John J. Reilly

Accurate Airway Wall Estimation Using Phase (2008)

Raúl San Joséestépar, Georgeg. Washko, Edwin K. Silverman, John J. Reilly, Carl-fredrik Westin

Abstract. Quantitative analysis of computed tomographic (CT) images of the lungs is becoming increasingly useful in the medical and surgical management of subjects with Chronic Obstructive Pulmonary...

Randomized, Controlled Trial of a Best-Practice Individualized Behavioral Program for Treatment of Childhood Overweight: Scottish Childhood Overweight Treatment Trial (SCOTT) (2008)

Hughes, Adrienne, Stewart, Laura, Chapple, Jan, McColl, John. H., Donaldson, Malcolm. D. C, Kelnar, Christopher J. H., ...

OBJECTIVE. To determine whether a generalisable best practice individualized behavioral intervention reduced BMI Z score relative to standard dietetic care among overweight children. METHODS. The...

Parents’ journey through treatment for their child’s obesity: a qualitative study (2008)

Hughes, Adrienne, Stewart, L., Chapple, Jan, Poustie, V., Reilly, John J.

Background: Treatment for childhood obesity is characterised by patient non-attendance and drop-out, and widespread failure to achieve weight maintenance. Qualitative methods may improve our...

Xenobiotic metabolizing enzyme gene polymorphisms predict response to lung volume reduction surgery (2007)

Hersh, Craig P, DeMeo, Dawn L, Reilly, John J, Silverman, Edwin K

Abstract Background In the National Emphysema Treatment Trial (NETT), marked variability in response to lung volume reduction surgery (LVRS) was observed. We sought to identify genetic differences...

Objectively Measured Physical Activity and Fat Mass in a Large Cohort of Children (2007)

Andy R. Ness, Sam D. Leary, Calum Mattocks, Steven N. Blair, John J. Reilly, Jonathan Wells, ...

BackgroundPrevious studies have been unable to characterise the association between physical activity and obesity, possibly because most relied on inaccurate measures of physical activity and...

Comparative Study Between Young Children of Different Societies to Evaluate the Impact of Feeding Style on the Nutritional Status (2006)

John J. Reilly, Neville R Belton

There were three Parental Feeing Styles (PFS) identified. This study was aimed to find differences between these three styles. One hundred and seventy seven Saudi children from Riyadh, Saudi Arabia...

Comparative Study Between Young Children of Different Societies to Evaluate the Impact of Feeding Style on the Nutritional Status (2006)

John J. Reilly, Neville R Belton

There were three Parental Feeing Styles (PFS) identified. This study was aimed to find differences between these three styles. One hundred and seventy seven Saudi children from Riyadh, Saudi Arabia...

Using hierarchical clustering methods to classify motor activities of COPD patients from wearable sensor data (2005)

Sherrill, Delsey M, Moy, Marilyn L, Reilly, John J, Bonato, Paolo

Abstract Background Advances in miniature sensor technology have led to the development of wearable systems that allow one to monitor motor activities in the field. A variety of classifiers have been...

The transforming growth factor-{beta}1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD) (2004)

Celedón, Juan C., Lange, Christoph, Raby, Benjamin A., Litonjua, Augusto A., Palmer, Lyle J., DeMeo, Dawn L., ...

Although cigarette smoking is the primary environmental risk factor, genetic risk factors likely influence the development of chronic obstructive pulmonary disease (COPD). Linkage analysis between...

The transforming growth factor-{beta}1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD) (2004)

Celedón, Juan C., Lange, Christoph, Raby, Benjamin A., Litonjua, Augusto A., Palmer, Lyle J., DeMeo, Dawn L., ...

Although cigarette smoking is the primary environmental risk factor, genetic risk factors likely influence the development of chronic obstructive pulmonary disease (COPD). Linkage analysis between...

The transforming growth factor-{beta}1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD) (2004)

Celedón, Juan C., Lange, Christoph, Raby, Benjamin A., Litonjua, Augusto A., Palmer, Lyle J., DeMeo, Dawn L., ...

Although cigarette smoking is the primary environmental risk factor, genetic risk factors likely influence the development of chronic obstructive pulmonary disease (COPD). Linkage analysis between...

Genome-wide linkage analysis of severe, early-onset chronic obstructive pulmonary disease: airflow obstruction and chronic bronchitis phenotypes (2002)

Silverman, Edwin K., Mosley, Jonathan D., Palmer, Lyle J., Barth, Matthew, Senter, Jody M., Brown, Alison, ...

Familial aggregation of chronic obstructive pulmonary disease (COPD) has been demonstrated, but linkage analysis of COPD-related phenotypes has not been reported previously. An autosomal 10 cM...

Polymer Composite Preform and Process for Producing Same. (1998)

Reilly, John J., Kamel, Ihab L.

The invention described herein may be manufactured and used by or for the Government of the United States of America for governmental purposes without the payment of any royalties thereon or...

Early life risk factors for obesity in childhood: cohort study

Reilly, John J, Armstrong, Julie, Dorosty, Ahmad R, Emmett, Pauline M, Ness, A, Rogers, I, ...

Objective To identify risk factors in early life (up to 3 years of age) for obesity in children in the United Kingdom.

The SERPINE2 Gene Is Associated with Chronic Obstructive Pulmonary Disease

DeMeo, Dawn L., Mariani, Thomas J., Lange, Christoph, Srisuma, Sorachai, Litonjua, Augusto A., Celedón, Juan C., ...

