John A. Martignetti

Loss of MMP-2 disrupts skeletal and craniofacial development and results in decreased bone mineralization, joint erosion and defects in osteoblast and osteoclast growth (2007)

Mosig, Rebecca A., Dowling, Oonagh, DiFeo, Analisa, Ramirez, Maria Celeste M., Parker, Ian C., Abe, Etsuko, ...

The ‘vanishing bone’ or inherited osteolysis/arthritis syndromes represent a heterogeneous group of skeletal disorders characterized by mineralization defects of affected bones and joints....

Sex steroids have differential effects on growth and gene expression in primary human prostatic epithelial cell cultures derived from the peripheral vs. transition zones (2005)

Kirschenbaum, Alexander, Liu, Xin-Hua, Yao, Shen, Narla, Goutham, Friedman, Scott L., Martignetti, John A., ...

The majority of human prostate cancers arise from the peripheral zone. Prostate epithelial stem cells have been localized to the basal epithelial cell compartment. In addition, basal cells have been...

Leukocyte common-antigen-related tyrosine phosphatase receptor: altered expression of mRNA and protein in the New England Deaconess Hospital rat line exhibiting spontaneous pheochromocytoma (2000)

Yang, Tao, Martignetti, John A., Massa, Stephen M., Longo, Frank M.

Regulation of cell proliferation by protein tyrosine phosphatases (PTPs) suggests that PTPs are important tumor suppressor genes. The gene encoding the leukocyte common-antigen-related (LAR) PTP...

Nonmuscle Myosin Heavy Chain IIA Mutations Define a Spectrum of Autosomal Dominant Macrothrombocytopenias: May-Hegglin Anomaly and Fechtner, Sebastian, Epstein, and Alport-Like Syndromes

Heath, Karen E., Campos-Barros, Angel, Toren, Amos, Rozenfeld-Granot, Galit, Carlsson, Lena E., Savige, Judy, ...

May-Hegglin anomaly (MHA) and Fechtner (FTNS) and Sebastian (SBS) syndromes are autosomal dominant platelet disorders that share macrothrombocytopenia and characteristic leukocyte inclusions. FTNS...

The Gene for May-Hegglin Anomaly Localizes to a

Martignetti, John A., Heath, Karen E., Harris, Juliette, Bizzaro, Nicola, Savoia, Anna, Balduini, Carlo L., ...

The May-Hegglin anomaly (MHA) is an autosomal dominant platelet disorder of unknown etiology. It is characterized by thrombocytopenia, giant platelets, and leukocyte inclusion bodies, and affected...

Mutations in Capillary Morphogenesis Gene-2 Result in the Allelic Disorders Juvenile Hyaline Fibromatosis and Infantile Systemic Hyalinosis

Dowling, Oonagh, Difeo, Analisa, Ramirez, Maria C., Tukel, Turgut, Narla, Goutham, Bonafe, Luisa, ...

Juvenile hyaline fibromatosis (JHF) and infantile systemic hyalinosis (ISH) are autosomal recessive syndromes of unknown etiology characterized by multiple, recurring subcutaneous tumors, gingival...

Nonmuscle Myosin Heavy Chain IIA Mutations Define a Spectrum of Autosomal Dominant Macrothrombocytopenias: May-Hegglin Anomaly and Fechtner, Sebastian, Epstein, and Alport-Like Syndromes

Heath, Karen E., Campos-Barros, Angel, Toren, Amos, Rozenfeld-Granot, Galit, Carlsson, Lena E., Savige, Judy, ...

May-Hegglin anomaly (MHA) and Fechtner (FTNS) and Sebastian (SBS) syndromes are autosomal dominant platelet disorders that share macrothrombocytopenia and characteristic leukocyte inclusions. FTNS...

The Gene for May-Hegglin Anomaly Localizes to a

Martignetti, John A., Heath, Karen E., Harris, Juliette, Bizzaro, Nicola, Savoia, Anna, Balduini, Carlo L., ...

The May-Hegglin anomaly (MHA) is an autosomal dominant platelet disorder of unknown etiology. It is characterized by thrombocytopenia, giant platelets, and leukocyte inclusion bodies, and affected...

Krüppel Cripples Prostate Cancer : KLF6 Progress and Prospects

Narla, Goutham, Friedman, Scott L., Martignetti, John A.

KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis

Narla, Goutham, DiFeo, Analisa, Fernandez, Yolanda, Dhanasekaran, Saravana, Huang, Fei, Sangodkar, Jaya, ...

Metastatic prostate cancer (PCa) is one of the leading causes of death from cancer in men. The molecular mechanisms underlying the transition from localized tumor to hormone-refractory metastatic PCa...