John D. Potter

Plausibility of stromal initiation of epithelial cancers without a mutation in the epithelium: a computer simulation of morphostats (2009)

Baker, Stuart G, Soto, Ana M, Sonnenschein, Carlos, Cappuccio, Antonio, Potter, John D, Kramer, Barnett S

Abstract Background There is experimental evidence from animal models favoring the notion that the disruption of interactions between stroma and epithelium plays an important role in the initiation...

Gene-set analysis and reduction (2009)

Dinu, Irina, Potter, John D., Mueller, Thomas, Liu, Qi, Adewale, Adeniyi J., Jhangri, Gian S., ...

Gene-set analysis aims to identify differentially expressed gene sets (pathways) by a phenotype in DNA microarray studies. We review here important methodological aspects of gene-set analysis and...

Food and Phytochemicals, Magic Bullets and Measurement Error: A Commentary (2008)

John D. Potter

The original explanation for a lower risk of colon cancer in the presence of a diet high in plant foods was attributed to effects of fiber—and there are both human studies (1) and an extensive...

SUMMARY (2008)

Margaret Pepe, Mary Lou Thompson, Bao-ling Adam, George L. Wright, Yinsheng Qu, John D. Potter, ...

A data-analytic strategy for protein biomarker discovery: profiling of high-dimensional proteomic data for cancer detection

Association of Epstein-Barr virus antibody titers with a human IL-10 promoter polymorphism in Japanese women (2008)

Yasui, Yutaka, Hamajima, Nobuyuki, Nakamura, Tsuneya, El-Din, Noha, Tajima, Kazuo, Potter, John D

Abstract Background Multiple sclerosis (MS) risk, over 10-fold higher in Western than in Asian countries, is associated with elevated IgG antibody titers against Epstein-Barr viral capcid antigen...

A Biological Evaluation of Six Gene Set Analysis Methods for Identification of Differentially Expressed Pathways in Microarray Data (2008)

Irina Dinu, Qi Liu, John D. Potter, Adeniyi J. Adewale, Gian S. Jhangri, Thomas Mueller, ...

Gene-set analysis of microarray data evaluates biological pathways, or gene sets, for their differential expression by a phenotype of interest. In contrast to the analysis of individual genes,...

Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk (2008)

Berndt, Sonja I., Potter, John D., Hazra, Aditi, Yeager, Meredith, Thomas, Gilles, Makar, Karen W., ...

Several different genetic variants at chromosome 8q24 have been related to prostate, breast and colorectal cancer risk with evidence of region-specific risk differentials for various tumor types. We...

Timing of Menarche and First Full-Term Birth in Relation to Breast Cancer Risk (2008)

Li, Christopher I., Malone, Kathleen E., Daling, Janet R., Potter, John D., Bernstein, Leslie, Marchbanks, Polly A., ...

Ages at menarche and first birth are established risk factors for breast cancer. The interval between these ages may also affect risk, since the breast is more susceptible to carcinogenic insults...

Pivotal Evaluation of the Accuracy of a Biomarker Used for Classification or Prediction: Standards for Study Design (2008)

Pepe, Margaret S., Feng, Ziding, Janes, Holly, Bossuyt, Patrick M., Potter, John D.

Research methods for biomarker evaluation lag behind those for evaluating therapeutic treatments. Although a phased approach to development of biomarkers exists and guidelines are available for...

Comparative evaluation of gene-set analysis methods (2007)

Liu, Qi, Dinu, Irina, Adewale, Adeniyi J, Potter, John D, Yasui, Yutaka

Abstract Background Multiple data-analytic methods have been proposed for evaluating gene-expression levels in specific biological pathways, assessing differential expression associated with a binary...

Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet (2007)

Curtin, Karen, Slattery, Martha L., Ulrich, Cornelia M., Bigler, Jeannette, Levin, Theodore R., Wolff, Roger K., ...

This study investigated associations between CpG island methylator phenotype (CIMP) colon cancer and genetic polymorphisms relevant to one-carbon metabolism and thus, potentially the provision of...

