Diskin, Sharon J., Eck, Thomas, Greshock, Joel, Mosse, Yael P., Naylor, Tara, Stoeckert, Christian J., ...
Regions of gain and loss of genomic DNA occur in many cancers and can drive the genesis and progression of disease. These copy number aberrations (CNAs) can be detected at high resolution by using...
Diskin, Sharon J., Eck, Thomas, Greshock, Joel, Mosse, Yael P., Naylor, Tara, Stoeckert, Christian J., ...
Regions of gain and loss of genomic DNA occur in many cancers and can drive the genesis and progression of disease. These copy number aberrations (CNAs) can be detected at high resolution by using...
Naylor, Tara L, Greshock, Joel, Wang, Yan, Colligon, Theresa, Yu, QC, Clemmer, Virginia, ...
Abstract Introduction Genomic aberrations in the form of subchromosomal DNA copy number changes are a hallmark of epithelial cancers, including breast cancer. The goal of the present study was to...
Margolin, Adam A., Greshock, Joel, Naylor, Tara L., Mosse, Yael, Maris, John M., Bignell, Graham, ...
Summary: This synopsis provides an overview of array-based comparative genomic hybridization data display, abstraction and analysis using CGHAnalyzer, a software suite, designed specifically for this...
Margolin, Adam A., Greshock, Joel, Naylor, Tara L., Mosse, Yael, Maris, John M., Bignell, Graham, ...
Summary: This synopsis provides an overview of array-based comparative genomic hybridization (aCGH) data display, abstraction and analysis using CGHAnalyzer, a software suite, designed specifically...
High-Resolution Analysis of DNA Copy Number Using Oligonucleotide Microarrays (2004)
Bignell, Graham R., Huang, Jing, Greshock, Joel, Watt, Stephen, Butler, Adam, West, Sofie, ...
Genomic copy number alterations are a feature of many human diseases including cancer. We have evaluated the effectiveness of an oligonucleotide array, originally designed to detect single-nucleotide...
Greshock, Joel, Naylor, Tara L., Margolin, Adam, Diskin, Sharon, Cleaver, Stephen H., Futreal, P. Andrew, ...
Array-based comparative genomic hybridization (aCGH) is a recently developed tool for genome-wide determination of DNA copy number alterations. This technology has tremendous potential for...
Greshock, Joel, Naylor, Tara L., Margolin, Adam, Diskin, Sharon, Cleaver, Stephen H., Futreal, P. Andrew, ...
Array-based comparative genomic hybridization (aCGH) is a recently developed tool for genome-wide determination of DNA copy number alterations. This technology has tremendous potential for...
Greshock, Joel, Naylor, Tara L., Margolin, Adam, Diskin, Sharon, Cleaver, Stephen H., Futreal, P. Andrew, ...
Array-based comparative genomic hybridization (aCGH) is a recently developed tool for genome-wide determination of DNA copy number alterations. This technology has tremendous potential for...
High-Resolution Analysis of DNA Copy Number Using Oligonucleotide Microarrays
Bignell, Graham R., Huang, Jing, Greshock, Joel, Watt, Stephen, Butler, Adam, West, Sofie, ...
Genomic copy number alterations are a feature of many human diseases including cancer. We have evaluated the effectiveness of an oligonucleotide array, originally designed to detect single-nucleotide...
microRNAs exhibit high frequency genomic alterations in human cancer
Zhang, Lin, Huang, Jia, Yang, Nuo, Greshock, Joel, Megraw, Molly S., Giannakakis, Antonis, ...
MicroRNAs (miRNAs) are endogenous noncoding RNAs, which negatively regulate gene expression. To determine genomewide miRNA DNA copy number abnormalities in cancer, 283 known human miRNA genes were...
Greshock, Joel, Naylor, Tara L., Margolin, Adam, Diskin, Sharon, Cleaver, Stephen H., Futreal, P. Andrew, ...
Array-based comparative genomic hybridization (aCGH) is a recently developed tool for genome-wide determination of DNA copy number alterations. This technology has tremendous potential for...
High-Resolution Analysis of DNA Copy Number Using Oligonucleotide Microarrays
Bignell, Graham R., Huang, Jing, Greshock, Joel, Watt, Stephen, Butler, Adam, West, Sofie, ...
Genomic copy number alterations are a feature of many human diseases including cancer. We have evaluated the effectiveness of an oligonucleotide array, originally designed to detect single-nucleotide...
microRNAs exhibit high frequency genomic alterations in human cancer
Zhang, Lin, Huang, Jia, Yang, Nuo, Greshock, Joel, Megraw, Molly S., Giannakakis, Antonis, ...
MicroRNAs (miRNAs) are endogenous noncoding RNAs, which negatively regulate gene expression. To determine genomewide miRNA DNA copy number abnormalities in cancer, 283 known human miRNA genes were...
Diskin, Sharon J., Eck, Thomas, Greshock, Joel, Mosse, Yael P., Naylor, Tara, Stoeckert, Christian J., ...
Regions of gain and loss of genomic DNA occur in many cancers and can drive the genesis and progression of disease. These copy number aberrations (CNAs) can be detected at high resolution by using...
Transcriptional Regulation of PIK3CA Oncogene by NF-κB in Ovarian Cancer Microenvironment
Yang, Nuo, Huang, Jia, Greshock, Joel, Liang, Shun, Barchetti, Andrea, Hasegawa, Kosei, ...
PIK3CA upregulation, amplification and mutation have been widely reported in ovarian cancers and other tumors, which strongly suggests that PIK3CA is a promising therapeutic target. However, to date...
Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer
Zhang, Lin, Volinia, Stefano, Bonome, Tomas, Calin, George Adrian, Greshock, Joel, Yang, Nuo, ...
MicroRNAs (miRNAs) are an abundant class of small noncoding RNAs that function as negative gene regulators. miRNA deregulation is involved in the initiation and progression of human cancer; however,...