Bao-zhu Yang, Henry R. Kranzler, Hongyu Zhao, Jeffrey R. Gruen, Xingguang Luo, Joel Gelernter
This is an Open Access article distributed under the terms of the Creative Commons Attribution
Koenen, Karestan C., Aiello, Allison E., Bakshis, Erin, Amstadter, Ananda B., Ruggiero, Kenneth J., Acierno, Ron, ...
Although both genetic factors and features of the social environment are important predictors of posttraumatic stress disorder (PTSD), there are few data examining gene-social environment...
Luo, Xingguang, Zuo, Lingjun, Kranzler, Henry R, Wang, Shuang, Anton, Raymond F, Gelernter, Joel
Abstract Background In our previous studies, we reported positive associations between seven ADH4 polymorphisms and substance dependence [i.e., alcohol dependence (AD) and/or drug dependence (DD)] in...
Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array (2008)
Hodgkinson, Colin A., Yuan, Qiaoping, Xu, Ke, Shen, Pei-Hong, Heinz, Elizabeth, Lobos, Elizabeth A., ...
Aims: To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes...
Nussbaum, Justin, Xu, Qing, Payne, Thomas J., Ma, Jennie Z., Huang, Weihua, Gelernter, Joel, ...
The neurexin-1 gene (NRXN1) has been shown to play a fundamental role in synaptogenesis and synaptic maintenance, as well as Ca2+ channel and NMDA receptor recruitment. A recent study reported that...
Yang, Bao-Zhu, Kranzler, Henry R., Zhao, Hongyu, Gruen, Jeffrey R., Luo, Xingguang, Gelernter, Joel
There have been many conflicting reports concerning the association of the DRD2 locus with alcohol dependence (AD). To investigate whether these findings could be reconciled by considering the...
Hirunsatit, Rungnapa, Ilomäki, Risto, Malison, Robert, Räsänen, Pirkko, Ilomäki, Essi, Kranzler, Henry R, ...
Abstract Background GABA transporter-1 (GAT-1; genetic locus SLC6A1 ) is emerging as a novel target for treatment of neuropsychiatric disorders. To understand how population differences might...
CHRM2 variation predisposes to personality traits of agreeableness and conscientiousness (2007)
Luo, Xingguang, Kranzler, Henry R., Zuo, Lingjun, Zhang, Huiping, Wang, Shuang, Gelernter, Joel
Personality traits are among the most complex quantitative traits. Certain personality traits have been postulated to be part of the inherited component of substance dependence (SD) risk. Association...
Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans (2007)
Luo, Xingguang, Kranzler, Henry R., Zuo, Lingjun, Wang, Shuang, Schork, Nicholas J., Gelernter, Joel
Drug dependence (DD) is commonly co-morbid with alcohol dependence (AD). Many studies have also shown common genetic risk factors for these disorders. We previously reported associations of AD with...
Variation at APOE and STH loci and Alzheimer's disease. (2006)
Zuo, Lingjun, Van Dyck, Christopher, Luo, Xingguang, Kranzler, Henry, Yang, Bao-Zhu, Gelernter, Joel
ABSTRACT: BACKGROUND: The apolipoprotein E (APOE) and tau proteins play important roles in the pathological development of Alzheimer's disease (AD). Many studies have shown an association between the...
Variation at APOEand STHloci and Alzheimer's disease (2006)
Zuo, Lingjun, Van Dyck, Christopher H, Luo, Xingguang, Kranzler, Henry R, Yang, Bao-zhu, Gelernter, Joel
Abstract Background The apolipoprotein E (APOE) and tau proteins play important roles in the pathological development of Alzheimer's disease (AD). Many studies have shown an association between the...
Kaabi, Belhassen, Gelernter, Joel, Woods, Scott W., Goddard, Andrew, Page, Grier P., Elston, Robert C.
We conducted a 10-centimorgan linkage autosomal genome scan in a set of 19 extended American pedigrees (219 subjects) ascertained through probands with panic disorder. Several anxiety...
Zhang, Huiping, Luo, Xingguang, Kranzler, Henry R., Lappalainen, Jaakko, Yang, Bao-Zhu, Krupitsky, Evgeny, ...
We examined 13 single nucleotide polymorphisms (SNPs) spanning the coding region of the µ-opioid receptor gene (OPRM1), among 382 European Americans (EAs) affected with substance dependence [alcohol...
Yu, Yi, Panhuysen, Carolien, Kranzler, Henry R., Hesselbrock, Victor, Rounsaville, Bruce, Weiss, Roger, ...
We report here a study considering association of alleles and haplotypes at the DOPA decarboxylase (DDC) locus with the DSM-IV diagnosis of nicotine dependence (ND) or a quantitative measure for ND...
Gelernter, Joel, Yu, Yi, Weiss, Roger, Brady, Kathleen, Panhuysen, Carolien, Yang, Bao-zhu, ...
