Duff, Gregory A., Taylor, Jay G., Prescott, John F., Swift, Michael A.
Legal context Many patent holders attempt to reap a benefit from their patents by identifying potential infringers and offering them a license. Negotiations often begin with the potential infringer...
Restriction Fragment Length Polymorphisms of Virulence Plasmids in Rhodococcus equi
Takai, Shinji, Shoda, Masato, Sasaki, Yukako, Tsubaki, Shiro, Fortier, Guillaume, Pronost, Stephane, ...
Virulent Rhodococcus equi, which is a well-known cause of pyogranulomatous pneumonia in foals, possesses a large plasmid encoding virulence-associated 15- to 17-kDa antigens. Foal and soil isolates...
MICs of Oxazolidinones for Rhodococcus equi Strains Isolated from Humans and Animals
Bowersock, Terry L., Salmon, Sarah A., Portis, Ellen S., Prescott, John F., Robison, Denise A., Ford, Charles W., ...
Eperezolid and linezolid are representatives of a new class of orally active, synthetic antimicrobial agents. The in vitro activity values (MICs) of linezolid, eperezolid, and comparator antibiotics...
Modulation of Cytokine Response of Pneumonic Foals by Virulent Rhodococcus equi
Giguère, Steeve, Wilkie, Bruce N., Prescott, John F.
The ability of Rhodococcus equi to induce pneumonia in foals depends on the presence of an 85- to 90-kb plasmid. In this study, we evaluated whether plasmid-encoded products mediate virulence by...
DNA Sequence and Comparison of Virulence Plasmids from Rhodococcus equi ATCC 33701 and 103
Takai, Shinji, Hines, Stephen A., Sekizaki, Tsutomu, Nicholson, Vivian M., Alperin, Debra A., Osaki, Makoto, ...
The virulence plasmids of the equine virulent strains Rhodococcus equi ATCC 33701 and 103 were sequenced, and their genetic structure was analyzed. p33701 was 80,610 bp in length, and p103 was 1 bp...
Virulence Plasmid of Rhodococcus equi Contains Inducible Gene Family Encoding Secreted Proteins
Byrne, Barbara A., Prescott, John F., Palmer, Guy H., Takai, Shinji, Nicholson, Vivian M., Alperin, Debra C., ...
Rhodococcus equi causes severe pyogranulomatous pneumonia in foals. This facultative intracellular pathogen produces similar lesions in immunocompromised humans, particularly in AIDS patients....
Cytokine Induction in Murine Macrophages Infected with Virulent and Avirulent Rhodococcus equi
Giguère, Steeve, Prescott, John F.
To look for a possible correlation between the virulence of Rhodococcus equi and its cytokine-inducing capacity, we evaluated intracellular survival and measured cytokine induction by mouse...
Giguère, Steeve, Hondalus, Mary K., Yager, Julie A., Darrah, Patricia, Mosser, David M., Prescott, John F.
Rhodococcus equi is a facultative intracellular pathogen of macrophages and a cause of pneumonia in young horses (foals) and immunocompromised people. Isolates of R. equi from pneumonic foals...
Performance of Five Serological Assays for Diagnosis of Rhodococcus equi Pneumonia in Foals
Giguère, Steeve, Hernandez, Jorge, Gaskin, Jack, Prescott, John F., Takai, Shinji, Miller, Corey
The performance of four enzyme-linked immunosorbent assays (ELISAs) (ELISA-6939, ELISA-33701, ELISA-VapA, and ELISA-California) and an agar gel immunodiffusion test for diagnosis of Rhodococcus equi...
A Fluoroquinolone Induces a Novel Mitogen-Encoding Bacteriophage in Streptococcus canis
Ingrey, Keely T., Ren, Jun, Prescott, John F.
This study investigated whether the recently recognized emergence of canine streptococcal toxic shock syndrome (STSS) and necrotizing fasciitis (NF) might be partly attributed to the use of...
Virulence of Rhodococcus equi Isolated from Cats and Dogs
Takai, Shinji, Martens, Ronald J., Julian, Alan, Garcia Ribeiro, Márcio, Rodrigues De Farias, Marconi, Sasaki, Yukako, ...
Nine cat isolates and nine dog isolates of Rhodococcus equi from clinical material were investigated for the presence of the virulence-associated antigens (VapA and VapB) and virulence plasmids. Five...
Antimicrobial drug use and resistance in dogs
Prescott, John F., Hanna, W. J. Brad, Reid-Smith, Richard, Drost, Kelli
Fifteen years (1984–1998) of records from a Veterinary Teaching Hospital were analyzed to determine whether antimicrobial drug resistance in coagulase-positive Staphylococcus spp. (S. aureus, S....
Rhodococcus equi pleuropneumonia in an adult horse
Vengust, Modest, Stæmpfli, Henry, Prescott, John F.
