John A. Eisman

New sequence variants associated with bone mineral density. (2009)

Styrkarsdottir, Unnur, Halldorsson, Bjarni V, Gretarsdottir, Solveig, Gudbjartsson, Daniel F, Walters, G Bragi, Ingvarsson, Thorvaldur, ...

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Association between LRP5 polymorphism and bone mineral density: a Bayesian meta-analysis (2008)

Tran, Bich NH, Nguyen, Nguyen D, Eisman, John A, Nguyen, Tuan V

Abstract Background The low-density lipoprotein receptor-related protein 5 gene (LRP5) was identified to be linked to the variation in BMD in high bone mass pedigrees. Subsequent population-based...

Multiple genetic loci for bone mineral density and fractures (2008)

Styrkarsdottir, Unnur, Halldorsson, Bjarni V, Gretarsdottir, Solveig, Gudbjartsson, Daniel F, Walters, G Bragi, Ingvarsson, Thorvaldur, ...

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Bone turnover in elderly men: relationships to change in bone mineral density (2007)

Nguyen, Tuan V, Meier, Christian, Center, Jacqueline R, Eisman, John A, Seibel, Markus J

Abstract Background It is not clear whether bone turnover markers can be used to make inference regarding changes in bone mineral density (BMD) in untreated healthy elderly men. The present study was...

Greater bone formation of Y2 knockout mice is associated with increased osteoprogenitor numbers and altered Y1-receptor expression (2007)

Lundberg, Pernilla, Allison, Susan J., Lee, Nicola J., Baldock, Paul A., Brouard, Nathalie, Rost, Stephanie, ...

Germ line or hypothalamus-specific deletion of Y2 receptors in mice results in a doubling of trabecular bone volume. However, the specific mechanism by which deletion of Y2 receptors increases bone...

β3-adrenergic receptor gene, body mass index, bone mineral density and fracture risk in elderly men and women: the Dubbo Osteoporosis Epidemiology Study (DOES) (2006)

Wang, Claire Y, Nguyen, Nguyen D, Morrison, Nigel A, Eisman, John A, Center, Jacqueline R, Nguyen, Tuan V

Abstract Background Recent studies have suggested that the Arg allele of β3-adrenergic receptor (ADRB3) gene is associated with body mass index (BMI), which is an important predictor of bone mineral...

Transient disturbance in physeal morphology is associated with long-term effects of nitrogen-containing bisphosphonates in growing rabbits. (2005)

Elisabeth J Smith, David G Little, Julie N Briody, Anthony McEvoy, Nicholas C Smith, John A Eisman, ...

This study addressed a long-standing clinical concern in an animal model and provided critical histological evidence for long-term structural changes in growing bone after treatment with...

Bone mineral density, body mass index and cigarette smoking among Iranian women: implications for prevention (2005)

Baheiraei, Azam, Pocock, Nicholas A, Eisman, John A, Nguyen, Nguyen D, Nguyen, Tuan V

Abstract Background While risk factors of osteoporosis in Western populations have been extensively documented, such a profile has not been well studied in Caucasians of non-European origin. This...

Abdominal fat and hip fracture risk in the elderly: The Dubbo Osteoporosis Epidemiology Study (2005)

Nguyen, Nguyen D, Pongchaiyakul, Chatlert, Center, Jacqueline R, Eisman, John A, Nguyen, Tuan V

Abstract Background Fat mass, which is a major component of body weight, is directly related to bone mineral density and reduced fracture risk. It is not known whether abdominal fat is associated...

Transient disturbance in physeal morphology is associated with long-term effects of nitrogen-containing bisphosphonates in growing rabbits. (2005)

Elisabeth J Smith, David G Little, Julie N Briody, Anthony McEvoy, Nicholas C Smith, John A Eisman, ...

This study addressed a long-standing clinical concern in an animal model and provided critical histological evidence for long-term structural changes in growing bone after treatment with...

Transient disturbance in physeal morphology is associated with long-term effects of nitrogen-containing bisphosphonates in growing rabbits (2005)

Smith, Elisabeth J., Little, David G., Briody, Julie N., McEvoy, Anthony, Smith, Nicholas C., Eisman, John A., ...

Bisphosphonates have clinical benefit in children with severe osteogenesis imperfecta or osteoporosis and potential benefit in children with Perthes disease or undergoing distraction osteogenesis....

Vitamin D in Australia: issues and recommendations (2004)

Nowson, Caryl, Diamond, Terrence H., Pasco, Julie A., Mason, Rebecca S., Sambrook, Philip N., Eisman, John A.