Nicotine dependence (ND) is a moderately heritable trait. We ascertained a set of 1615 subjects in 632 families [319 African-American (AA) and 313 European-American (EA)] based on affected sibling...
Zhang, Huiping, Luo, Xingguang, Kranzler, Henry R., Lappalainen, Jaakko, Yang, Bao-Zhu, Krupitsky, Evgeny, ...
We examined 13 single nucleotide polymorphisms (SNPs) spanning the coding region of the µ-opioid receptor gene (OPRM1), among 382 European Americans (EAs) affected with substance dependence [alcohol...
Yu, Yi, Panhuysen, Carolien, Kranzler, Henry R., Hesselbrock, Victor, Rounsaville, Bruce, Weiss, Roger, ...
We report here a study considering association of alleles and haplotypes at the DOPA decarboxylase (DDC) locus with the DSM-IV diagnosis of nicotine dependence (ND) or a quantitative measure for ND...
Gelernter, Joel, Yu, Yi, Weiss, Roger, Brady, Kathleen, Panhuysen, Carolien, Yang, Bao-zhu, ...
Nicotine dependence (ND) is a moderately heritable trait. We ascertained a set of 1615 subjects in 632 families (319 African American [AA] and 313 European American [EA]) based on affected sibling...
Multiple ADH genes modulate risk for drug dependence (2006)
Luo, Xingguang, Kranzler, Henry R., Zuo, Lingjun, Wang, Shuang, Schork, Nicholas J., Gelernter, Joel
Drug dependence (DD) is commonly co-morbid with alcohol dependence (AD). Many studies have also shown common genetic risk factors for these disorders. We previously reported associations of AD with...
Yang, Bao-Zhu, Zhao, Hongyu, Kranzler, Henry R, Gelernter, Joel
BACKGROUND: Detection and evaluation of population stratification are crucial issues in the conduct of genetic association studies. Statistical approaches useful for understanding these issues have...
Yang, Bao-Zhu, Zhao, Hongyu, Kranzler, Henry R, Gelernter, Joel
Abstract Background Detection and evaluation of population stratification are crucial issues in the conduct of genetic association studies. Statistical approaches useful for understanding these...
Luo, Xingguang, Kranzler, Henry R., Zuo, Lingjun, Wang, Shuang, Blumberg, Hilary P., Gelernter, Joel
Cholinergic muscarinic 2 receptor (CHRM2) is implicated in memory and cognition, functions impaired in many neuropsychiatric disorders. Wang et al. (2004) reported that variation in CHRM2 gene...
Luo, Xingguang, Kranzler, Henry R., Zuo, Lingjun, Wang, Shuang, Blumberg, Hilary P., Gelernter, Joel
Cholinergic muscarinic 2 receptor (CHRM2) is implicated in memory and cognition, functions impaired in many neuropsychiatric disorders. Wang et al. [Wang, J.C., Hinrichs, A.L., Stock, H., Budde, J.,...
Zabetian, Cyrus P., Buxbaum, Sarah G., Elston, Robert C., K Hnke, Michael D., Anderson, George M., Gelernter, Joel, ...
There is currently a great deal of interest in using linkage disequilibrium (LD) mapping to locate both disease and quantitative-trait loci on a genomewide scale. Recent findings suggest that much of...
Duan, Jubao, Wainwright, Mark S., Comeron, Josep M., Saitou, Naruya, Sanders, Alan R., Gelernter, Joel, ...
Although changes in nucleotide sequence affecting the composition and the structure of proteins are well known, functional changes resulting from nucleotide substitutions cannot always be inferred...
Zabetian, Cyrus P., Anderson, George M., Buxbaum, Sarah G., Elston, Robert C., Ichinose, Hiroshi, Nagatsu, Toshiharu, ...
Dopamine-beta-hydroxylase (D beta H) catalyzes the conversion of dopamine to norepinephrine and is released from sympathetic neurons into the circulation. Plasma-D beta H activity varies widely...
Taql RFLP at norepinephrine transporter protein (NET) locus (1993)
Gelernter, Joel, Kruger, Susan, Kidd, Kenneth K., Amara, Susan
Social supports and serotonin transporter gene moderate depression in maltreated children
Kaufman, Joan, Yang, Bao-Zhu, Douglas-Palumberi, Heather, Houshyar, Shadi, Lipschitz, Deborah, Krystal, John H., ...
In this study, measures of the quality and availability of social supports were found to moderate risk for depression associated with a history of maltreatment and the presence of the short (s)...
Zabetian, Cyrus P., Anderson, George M., Buxbaum, Sarah G., Elston, Robert C., Ichinose, Hiroshi, Nagatsu, Toshiharu, ...
Dopamine-β-hydroxylase (DβH) catalyzes the conversion of dopamine to norepinephrine and is released from sympathetic neurons into the circulation. Plasma-DβH activity varies widely between...
DCDC2 is associated with reading disability and modulates neuronal development in the brain
Meng, Haiying, Smith, Shelley D., Hager, Karl, Held, Matthew, Liu, Jonathan, Olson, Richard K., ...