Improving gene set analysis of microarray data by SAM-GS (2007)

Dinu, Irina, Potter, John D, Mueller, Thomas, Liu, Qi, Adewale, Adeniyi J, Jhangri, Gian S, ...

Abstract Background Gene-set analysis evaluates the expression of biological pathways, or a priori defined gene sets, rather than that of individual genes, in association with a binary phenotype, and...

Inherited variation in carcinogen-metabolizing enzymes and risk of colorectal polyps (2007)

Goode, Ellen L., Potter, John D., Bamlet, William R., Rider, David N., Bigler, Jeannette

Exposures such as cigarette smoke and meat contain a variety of procarcinogens, which are thought to play a role in elevation of risk for colorectal polyps and/or cancer. These procarcinogens...

Genetic variability in prostaglandin synthesis, fish intake, and risk of colorectal polyps (2007)

Poole, Elizabeth M., Bigler, Jeannette, Whitton, John, Sibert, Justin G., Kulmacz, Richard J., Potter, John D., ...

Dietary polyunsaturated fatty acids (PUFAs) can be converted to prostaglandins and leukotrienes. Metabolism of omega-6 (n-6) PUFAs results in the production of pro-inflammatory mediators while...

Inherited variation in carcinogen-metabolizing enzymes and risk of colorectal polyps (2006)

Goode, Ellen L., Potter, John D., Bamlet, William R., Rider, David N., Bigler, Jeannette

Exposures such as cigarette smoke and meat contain a variety of procarcinogens, which are thought to play a role in elevation of risk for colorectal polyps and/or cancer. These procarcinogens...

Associations between apoE genotype and colon and rectal cancer (2005)

Slattery, Martha L., Sweeney, Carol, Murtaugh, Maureen, Ma, Khe Ni, Potter, John D., Levin, Theodore R., ...

Apolipoprotein E (apoE) plays a major role in the metabolism of bile acids, cholesterol and triglycerides, and has recently been proposed as being involved in the carcinogenic process. Given the...

Associations between ApoE genotype and colon and rectal cancer (2005)

Slattery, Martha L., Sweeney, Carol, Murtaugh, Maureen, Ma, Khe Ni, Potter, John D., Levin, Theodore R., ...

Apolipoprotein E (apoE) plays a major role in the metabolism of bile acids, cholesterol, and triglycerides and has recently been proposed as being involved in the carcinogenic process. Given the...

Dairy Foods, Calcium, and Colorectal Cancer: A Pooled Analysis of 10 Cohort Studies (2004)

Cho, Eunyoung, Smith-Warner, Stephanie A., Spiegelman, Donna, Beeson, W. Lawrence, Van Den Brandt, Piet A., Colditz, Graham A., ...

Background: Studies in animals have suggested that calcium may reduce the risk of colorectal cancer. However, results from epidemiologic studies of intake of calcium or dairy foods and colorectal...

VITamins And Lifestyle Cohort Study: Study Design and Characteristics of Supplement Users (2004)

White, Emily, Patterson, Ruth E., Kristal, Alan R., Thornquist, Mark, King, Irena, Shattuck, Ann L., ...

Vitamin and mineral supplements are among the most commonly used drugs in the United States, despite limited evidence on their benefits or risks. This paper describes the design, implementation, and...

TGF{beta}1 polymorphism (L10P) and risk of colorectal adenomatous and hyperplastic polyps (2004)

Sparks, Rachel, Bigler, Jeannette, Sibert, Justin G., Potter, John D., Yasui, Yutaka, Ulrich, Cornelia M.

Background Transforming growth factor-β1 (TGFβ1) is a multifunctional signalling molecule with a wide array of roles. Animal experiments suggest that TGFβ1 plays a biphasic role in carcinogenesis...

Nutrition and Physical Activity and Chronic Disease Prevention: Research Strategies and Recommendations (2004)

Prentice, Ross L., Willett, Walter C., Greenwald, Peter, Alberts, David, Bernstein, Leslie, Boyd, Norman F., ...

