested within national maternity cohorts with altogether...

Population-based type-specific prevalence of high-risk human papillomavirus infection in middle-aged Swedish Women. (2002)

Forslund, Ola, Antonsson, Annika, Edlund, Karin, Hansson, Bengt-Göran, ...

Human papillomavirus (HPV) DNA testing can be used to identify women at risk of the development of cervical cancer. The cost-effectiveness of HPV screening is dependent on the type-specific HPV...

Herpes Simplex Virus and Risk of Cervical Cancer: A Longitudinal, Nested Case-Control Study in the Nordic Countries (2002)

Lehtinen, Matti, Koskela, Pentti, Jellum, Egil, Bloigu, Aini, Anttila, Tarja, Hallmans, Göran, ...

Human papillomaviruses (HPVs) play the major role in cervical carcinogenesis. The authors reevaluated the role of herpes simplex virus type 2 (HSV-2) in this multistage process by conducting a...

Safety and Immunogenicity Trial in Adult Volunteers of a Human Papillomavirus 16 L1 Virus-Like Particle Vaccine (2001)

Harro, Clayton D., Pang, Yuk-Ying Susana, Roden, Richard B. S., Hildesheim, Allan, Wang, Zhaohui, Reynolds, Mary Jane, ...

Background: Studies in animal models have shown that systemic immunization with a papillomavirus virus-like particle (VLP) vaccine composed of L1, a major structural viral protein, can confer...

Association of Serum Immunoglobulin G Antibodies Against Human Papillomavirus Type 16 Capsids With Anal Epidermoid Carcinoma (1995)

Heino, Pirkko, Eklund, Carina, Fredriksson-Shanazarian, Vanoohi, Goldman, Sven, Schiller, John T., Dillner, Joakim

Background: Anal epidermoid carcinoma is a relatively rare tumor, but its incidence has been increasing rapidly during the past few years. Genetic material from the major oncogenic types of human...

HLA-A0201 and HLA-B7 binding peptides in the EBV-encoded EBNA-1, EBNA-2 and BZLF-1 proteins detected in the MHC class I stabilization assay. Low proportion of binding motifs for several HLA class I alleles in EBNA-1 (1995)

Stuber, György, Dillner, Joakim, Modrow, Susanne, Wolf, Hans, Székely, László, Klein, George, ...

B lymphocytes immortalized with EBV in vitro, lymphoblastoid cell lines (LCL), express eight EBV-encoded proteins, EBV nuclear antigens -1 to -6 (EBNA-1 to -6), and latent membrane proteins 1 and 2...

Structural analysis of the human papillomavirus type 16-E2 transactivator with antipeptide antibodies reveals a high mobility region linking the transactivation and the DNA-binding domains (1991)

Gauthier, Jean-Michel, Dillner, Joakim, Yaniv, Moshe

In order to probe the structure of the transcription factor encoded by the E2 Open Reading Frame of papillomaviruses, we raised polyclonal antibodies against a series of synthetic peptides thai cover...

A Novel and Rapid PCR-Based Method for Genotyping Human Papillomaviruses in Clinical Samples

Nelson, Joshua H., Hawkins, Gregory A., Edlund, Karin, Evander, Magnus, Kjellberg, Lennart, Wadell, Göran, ...

Many human papillomavirus (HPV) genotypes are associated with cervical carcinoma. We demonstrate the utility of an innovative technique for genotyping of HPV in cervical tissue samples. This method...

Viral Load of Human Herpesvirus 8 in Peripheral Blood of Human Immunodeficiency Virus-Infected Patients with Kaposi's Sarcoma

Tedeschi, Rosamaria, Enbom, Malin, Bidoli, Ettore, Linde, Annika, De Paoli, Paolo, Dillner, Joakim

Viral load is an important marker of activity of viral diseases for a number of viruses. We wished to evaluate whether the viral load of human herpesvirus 8 (HHV-8) in peripheral blood was a...

Comparison between the Hybrid Capture II Test and a PCR-Based Human Papillomavirus Detection Method for Diagnosis and Posttreatment Follow-Up of Cervical Intraepithelial Neoplasia

Söderlund-Strand, Anna, Rymark, Per, Andersson, Pia, Dillner, Joakim, Dillner, Lena

Human papillomavirus (HPV) infection is the major cause of cervical cancer and its precursor, cervical intraepithelial neoplasia (CIN), and HPV testing has therefore been proposed for improved...

A Novel and Rapid PCR-Based Method for Genotyping Human Papillomaviruses in Clinical Samples

Nelson, Joshua H., Hawkins, Gregory A., Edlund, Karin, Evander, Magnus, Kjellberg, Lennart, Wadell, Göran, ...

Many human papillomavirus (HPV) genotypes are associated with cervical carcinoma. We demonstrate the utility of an innovative technique for genotyping of HPV in cervical tissue samples. This method...

Viral Load of Human Herpesvirus 8 in Peripheral Blood of Human Immunodeficiency Virus-Infected Patients with Kaposi's Sarcoma

Tedeschi, Rosamaria, Enbom, Malin, Bidoli, Ettore, Linde, Annika, De Paoli, Paolo, Dillner, Joakim

Viral load is an important marker of activity of viral diseases for a number of viruses. We wished to evaluate whether the viral load of human herpesvirus 8 (HHV-8) in peripheral blood was a...

Comparison between the Hybrid Capture II Test and a PCR-Based Human Papillomavirus Detection Method for Diagnosis and Posttreatment Follow-Up of Cervical Intraepithelial Neoplasia

Söderlund-Strand, Anna, Rymark, Per, Andersson, Pia, Dillner, Joakim, Dillner, Lena

Human papillomavirus (HPV) infection is the major cause of cervical cancer and its precursor, cervical intraepithelial neoplasia (CIN), and HPV testing has therefore been proposed for improved...

In Vivo and In Vitro Intragenomic Rearrangement of TT Viruses▿

Leppik, Ludmila, Gunst, Karin, Lehtinen, Matti, Dillner, Joakim, Streker, Karin, De Villiers, Ethel-Michele

The in vitro replication of the Torque teno virus (TT virus) tth8 full-length genome and particle formation in a Hodgkin's lymphoma-derived cell line after transfection with cloned viral DNA were...

Multiplex Detection of Human Herpesviruses from Archival Specimens by Using Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry▿

Sjöholm, Malin I. L., Dillner, Joakim, Carlson, Joyce

The human herpesviruses are involved in a variety of diseases. Large-scale evaluation of the clinical and epidemiological importance of different herpesviruses requires high-throughput methods....

Long term predictive values of cytology and human papillomavirus testing in cervical cancer screening: joint European cohort study

Dillner, Joakim, Rebolj, Matejka, Birembaut, Philippe, Petry, Karl-Ulrich, Szarewski, Anne, Munk, Christian, ...

Objective To obtain large scale and generalisable data on the long term predictive value of cytology and human papillomavirus (HPV) testing for development of cervical intraepithelial neoplasia grade...

Modified General Primer PCR System for Sensitive Detection of Multiple Types of Oncogenic Human Papillomavirus▿

Söderlund-Strand, Anna, Carlson, Joyce, Dillner, Joakim

Human papillomavirus (HPV) infection is a necessary cause of cervical cancer and cervical dysplasia. Accurate and sensitive genotyping of multiple oncogenic HPVs is essential for a multitude of both...