John H. N. Meerman

Deuterium Isotope Effect on the Metabolism of the Flame Retardant Tris(2,3-dibromopropyl) Phosphate in the Isolated Perfused Rat Liver (1995)

PEARSON, PAUL G., MEIJER, DIRK K. F., MULDER, GERARD J., NELSON, SIDNEY D., MEERMAN, JOHN H. N.

The metabolism of tris(2,3-dibromopropyl) phosphate (Tris-BP) was compared with that of completely deuterated Tris-BP (D15-Tris-BP) in an isolated, recirculating rat liver perfusion system in order...

Genotoxicity of the flame retardant tris(2,3-dibromopropyl)phosphate in the rat and Drosophila: effects of deuterium substitution (1994)

Nivard, Madeleine J.M., Vogel, Ekkehart W., Nelson, Sidney D., Meerman, John H.N.

Formation of 2-bromoacrolein (2BA) from tris(2,3-dibromo- propyl)phosphate (Tris-BP) by cytochrome P450 (cyt. P450) activity is most likely responsible for the high mutagenicity of Tris-BP for...

Formation of thymidine adducts and cross-linking potential of 2-bromoacrolein, a reactive metabolite of tris(2,3-dibromopropyl)phosphate (1992)

Nivard, Madeleine J.M., Vogel, Ekkehart W., Nelson, Sidney D., Meerman, John H.N.

DNA-adduct formation by the mutagen 2-bromoacrolein (2BA) with DNA was studied. [3-3H]2BA was reacted with single-stranded (ss) DNA or double-stranded (ds) DNA and subsequently incubated with...

Sulfation of hydroxylamines and hydroxamic acids in liver cytosol from male and female rats and purified aryl sulfotransferase IV (1992)

Ringer, David P., Mulder, Gerard J., Meerman, John H.N.

Sulfation activity towards hydroxamic acids and hydroxylamines was determined in liver cytosols for juvenile and adult males and female rats, as well as in purified rat liver aryl sulfotransferase IV...

Photoactivation of 2-nitrofluorene in vitro and in the rat in vivo. UVA-induced formation of reactive intermediates that bind covalently to RNA and protein (1992)

Wierckx, Frank C.J., Van Den Broeke, Leon T., De Vries, Henk, Meerman, John H.N., Mulder, Gerard J.

2-Nitrofluorene (2-NF), an environmental pollutant, can be activated by UV light to reactive intermediates that bind covalently to RNA and protein in vitro: high levels of covalent binding were...

DNA adduct formation in liver following the administration of [3H]2-nitrofluorene to rats in vivo (1991)

Wierckx, Frank C.J., Wedzinga, Rinny, Beland, Frederick A., Meerman, John H.N., Mulder, Gerard J.

The formation of RNA and DNA adducts by the environmental pollutant 2-nitrofluorene (2-NF) has been investigated in rat liver in vivo. The adduct pattern was studied after trifluoroacetic acid...

Correlation between clastogenicity and promotion activity in liver carcinogenesis by N-hydroxy-2-acetylaminofluorene, N-hydroxy-4'-fluoro-4-acetylaminobiphenyl and N-hydroxy-4-acetylaminobiphenyl (1990)

Tates, Ad D., Meerman, John H.N.

N-Hydroxy-2-acetylaminofluorene (N-OH-AAF), N-hydroxy-4'-fluoro-4-acetylaminobiphenyl (N-OH-FAABP) and N-hydroxy-4-acetylaminobiphenyl (N-OH-AABP) were compared for their initiation and promotion...

Bioactivation of 2-nitrofluorene to reactive intermediates that bind covalenty to DNA, RNA and protein in vitro and in vivo in the rat (1990)

Wierckx, Frant C.J., Wedzinga, Rinny, Meerman, John H.N., Mulder, Gerard

The activation of 2-nitrofluorene (2-NF) to reactive intermediates that bind covalently to DNA, RNA and protein has been investigated both in vitro and in the rat in vivo. In vitro, such binding was...

Sulfation-dependent formation of N-acetylated and deacetylated DNA adducts of N-hydroxy-4-acetylamlnobiphenyl in male rat liver in vivo and in isolated hepatocytes (1990)

Venizelos, Vicki, Meerman, John H.N.

Administration of 3H-labeled N-hydroxy-4-acetylamino-biphenyl (N-OH-AABP) to male Wistar rats with or without prior partial hepatectomy (PH) resulted in covalent binding of 3H activity to liver...

The role of sulfation in the metabolic activation of N-hydroxy-4'-fluoro-4-acetylaminobiphenyl (1989)

Tijdens, Roeline B., Vondrácek, Paul, Bruins, Andries P., Meijer, Dirk K. F., Meerman, John H. N.

The role of sulfation in the metabolic activation of the liver carcinogen N-hydroxy-4′-fluoro-4-acetylaminobiphenyl (N-OH-FAABP) in male rat liver was investigated. N-OH-FAABP was a substrate for...

The role of N-sulfation in the Nhydroxy-2-acetylaminofluorene-mediated outgrowth of diethylnitrosamine-initiated hepatocytes to {gamma}-glutamyltranspeptidase-positive foci in male rat liver (1988)

Kroese, E. Dinant, Mulder, Gerard J., Meerman, John H. N.

The ability of N-hydroxy-2-acetylaminofluorene (N-OH-AAF) to promote the appearance of γglutamyltranspeptidase-positive (GGT+) foci initiated by diethylnitrosamine (DEN) was studied in a...