Narrative-based computational modelling of the Gp130/JAK/STAT signalling pathway (2009)
Guerriero, Maria Luisa, Dudka, Anna, Underhill-Day, Nicholas, Heath, John K, Priami, Corrado
Abstract Background Appropriately formulated quantitative computational models can support researchers in understanding the dynamic behaviour of biological pathways and support hypothesis formulation...
Developmental expression of tissue inhibitor of metalloproteinase (TIMP) RNA (2008)
Shintaro Nomura, Alan J. Wills, John K. Heath, Dylan R. Edwards
Single-stranded antisense RNA probes have been used to study the expression of the metalloproteinase inhibitor TIMP (tissue inhibitor of raetalloproteinases), during mouse embryogenesis and in adult...
Oksana Tymchyshyn, Gethin Norman, John K Heath, Marta Z Kwiatkowska
Signalling pathways prove difficult to analyze by intuition because of inherent concurrency and non-linearity of underlying interactions. We present the application of computational methods based on...
Haines, Bryan Peter, Wheldon, Lee M., Summerbell, Dennis, Heath, John K., Rigby, Peter W. J.
Copyright © 2006 Elsevier Inc. All rights reserved.
Haines, Bryan Peter, Wheldon, Lee M., Summerbell, Dennis, Heath, John K., Rigby, Peter W. J.
Copyright © 2006 Elsevier Inc. All rights reserved.
Expression and function of interleukin-11 and its receptor {alpha} in the human endometrium (2003)
Karpovich, Natalia, Chobotova, Katya, Carver, Janet, Heath, John K., Barlow, David H., Mardon, Helen J.
The interleukin‐11 (IL‐11) receptor α has an important function in decidualization of mouse endometrial stroma but the function of IL‐11 and its receptor in the human endometrium...
Lalioti, Maria D., Heath, John K.
Bacterial artificial chromosomes (BACs) and P1 artificial chromosomes (PACs), which contain large fragments of genomic DNA, have been successfully used as transgenes to create mouse models of...
Growth factors in embryogenesis (1989)
Heath, John K, Smith, Austin G
The growing appreciation that embryonic material is a rich source of growth factors underlies increasing interest in the role of growth factors in early development. These developments have arisen...
Arman, Esther, Haffner-Krausz, Rebecca, Chen, Yali, Heath, John K., Lonai, Peter
We disrupted the fibroblast growth factor (FGF) receptor 2 (FGFR2) gene by introducing a neo cassette into the IIIc ligand binding exon and by deleting a genomic DNA fragment encoding its...
Lalioti, Maria D., Heath, John K.
Bacterial artificial chromosomes (BACs) and P1 artificial chromosomes (PACs), which contain large fragments of genomic DNA, have been successfully used as transgenes to create mouse models of...
NEW EMBO MEMBERS’ REVIEW: Receptor recognition by gp130 cytokines
Bravo, Jerónimo, Heath, John K.
Cytokines of the gp130 family exert their diverse biological effects by formation of stable high affinity transmembrane receptor complexes that are characterized by the presence of the shared...
Isacke, Clare M., Heath, John K.
The dexamethasone binding capacity of embryonal carcinoma cells and their differentiated derivatives was investigated. Manipulation of the embryonal carcinoma cell-culture conditions resulted in an...
Arman, Esther, Haffner-Krausz, Rebecca, Chen, Yali, Heath, John K., Lonai, Peter
We disrupted the fibroblast growth factor (FGF) receptor 2 (FGFR2) gene by introducing a neo cassette into the IIIc ligand binding exon and by deleting a genomic DNA fragment encoding its...
Lalioti, Maria D., Heath, John K.
Bacterial artificial chromosomes (BACs) and P1 artificial chromosomes (PACs), which contain large fragments of genomic DNA, have been successfully used as transgenes to create mouse models of...
NEW EMBO MEMBERS’ REVIEW: Receptor recognition by gp130 cytokines
Bravo, Jerónimo, Heath, John K.
Cytokines of the gp130 family exert their diverse biological effects by formation of stable high affinity transmembrane receptor complexes that are characterized by the presence of the shared...
Isacke, Clare M., Heath, John K.
The dexamethasone binding capacity of embryonal carcinoma cells and their differentiated derivatives was investigated. Manipulation of the embryonal carcinoma cell-culture conditions resulted in an...
The Dynamics of Signal Triggering in a gp130-Receptor Complex
Matadeen, Rishi, Hon, Wai-Ching, Heath, John K., Jones, E. Yvonne, Fuller, Stephen
gp130 is a shared signal-transducing membrane-associated receptor for several hematopoietic cytokines. The 30 Å resolution cryo-electron microscopy (cryo-EM) structure of the Interleukin...
Residue-specific immobilization of protein molecules by size-selected clusters
Prisco, Umberto, Leung, Carl, Xirouchaki, Chrisa, Jones, Celine H, Heath, John K, Palmer, Richard E
The atomic force microscope (AFM), operating in contact mode, has been employed in buffer solution to study two proteins; (i) green fluorescent protein (GFP), from the hydromedusan jellyfish Aequorea...
Akbarzadeh, Shiva, Wheldon, Lee M., Sweet, Steve M. M., Talma, Sonia, Mardakheh, Faraz Khosravi, Heath, John K.
The transmembrane receptor ‘ROR2’ resembles members of the receptor tyrosine kinase family of signalling receptors in sequence but its' signal transduction mechanisms remain enigmatic. This...
Sandilands, Emma, Akbarzadeh, Shiva, Vecchione, Anna, McEwan, David G, Frame, Margaret C, Heath, John K
The non-receptor tyrosine kinase Src is recruited to activated fibroblast growth factor receptor (FGFR) complexes through the adaptor protein factor receptor substrate 2 (FRS2). Here, we show that...
Narrative-based computational modelling of the Gp130/JAK/STAT signalling pathway
Guerriero, Maria Luisa, Dudka, Anna, Underhill-Day, Nicholas, Heath, John K, Priami, Corrado
Sweet, Steve M. M., Bailey, Christopher M., Cunningham, Debbie L., Heath, John K., Cooper, Helen J.
We used on-line electron capture dissociation (ECD) for the large scale identification and localization of sites of phosphorylation. Each FT-ICR ECD event was paired with a linear ion trap...