John A. Oates

Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H2 synthases

Boutaud, Olivier, Aronoff, David M., Richardson, Jacob H., Marnett, Lawrence J., Oates, John A.

Acetaminophen has antipyretic and analgesic properties yet differs from the nonsteroidal antiinflammatory drugs and inhibitors of prostaglandin H synthase (PGHS)-2 by exhibiting little effect on...

Herpesvirus DNA Is Consistently Detected in Lungs of Patients with Idiopathic Pulmonary Fibrosis

Tang, Yi-Wei, Johnson, Joyce E., Browning, Philip J., Cruz-Gervis, Roberto A., Davis, Angela, Graham, Barney S., ...

On the basis of earlier reports associating Epstein-Barr Virus (EBV) with half of the cases of idiopathic pulmonary fibrosis (IPF), we hypothesized that chronic infection with EBV or a closely...

Guanethidine and related agents: III. Antagonism by drugs which inhibit the norepinephrine pump in man

Mitchell, Jerry R., Cavanaugh, John H., Arias, Luis, Oates, John A.

Antagonism of the antihypertensive action of guanethidine by the tricyclic antidepressants, desipramine and protriptyline, has been demonstrated in controlled studies. These antidepressants also...

Effects of Prostaglandin Cyclic Endoperoxides on the Lung Circulation of Unanesthetized Sheep

Bowers, Ronald E., Ellis, Earl F., Brigham, Kenneth L., Oates, John A.

Although prostaglandins E2 and F2α have been suggested as mediators of the pulmonary hypertension seen after endotoxin infusion or during alveolar hypoxia, their precursors, the endoperoxides...

Ionophores stimulate prostaglandin and thromboxane biosynthesis*

Knapp, Howard R., Oelz, Oswald, Roberts, L. Jackson, Sweetman, Brian J., Oates, John A., Reed, Peter W.

The role of calcium in triggering prostaglandin and thromboxane synthesis was studied in several systems with ionophores of different ion specificities. Divalent cationophore A23187 stimulates...

Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H2 synthases

Boutaud, Olivier, Aronoff, David M., Richardson, Jacob H., Marnett, Lawrence J., Oates, John A.

Acetaminophen has antipyretic and analgesic properties yet differs from the nonsteroidal antiinflammatory drugs and inhibitors of prostaglandin H synthase (PGHS)-2 by exhibiting little effect on...

Herpesvirus DNA Is Consistently Detected in Lungs of Patients with Idiopathic Pulmonary Fibrosis

Tang, Yi-Wei, Johnson, Joyce E., Browning, Philip J., Cruz-Gervis, Roberto A., Davis, Angela, Graham, Barney S., ...

On the basis of earlier reports associating Epstein-Barr Virus (EBV) with half of the cases of idiopathic pulmonary fibrosis (IPF), we hypothesized that chronic infection with EBV or a closely...

Guanethidine and related agents: III. Antagonism by drugs which inhibit the norepinephrine pump in man

Mitchell, Jerry R., Cavanaugh, John H., Arias, Luis, Oates, John A.

Antagonism of the antihypertensive action of guanethidine by the tricyclic antidepressants, desipramine and protriptyline, has been demonstrated in controlled studies. These antidepressants also...

Effects of Prostaglandin Cyclic Endoperoxides on the Lung Circulation of Unanesthetized Sheep

Bowers, Ronald E., Ellis, Earl F., Brigham, Kenneth L., Oates, John A.

Although prostaglandins E2 and F2α have been suggested as mediators of the pulmonary hypertension seen after endotoxin infusion or during alveolar hypoxia, their precursors, the endoperoxides...

Ionophores stimulate prostaglandin and thromboxane biosynthesis*

Knapp, Howard R., Oelz, Oswald, Roberts, L. Jackson, Sweetman, Brian J., Oates, John A., Reed, Peter W.

The role of calcium in triggering prostaglandin and thromboxane synthesis was studied in several systems with ionophores of different ion specificities. Divalent cationophore A23187 stimulates...

Inherited human cPLA2α deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction

Adler, David H., Cogan, Joy D., Phillips, John A., Schnetz-Boutaud, Nathalie, Milne, Ginger L., Iverson, Tina, ...

Cytosolic phospholipase A2α (cPLA2α) hydrolyzes arachidonic acid from cellular membrane phospholipids, thereby providing enzymatic substrates for the synthesis of eicosanoids, such as...