A 10-year-old warmblood gelding was evaluated for intermittent pyrexia, dullness, weight loss, and progressive respiratory disease. Multifocal necrotic pneumonia and pleuritis due to Rhodococcus equi...
CVMA Task Force on “education, licensing, and the expanding scope of veterinary practice”
Prescott, John F., Bailey, Jeremy, Hagele, W. Curt, Leung, Dominic, Lofstedt, Jeanne, Radostits, Otto M., ...
Resurgence of leptospirosis in dogs in Ontario: recent findings
Prescott, John F., McEwen, Beverly, Taylor, Judith, Woods, J. Paul, Abrams-Ogg, Anthony, Wilcock, Brian
A marked increase in leptospirosis in dogs was observed in 2000, part of an increasing trend observed in previous years in Ontario. The highest frequency of seropositive cases occurred from September...
Miranda-CasoLuengo, Raúl, Duffy, Pamela S., O'Connell, Enda P., Graham, Brian J., Mangan, Michael W., Prescott, John F., ...
Rhodococcus equi is a facultative intracellular pathogen which proliferates rapidly in both manure-enriched soil and alveolar macrophages. Although both environments are characterized by extremely...
Isocitrate Lyase Activity Is Required for Virulence of the Intracellular Pathogen Rhodococcus equi
Wall, Daniel M., Duffy, Pamela S., DuPont, Chris, Prescott, John F., Meijer, Wim G.
Rhodococcus equi is an important pathogen of foals, causing severe pyogranulomatous pneumonia. Virulent R. equi strains grow within macrophages, a process which remains poorly characterized. A...
Hooper-McGrevy, Kathleen E., Wilkie, Bruce N., Prescott, John F.
Rhodococcus equi causes severe pyogranulomatous pneumonia in foals and in immunocompromised humans. Replication of virulent isolates within macrophages correlates with the presence of a large plasmid...
Sporadic, severe bronchointerstitial pneumonia of foals
Prescott, John F., Wilcock, Brian P., Carman, P. Suzanne, Hoffman, Andrew M.
Bronchointerstitial pneumonia was diagnosed postmortem in 19 foals in a 10 year retrospective study of submissions to a diagnostic center in Ontario. Mean age at death was 2.0 ± 0.05 (SEM) mo (range...
Is canine leptospirosis underdiagnosed in southern Ontario? A case report and serological survey
Prescott, John F., Ferrier, Rebecca L., Nicholson, Vivian M., Johnston, Kathleen M., Hoff, Brent
An eight-year-old city-dwelling Cairn Terrier was presented to a veterinary hospital in acute renal failure with evidence of hepatic insufficiency. The dog was treated symptomatically over three...
Ontario. Leptospira bratislava infection in aborted pigs in Ontario
Rehmtulla, Abdul J., Prescott, John F., Nicholson, Vivian M., Bolin, Carole A.
Prognostic features and clinical presentation of acute idiopathic enterocolitis in horses
Staempfli, Henry R., Townsend, Hugh G.G., Prescott, John F.
Clinical and hematological changes observed on presentation of 47 horses referred to the Ontario Veterinary College with acute idiopathic colitis were analyzed for their prognostic features. Cases of...
Giant cell hepatitis in four aborted foals: A possible leptospiral infection
Wilkie, Ian W., Prescott, John F., Hazlett, Murray J., Maxie, M. Grant, Van Dreumel, Antony A.
Prevention of foal mortality due to Rhodococcus equi pneumonia on an endemically affected farm
Prescott, John F., Machang'u, Robert, Kwiecien, Jacek, Delaney, Kathy
Over the course of one summer, foals on a horse breeding farm where Rhodococcus equi infection was endemic were examined clinically twice weekly for evidence of R. equi pneumonia. Examination usually...
Restriction Fragment Length Polymorphisms of Virulence Plasmids in Rhodococcus equi
Takai, Shinji, Shoda, Masato, Sasaki, Yukako, Tsubaki, Shiro, Fortier, Guillaume, Pronost, Stephane, ...
Virulent Rhodococcus equi, which is a well-known cause of pyogranulomatous pneumonia in foals, possesses a large plasmid encoding virulence-associated 15- to 17-kDa antigens. Foal and soil isolates...
MICs of Oxazolidinones for Rhodococcus equi Strains Isolated from Humans and Animals
Bowersock, Terry L., Salmon, Sarah A., Portis, Ellen S., Prescott, John F., Robison, Denise A., Ford, Charles W., ...
Eperezolid and linezolid are representatives of a new class of orally active, synthetic antimicrobial agents. The in vitro activity values (MICs) of linezolid, eperezolid, and comparator antibiotics...
