Molecular Determinant of Regioselective Hydroxylation of Docetaxel by CYP3A4 (2009)
Bernard Monsarrat, Odile Thoison, Joelle Dubois, Thierry Cresteil
The metabolism of taxanes by human liver microsomes is regioselective: the major metabolite of paclitaxel formed by CYP2C8 results from the hydroxylation on the taxane ring at C-6. Hydroxylations on...