John A. Copland, Peter J. Davies, Gregory L. Shipley, Christopher G. Wood, Bruce A. Luxon, Randall J. Urban
The advent of gene array technology brings the ability to classify disease states to the molecular level by examining changes in all mRNAs expressed in cells or tissues. Comparing changes in gene...
Expression of the type III TGF-{beta} receptor is negatively regulated by TGF-{beta} (2008)
Hempel, Nadine, How, Tam, Cooper, Simon J., Green, Tyler R., Dong, Mei, Copland, John A., ...
The type III transforming growth factor-beta receptor (TβRIII or betaglycan) is a ubiquitously expressed transforming growth factor-beta (TGF-β) superfamily coreceptor with essential roles in...
Treating anaplastic thyroid carcinoma with an oncolytic adenovirus (2007)
Reichert-Eberhardt, Aliana, Reddi, Honey V., Copland, John A., Galanis, Evanthia, McIver, Bryan, Grebe, Stefan K.G., ...
Anaplastic thyroid carcinoma (ATC) is the most aggressive form of thyroid cancer. Standard therapy is rarely curative, and the tumors are resistant to radioiodine or chemotherapy. Oncolytic viruses...
p120 catenin induces opposing effects on tumor cell growth depending on E-cadherin expression
Soto, Edwin, Yanagisawa, Masahiro, Marlow, Laura A., Copland, John A., Perez, Edith A., Anastasiadis, Panos Z.
p120 catenin regulates the activity of the Rho family guanosine triphosphatases (including RhoA and Rac1) in an adhesion-dependent manner. Through this action, p120 promotes a sessile cellular...
Yanagisawa, Masahiro, Huveldt, Deborah, Kreinest, Pamela, Lohse, Christine M., Cheville, John C., Parker, Alexander S., ...
p120 catenin is a cadherin-associated protein that regulates Rho GTPases and promotes the invasiveness of E-cadherin-deficient cancer cells. Multiple p120 isoforms are expressed in cells via...
Schweppe, Rebecca E., Klopper, Joshua P., Korch, Christopher, Pugazhenthi, Umarani, Benezra, Miriam, Knauf, Jeffrey A., ...
Context: Cell lines derived from human cancers provide critical tools to study disease mechanisms and develop novel therapies. Recent reports indicate that up to 36% of cell lines are cross-...