Barreto, Marta, Ferreira, Ricardo C, Lourenço, Lara, Moraes-Fontes, Maria F, Santos, Eugénia, Alves, Miguel, ...
Abstract Background CD4 + CD25 + regulatory T cells play an essential role in maintaining immune homeostasis and preventing autoimmunity. Therefore, defects in Treg development, maintenance or...
Heme oxygenase-1 is not required for mouse regulatory T cell development and function (2007)
Zelenay, Santiago, Chora, Angelo, Soares, Miguel P., Demengeot, Jocelyne
CD4 regulatory T cells (Treg) ensure peripheral tolerance to self-antigens and limit the deleterious effects associated with inflammatory and immune responses by mechanisms that remain to be fully...
Heme oxygenase-1 is not required for mouse regulatory T cell development and function (2006)
Zelenay, Santiago, Chora, Angelo, Soares, Miguel P., Demengeot, Jocelyne
CD4 regulatory T cells (Treg) ensure peripheral tolerance to self-antigens and limit the deleterious effects associated with inflammatory and immune responses by mechanisms that remain to be fully...
Protection against systemic candidiasis in mice immunized with secreted aspartic proteinase 2 (2004)
Vilanova, Manuel, Teixeira, Luzia, Caramalho, Íris, Torrado, Egídio, Marques, Andreia, Madureira, Pedro, ...
Secreted aspartic proteinases (Sap) have been described as virulence factors implicated in the mechanisms of host colonization by the yeast Candida albicans in different types of candidiasis....
IFN-{alpha}/{beta} enhances BCR-dependent B cell responses (2002)
Braun, Déborah, Caramalho, Iris, Demengeot, Jocelyne
Type I interferon (IFN‐I) is constitutively produced in the bone marrow (BM), and induced at sites of inflammation and following infection by viruses or microorganisms. We have previously shown...
Type I IFN sets the stringency of B cell repertoire selection in the bone marrow (1999)
Vasconcellos, Rita, Braun, Deborah, Coutinho, Antonio, Demengeot, Jocelyne
Locally produced type I interferon (IFN-I) enhances the sensitivity of bone marrow B cell to IgM receptor ligation. The establishment of B cell repertoires, on the other hand, seems to involve...
Generation of normal lymphocytes derived from N-myc-deficient embryonic stem cells (1995)
Malynn, Barbara A., Demengeot, Jocelyne, Stewart, Valerie, Charron, Jean, Alt, Frederick W., Hardy, R. R.
Myc family proteins are thought to be transcription factors involved in regulation of cell growth and differentiation. N-myc. is expressed at the pre-B cell stage of B cell differentiation and is...
Demengeot, Jocelyne, Oltz, Eugene M., Alt, Frederick W., Pioegh, H.
The accessibility of a chromosomally integrated TCRβ minilocus recombination substrate in a V(D)J recombinase-inducible cell line (HDR37) depends on incorporation of transcrlptlonal enhancer...
Hori, Shohei, Haury, Matthias, Coutinho, António, Demengeot, Jocelyne
CD25+4+ regulatory T cells (Treg) play an indispensable role in preventing autoimmunity. Little is known, however, about the antigen specificities required for their development and effector...
Zelenay, Santiago, Lopes-Carvalho, Thiago, Caramalho, Iris, Moraes-Fontes, Maria Francisca, Rebelo, Manuel, Demengeot, Jocelyne
Expression of the IL-2 receptor α chain (CD25) by peripheral CD4 T cells follows cellular activation. However, CD25 expression by CD4 cells is widely used as a marker to identify regulatory T cells...
Demengeot, Jocelyne, Hori, Shohei
Workshop on the Molecular and Genetic Basis of Autoimmune Diseases: SLE and RA
Hori, Shohei, Haury, Matthias, Coutinho, António, Demengeot, Jocelyne
CD25+4+ regulatory T cells (Treg) play an indispensable role in preventing autoimmunity. Little is known, however, about the antigen specificities required for their development and effector...
Zelenay, Santiago, Lopes-Carvalho, Thiago, Caramalho, Iris, Moraes-Fontes, Maria Francisca, Rebelo, Manuel, Demengeot, Jocelyne
Expression of the IL-2 receptor α chain (CD25) by peripheral CD4 T cells follows cellular activation. However, CD25 expression by CD4 cells is widely used as a marker to identify regulatory T cells...
Demengeot, Jocelyne, Hori, Shohei
Workshop on the Molecular and Genetic Basis of Autoimmune Diseases: SLE and RA
Protection against systemic candidiasis in mice immunized with secreted aspartic proteinase 2
Vilanova, Manuel, Teixeira, Luzia, Caramalho, Íris, Torrado, Egídio, Marques, Andreia, Madureira, Pedro, ...
Secreted aspartic proteinases (Sap) have been described as virulence factors implicated in the mechanisms of host colonization by the yeast Candida albicans in different types of candidiasis....
Santos, Margarida Almeida, Sarmento, Leonor Morais, Rebelo, Manuel, Doce, Ana Agua, Maillard, Ivan, Dumortier, Alexis, ...
Notch signaling regulates B and T lymphocyte development and T cell effector class decision. In this work, we tested whether Notch activity affects mature B cell activation and differentiation to...
Regulatory T Cells Selectively Express Toll-like Receptors and Are Activated by Lipopolysaccharide
Caramalho, Iris, Lopes-Carvalho, Thiago, Ostler, Dominique, Zelenay, Santiago, Haury, Matthias, Demengeot, Jocelyne
Regulatory CD4 T cells (Treg) control inflammatory reactions to commensal bacteria and opportunist pathogens. Activation of Treg functions during these processes might be mediated by host-derived...
Arrested B Lymphopoiesis and Persistence of Activated B Cells in Adult Interleukin 7−/− Mice
Carvalho, Thiago L., Mota-Santos, Tomaz, Cumano, Ana, Demengeot, Jocelyne, Vieira, Paulo
Interleukin 7 is a crucial factor for the development of murine T and B lymphocytes. We now report that, in the absence of interleukin 7, B lymphocyte production takes place exclusively during fetal...