Effect of Emetine on T-2 Toxin-Induced Inhibition of Protein Synthesis in Mammalian Cells (2006)
Leatherman, Dennis L., Middlebrook, John L.
Chinese hamster ovary cells were used to examine the effect of emetine upon the toxicity of T-2 toxin and several related trichothecene inhibitors of polypeptide synthesis. Emetine inhibited protein...
Exogenous Nucleotide Protection of Mammalian Cells from Diphtheria Toxin. (2002)
Middlebrook,John L., Dorland,Rebecca B.
Exogenous nucleotides were found to protect mammalian cells from the lethal effects of diphtheria toxin. Protective potency of a given nucleotide was base-specific and phosphate chain-length...
Middlebrook,John L., Dorland,Rebecca B.
Exogenous nucleotides were found to protect mammalian cells from Pseudomonas (PE) and diphtheria (DE) exotoxins. The protection was dose-dependent and required the simultaneous presence of nucleotide...
Effects of Lectins on the Interaction of Diphtheria Toxin with Mammalian Cells. (2002)
Middlebrook,John L., Dorland,Rebecca B., Leppla,Stephen H.
The effects of concanavalin A (Con A) on diphtheria toxin-cell receptor interactions were studied. Con A had no measurable effect on toxin-receptor binding at 4 C but increased the total...
Receptor-mediated Internalization and Degradation of Diphtheria Toxin by Monkey Kidney Cells. (2002)
Dorland,Rebecca B., Middlebrook,John L., Leppla,Stephen H.
The receptor-mediated internalization and degradation of radiolabeled diphtheria toxin by cultured monkey kidney cells was studied. The ability of a number of enzymes and chemicals to remove cell...
The Secondary Structure of Staphylococcal Enterotoxins A, B and C, (2002)
Middlebrook,John L., Spero,Leonard, Argos,Patrick
Supersedes report dated 10 Apr 79, AD-A067 759.
Ion-Conducting Channels Produced by Botulinum Toxin in Planar Lipid Membranes, (2002)
Donovan,James J., Middlebrook,John L.
The interaction of botulinum neurotoxin (Botx) with planar lipid membranes was studied by measuring the ability of the toxin to form ion-conducting channels. Channel formation was pH dependent. At...
Ion-Conducting Channels Produced by Botulinum Toxin in Planar Lipid Membranes, (2002)
Donovan,James J., Middlebrook,John L.
The interaction of botulinum neurotoxin (Botx) with planar lipid membranes was studied by measuring the ability of the toxin to form ion-conducting channels. Channel formation was pH dependent. At...
Monoclonal Antibodies against Vero Cells That Protect against Diphtheria Toxin, (1998)
Roennberg, Bengt J., Lidgerding, Burt C., Middlebrook, John L.
Mice were immunized with a cell line (Vero) that possesses a high number of membrane receptors for diphtheria toxin. Spleen cells from these mice were fused with SP2/0-Ag14 cells and two cell lines...
Differential Association of T-2 and T-2 Tetraol with Mammalian Cells, (1998)
Middlebrook, John L., Leatherman, Dennis L.
The interactions of T-2 and its metabolite T-2 tetraol (hereafter tetraol) with CHO (Chinese hamster ovary cells) and ribosomes were studied. Trichothescenes are a group of structurally related...