VEGF Trap induces antiglioma effect at different stages of disease (2008)
Gomez-Manzano, Candelaria, Holash, Jocelyn, Fueyo, Juan, Xu, Jing, Conrad, Charles A., Aldape, Kenneth D., ...
Pathological angiogenesis is a hallmark of cancer, specifically of glioblastomas, the most malignant and common primary brain tumor. Vascular endothelial growth factor (VEGF) is the key protein in...
Excessive tumor-elaborated VEGF and its neutralization define a lethal paraneoplastic syndrome
Wong, Alex K., Alfert, Myra, Castrillon, Diego H., Shen, Qiong, Holash, Jocelyn, Yancopoulos, George D., ...
Vascular endothelial growth factor (VEGF) is a potent endothelial cell mitogen and key regulator of both physiologic and pathologic (e.g., tumor) angiogenesis. In the course of studies designed to...
VEGF-Trap: A VEGF blocker with potent antitumor effects
Holash, Jocelyn, Davis, Sam, Papadopoulos, Nick, Croll, Susan D., Ho, Lillian, Russell, Michelle, ...
Vascular endothelial growth factor (VEGF) plays a critical role during normal embryonic angiogenesis and also in the pathological angiogenesis that occurs in a number of diseases, including cancer....
Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma
Kim, Eugene S., Serur, Anna, Huang, Jianzhong, Manley, Christina A., McCrudden, Kimberly W., Frischer, Jason S., ...
Vascular endothelial growth factor (VEGF) plays a key role in human tumor angiogenesis. We compared the effects of inhibitors of VEGF with different specificities in a xenograft model of...
Huang, Jianzhong, Frischer, Jason S., Serur, Anna, Kadenhe, Angela, Yokoi, Akiko, McCrudden, Kimberly W., ...
Vascular endothelial growth factor (VEGF) is a critical promoter of blood vessel growth during embryonic development and tumorigenesis. To date, studies of VEGF antagonists have primarily focused on...
Saucier, Caroline, Khoury, Hanane, Lai, Ka-Man Venus, Peschard, Pascal, Dankort, David, Naujokas, Monica A., ...
The etiology and progression of a variety of human malignancies are linked to the deregulation of receptor tyrosine kinases (RTKs). To define the role of RTK-dependent signals in various oncogenic...
Gale, Nicholas W., Dominguez, Melissa G., Noguera, Irene, Pan, Li, Hughes, Virginia, Valenzuela, David M., ...
Vascular development depends on the highly coordinated actions of a variety of angiogenic regulators, most of which apparently act downstream of vascular endothelial growth factor (VEGF). One...
Excessive tumor-elaborated VEGF and its neutralization define a lethal paraneoplastic syndrome
Wong, Alex K., Alfert, Myra, Castrillon, Diego H., Shen, Qiong, Holash, Jocelyn, Yancopoulos, George D., ...
Vascular endothelial growth factor (VEGF) is a potent endothelial cell mitogen and key regulator of both physiologic and pathologic (e.g., tumor) angiogenesis. In the course of studies designed to...
VEGF-Trap: A VEGF blocker with potent antitumor effects
Holash, Jocelyn, Davis, Sam, Papadopoulos, Nick, Croll, Susan D., Ho, Lillian, Russell, Michelle, ...
Vascular endothelial growth factor (VEGF) plays a critical role during normal embryonic angiogenesis and also in the pathological angiogenesis that occurs in a number of diseases, including cancer....
Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma
Kim, Eugene S., Serur, Anna, Huang, Jianzhong, Manley, Christina A., McCrudden, Kimberly W., Frischer, Jason S., ...
Vascular endothelial growth factor (VEGF) plays a key role in human tumor angiogenesis. We compared the effects of inhibitors of VEGF with different specificities in a xenograft model of...
Huang, Jianzhong, Frischer, Jason S., Serur, Anna, Kadenhe, Angela, Yokoi, Akiko, McCrudden, Kimberly W., ...
Vascular endothelial growth factor (VEGF) is a critical promoter of blood vessel growth during embryonic development and tumorigenesis. To date, studies of VEGF antagonists have primarily focused on...
Saucier, Caroline, Khoury, Hanane, Lai, Ka-Man Venus, Peschard, Pascal, Dankort, David, Naujokas, Monica A., ...
The etiology and progression of a variety of human malignancies are linked to the deregulation of receptor tyrosine kinases (RTKs). To define the role of RTK-dependent signals in various oncogenic...
Gale, Nicholas W., Dominguez, Melissa G., Noguera, Irene, Pan, Li, Hughes, Virginia, Valenzuela, David M., ...
Vascular development depends on the highly coordinated actions of a variety of angiogenic regulators, most of which apparently act downstream of vascular endothelial growth factor (VEGF). One...
Rudge, John S., Holash, Jocelyn, Hylton, Donna, Russell, Michelle, Jiang, Shelly, Leidich, Raymond, ...
VEGF is the best characterized mediator of tumor angiogenesis. Anti-VEGF agents have recently demonstrated impressive efficacy in human cancer trials, but the optimal dosing of such agents must still...
Luqman, Mohammad, Klabunde, Sha, Lin, Karen, Georgakis, Georgios V., Cherukuri, Anu, Holash, Jocelyn, ...
B-cell chronic lymphocytic leukemia (B-CLL) is a lymphoproliferative disorder characterized by the surface expression of CD20, CD5 antigens, as well as the receptor CD40. Activation of CD40 by its...