Modulation of Cytokine Response of Pneumonic Foals by Virulent Rhodococcus equi
Giguère, Steeve, Wilkie, Bruce N., Prescott, John F.
The ability of Rhodococcus equi to induce pneumonia in foals depends on the presence of an 85- to 90-kb plasmid. In this study, we evaluated whether plasmid-encoded products mediate virulence by...
DNA Sequence and Comparison of Virulence Plasmids from Rhodococcus equi ATCC 33701 and 103
Takai, Shinji, Hines, Stephen A., Sekizaki, Tsutomu, Nicholson, Vivian M., Alperin, Debra A., Osaki, Makoto, ...
The virulence plasmids of the equine virulent strains Rhodococcus equi ATCC 33701 and 103 were sequenced, and their genetic structure was analyzed. p33701 was 80,610 bp in length, and p103 was 1 bp...
Virulence Plasmid of Rhodococcus equi Contains Inducible Gene Family Encoding Secreted Proteins
Byrne, Barbara A., Prescott, John F., Palmer, Guy H., Takai, Shinji, Nicholson, Vivian M., Alperin, Debra C., ...
Rhodococcus equi causes severe pyogranulomatous pneumonia in foals. This facultative intracellular pathogen produces similar lesions in immunocompromised humans, particularly in AIDS patients....
Cytokine Induction in Murine Macrophages Infected with Virulent and Avirulent Rhodococcus equi
Giguère, Steeve, Prescott, John F.
To look for a possible correlation between the virulence of Rhodococcus equi and its cytokine-inducing capacity, we evaluated intracellular survival and measured cytokine induction by mouse...
Giguère, Steeve, Hondalus, Mary K., Yager, Julie A., Darrah, Patricia, Mosser, David M., Prescott, John F.
Rhodococcus equi is a facultative intracellular pathogen of macrophages and a cause of pneumonia in young horses (foals) and immunocompromised people. Isolates of R. equi from pneumonic foals...
Performance of Five Serological Assays for Diagnosis of Rhodococcus equi Pneumonia in Foals
Giguère, Steeve, Hernandez, Jorge, Gaskin, Jack, Prescott, John F., Takai, Shinji, Miller, Corey
The performance of four enzyme-linked immunosorbent assays (ELISAs) (ELISA-6939, ELISA-33701, ELISA-VapA, and ELISA-California) and an agar gel immunodiffusion test for diagnosis of Rhodococcus equi...
Hooper-McGrevy, Kathleen E., Wilkie, Bruce N., Prescott, John F.
Rhodococcus equi causes severe pyogranulomatous pneumonia in foals and in immunocompromised humans. Replication of virulent isolates within macrophages correlates with the presence of a large plasmid...
A Fluoroquinolone Induces a Novel Mitogen-Encoding Bacteriophage in Streptococcus canis
Ingrey, Keely T., Ren, Jun, Prescott, John F.
This study investigated whether the recently recognized emergence of canine streptococcal toxic shock syndrome (STSS) and necrotizing fasciitis (NF) might be partly attributed to the use of...
Virulence of Rhodococcus equi Isolated from Cats and Dogs
Takai, Shinji, Martens, Ronald J., Julian, Alan, Garcia Ribeiro, Márcio, Rodrigues De Farias, Marconi, Sasaki, Yukako, ...
Nine cat isolates and nine dog isolates of Rhodococcus equi from clinical material were investigated for the presence of the virulence-associated antigens (VapA and VapB) and virulence plasmids. Five...
Antimicrobial drug use and resistance in dogs
Prescott, John F., Hanna, W. J. Brad, Reid-Smith, Richard, Drost, Kelli
Fifteen years (1984–1998) of records from a Veterinary Teaching Hospital were analyzed to determine whether antimicrobial drug resistance in coagulase-positive Staphylococcus spp. (S. aureus, S....
Rhodococcus equi pleuropneumonia in an adult horse
Vengust, Modest, Stæmpfli, Henry, Prescott, John F.
A 10-year-old warmblood gelding was evaluated for intermittent pyrexia, dullness, weight loss, and progressive respiratory disease. Multifocal necrotic pneumonia and pleuritis due to Rhodococcus equi...
CVMA Task Force on “education, licensing, and the expanding scope of veterinary practice”
Prescott, John F., Bailey, Jeremy, Hagele, W. Curt, Leung, Dominic, Lofstedt, Jeanne, Radostits, Otto M., ...
Resurgence of leptospirosis in dogs in Ontario: recent findings
Prescott, John F., McEwen, Beverly, Taylor, Judith, Woods, J. Paul, Abrams-Ogg, Anthony, Wilcock, Brian
A marked increase in leptospirosis in dogs was observed in 2000, part of an increasing trend observed in previous years in Ontario. The highest frequency of seropositive cases occurred from September...
