Thanh N. Huynh, S. Sam Weigt, John A. Belperio, Mary Territo, Michael P. Keane
The prognosis of patients with hematopoietic stem cell transplants (HSCTs) who require admission to the intensive care unit (ICU) has been regarded as extremely poor. We sought to re-evaluate recent...
Thanh N. Huynh, S. Sam Weigt, John A. Belperio, Mary Territo, Michael P. Keane
The prognosis of patients with hematopoietic stem cell transplants (HSCTs) who require admission to the intensive care unit (ICU) has been regarded as extremely poor. We sought to re-evaluate recent...
Stromal Derived Factor-1 (SDF-1/CXCL12) and CXCR4 in renal cell carcinoma metastasis (2006)
Pan, Judong, Mestas, Javier, Burdick, Marie D, Phillips, Roderick J, Thomas, George V, Reckamp, Karen, ...
Abstract Renal cell carcinoma (RCC) is characterized by organ-specific metastases. The chemokine stromal derived factor-1 (SDF-1/CXCL12) and its receptor CXCR4 have been suggested to regulate...
CXCR2 is critical for dsRNA-induced lung injury: relevance to viral lung infection (2005)
Londhe, Vedang A, Belperio, John A, Keane, Michael P, Burdick, Marie D, Xue, Ying, Strieter, Robert M
Abstract Background Respiratory viral infections are characterized by the infiltration of leukocytes, including activated neutrophils into the lung that can lead to sustained lung injury and...
Addison, Christina L, Belperio, John A, Burdick, Marie D, Strieter, Robert M
Abstract Background The Duffy antigen receptor for chemokines (DARC) is known to be a promiscuous chemokine receptor that binds a variety of CXC and CC chemokines in the absence of any detectable...
Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury
Belperio, John A., Keane, Michael P., Burdick, Marie D., Londhe, Vedang, Xue, Ying Ying, Li, Kewang, ...
Mortality related to adult respiratory distress syndrome (ARDS) ranges from 35% to 65%. Lung-protective ventilator strategies can reduce mortality during ARDS. The protective strategies limit tidal...
Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome
Belperio, John A., Keane, Michael P., Burdick, Marie D., Lynch, Joseph P., Xue, Ying Ying, Berlin, Aaron, ...
Bronchiolitis obliterans syndrome (BOS) is the major limitation to survival after lung transplantation. Acute rejection, its main risk factor, is characterized by perivascular/bronchiolar leukocyte...
Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis
Phillips, Roderick J., Burdick, Marie D., Hong, Kurt, Lutz, Marin A., Murray, Lynne A., Xue, Ying Ying, ...
Previous reports have identified a circulating pool of CD45+ collagen I+ CXCR4+ (CD45+Col I+CXCR4+) cells, termed fibrocytes, that traffic to areas of fibrosis. No studies have demonstrated that...
Role of CXCR2/CXCR2 ligands in vascular remodeling during bronchiolitis obliterans syndrome
Belperio, John A., Keane, Michael P., Burdick, Marie D., Gomperts, Brigitte, Xue, Ying Ying, Hong, Kurt, ...
Angiogenesis and vascular remodeling support fibroproliferative processes; however, no study has addressed the importance of angiogenesis during fibro-obliteration of the allograft airway during...
CXCR2 is critical for dsRNA-induced lung injury: relevance to viral lung infection
Londhe, Vedang A, Belperio, John A, Keane, Michael P, Burdick, Marie D, Xue, Ying Ying, Strieter, Robert M
Stromal Derived Factor-1 (SDF-1/CXCL12) and CXCR4 in renal cell carcinoma metastasis
Pan, Judong, Mestas, Javier, Burdick, Marie D, Phillips, Roderick J, Thomas, George V, Reckamp, Karen, ...
Renal cell carcinoma (RCC) is characterized by organ-specific metastases. The chemokine stromal derived factor-1 (SDF-1/CXCL12) and its receptor CXCR4 have been suggested to regulate organ-specific...
Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury
Belperio, John A., Keane, Michael P., Burdick, Marie D., Londhe, Vedang, Xue, Ying Ying, Li, Kewang, ...
Mortality related to adult respiratory distress syndrome (ARDS) ranges from 35% to 65%. Lung-protective ventilator strategies can reduce mortality during ARDS. The protective strategies limit tidal...
Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome
Belperio, John A., Keane, Michael P., Burdick, Marie D., Lynch, Joseph P., Xue, Ying Ying, Berlin, Aaron, ...
Bronchiolitis obliterans syndrome (BOS) is the major limitation to survival after lung transplantation. Acute rejection, its main risk factor, is characterized by perivascular/bronchiolar leukocyte...
Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis
Phillips, Roderick J., Burdick, Marie D., Hong, Kurt, Lutz, Marin A., Murray, Lynne A., Xue, Ying Ying, ...
Previous reports have identified a circulating pool of CD45+ collagen I+ CXCR4+ (CD45+Col I+CXCR4+) cells, termed fibrocytes, that traffic to areas of fibrosis. No studies have demonstrated that...
Role of CXCR2/CXCR2 ligands in vascular remodeling during bronchiolitis obliterans syndrome
Belperio, John A., Keane, Michael P., Burdick, Marie D., Gomperts, Brigitte, Xue, Ying Ying, Hong, Kurt, ...
Angiogenesis and vascular remodeling support fibroproliferative processes; however, no study has addressed the importance of angiogenesis during fibro-obliteration of the allograft airway during...
CXCR2 is critical for dsRNA-induced lung injury: relevance to viral lung infection
Londhe, Vedang A, Belperio, John A, Keane, Michael P, Burdick, Marie D, Xue, Ying Ying, Strieter, Robert M
Stromal Derived Factor-1 (SDF-1/CXCL12) and CXCR4 in renal cell carcinoma metastasis
Pan, Judong, Mestas, Javier, Burdick, Marie D, Phillips, Roderick J, Thomas, George V, Reckamp, Karen, ...
Renal cell carcinoma (RCC) is characterized by organ-specific metastases. The chemokine stromal derived factor-1 (SDF-1/CXCL12) and its receptor CXCR4 have been suggested to regulate organ-specific...
Keratinocyte Growth Factor Improves Repair in the Injured Tracheal Epithelium
Gomperts, Brigitte N., Belperio, John A., Fishbein, Michael C., Keane, Michael P., Burdick, Marie D., Strieter, Robert M.
Keratinocyte growth factor (KGF) is a critical growth factor in lung development and is a protective agent after lung injury, although the exact mechanisms of this protective effect have not yet been...
Nickerson, Derek W., Presson, Angela P., Weigt, Stephen S., Gregson, Aric L., Belperio, John A., Gomperts, Brigitte N.
Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice
Shahangian, Arash, Chow, Edward K., Tian, Xiaoli, Kang, Jason R., Ghaffari, Amir, Liu, Su Y., ...
Influenza-related complications continue to be a major cause of mortality worldwide. Due to unclear mechanisms, a substantial number of influenza-related deaths result from bacterial superinfections,...