Chronic obstructive pulmonary disease (COPD) is a complex human disease likely influenced by multiple genes, cigarette smoking, and gene-by-smoking interactions, but only severe alpha 1-antitrypsin...

Genomewide Linkage Analysis of Quantitative Spirometric Phenotypes in Severe Early-Onset Chronic Obstructive Pulmonary Disease

Silverman, Edwin K., Palmer, Lyle J., Mosley, Jonathan D., Barth, Matthew, Senter, Jody M., Brown, Alison, ...

Chronic obstructive pulmonary disease (COPD) is a common, complex disease associated with substantial morbidity and mortality. COPD is defined by irreversible airflow obstruction; airflow obstruction...

Early life risk factors for obesity in childhood: cohort study

Reilly, John J, Armstrong, Julie, Dorosty, Ahmad R, Emmett, Pauline M, Ness, A, Rogers, I, ...

Objective To identify risk factors in early life (up to 3 years of age) for obesity in children in the United Kingdom.

The SERPINE2 Gene Is Associated with Chronic Obstructive Pulmonary Disease

DeMeo, Dawn L., Mariani, Thomas J., Lange, Christoph, Srisuma, Sorachai, Litonjua, Augusto A., Celedón, Juan C., ...

Chronic obstructive pulmonary disease (COPD) is a complex human disease likely influenced by multiple genes, cigarette smoking, and gene-by-smoking interactions, but only severe alpha 1-antitrypsin...

Objectively Measured Physical Activity and Fat Mass in a Large Cohort of Children

Ness, Andy R, Leary, Sam D, Mattocks, Calum, Blair, Steven N, Reilly, John J, Wells, Jonathan, ...

A study with 5,500 12-year-olds shows an inverse association between physical activity and obesity, which is stronger in boys, and suggests that high-intensity activity is more important than total...

Genetic Determinants of Emphysema Distribution in the National Emphysema Treatment Trial

DeMeo, Dawn L., Hersh, Craig P., Hoffman, Eric A., Litonjua, Augusto A., Lazarus, Ross, Sparrow, David, ...

Rationale: Computed tomography (CT) scanning of the lung may reduce phenotypic heterogeneity in defining subjects with chronic obstructive pulmonary disease (COPD), and allow identification of...

Disease Management Programs Targeting Obesity in Children: Setting the Scene for Wellness in the Future

Adrienne R. Hughes, John J. Reilly

An epidemic of childhood obesity has been recognized over the past few decades and obesity is now the most common health problem among children in the developed world. Pediatric obesity rates have...

The Effect of Lung Volume Reduction Surgery on Chronic Obstructive Pulmonary Disease Exacerbations

Washko, George R., Fan, Vincent S., Ramsey, Scott D., Mohsenifar, Zab, Martinez, Fernando, Make, Barry J., ...

Rationale: Lung volume reduction surgery (LVRS) has been demonstrated to provide a functional and mortality benefit to a select group of subjects with chronic obstructive pulmonary disease (COPD)....

Genetic Association Analysis of Functional Impairment in Chronic Obstructive Pulmonary Disease

Hersh, Craig P., DeMeo, Dawn L., Lazarus, Ross, Celedón, Juan C., Raby, Benjamin A., Benditt, Joshua O., ...

Rationale: Patients with severe chronic obstructive pulmonary disease (COPD) may have varying levels of disability despite similar levels of lung function. This variation may reflect different COPD...

Radiographic Evaluation of the Potential Lung Volume Reduction Surgery Candidate

Washko, George R., Hoffman, Eric, Reilly, John J.

Delineating the extent and distribution of emphysema is an essential component of the evaluation of candidates for lung volume reduction surgery (LVRS). Imaging also may identify contraindications to...

Pulmonary Rehabilitation in Emphysema

Ries, Andrew L., Make, Barry J., Reilly, John J.

Pulmonary rehabilitation is an established treatment for patients with chronic lung disease. Benefits include improvement in exercise tolerance, symptoms, and quality of life, with a reduction in the...

Attempted Replication of Reported Chronic Obstructive Pulmonary Disease Candidate Gene Associations

Hersh, Craig P., DeMeo, Dawn L., Lange, Christoph, Litonjua, Augusto A., Reilly, John J., Kwiatkowski, David, ...

Case-control studies have successfully identified many significant genetic associations for complex diseases, but lack of replication has been a criticism of case-control genetic association studies...

A Functional Mutation in the Terminal Exon of Elastin in Severe, Early-Onset Chronic Obstructive Pulmonary Disease

Kelleher, Cassandra M., Silverman, Edwin K., Broekelmann, Thomas, Litonjua, Augusto A., Hernandez, Melvin, Sylvia, Jody S., ...

We describe a novel variant in the terminal exon of human elastin, c.2318 G>A, resulting in an amino acid substitution of glycine 773 to aspartate (G773D) in a pedigree with severe early-onset...

Concordance of Genotypes in Pre– and Post–Lung Transplantation DNA Samples

DeMeo, Dawn L., Reilly, John J., Ginns, Leo C., Sylvia, Jody S., Silverman, Edwin K.

Genetic epidemiology studies of end-stage lung disease are potentially hindered by low numbers of participants due to early death of patients from the underlying disease, or due to exclusion from...