A shortage of credible information exists on practical dietary and physical activity patterns that have potential to reverse the national obesity epidemic and reduce the risk of major cancers and...

TGF{beta}1 polymorphism (L10P) and risk of colorectal adenomatous and hyperplastic polyps (2004)

Sparks, Rachel, Bigler, Jeannette, Sibert, Justin G, Potter, John D, Yasui, Yutaka, Ulrich, Cornelia M

Background Transforming growth factor-β1 (TGFb1) is a multifunctional signalling molecule with a wide array of roles. Animal experiments suggest that TGFb1 plays a biphasic role in carcinogenesis by...

Effects of Exercise on Total and Intra-abdominal Body Fat in Postmenopausal Women (2003)

Irwin, Melinda L., Yasui, Yutaka, Ulrich, Cornelia M., Bowen, Deborah, Rudolph, Rebecca E., Schwartz, Robert S., ...

Context The increasing prevalence of obesity is a major public health concern. Physical activity may promote weight and body fat loss. Objective To examine the effects of exercise on total and...

Associations of Total Energy and Macronutrients with Colon Cancer Risk in African Americans and Whites: Results from the North Carolina Colon Cancer Study (2003)

Satia-Abouta, Jessie, Galanko, Joseph A., Potter, John D., Ammerman, Alice, Martin, Christopher F., Sandler, Robert S.

The higher incidence of colon cancer in African Americans compared with other US racial/ethnic groups is largely unexplained. This report describes associations of total energy and macronutrients...

Waist-to-Hip Ratio and Breast Cancer Mortality (2003)

Borugian, Marilyn J., Sheps, Samuel B., Kim-Sing, Charmaine, Olivotto, Ivo A., Van Patten, Cheri, Dunn, Bruce P., ...

High insulin levels have been associated with increased risk of breast cancer and poorer survival after a breast cancer diagnosis. Waist-to-hip ratio (WHR) is a marker for insulin resistance and...

Long-Term Efficacy of Sigmoidoscopy in the Reduction of Colorectal Cancer Incidence (2003)

Newcomb, Polly A., Storer, Barry E., Morimoto, Libby M., Templeton, Allyson, Potter, John D.

Screening sigmoidoscopy is associated with a reduction in both the incidence and mortality of colorectal cancer. Although current guidelines recommend sigmoidoscopy screening every 5 years, the...

Reliability and Validity of Self-Report of Vitamin and Mineral Supplement Use in the Vitamins and Lifestyle Study (2003)

Satia-Abouta, Jessie, Patterson, Ruth E., King, Irena B., Stratton, Kayla L., Shattuck, Ann L., Kristal, Alan R., ...

In the United States, dietary supplements contribute a large proportion of micronutrient intakes. Therefore, it is important to collect accurate information on supplement use for studies of...

A Data-Analytic Strategy for Protein-Biomarker Discovery: Profiling of High-Dimensional Proteomic Data for Cancer Detection (2002)

Yasui, Yutaka, Pepe, Margaret S., Thompson, Mary Lou, Adam, Bao-Ling, Wright, George L., Qu, Yinsheng, ...

With recent advances in mass spectrometry techniques, it is now possible to investigate proteins over a wide range of molecular weights in small biological specimens. This advance has generated...

A Data-Analytic Strategy for Protein-Biomarker Discovery: Profiling of High-Dimensional Proteomic Data for Cancer Detection (2002)

Yasui, Yutaka, Pepe, Margaret S., Thompson, Mary Lou, Adam, Bao-Ling, Wright, George L., Qu, Yinsheng, ...

With recent advances in mass spectrometry techniques, it is now possible to investigate proteins over a wide range of molecular weights in small biological specimens. This advance has generated...

A Data-Analytic Strategy for Protein-Biomarker Discovery: Profiling of High-Dimensional Proteomic Data for Cancer Detection (2002)

Yasui, Yutaka, Pepe, Margaret S., Thompson, Mary Lou, Adam, Bao-Ling, Wright, George L., Qu, Yinsheng, ...