DYX2 on 6p22 is the most replicated reading disability (RD) locus. By saturating a previously identified peak of association with single nucleotide polymorphism markers, we identified a large...
Variation at APOE and STH loci and Alzheimer's disease
Zuo, Lingjun, Van Dyck, Christopher H, Luo, Xingguang, Kranzler, Henry R, Yang, Bao-zhu, Gelernter, Joel
Kaabi, Belhassen, Gelernter, Joel, Woods, Scott W., Goddard, Andrew, Page, Grier P., Elston, Robert C.
We conducted a 10-centimorgan linkage autosomal genome scan in a set of 19 extended American pedigrees (219 subjects) ascertained through probands with panic disorder. Several anxiety...
Genomewide Linkage Scan for Opioid Dependence and Related Traits
Gelernter, Joel, Panhuysen, Carolien, Wilcox, Marsha, Hesselbrock, Victor, Rounsaville, Bruce, Poling, James, ...
Risk of opioid dependence is genetically influenced. We recruited a sample of 393 small nuclear families (including 250 full-sib and 46 half-sib pairs), each with at least one individual with opioid...
Luo, Xingguang, Kranzler, Henry R., Zuo, Lingjun, Wang, Shuang, Schork, Nicholas J., Gelernter, Joel
The set of alcohol-metabolizing enzymes has considerable genetic and functional complexity. The relationships between some alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) genes and...
Social supports and serotonin transporter gene moderate depression in maltreated children
Kaufman, Joan, Yang, Bao-Zhu, Douglas-Palumberi, Heather, Houshyar, Shadi, Lipschitz, Deborah, Krystal, John H., ...
In this study, measures of the quality and availability of social supports were found to moderate risk for depression associated with a history of maltreatment and the presence of the short (s)...
Zabetian, Cyrus P., Buxbaum, Sarah G., Elston, Robert C., Köhnke, Michael D., Anderson, George M., Gelernter, Joel, ...
There is currently a great deal of interest in using linkage disequilibrium (LD) mapping to locate both disease and quantitative-trait loci on a genomewide scale. Recent findings suggest that much of...
Zabetian, Cyrus P., Anderson, George M., Buxbaum, Sarah G., Elston, Robert C., Ichinose, Hiroshi, Nagatsu, Toshiharu, ...
Dopamine-β-hydroxylase (DβH) catalyzes the conversion of dopamine to norepinephrine and is released from sympathetic neurons into the circulation. Plasma-DβH activity varies widely between...
DCDC2 is associated with reading disability and modulates neuronal development in the brain
Meng, Haiying, Smith, Shelley D., Hager, Karl, Held, Matthew, Liu, Jonathan, Olson, Richard K., ...
DYX2 on 6p22 is the most replicated reading disability (RD) locus. By saturating a previously identified peak of association with single nucleotide polymorphism markers, we identified a large...
Kaabi, Belhassen, Gelernter, Joel, Woods, Scott W., Goddard, Andrew, Page, Grier P., Elston, Robert C.
We conducted a 10-centimorgan linkage autosomal genome scan in a set of 19 extended American pedigrees (219 subjects) ascertained through probands with panic disorder. Several anxiety...
Genomewide Linkage Scan for Opioid Dependence and Related Traits
Gelernter, Joel, Panhuysen, Carolien, Wilcox, Marsha, Hesselbrock, Victor, Rounsaville, Bruce, Poling, James, ...
Risk of opioid dependence is genetically influenced. We recruited a sample of 393 small nuclear families (including 250 full-sib and 46 half-sib pairs), each with at least one individual with opioid...
Luo, Xingguang, Kranzler, Henry R., Zuo, Lingjun, Wang, Shuang, Schork, Nicholas J., Gelernter, Joel
The set of alcohol-metabolizing enzymes has considerable genetic and functional complexity. The relationships between some alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) genes and...
Variation at APOE and STH loci and Alzheimer's disease
Zuo, Lingjun, Van Dyck, Christopher H, Luo, Xingguang, Kranzler, Henry R, Yang, Bao-zhu, Gelernter, Joel
Demographic changes and marker properties affect detection of human population differentiation
Listman, Jennifer B, Malison, Robert T, Sughondhabirom, Atapol, Yang, Bao-Zhu, Raaum, Ryan L, Thavichachart, Nuntika, ...
Hirunsatit, Rungnapa, Ilomäki, Risto, Malison, Robert, Räsänen, Pirkko, Ilomäki, Essi, Kranzler, Henry R, ...
Expert Systems and Diagnostic Monitors in Psychiatry
Gelernter, David, Gelernter, Joel
We argue that existing expert systems for medical diagnosis have not satisfactorily addressed an important problem: how are such systems to be integrated into the clinical environment? This problem...
Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array
Hodgkinson, Colin A., Yuan, Qiaoping, Xu, Ke, Shen, Pei-Hong, Heinz, Elizabeth, Lobos, Elizabeth A., ...
Aims: To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes...