Linnstaedt, Sarah D., Kasprzak, Wojciech K., Shapiro, Bruce A., Casey, John L.
RNA editing by the host RNA adenosine deaminase ADAR1 at the amber/W site of hepatitis delta virus RNA plays a central role in the viral replication cycle by affecting the balance between viral RNA...
Linnstaedt, Sarah D., Kasprzak, Wojciech K., Shapiro, Bruce A., Casey, John L.
RNA editing plays a critical role in the life cycle of hepatitis delta virus (HDV). The host editing enzyme ADAR1 recognizes specific RNA secondary structure features around the amber/W site in the...
Linnstaedt, Sarah D., Kasprzak, Wojciech K., Shapiro, Bruce A., Casey, John L.
RNA editing plays a critical role in the life cycle of hepatitis delta virus (HDV). The host editing enzyme ADAR1 recognizes specific RNA secondary structure features around the amber/W site in the...
Linnstaedt, Sarah D., Kasprzak, Wojciech K., Shapiro, Bruce A., Casey, John L.
RNA editing plays a critical role in the life cycle of hepatitis delta virus (HDV). The host editing enzyme ADAR1 recognizes specific RNA secondary structure features around the amber/W site in the...
Deletional analysis of the promoter region of the human transferrin receptor gene (1988)
Casey, John L., Jeso, Bruno Di, Rao, Krishnamurthy K., Rouault, Tracey A., Klausner, Richard D., Harford, Joe B.
Fragments of human genomic DNA corresponding to the promoter region of the gene for the transferrin receptor have been cloned upstream or the bacterial gene for chloramphenicol acetyltransferase and...
Casey, John L., Gerin, John L.
Characterizations of genetic variations among hepatitis delta virus (HDV) isolates have focused principally on phylogenetic analysis of sequences, which vary by 30 to 40% among three genotypes and...
Polson, Andrew G., Ley, Herbert L., Bass, Brenda L., Casey, John L.
RNA editing at adenosine 1012 (amber/W site) in the antigenomic RNA of hepatitis delta virus (HDV) allows two essential forms of the viral protein, hepatitis delta antigen (HDAg), to be synthesized...
Jayan, Geetha C., Casey, John L.
Hepatitis delta virus (HDV) is a subviral human pathogen that uses specific RNA editing activity of the host to produce two essential forms of the sole viral protein, hepatitis delta antigen (HDAg)....
RNA Editing in Hepatitis Delta Virus Genotype III Requires a Branched Double-Hairpin RNA Structure
RNA editing at the amber/W site plays a central role in the replication scheme of hepatitis delta virus (HDV), allowing the virus to produce two functionally distinct forms of the sole viral protein,...
A Prenylation Inhibitor Prevents Production of Infectious Hepatitis Delta Virus Particles
Bordier, Bruno B., Marion, Patricia L., Ohashi, Kazuo, Kay, Mark A., Greenberg, Harry B., Casey, John L., ...
Hepatitis delta virus (HDV) causes both acute and chronic liver disease throughout the world. Effective medical therapy is lacking. Previous work has shown that the assembly of HDV virus-like...
Jayan, Geetha C., Casey, John L.
Hepatitis delta virus (HDV) requires host RNA editing at the viral RNA amber/W site. Of the two host genes responsible for RNA editing via deamination of adenosines in double-stranded RNAs, short...
Cheng, Qiufang, Jayan, Geetha C., Casey, John L.
Hepatitis delta virus (HDV) produces two essential forms of the sole viral protein from the same open reading frame by using host RNA editing activity at the amber/W site in the antigenomic RNA. The...
In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus
Bordier, Bruno B., Ohkanda, Junko, Liu, Ping, Lee, So-Young, Salazar, F.H., Marion, Patricia L., ...
Hepatitis delta virus (HDV) can dramatically worsen liver disease in patients coinfected with hepatitis B virus (HBV). No effective medical therapy exists for HDV. The HDV envelope requires HBV...
Jayan, Geetha C., Casey, John L.
RNA editing of the hepatitis delta virus (HDV) antigenome at the amber/W site by the host RNA adenosine deaminase ADAR1 is a critical step in the HDV replication cycle. Editing is required for...
Genetic Changes in Hepatitis Delta Virus from Acutely and Chronically Infected Woodchucks
Casey, John L., Tennant, Bud C., Gerin, John L.
