A newly discovered cholesteryl galactoside from Borrelia burgdorferi
Ben-Menachem, Gil, Kubler-Kielb, Joanna, Coxon, Bruce, Yergey, Alfred, Schneerson, Rachel
Two major glycolipids, which comprise ≈36% of the total lipid mass from Borrelia burgdorferi, the etiological agent of Lyme disease, were investigated. We determined the fatty acid type, sugar...
Schneerson, Rachel, Kubler-Kielb, Joanna, Liu, Teh-Yung, Dai, Zhong-Dong, Leppla, Stephen H., Yergey, Alfred, ...
Both the protective antigen (PA) and the poly(γ-d-glutamic acid) capsule (γdPGA) are essential for the virulence of Bacillus anthracis. A critical level of vaccine-induced IgG anti-PA confers...
Kubler-Kielb, Joanna, Coxon, Bruce, Schneerson, Rachel
Bacillus pumilus strain Sh18 cell wall polysaccharide (CWP), cross-reactive with the capsular polysaccharide of Haemophilus influenzae type b, was purified and its chemical structure was elucidated...
Kubler-Kielb, Joanna, Liu, Teh-Yung, Mocca, Christopher, Majadly, Fathy, Robbins, John B., Schneerson, Rachel
The capsule of Bacillus anthracis, composed of poly-γ-d-glutamic acid (γDPGA), is an essential virulence factor of B. anthracis. The capsule inhibits innate host defense through its antiphagocytic...
A newly discovered cholesteryl galactoside from Borrelia burgdorferi
Ben-Menachem, Gil, Kubler-Kielb, Joanna, Coxon, Bruce, Yergey, Alfred, Schneerson, Rachel
Two major glycolipids, which comprise ≈36% of the total lipid mass from Borrelia burgdorferi, the etiological agent of Lyme disease, were investigated. We determined the fatty acid type, sugar...
Schneerson, Rachel, Kubler-Kielb, Joanna, Liu, Teh-Yung, Dai, Zhong-Dong, Leppla, Stephen H., Yergey, Alfred, ...
Both the protective antigen (PA) and the poly(γ-d-glutamic acid) capsule (γdPGA) are essential for the virulence of Bacillus anthracis. A critical level of vaccine-induced IgG anti-PA confers...
Kubler-Kielb, Joanna, Coxon, Bruce, Schneerson, Rachel
Bacillus pumilus strain Sh18 cell wall polysaccharide (CWP), cross-reactive with the capsular polysaccharide of Haemophilus influenzae type b, was purified and its chemical structure was elucidated...
Kubler-Kielb, Joanna, Liu, Teh-Yung, Mocca, Christopher, Majadly, Fathy, Robbins, John B., Schneerson, Rachel
The capsule of Bacillus anthracis, composed of poly-γ-d-glutamic acid (γDPGA), is an essential virulence factor of B. anthracis. The capsule inhibits innate host defense through its antiphagocytic...
Kubler-Kielb, Joanna, Majadly, Fathy, Wu, Yimin, Narum, David L., Guo, Chunyan, Miller, Louis H., ...
Malaria is a leading cause of morbidity and mortality, estimated to cause >1 million childhood deaths annually. Plasmodium falciparum causes the most severe form of the disease. There is as yet no...
Pozsgay, Vince, Kubler-Kielb, Joanna, Schneerson, Rachel, Robbins, John B.
Endemic and epidemic shigellosis, an acute invasive disease of the lower intestines, afflicts millions of people worldwide with an estimated one million fatalities per annum at a low infectious dose....
Kubler-Kielb, Joanna, Vinogradov, Evgeny, Hu, Haijing, Leppla, Stephen H., Robbins, John B., Schneerson, Rachel
Bacillus anthracis is a spore-forming bacterium that causes anthrax in humans and in other mammals. The glycoprotein BclA (Bacillus collagen-like protein of anthracis) is a major constituent of the...
Robbins, John B., Kubler-Kielb, Joanna, Vinogradov, Evguenii, Mocca, Christopher, Pozsgay, Vince, Shiloach, Joseph, ...
Shigellosis, an enteric disease, is on the World Health Organization's priority prevention list. In one study, the Shigella sonnei O-specific polysaccharide (O-SP)-protein conjugate showed 72%...