Kaukinen, Pasi, Sillanpää, Maarit, Kotenko, Sergei, Lin, Rongtuan, Hiscott, John, Melén, Krister, ...
Abstract Background Hepatitis C virus (HCV) encodes several proteins that interfere with the host cell antiviral response. Previously, the serine protease NS3/4A was shown to inhibit IFN-β gene...
Typescript.
Lin, Rongtuan, Mamane, Yael, Hiscott, John
The interferon regulatory factor 3 (IRF-3) gene encodes a 55-kDa protein which is expressed constitutively in all tissues. In unstimulated cells, IRF-3 is present in an inactive cytoplasmic form;...
Algarté, Michèle, Kwon, Hakju, Génin, Pierre, Hiscott, John
In unstimulated cells, NF-κB transcription factors are retained in the cytoplasm by inhibitory IκB proteins. Upon stimulation by multiple inducers including cytokines or viruses, IκBα is rapidly...
Lin, Rongtuan, Génin, Pierre, Mamane, Yaël, Hiscott, John
Recent studies implicate the interferon (IFN) regulatory factors (IRF) IRF-3 and IRF-7 as key activators of the alpha/beta IFN (IFN-α/β) genes as well as the RANTES chemokine gene. Using...
IκB-Mediated Inhibition of Virus-Induced Beta Interferon Transcription
Algarté, Michèle, Nguyen, Hannah, Heylbroeck, Christophe, Lin, Rongtuan, Hiscott, John
We have examined the consequences of overexpression of the IκBα and IκBβ inhibitory proteins on the regulation of NF-κB-dependent beta interferon (IFN-β) gene transcription in human cells after...
Lin, Rongtuan, Heylbroeck, Christophe, Pitha, Paula M., Hiscott, John
The interferon regulatory factors (IRF) consist of a growing family of related transcription proteins first identified as regulators of the alpha beta interferon (IFN-α/β) gene promoters, as well...
The IRF-3 Transcription Factor Mediates Sendai Virus-Induced Apoptosis
Heylbroeck, Christophe, Balachandran, Siddharth, Servant, Marc J., DeLuca, Carmela, Barber, Glen N., Lin, Rongtuan, ...
Virus infection of target cells can result in different biological outcomes: lytic infection, cellular transformation, or cell death by apoptosis. Cells respond to virus infection by the activation...
Lin, Rongtuan, Heylbroeck, Christophe, Genin, Pierre, Pitha, Paula M., Hiscott, John
Localized and systemic cytokine production in virus-infected cells play an important role in the outcome of viral infection and pathogenicity. Activation of the interferon regulatory factors (IRF) in...
Recognition of the Measles Virus Nucleocapsid as a Mechanism of IRF-3 Activation
TenOever, Benjamin R., Servant, Marc J., Grandvaux, Nathalie, Lin, Rongtuan, Hiscott, John
The mechanisms of cellular recognition for virus infection remain poorly understood despite the wealth of information regarding the signaling events and transcriptional responses that ensue. Host...
Recognition of the Measles Virus Nucleocapsid as a Mechanism of IRF-3 Activation
TenOever, Benjamin R., Servant, Marc J., Grandvaux, Nathalie, Lin, Rongtuan, Hiscott, John
Grandvaux, Nathalie, Servant, Marc J., TenOever, Benjamin, Sen, Ganes C., Balachandran, Siddarth, Barber, Glen N., ...
Ubiquitously expressed interferon regulatory factor 3 (IRF-3) is directly activated after virus infection and functions as a key activator of the immediate-early alpha/beta interferon (IFN) genes, as...
TenOever, Benjamin R., Sharma, Sonia, Zou, Wen, Sun, Qiang, Grandvaux, Nathalie, Julkunen, Ilkka, ...
Mounting an immune response to a viral pathogen involves the initial recognition of viral antigens through Toll-like receptor-dependent and -independent pathways and the subsequent triggering of...
Breiman, Adrien, Grandvaux, Nathalie, Lin, Rongtuan, Ottone, Catherine, Akira, Shizuo, Yoneyama, Mitsutoshi, ...
Interferon (IFN) is one important effector of the innate immune response, induced by different viral or bacterial components through Toll-like receptor (TLR)-dependent and -independent mechanisms. As...