BACKGROUND A significant number of Australians and people from specific groups within the community are suffering from vitamin D deficiency. It is no longer acceptable to assume that all people in...

Vitamin D in Australia: issues and recommendations (2004)

Nowson, Caryl, Diamond, Terrence H., Pasco, Julie A., Mason, Rebecca S., Sambrook, Philip N., Eisman, John A.

BACKGROUND A significant number of Australians and people from specific groups within the community are suffering from vitamin D deficiency. It is no longer acceptable to assume that all people in...

Ski-interacting Protein, a Bifunctional Nuclear Receptor Coregulator that interacts with N-CoR/SMRT and p300 (2004)

Leong, Gary M., Subramaniam, Nanthakumar, Issa, Laura L., Barry, Janelle B., Kino, Tomoshige, Driggers, Paul H., ...

Ski-interacting protein (SKIP), a vitamin D receptor (VDR) coactivator, also functions as a repressor in Notch signalling in association with the corepressor SMRT. Here we show that SKIP...

Vitamin D in Australia: issues and recommendations (2004)

Nowson, Caryl, Diamond, Terrence H., Pasco, Julie A., Mason, Rebecca S., Sambrook, Philip N., Eisman, John A.

BACKGROUND A significant number of Australians and people from specific groups within the community are suffering from vitamin D deficiency. It is no longer acceptable to assume that all people in...

Interactions of SKIP/NCoA-62, TFIIB, and retinoid X receptor with vitamin D receptor helix H10 residues (2003)

Barry, Janelle B., Leong, Gary M., Church, W. Bret, Issa, Laura L., Eisman, John A., Gardiner, Edith M.

The vitamin D receptor (VDR) is a ligand-dependent transcription factor that heterodimerizes with retinoid X receptor (RXR) and interacts with the basal transcription machinery and transcriptional...

Cross-talk between 1,25-dihydroxyvitamin D-3 and Transforming Growth Factor-beta Signaling requires Binding of VDR and Smad3 Proteins to their cognate DNA Recognition Elements (2001)

Subramaniam, Nanthakumar, Leong, Gary M., Cock, Terrie-Anne, Flanagan, Judith L., Fong, Colette, Eisman, John A., ...

1,25-Dihydroxyvitamin D-3 (vitamin D) and transforming growth factor-beta (TGF-beta) regulate diverse biological processes including cell proliferation and differentiation through modulation of the...

Ski-interacting Protein Interacts with Smad Proteins to Augment Transforming Growth Factor-beta-dependent Transcription (2001)

Leong, Gary M., Subramaniam, Nanthakumar, Figueroa, Jonine, Flanagan, Judith L., Hayman, Michael J., Eisman, John A., ...

Transforming growth factor-beta (TGF-beta) signaling requires the action of Smad proteins in association with other DNA-binding factors and coactivator and corepressor proteins to modulate target...

Risk Factors for Proximal Humerus, Forearm, and Wrist Fractures in Elderly Men and Women The Dubbo Osteoporosis Epidemiology Study (2001)

Nguyen, Tuan V., Center, Jacqueline R., Sambrook, Philip N., Eisman, John A.

Fractures of the proximal humerus, forearm, and wrist account for approximately one third of total osteoporotic fractures in the elderly. Several risk factors for these fractures were evaluated in...

Risk Factors for Osteoporotic Fractures in Elderly Men (1996)

Ngugyen, Tuan V., Eisman, John A., Kelly, Paul J., Sambroak, Philip N.

Osteoporosis is recognized as an important cause of morbidity and mortality in aging women, but there have been few epidemiologic studies in men. Potential risk factors for osteoporotic fractures...

Whole-cell uptake and nuclear localization of 1,25-dihydroxycholecalciferol by breast cancer cells (T47 D) in culture

Sher, Elizabeth, Eisman, John A., Moseley, Jane M., Martin, T. John

Specific high-affinity receptors for 1,25-dihydroxycholecalciferol [1,25-(OH)2D3] have been described recently in broken-cell preparations of several cultured human breast cancer cell lines including...

Whole-cell uptake and nuclear localization of 1,25-dihydroxycholecalciferol by breast cancer cells (T47 D) in culture

Sher, Elizabeth, Eisman, John A., Moseley, Jane M., Martin, T. John

Specific high-affinity receptors for 1,25-dihydroxycholecalciferol [1,25-(OH)2D3] have been described recently in broken-cell preparations of several cultured human breast cancer cell lines including...