Miranda-CasoLuengo, Raúl, Duffy, Pamela S., O'Connell, Enda P., Graham, Brian J., Mangan, Michael W., Prescott, John F., ...
Rhodococcus equi is a facultative intracellular pathogen which proliferates rapidly in both manure-enriched soil and alveolar macrophages. Although both environments are characterized by extremely...
Isocitrate Lyase Activity Is Required for Virulence of the Intracellular Pathogen Rhodococcus equi
Wall, Daniel M., Duffy, Pamela S., DuPont, Chris, Prescott, John F., Meijer, Wim G.
Rhodococcus equi is an important pathogen of foals, causing severe pyogranulomatous pneumonia. Virulent R. equi strains grow within macrophages, a process which remains poorly characterized. A...
Sporadic, severe bronchointerstitial pneumonia of foals
Prescott, John F., Wilcock, Brian P., Carman, P. Suzanne, Hoffman, Andrew M.
Bronchointerstitial pneumonia was diagnosed postmortem in 19 foals in a 10 year retrospective study of submissions to a diagnostic center in Ontario. Mean age at death was 2.0 ± 0.05 (SEM) mo (range...
Is canine leptospirosis underdiagnosed in southern Ontario? A case report and serological survey
Prescott, John F., Ferrier, Rebecca L., Nicholson, Vivian M., Johnston, Kathleen M., Hoff, Brent
An eight-year-old city-dwelling Cairn Terrier was presented to a veterinary hospital in acute renal failure with evidence of hepatic insufficiency. The dog was treated symptomatically over three...
Ontario. Leptospira bratislava infection in aborted pigs in Ontario
Rehmtulla, Abdul J., Prescott, John F., Nicholson, Vivian M., Bolin, Carole A.
Prognostic features and clinical presentation of acute idiopathic enterocolitis in horses
Staempfli, Henry R., Townsend, Hugh G.G., Prescott, John F.
Clinical and hematological changes observed on presentation of 47 horses referred to the Ontario Veterinary College with acute idiopathic colitis were analyzed for their prognostic features. Cases of...
Giant cell hepatitis in four aborted foals: A possible leptospiral infection
Wilkie, Ian W., Prescott, John F., Hazlett, Murray J., Maxie, M. Grant, Van Dreumel, Antony A.
Prevention of foal mortality due to Rhodococcus equi pneumonia on an endemically affected farm
Prescott, John F., Machang'u, Robert, Kwiecien, Jacek, Delaney, Kathy
Over the course of one summer, foals on a horse breeding farm where Rhodococcus equi infection was endemic were examined clinically twice weekly for evidence of R. equi pneumonia. Examination usually...
Mutation and virulence assessment of chromosomal genes of Rhodococcus equi 103
Pei, Yanlong, Parreira, Valeria, Nicholson, Vivian M., Prescott, John F.
Rhodococcus equi can cause severe or fatal pneumonia in foals as well as in immunocompromised animals and humans. Its ability to persist in macrophages is fundamental to how it causes disease, but...
Jacks, Stephanie, Giguère, Steeve, Prescott, John F.
Rhodococcus equi is a facultative intracellular pathogen that causes pneumonia in foals but does not induce disease in adult horses. Virulence of R. equi depends on the presence of a large plasmid,...
Harrington, Noel P., Surujballi, Om P., Waters, W. Ray, Prescott, John F.
Tuberculosis of free-ranging and captive wildlife, including species implicated in the maintenance and transmission of Mycobacterium bovis, is a difficult disease to diagnose and control....
Miranda-CasoLuengo, Raúl, Prescott, John F., Vázquez-Boland, José A., Meijer, Wim G.
Little is known about the iron acquisition systems of the soilborne facultative intracellular pathogen Rhodococcus equi. We previously reported that expression of iupABC, encoding a putative...
Kamrani, Ali, Parreira, Valeria R., Greenwood, Janice, Prescott, John F.
The prevalence of persistent bacteremic Bartonella spp. and hemoplasma infections was determined in healthy pet cats in Ontario. Blood samples from healthy cats sent to a diagnostic laboratory for...
Harrington, Noel P., Surujballi, Om P., Prescott, John F., Duncan, J. Robert, Waters, W. Ray, Lyashchenko, Konstantin, ...
Captive and free-ranging wildlife animals are implicated in the maintenance and transmission of bovine tuberculosis and therefore pose a significant obstacle to eradication of the disease from...
Increase in seroprevalence of canine leptospirosis and its risk factors, Ontario 1998–2006
Alton, Gillian D., Berke, Olaf, Reid-Smith, Richard, Ojkic, Davor, Prescott, John F.
Canine leptospirosis has been described as having re-emerged in North America around the mid-1990s, with a change in the epidemiology of the infecting serovars responsible for the disease emergence....