A woodchuck-derived hepatitis delta virus (HDV) inoculum was created by transfection of a genotype I HDV cDNA clone directly into the liver of a woodchuck that was chronically infected with woodchuck...
Casey, John L., Gerin, John L.
Characterizations of genetic variations among hepatitis delta virus (HDV) isolates have focused principally on phylogenetic analysis of sequences, which vary by 30 to 40% among three genotypes and...
Polson, Andrew G., Ley, Herbert L., Bass, Brenda L., Casey, John L.
RNA editing at adenosine 1012 (amber/W site) in the antigenomic RNA of hepatitis delta virus (HDV) allows two essential forms of the viral protein, hepatitis delta antigen (HDAg), to be synthesized...
Jayan, Geetha C., Casey, John L.
Hepatitis delta virus (HDV) is a subviral human pathogen that uses specific RNA editing activity of the host to produce two essential forms of the sole viral protein, hepatitis delta antigen (HDAg)....
RNA Editing in Hepatitis Delta Virus Genotype III Requires a Branched Double-Hairpin RNA Structure
RNA editing at the amber/W site plays a central role in the replication scheme of hepatitis delta virus (HDV), allowing the virus to produce two functionally distinct forms of the sole viral protein,...
A Prenylation Inhibitor Prevents Production of Infectious Hepatitis Delta Virus Particles
Bordier, Bruno B., Marion, Patricia L., Ohashi, Kazuo, Kay, Mark A., Greenberg, Harry B., Casey, John L., ...
Hepatitis delta virus (HDV) causes both acute and chronic liver disease throughout the world. Effective medical therapy is lacking. Previous work has shown that the assembly of HDV virus-like...
Jayan, Geetha C., Casey, John L.
Hepatitis delta virus (HDV) requires host RNA editing at the viral RNA amber/W site. Of the two host genes responsible for RNA editing via deamination of adenosines in double-stranded RNAs, short...
Cheng, Qiufang, Jayan, Geetha C., Casey, John L.
Hepatitis delta virus (HDV) produces two essential forms of the sole viral protein from the same open reading frame by using host RNA editing activity at the amber/W site in the antigenomic RNA. The...
In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus
Bordier, Bruno B., Ohkanda, Junko, Liu, Ping, Lee, So-Young, Salazar, F.H., Marion, Patricia L., ...
Hepatitis delta virus (HDV) can dramatically worsen liver disease in patients coinfected with hepatitis B virus (HBV). No effective medical therapy exists for HDV. The HDV envelope requires HBV...
Jayan, Geetha C., Casey, John L.
RNA editing of the hepatitis delta virus (HDV) antigenome at the amber/W site by the host RNA adenosine deaminase ADAR1 is a critical step in the HDV replication cycle. Editing is required for...
Genetic Changes in Hepatitis Delta Virus from Acutely and Chronically Infected Woodchucks
Casey, John L., Tennant, Bud C., Gerin, John L.
A woodchuck-derived hepatitis delta virus (HDV) inoculum was created by transfection of a genotype I HDV cDNA clone directly into the liver of a woodchuck that was chronically infected with woodchuck...
The role of a metastable RNA secondary structure in hepatitis delta virus genotype III RNA editing
Linnstaedt, Sarah D., Kasprzak, Wojciech K., Shapiro, Bruce A., Casey, John L.
RNA editing plays a critical role in the life cycle of hepatitis delta virus (HDV). The host editing enzyme ADAR1 recognizes specific RNA secondary structure features around the amber/W site in the...
Gandy, Sharon Z., Linnstaedt, Sarah D., Muralidhar, Sumitra, Cashman, Kathleen A., Rosenthal, Leonard J., Casey, John L.
Human herpesvirus 8 is the etiologic agent associated with Kaposi's sarcoma and primary effusion lymphoma (PEL). The K12 RNA, which produces as many as three variants of the kaposin protein, as well...
Defenbaugh, Dawn A., Johnson, Matthew, Chen, Renxiang, Zheng, Ying Yi, Casey, John L.
Hepatitis delta virus (HDV) is a subviral pathogen that increases the severity of liver disease caused by hepatitis B virus. Both the small circular RNA genome and its complement, the antigenome,...