Österlund, Pamela, Veckman, Ville, Sirén, Jukka, Klucher, Kevin M., Hiscott, John, Matikainen, Sampsa, ...
Dendritic cells (DCs) respond to microbial infections by undergoing phenotypic maturation and by producing multiple cytokines. In the present study, we analyzed the ability of influenza A and Sendai...
Regulation of Human Immunodeficiency Virus Type 1 Gene Expression by Clade-Specific Tat Proteins
Desfosses, Yan, Solis, Mayra, Sun, Qiang, Grandvaux, Nathalie, Van Lint, Carine, Burny, Arsene, ...
The major group of human immunodeficiency virus type 1 (HIV-1) strains that comprise the current global pandemic have diversified during their worldwide spread into at least 10 distinct subtypes, or...
Berro, Reem, Kehn, Kylene, De La Fuente, Cynthia, Pumfery, Anne, Adair, Richard, Wade, John, ...
The human immunodeficiency virus type 1 (HIV-1) potent transactivator Tat protein mediates pleiotropic effects on various cell functions. Posttranslational modification of Tat affects its activity...
Matikainen, Sampsa, Sirén, Jukka, Tissari, Jorma, Veckman, Ville, Pirhonen, Jaana, Severa, Martina, ...
Epithelial cells of the lung are the primary targets for respiratory viruses. Virus-carried single-stranded RNA (ssRNA) can activate Toll-like receptors (TLRs) 7 and 8, whereas dsRNA is bound by TLR3...
Kaukinen, Pasi, Sillanpää, Maarit, Kotenko, Sergei, Lin, Rongtuan, Hiscott, John, Melén, Krister, ...
Lin, Rongtuan, Lacoste, Judith, Nakhaei, Peyman, Sun, Qiang, Yang, Long, Paz, Suzanne, ...
Intracellular RNA virus infection is detected by the cytoplasmic RNA helicase RIG-I that plays an essential role in signaling to the host antiviral response. Recently, the adapter molecule that links...
Lin, Rongtuan, Mamane, Yael, Hiscott, John
The interferon regulatory factor 3 (IRF-3) gene encodes a 55-kDa protein which is expressed constitutively in all tissues. In unstimulated cells, IRF-3 is present in an inactive cytoplasmic form;...
Algarté, Michèle, Kwon, Hakju, Génin, Pierre, Hiscott, John
In unstimulated cells, NF-κB transcription factors are retained in the cytoplasm by inhibitory IκB proteins. Upon stimulation by multiple inducers including cytokines or viruses, IκBα is rapidly...
Lin, Rongtuan, Génin, Pierre, Mamane, Yaël, Hiscott, John
Recent studies implicate the interferon (IFN) regulatory factors (IRF) IRF-3 and IRF-7 as key activators of the alpha/beta IFN (IFN-α/β) genes as well as the RANTES chemokine gene. Using...
IκB-Mediated Inhibition of Virus-Induced Beta Interferon Transcription
Algarté, Michèle, Nguyen, Hannah, Heylbroeck, Christophe, Lin, Rongtuan, Hiscott, John
We have examined the consequences of overexpression of the IκBα and IκBβ inhibitory proteins on the regulation of NF-κB-dependent beta interferon (IFN-β) gene transcription in human cells after...
Lin, Rongtuan, Heylbroeck, Christophe, Pitha, Paula M., Hiscott, John
The interferon regulatory factors (IRF) consist of a growing family of related transcription proteins first identified as regulators of the alpha beta interferon (IFN-α/β) gene promoters, as well...
The IRF-3 Transcription Factor Mediates Sendai Virus-Induced Apoptosis
Heylbroeck, Christophe, Balachandran, Siddharth, Servant, Marc J., DeLuca, Carmela, Barber, Glen N., Lin, Rongtuan, ...
Virus infection of target cells can result in different biological outcomes: lytic infection, cellular transformation, or cell death by apoptosis. Cells respond to virus infection by the activation...
Lin, Rongtuan, Heylbroeck, Christophe, Genin, Pierre, Pitha, Paula M., Hiscott, John
Localized and systemic cytokine production in virus-infected cells play an important role in the outcome of viral infection and pathogenicity. Activation of the interferon regulatory factors (IRF) in...
