John G. McCarron

Elevations of intracellular calcium reflect normal voltage-dependent behavior, and not constitutive activity, of voltage-dependent calcium channels in gastrointestinal and vascular smooth muscle (2009)

McCarron, John G., Olson, M., Currie, S., Wright, A., Anderson, Kurt I., Girkin, J.M.

In smooth muscle, the gating of dihydropyridine-sensitive Ca2+ channels may either be stochastic and voltage dependent or coordinated among channels and constitutively active. Each form of gating has...

Caged AG10: new tools for spatially predefined mitochondrial uncoupling (2009)

Avionitis, Nicolaos, Chalmers, S., McDougall, Craig, Stanton-Humphreys, Megan N., Brown, C.T.A., McCarron, John G., ...

The study of mitochondria and mitochondrial Ca2+ signalling in localised regions is hampered by the lack of tools that can uncouple the mitochondrial membrane potential (m) in a spatially predefined...

IP3R-mediated Ca2+ release is modulated by anandamide in isolated cardiac nuclei (2008)

Currie, S., Rainbow, R., Ewart, Marie-Ann, Kitson, Susan, Pliego, Esperanza Herradon, Kane, K.A., ...

Cannabinoids (CBs) are known to alter coronary vascular tone and cardiac performance. They also exhibit cardioprotective properties, particularly in their ability to limit the damage produced by...

FK506-binding protein (FKBP12) regulates ryanodine receptor-evoked Ca2+ release in colonic but not aortic smooth muscle (2008)

MacMillan, Debbi, Currie, Susan, McCarron, John G.

In smooth muscle, the ryanodine receptor (RyR) mediates Ca2+ release from the sarcoplasmic reticulum (SR) Ca2+ store. Release may be regulated by the RyR accessory FK506-binding protein (FKBP12)...

Ca(2+) spark sites in smooth muscle cells are numerous and differ in number of ryanodine receptors, large-conductance K(+) channels, and coupling ratio between them (2004)

Zhuge, Ronghua, Fogarty, Kevin E., Baker, Stephen P., McCarron, John G., Tuft, Richard A., Lifshitz, Lawrence M., ...

Ca(2+) sparks are highly localized Ca(2+) transients caused by Ca(2+) release from sarcoplasmic reticulum through ryanodine receptors (RyR). In smooth muscle, Ca(2+) sparks activate nearby...

Research Article Cyclic ADP-ribose increases Ca 2+ removal in smooth muscle (2003)

Karen N. Bradley, Susan Currie, Debbi Macmillan, Thomas C. Muir, John G. Mccarron

Ca2+ release via ryanodine receptors (RyRs) is vital in cell signalling and regulates diverse activities such as gene expression and excitation-contraction coupling. Cyclic ADP ribose (cADPR), a...

IP3-mediated Ca2+ increases do not involve the ryanodine receptor, but ryanodine receptor antagonists reduce IP3-mediated Ca2+ increases in guinea-pig colonic smooth muscle cells

MacMillan, Debbi, Chalmers, Susan, Muir, Thomas C, McCarron, John G

Smooth muscle responds to IP3-generating (sarcolemma acting) neurotransmitters and hormones by releasing Ca2+ from the sarcoplasmic reticulum (SR) via IP3 receptors (IP3Rs). This release may...

IP3-mediated Ca2+ increases do not involve the ryanodine receptor, but ryanodine receptor antagonists reduce IP3-mediated Ca2+ increases in guinea-pig colonic smooth muscle cells

MacMillan, Debbi, Chalmers, Susan, Muir, Thomas C, McCarron, John G

Smooth muscle responds to IP3-generating (sarcolemma acting) neurotransmitters and hormones by releasing Ca2+ from the sarcoplasmic reticulum (SR) via IP3 receptors (IP3Rs). This release may...

Mitochondrial regulation of the cytosolic Ca2+ concentration and the InsP3-sensitive Ca2+ store in guinea-pig colonic smooth muscle

McCarron, John G, Muir, Thomas C

Mitochondrial regulation of the cytosolic Ca2+ concentration ([Ca2+]c) in guinea-pig single colonic myocytes has been examined, using whole-cell recording, flash photolysis of caged InsP3 and...

Two Ca2+ entry pathways mediate InsP3-sensitive store refilling in guinea-pig colonic smooth muscle

McCarron, John G, Flynn, Elaine R M, Bradley, Karen N, Muir, Thomas C

Sarcolemma Ca2+ influx, necessary for store refilling, was well maintained, over a wide range (-70 to + 40 mV) of membrane voltages, in guinea-pig single circular colonic smooth muscle cells, as...

Ca2+ regulation in guinea-pig colonic smooth muscle: the role of the Na+-Ca2+ exchanger and the sarcoplasmic reticulum

Bradley, Karen N, Flynn, Elaine R M, Muir, Thomas C, McCarron, John G

To study the contribution of the Na+-Ca2+ exchanger to Ca2+ regulation and its interaction with the sarcoplasmic reticulum (SR), changes in cytoplasmic Ca2+ concentration ([Ca2+]c) were measured in...

Quantal' Ca2+ release at the cytoplasmic aspect of the Ins(1,4,5)P3R channel in smooth muscle

McCarron, John G., Chalmers , Susan, Muir, Thomas C.

Smooth muscle responds to activation of the inositol (1,4,5)-trisphosphate receptor [Ins(1,4,5)P3R] with a graded concentration-dependent ('quantal') Ca2+ release from the sarcoplasmic reticulum (SR)...

Elevations of intracellular calcium reflect normal voltage-dependent behavior, and not constitutive activity, of voltage-dependent calcium channels in gastrointestinal and vascular smooth muscle

McCarron, John G., Olson, Marnie L., Currie, Susan, Wright, Amanda J., Anderson, Kurt I., Girkin, John M.

In smooth muscle, the gating of dihydropyridine-sensitive Ca2+ channels may either be stochastic and voltage dependent or coordinated among channels and constitutively active. Each form of gating has...

Inhibition of mitochondrial calcium uptake rather than efflux impedes calcium release by inositol-1,4,5-trisphosphate-sensitive receptors

Chalmers, S., McCarron, John G.

Mitochondria modulate cellular Ca2+ signals by accumulating the ion via a uniporter and releasing it via Na+- or H+-exchange. In smooth muscle, inhibition of mitochondrial Ca2+ uptake inhibits Ca2+...