John B. Welsh

2HAPI: a microarray data analysis system (2003)

Fink, J. Lynn, Drewes, Scott, Patel, Hiren, Welsh, John B., Masys, Daniel R., Corbeil, Jacques, ...

Summary: 2HAPI (version 2 of High density Array Pattern Interpreter) is a web-based, publicly-available analytical tool designed to aid researchers in microarray data analysis. 2HAPI includes tools...

Use of keyword hierarchies to interpret gene expression patterns (2001)

Masys, Daniel R., Welsh, John B., Lynn Fink, J., Gribskov, Michael, Klacansky, Igor, Corbeil, Jacques

Motivation: High-density microarray technology permits the quantitative and simultaneous monitoring of thousands of genes. The interpretation challenge is to extract relevant information from this...

Analysis of gene expression profiles in normal and neoplastic ovarian tissue samples identifies candidate molecular markers of epithelial ovarian cancer

Welsh, John B., Zarrinkar, Patrick P., Sapinoso, Lisa M., Kern, Suzanne G., Behling, Cynthia A., Monk, Bradley J., ...

Epithelial ovarian cancer is the leading cause of death from gynecologic cancer, in part because of the lack of effective early detection methods. Although alterations of several genes, such as...

Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum

Welsh, John B., Sapinoso, Lisa M., Kern, Suzanne G., Brown, David A., Liu, Tao, Bauskin, Asne R., ...

Genetic alterations in tumor cells often lead to the emergence of growth-stimulatory autocrine and paracrine signals, involving overexpression of secreted peptide growth factors, cytokines, and...

Arrays of Arrays for High-Throughput Gene Expression Profiling

Zarrinkar, Patrick P., Mainquist, James K., Zamora, Matthew, Stern, David, Welsh, John B., Sapinoso, Lisa M., ...

Gene expression profiling using DNA arrays is rapidly becoming an essential tool for research and drug discovery and may soon play a central role in disease diagnosis. Although it is possible to make...

Temporal Gene Regulation During HIV-1 Infection of Human CD4+ T Cells

Corbeil, Jacques, Sheeter, Dennis, Genini, Davide, Rought, Steffney, Leoni, Lorenzo, Du, Pinyi, ...

CD4+ T-cell depletion is a characteristic of human immunodeficiency virus type 1 (HIV-1) infection. In this study, modulation of mRNA expression of 6800 genes was monitored simultaneously at eight...

Analysis of gene expression profiles in normal and neoplastic ovarian tissue samples identifies candidate molecular markers of epithelial ovarian cancer

Welsh, John B., Zarrinkar, Patrick P., Sapinoso, Lisa M., Kern, Suzanne G., Behling, Cynthia A., Monk, Bradley J., ...

Epithelial ovarian cancer is the leading cause of death from gynecologic cancer, in part because of the lack of effective early detection methods. Although alterations of several genes, such as...

Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum

Welsh, John B., Sapinoso, Lisa M., Kern, Suzanne G., Brown, David A., Liu, Tao, Bauskin, Asne R., ...

Genetic alterations in tumor cells often lead to the emergence of growth-stimulatory autocrine and paracrine signals, involving overexpression of secreted peptide growth factors, cytokines, and...

Arrays of Arrays for High-Throughput Gene Expression Profiling

Zarrinkar, Patrick P., Mainquist, James K., Zamora, Matthew, Stern, David, Welsh, John B., Sapinoso, Lisa M., ...

Gene expression profiling using DNA arrays is rapidly becoming an essential tool for research and drug discovery and may soon play a central role in disease diagnosis. Although it is possible to make...

Temporal Gene Regulation During HIV-1 Infection of Human CD4+ T Cells

Corbeil, Jacques, Sheeter, Dennis, Genini, Davide, Rought, Steffney, Leoni, Lorenzo, Du, Pinyi, ...

CD4+ T-cell depletion is a characteristic of human immunodeficiency virus type 1 (HIV-1) infection. In this study, modulation of mRNA expression of 6800 genes was monitored simultaneously at eight...

Large Scale Molecular Analysis Identifies Genes with Altered Expression in Salivary Adenoid Cystic Carcinoma

Frierson, Henry F., El-Naggar, Adel K., Welsh, John B., Sapinoso, Lisa M., Su, Andrew I., Cheng, Jun, ...

Salivary gland cancers comprise a heterogeneous group of neoplasms whose biological and clinical characteristics differ considerably from those of mucosal squamous cell carcinomas of the head and...