With recent advances in mass spectrometry techniques, it is now possible to investigate proteins over a wide range of molecular weights in small biological specimens. This advance has generated...

A Data-Analytic Strategy for Protein-Biomarker Discovery: Profiling of High-Dimensional Proteomic Data for Cancer Detection (2002)

Yasui, Yutaka, Pepe, Margaret S., Thompson, Mary Lou, Adam, Bao-Ling, Wright, George L., Qu, Yinsheng, ...

With recent advances in mass spectrometry techniques, it is now possible to investigate proteins over a wide range of molecular weights in small biological specimens. This advance has generated...

Interaction of Waist/Hip Ratio and Family History on the Risk of Hormone Receptor-defined Breast Cancer in a Prospective Study of Postmenopausal Women (2002)

Sellers, Thomas A., Davis, Jenny, Cerhan, James R., Vierkant, Robert A., Olson, Janet E., Pankratz, V. Shane, ...

The authors previously reported an interaction of waist/hip ratio and family history on the risk of breast cancer in the Iowa Women's Health Study. Here they reexamine this association based on 9...

Anthropometric Characteristics, Physical Activity, and Risk of Non-Hodgkin's Lymphoma Subtypes and B-Cell Chronic Lymphocytic Leukemia: A Prospective Study (2002)

Cerhan, James R., Janney, Carol A., Vachon, Celine M., Habermann, Thomas M., Kay, Neil E., Potter, John D., ...

Anthropometric characteristics, physical activity, and risk of non-Hodgkin’s lymphoma, its subtypes, and B-cell chronic lymphocytic leukemia (B-CLL) were evaluated in a prospective cohort study of...

Meat and dairy food consumption and breast cancer: a pooled analysis of cohort studies (2002)

Missmer, Stacey A, Smith-Warner, Stephanie A, Spiegelman, Donna, Yaun, Shiaw-Shyuan, Adami, Hans-Olov, Beeson, W Lawrence, ...

Background More than 20 studies have investigated the relation between meat and dairy food consumption and breast cancer risk with conflicting results. Our objective was to evaluate the risk of...

Brassica vegetables increase and apiaceous vegetables decrease cytochrome P450 1A2 activity in humans: changes in caffeine metabolite ratios in response to controlled vegetable diets (2000)

Lampe, Johanna W., King, Irena B., Li, Sue, Grate, Margaret T., Barale, Karen V., Chen, Chu, ...

Induction or inhibition of biotransformation enzymes, enzymes that activate or detoxify numerous xenobiotics, is one mechanism by which vegetables may alter cancer risk. Using a randomized crossover...

Breast-Feeding and Risk of Childhood Acute Leukemia (1999)

Shu, Xiao Ou, Linet, Martha S., Steinbuch, Michael, Wen, Wan Qing, Buckley, Jonathan D., Neglia, Joseph P., ...

BACKGROUND: Breast-feeding is well known to have a protective effect against infection in infants. Although the long-term effects of breast-feeding on childhood cancer have not been studied...

Colorectal Cancer: Molecules and Populations (1999)

Potter, John D.

The epidemiology and molecular biology of colorectal cancer are reviewed with a view to understanding their interrelationship. Risk factors for colorectal neoplasia include a positive family history,...

Eating Patterns and Risk of Colon Cancer (1998)

Slattery, Martha L., Boucher, Kenneth M., Caan, Bette J., Potter, John D., Ma, Khe-Ni

Colon cancer has been associated with several nutrients and foods. The authors used data from a population-based study conducted in Northern California, Utah, and Minnesota to examine associations...

Pathologic Features of Initial Adenomas as Predictors for Metachronous Adenomas of the Rectum (1998)

Yang, Gong, Zheng, Wei, Sun, Qi-Rong, Shu, Xiao-Ou, Li, Wei-Dong, Yu, Hai, ...