Recognition of the Measles Virus Nucleocapsid as a Mechanism of IRF-3 Activation
TenOever, Benjamin R., Servant, Marc J., Grandvaux, Nathalie, Lin, Rongtuan, Hiscott, John
The mechanisms of cellular recognition for virus infection remain poorly understood despite the wealth of information regarding the signaling events and transcriptional responses that ensue. Host...
Recognition of the Measles Virus Nucleocapsid as a Mechanism of IRF-3 Activation
TenOever, Benjamin R., Servant, Marc J., Grandvaux, Nathalie, Lin, Rongtuan, Hiscott, John
Grandvaux, Nathalie, Servant, Marc J., TenOever, Benjamin, Sen, Ganes C., Balachandran, Siddarth, Barber, Glen N., ...
Ubiquitously expressed interferon regulatory factor 3 (IRF-3) is directly activated after virus infection and functions as a key activator of the immediate-early alpha/beta interferon (IFN) genes, as...
TenOever, Benjamin R., Sharma, Sonia, Zou, Wen, Sun, Qiang, Grandvaux, Nathalie, Julkunen, Ilkka, ...
Mounting an immune response to a viral pathogen involves the initial recognition of viral antigens through Toll-like receptor-dependent and -independent pathways and the subsequent triggering of...
Breiman, Adrien, Grandvaux, Nathalie, Lin, Rongtuan, Ottone, Catherine, Akira, Shizuo, Yoneyama, Mitsutoshi, ...
Interferon (IFN) is one important effector of the innate immune response, induced by different viral or bacterial components through Toll-like receptor (TLR)-dependent and -independent mechanisms. As...
Regulation of Human Immunodeficiency Virus Type 1 Gene Expression by Clade-Specific Tat Proteins
Desfosses, Yan, Solis, Mayra, Sun, Qiang, Grandvaux, Nathalie, Van Lint, Carine, Burny, Arsene, ...
The major group of human immunodeficiency virus type 1 (HIV-1) strains that comprise the current global pandemic have diversified during their worldwide spread into at least 10 distinct subtypes, or...
Österlund, Pamela, Veckman, Ville, Sirén, Jukka, Klucher, Kevin M., Hiscott, John, Matikainen, Sampsa, ...
Dendritic cells (DCs) respond to microbial infections by undergoing phenotypic maturation and by producing multiple cytokines. In the present study, we analyzed the ability of influenza A and Sendai...
Berro, Reem, Kehn, Kylene, De La Fuente, Cynthia, Pumfery, Anne, Adair, Richard, Wade, John, ...
The human immunodeficiency virus type 1 (HIV-1) potent transactivator Tat protein mediates pleiotropic effects on various cell functions. Posttranslational modification of Tat affects its activity...
Matikainen, Sampsa, Sirén, Jukka, Tissari, Jorma, Veckman, Ville, Pirhonen, Jaana, Severa, Martina, ...
Epithelial cells of the lung are the primary targets for respiratory viruses. Virus-carried single-stranded RNA (ssRNA) can activate Toll-like receptors (TLRs) 7 and 8, whereas dsRNA is bound by TLR3...
Lin, Rongtuan, Lacoste, Judith, Nakhaei, Peyman, Sun, Qiang, Yang, Long, Paz, Suzanne, ...
Intracellular RNA virus infection is detected by the cytoplasmic RNA helicase RIG-I that plays an essential role in signaling to the host antiviral response. Recently, the adapter molecule that links...
Kaukinen, Pasi, Sillanpää, Maarit, Kotenko, Sergei, Lin, Rongtuan, Hiscott, John, Melén, Krister, ...
Gautier, Grégory, Humbert, Martine, Deauvieau, Florence, Scuiller, Mathieu, Hiscott, John, Bates, Elizabeth E.M., ...
Dendritic cells (DC) produce interleukin-12 (IL-12) in response to Toll-like receptor (TLR) activation. Two major TLR signaling pathways participate in the response to pathogens: the nuclear...
Oliere, Stephanie, Arguello, Meztli, Mesplede, Thibault, Tumilasci, Vanessa, Nakhaei, Peyman, Stojdl, David, ...
Vesicular stomatitis virus (VSV) is a candidate oncolytic virus that replicates and induces cell death in cancer cells while sparing normal cells. Although defects in the interferon antiviral...