John C. Cheville

Optimization of laser capture microdissection and RNA amplification for gene expression profiling of prostate cancer (2007)

Kube, Dagmar M, Savci-Heijink, Cemile D, Lamblin, Anne-Françoise, Kosari, Farhad, Vasmatzis, George, Cheville, John C, ...

Abstract Background To discover prostate cancer biomarkers, we profiled gene expression in benign and malignant cells laser capture microdissected (LCM) from prostate tissues and metastatic prostatic...

Optimization of laser capture microdissection and RNA amplification for gene expression profiling of prostate cancer (2007)

Kube, Dagmar M, Savci-Heijink, Cemile D, Lamblin, Anne-Françoise, Kosari, Farhad, Vasmatzis, George, Cheville, John C, ...

Abstract Background To discover prostate cancer biomarkers, we profiled gene expression in benign and malignant cells laser capture microdissected (LCM) from prostate tissues and metastatic prostatic...

Identification of differentially expressed genes in normal and malignant prostate by electronic profiling of expressed sequence tags (2002)

Yan W. Asmann, Farhad Kosari, Kai Wang, John C. Cheville, George Vasmatzis

Differentially expressed genes between corresponding normal and cancer tissue can advance our understanding of the molecular basis of malignancy and potentially serve as biomarkers or prognostic...

Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target

Thompson, R. Houston, Gillett, Michael D., Cheville, John C., Lohse, Christine M., Dong, Haidong, Webster, W. Scott, ...

Expression of B7-H1, a costimulating glycoprotein in the B7 family, is normally restricted to macrophage-lineage cells, providing a potential costimulatory signal source for regulation of T cell...

Mutations in CHEK2 Associated with Prostate Cancer Risk

Dong, Xiangyang, Wang, Liang, Taniguchi, Ken, Wang, Xianshu, Cunningham, Julie M., McDonnell, Shannon K., ...

The DNA-damage–signaling pathway has been implicated in all human cancers. However, the genetic defects and the mechanisms of this pathway in prostate carcinogenesis remain poorly understood. In...

Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target

Thompson, R. Houston, Gillett, Michael D., Cheville, John C., Lohse, Christine M., Dong, Haidong, Webster, W. Scott, ...

Expression of B7-H1, a costimulating glycoprotein in the B7 family, is normally restricted to macrophage-lineage cells, providing a potential costimulatory signal source for regulation of T cell...

B7-H4 expression in renal cell carcinoma and tumor vasculature: Associations with cancer progression and survival

Krambeck, Amy E., Thompson, R. Houston, Dong, Haidong, Lohse, Christine M., Park, Eugene S., Kuntz, Susan M., ...

B7-H4 is a recently described B7 family coregulatory ligand that has been implicated as an inhibitor of T cell-mediated immunity. Although expression of B7-H4 is typically limited to lymphoid cells,...

p27kip1: A Multifunctional Cyclin-Dependent Kinase Inhibitor with Prognostic Significance in Human Cancers

Lloyd, Ricardo V., Erickson, Lori A., Jin, Long, Kulig, Elzbieta, Qian, Xiang, Cheville, John C., ...

p27kip1 (p27) is a member of the universal cyclin-dependent kinase inhibitor (CDKI) family. p27 expression is regulated by cell contact inhibition and by specific growth factors, such as transforming...

A p120 Catenin Isoform Switch Affects Rho Activity, Induces Tumor Cell Invasion, and Predicts Metastatic Disease*S⃞

Yanagisawa, Masahiro, Huveldt, Deborah, Kreinest, Pamela, Lohse, Christine M., Cheville, John C., Parker, Alexander S., ...

p120 catenin is a cadherin-associated protein that regulates Rho GTPases and promotes the invasiveness of E-cadherin-deficient cancer cells. Multiple p120 isoforms are expressed in cells via...