Background: Colorectal cancer is the third most common cancer in the world, arising mostly from pre-existing adenomatous polyps (adenomas) of the large bowel. Patients with colorectal adenomas are at...

Dietary Energy Sources and Colon Cancer Risk (1997)

Slattery, Martha L., Caan, Bette J., Potter, John D., Berry, T. Dennis, Coates, Ashley, Duncan, Debra, ...

Because energy-contributing nutrients are highly correlated with total energy, the association with colon cancer from energy versus other components of energy-providing nutrients is often not clear....

Genetic Services for Familial Cancer Patients: A Survey of National Cancer Institute Cancer Centers (1995)

Thompson, Julie A., Sellers, Thomas A., Vachon, Celine, Ahrens, Mary, Sumpmann, Mary, Kersey, John, ...

In the past d3ecade, significant progress has been made in understanding the genetic component of familial cancers.Genes associated with familial colon and breast cancers have recently been isolated...

Association of Body Mass Index and Body Fat Distribution with Risk of Lung Cancer in Older Women (1995)

Drinkard, Carol R., Sellers, Thomas A., Potter, John D., Zheng, Wei, Bostlck, Roberd M., Nelson, Christine L., ...

Obesity has been associated with an increased risk of cancer at a number of sites. A notable exception appears to be lung cancer, for which several studies suggest a modest inverse association....

Calcium and Colorectal Epithelial Cell Proliferation in Sporadic Adenoma Patients: a Randomized, Double– Blinded, Placebo-Controlled Clinical Trial (1995)

Bostick, Roberd M., Fosdick, Lisa, Grambsch, Patricia, Grandits, Greg A., Louis, Thomas A., Potter, John D., ...

Background: The kinetics of colorectal epithelial cell proliferation is altered in patients at increased risk for colon cancer. Calcium administration ameliorates such proliferative changes in...

Dietary Intake of Energy and Animal Foods and Endometrial Cancer Incidence: The lowa Women's Health Study (1995)

Zheng, Wei, Kushi, Lawrence H., Potter, John D., Sellers, Thomas A., Doyle, Timothy J., Bostick, Roberd M., ...

To assess the relations of dietary intake of energy and animal foods to endometrial cancer risk, dietary analyses were performed using data from a prospective cohort study of over 23,000...

Retinol, Antioxidant Vitamins, and Cancers of the Upper Digestive Tract in a Prospective Cohort Study of Postmenopausal Women (1995)

Zheng, Wei, Sellers, Thomas A., Doyle, Timothy J., Kushi, Lawrence H., Potter, John D., Folsom, Aaron R.

Very few prospective studies have reported previously on the association of micronutrient intake and the risk of cancers of the upper digestive tract (mouth, pharynx, esophagus, and stomach) in...

Vegetables, Fruit, and Colon Cancer in the lowa Women's Health Study (1994)

Steinmetz, Kristi A., Kushi, Lawrence H., Bostick, Roberd M., Folsom, Aaron R., Potter, John D.

Previous epidemiologic studies have shown an inverse association between vegetable and fruit consumption and colon cancer risk; few of these studies have been prospective or have focused on women....

Familial Clustering of Breast and Prostate Cancers and Risk of Postmenopausal Breast Cancer (1994)

Sellers, Thomas A., Potter, John D., Rich, Stephen S., Drinkard, Carol R., Bostick, Roberd M., Kushi, Lawrence H., ...

Background: Previous studies have suggested that cancers of the breast and prostate cluster in families and that the presence of both diseases in a family may be associated with increased risk of...

EVIDENCE FOR THE FORMATION OF MULTIPLE TYPES OF ACETALDEHYDE-HAEMOGLOBIN ADDUCTS (1994)

GROSS, MYRON D., HAYS, REBECCA, GAPSTUR, SUSAN M., CHAUSSEE, MIKE, POTTER, JOHN D.

Acetaldehyde readily reacted with red blood cells and isolated haemoglobin to form adducts. We examined acetaldehyde-haemoglobin reaction products, isolated from red blood cells incubated with...

