Pimanda, John E., Silberstein, Lev, Dominici, Massimo, Dekel, Benjamin, Bowen, Mark, Oldham, Scott, ...
Blood and vascular cells are generated during early embryogenesis from a common precursor, the hemangioblast. The stem cell leukemia gene (SCL/tal 1) encodes a basic helix-loop-helix transcription...
Pimanda, John E., Silberstein, Lev, Dominici, Massimo, Dekel, Benjamin, Bowen, Mark, Oldham, Scott, ...
Blood and vascular cells are generated during early embryogenesis from a common precursor, the hemangioblast. The stem cell leukemia gene (SCL/tal 1) encodes a basic helix-loop-helix transcription...
The SCL transcriptional network and BMP signaling pathway interact to regulate RUNX1 activity
Pimanda, John E., Donaldson, Ian J., De Bruijn, Marella F. T. R., Kinston, Sarah, Knezevic, Kathy, Huckle, Liz, ...
Hematopoietic stem cell (HSC) development is regulated by several signaling pathways and a number of key transcription factors, which include Scl/Tal1, Runx1, and members of the Smad family. However,...
Pimanda, John E., Ottersbach, Katrin, Knezevic, Kathy, Kinston, Sarah, Chan, Wan Y. I., Wilson, Nicola K., ...
Conservation of the vertebrate body plan has been attributed to the evolutionary stability of gene-regulatory networks (GRNs). We describe a regulatory circuit made up of Gata2, Fli1, and Scl/Tal1...