Joann Hoskins

Identification and Characterization of the Penicillin-Binding Protein 2a of Streptococcus pneumoniae and Its Possible Role in Resistance to β-Lactam Antibiotics

Zhao, Genshi, Meier, Timothy I., Hoskins, Joann, McAllister, Kelly A.

To further understand the role of penicillin-binding protein 2a (PBP 2a) of Streptococcus pneumoniae in penicillin resistance, we confirmed the identity of the protein as PBP 2a. The PBP 2a protein...

Glycosyltransferase Domain of Penicillin-Binding Protein 2a from Streptococcus pneumoniae Is Membrane Associated†

Di Guilmi, Anne Marie, Mouz, Nicolas, Martin, Lydie, Hoskins, JoAnn, Jaskunas, S. Richard, Dideberg, Otto, ...

Penicillin-binding proteins (PBPs) are bacterial cytoplasmic membrane proteins that catalyze the final steps of the peptidoglycan synthesis. Resistance to β-lactams in Streptococcus pneumoniae is...

Genome of the Bacterium Streptococcus pneumoniae Strain R6

Hoskins, JoAnn, Alborn, William E., Arnold, Jeffrey, Blaszczak, Larry C., Burgett, Stanley, DeHoff, Bradley S., ...

Streptococcus pneumoniae is among the most significant causes of bacterial disease in humans. Here we report the 2,038,615-bp genomic sequence of the gram-positive bacterium S. pneumoniae R6. Because...

Gene Disruption Studies of Penicillin-Binding Proteins 1a, 1b, and 2a in Streptococcus pneumoniae

Hoskins, JoAnn, Matsushima, Patti, Mullen, Deborah L., Tang, Joseph, Zhao, Genshi, Meier, Timothy I., ...

The effects of inactivation of the genes encoding penicillin-binding protein 1a (PBP1a), PBP1b, and PBP2a in Streptococcus pneumoniae were examined. Insertional mutants did not exhibit detectable...

Identification, Purification, and Characterization of Transpeptidase and Glycosyltransferase Domains of Streptococcus pneumoniae Penicillin-Binding Protein 1a†

Di Guilmi, Anne Marie, Mouz, Nicolas, Andrieu, Jean-Pierre, Hoskins, JoAnn, Jaskunas, S. Richard, Gagnon, Jean, ...

Resistance to β-lactam antibiotics in Streptococcus pneumoniae is due to alteration of penicillin-binding proteins (PBPs). S. pneumoniae PBP 1a belongs to the class A high-molecular-mass PBPs, which...

Identification and Characterization of the Penicillin-Binding Protein 2a of Streptococcus pneumoniae and Its Possible Role in Resistance to β-Lactam Antibiotics

Zhao, Genshi, Meier, Timothy I., Hoskins, Joann, McAllister, Kelly A.

To further understand the role of penicillin-binding protein 2a (PBP 2a) of Streptococcus pneumoniae in penicillin resistance, we confirmed the identity of the protein as PBP 2a. The PBP 2a protein...

Glycosyltransferase Domain of Penicillin-Binding Protein 2a from Streptococcus pneumoniae Is Membrane Associated†

Di Guilmi, Anne Marie, Mouz, Nicolas, Martin, Lydie, Hoskins, JoAnn, Jaskunas, S. Richard, Dideberg, Otto, ...

Penicillin-binding proteins (PBPs) are bacterial cytoplasmic membrane proteins that catalyze the final steps of the peptidoglycan synthesis. Resistance to β-lactams in Streptococcus pneumoniae is...

Genome of the Bacterium Streptococcus pneumoniae Strain R6

Hoskins, JoAnn, Alborn, William E., Arnold, Jeffrey, Blaszczak, Larry C., Burgett, Stanley, DeHoff, Bradley S., ...

Streptococcus pneumoniae is among the most significant causes of bacterial disease in humans. Here we report the 2,038,615-bp genomic sequence of the gram-positive bacterium S. pneumoniae R6. Because...

Gene Disruption Studies of Penicillin-Binding Proteins 1a, 1b, and 2a in Streptococcus pneumoniae

Hoskins, JoAnn, Matsushima, Patti, Mullen, Deborah L., Tang, Joseph, Zhao, Genshi, Meier, Timothy I., ...

The effects of inactivation of the genes encoding penicillin-binding protein 1a (PBP1a), PBP1b, and PBP2a in Streptococcus pneumoniae were examined. Insertional mutants did not exhibit detectable...

Identification, Purification, and Characterization of Transpeptidase and Glycosyltransferase Domains of Streptococcus pneumoniae Penicillin-Binding Protein 1a†

Di Guilmi, Anne Marie, Mouz, Nicolas, Andrieu, Jean-Pierre, Hoskins, JoAnn, Jaskunas, S. Richard, Gagnon, Jean, ...

Resistance to β-lactam antibiotics in Streptococcus pneumoniae is due to alteration of penicillin-binding proteins (PBPs). S. pneumoniae PBP 1a belongs to the class A high-molecular-mass PBPs, which...