Handedness and Mortality Risk in Older Women (1994)

Cerhan, James R., Folsom, Aaron R., Potter, John D., Prineas, Ronald J.

Left-handedness has been associated with decreased longevity, although this finding is controversial and not universal. The authors prospectively studied 39,691 women aged 55–69 years from the Iowa...

Relation of Calcium, Vitamin D, and Dairy Food Intake to Incidence of Colon Cancer among Older Women: The Iowa Women's Health Study (1993)

Bostick, Roberd M., Potter, John D., Sellers, Thomas A., McKenzie, David R., Kushi, Lawrence H., Folsom, Aaron R.

To investigate whether a high intake of calcium, vitamin D, or dairy products may protect against colon cancer, the authors analyzed data from a prospective cohort study of 35,216 Iowa women aged...

Association of Body Fat Distribution and Family Histories of Breast and Ovarian Cancer with Risk of Postmenopausal Breast Cancer (1993)

Sellers, Thomas A., Gapstur, Susan M., Potter, John D., Kushi, Lawrence H., Bostick, Roberd M., Folsom, Aaron R.

The authors recently published data from a prospective cohort study of postmeno-pausal women (N Engl J Med 1992; 326:1323–9) which suggested that a high waist/hip ratio was associated with a...

Calcium and Colorectal Epithelial Cell Proliferation: A Preliminary Randomized, Double-Blinded, Placebo-Controlled Clinical Trial (1993)

Bostick, Roberd M., Potter, John D., Fosdick, Lisa, Grambsch, Patricia, Lampe, Johanna W., Wood, James R., ...

Background Colonic epithelial cell proliferation is increased in patients at high risk for colon cancer. Calcium administration has ameliorated the proliferative changes in rodents, and findings in...

Increased Risk of Breast Cancer with Alcohol Consumption in Postmenopausal Women (1992)

Gapstur, Susan M., Potter, John D., Sellers, Thomas A., Folsom, Aaron R.

The association between breast cancer incidence and alcohol consumption among postmenopausal women was examined in the lowa Women‘s Health Study. In January 1986, a cohort of 41, 837 postmenopausal...

Dietary Fat and Postmenopausal Breast Cancer (1992)

Kushi, Lawrence H., Sellers, Thomas A., Potter, John D., Nelson, Christine L., Munger, Ronald G., Kaye, Susan A., ...

Background: Although the results of animal studies and cross-cultural comparisons generally support a role for dietary fat in the etiology of breast cancer, results of analytic epidemiology studies...

Dietary Intake of Fiber and Decreased Risk of Cancers of the Colon and Rectum: Evidence From the Combined Analysis of 13 Case-Control Studies (1992)

Howe, Geoffrey R., Benito, Enrique, Castelleto, Roberto, Cornée, Jacqueline, Estève, Jacques, Gallagher, Richard P., ...

Background: Colorectal cancer is a major public health problem in both North America and western Europe, and incidence and mortality rates are rapidly increasing in many previously low-risk...

Associations of Body Mass and Fat Distribution with Sex Hormone Concentrations in Postmenopausal Women (1991)

KAYE, SUSAN A, FOLSOM, AARON R, SOLER, JOHN T, PRINEAS, RONALD J, POTTER, JOHN D

The associations of body mass and body fat distribution, as measured by waist-to-hip circumference ratio, with serum concentrations of sex hormones and sex hormone binding globulin were examined in...

INCREASED INCIDENCE OF CARCINOMA OF THE BREAST ASSOCIATED WITH ABDOMINAL ADIPOSITY IN POSTMENOPAUSAL WOMEN (1990)

FOLSOM, AARON R., KAYE, SUSAN A., PRINEAS, RONALD J., POTTER, JOHN D, GAPSTUR, SUSAN M., WALLACE, ROBERT B.

Epidemiologic studies have established that increased body weight is associated with a greater incidence of breast cancer in postmenopausal women. The authors hypothesized that abdominal adiposity...

The Cancer and Diet Intervention Project: a community-based intervention to reduce nutrition-related risk of cancer (1990)

Potter, John D., Graves, Karen L., Finnegan, John R., M.Mullis, Rebecca, S.Baxter, Judith, Crockett, Susan, ...

This paper describes a community-based intervention program designed to lower diet-related risk of cancer. The program is one of the first to attempt to make operational cancer-related dietary...

Alcohol, Beer and Lung Cancer--A Meaningful Relationship? (1984)

POTTER, JOHN D, McMICHAEL, ANTHONY J

Potter, JD (Commonwealth Scientific and Industrial Research Organization, Division of Human Nutrition, Kintore Avenue, Adelaide, South Australia 5000) and McMichael A J. Alcohol, beer and lung cancer...

RETROSPECTIVE ASSESSMENT OF DIETARY INTAKE (1984)

ROHAN, THOMAS E., POTTER, JOHN D.

In studying the role of diet in chronic disease etioiogy, measurement of past intake may be of more relevance than measurement of that existing either at the time of or just preceding the clinicai...

Common stocks of public utilities as long term investments / (1949)

Potter, John D.

Thesis (M.S.)--Texas College of Arts and Industries, 1949.

A thesis on etiology / (1871)

Potter, John D. (John Donaldson)

Binder's title: Cleveland medical thesis, 1870-1871, v. 36.

Understanding missense mutations in the BRCA1 gene: An evolutionary approach

Fleming, Melissa A., Potter, John D., Ramirez, Christina J., Ostrander, Gary K., Ostrander, Elaine A.

The role of missense changes in BRCA1 in breast cancer susceptibility has been difficult to establish. We used comparative evolutionary methods to identify potential functionally important amino acid...

Personalized Exposure Assessment: Promising Approaches for Human Environmental Health Research

Weis, Brenda K., Balshaw, David, Barr, John R., Brown, David, Ellisman, Mark, Lioy, Paul, ...

New technologies and methods for assessing human exposure to chemicals, dietary and lifestyle factors, infectious agents, and other stressors provide an opportunity to extend the range of human...

Understanding missense mutations in the BRCA1 gene: An evolutionary approach

Fleming, Melissa A., Potter, John D., Ramirez, Christina J., Ostrander, Gary K., Ostrander, Elaine A.

The role of missense changes in BRCA1 in breast cancer susceptibility has been difficult to establish. We used comparative evolutionary methods to identify potential functionally important amino acid...

Personalized Exposure Assessment: Promising Approaches for Human Environmental Health Research

Weis, Brenda K., Balshaw, David, Barr, John R., Brown, David, Ellisman, Mark, Lioy, Paul, ...

New technologies and methods for assessing human exposure to chemicals, dietary and lifestyle factors, infectious agents, and other stressors provide an opportunity to extend the range of human...

BAT-26 and BAT-40 Instability in Colorectal Adenomas and Carcinomas and Germline Polymorphisms

Samowitz, Wade S., Slattery, Martha L., Potter, John D., Leppert, Mark F.

Analysis of the mononucleotide repeats BAT-26 and BAT-40 has reportedly revealed significant microsatellite instability in sporadic colorectal adenomas, whereas studies with dinucleotide and...

Pivotal Evaluation of the Accuracy of a Biomarker Used for Classification or Prediction: Standards for Study Design

Pepe, Margaret S., Feng, Ziding, Janes, Holly, Bossuyt, Patrick M., Potter, John D.

Research methods for biomarker evaluation lag behind those for evaluating therapeutic treatments. Although a phased approach to development of biomarkers exists and guidelines are available for...

A Biological Evaluation of Six Gene Set Analysis Methods for Identification of Differentially Expressed Pathways in Microarray Data

Dinu, Irina, Liu, Qi, Potter, John D., Adewale, Adeniyi J., Jhangri, Gian S., Mueller, Thomas, ...

Gene-set analysis of microarray data evaluates biological pathways, or gene sets, for their differential expression by a phenotype of interest. In contrast to the analysis of individual genes,...