John M. Maris

Genomic copy number determination in cancer cells from single nucleotide polymorphism microarrays based on quantitative genotyping corrected for aneuploidy (2009)

Attiyeh, Edward F., Diskin, Sharon J., Attiyeh, Marc A., Mossé, Yaël P., Hou, Cuiping, Jackson, Eric M., ...

Microarrays are frequently used to profile genome-wide copy number (CN) aberrations. While generally robust for detecting CN variants in germline DNA, the methods used to derive CN from signal...

Adjustment of genomic waves in signal intensities from whole-genome SNP genotyping platforms (2008)

Diskin, Sharon J., Li, Mingyao, Hou, Cuiping, Yang, Shuzhang, Glessner, Joseph, Hakonarson, Hakon, ...

Whole-genome microarrays with large-insert clones designed to determine DNA copy number often show variation in hybridization intensity that is related to the genomic position of the clones. We found...

The kinesin KIF1B{beta} acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor (2008)

Schlisio, Susanne, Kenchappa, Rajappa S., Vredeveld, Liesbeth C.W., George, Rani E., Stewart, Rodney, Greulich, Heidi, ...

VHL, NF-1, c-Ret, and Succinate Dehydrogenase Subunits B and D act on a developmental apoptotic pathway that is activated when nerve growth factor (NGF) becomes limiting for neuronal progenitor cells...

STAC: A method for testing the significance of DNA copy number aberrations across multiple array-CGH experiments (2006)

Diskin, Sharon J., Eck, Thomas, Greshock, Joel, Mosse, Yael P., Naylor, Tara, Stoeckert, Christian J., ...

Regions of gain and loss of genomic DNA occur in many cancers and can drive the genesis and progression of disease. These copy number aberrations (CNAs) can be detected at high resolution by using...

STAC: A method for testing the significance of DNA copy number aberrations across multiple array-CGH experiments (2006)

Diskin, Sharon J., Eck, Thomas, Greshock, Joel, Mosse, Yael P., Naylor, Tara, Stoeckert, Christian J., ...

Regions of gain and loss of genomic DNA occur in many cancers and can drive the genesis and progression of disease. These copy number aberrations (CNAs) can be detected at high resolution by using...

CGHAnalyzer: a stand-alone software package for cancer genome analysis using array-based DNA copy number data (2005)

Margolin, Adam A., Greshock, Joel, Naylor, Tara L., Mosse, Yael, Maris, John M., Bignell, Graham, ...

Summary: This synopsis provides an overview of array-based comparative genomic hybridization data display, abstraction and analysis using CGHAnalyzer, a software suite, designed specifically for this...

Region-specific detection of neuroblastoma loss of heterozygosity at multiple loci simultaneously using a SNP-based tag-array platform (2005)

Maris, John M., Hii, George, Gelfand, Craig A., Varde, Shobha, White, Peter S., Rappaport, Eric, ...

Many cancers are characterized by chromosomal aberrations that may be predictive of disease outcome. Human neuroblastomas are characterized by somatically acquired copy number changes, including loss...

CGHAnalyzer: a stand-alone software package for cancer genome analysis using array-based DNA copy number data (2005)

Margolin, Adam A., Greshock, Joel, Naylor, Tara L., Mosse, Yael, Maris, John M., Bignell, Graham, ...

Summary: This synopsis provides an overview of array-based comparative genomic hybridization (aCGH) data display, abstraction and analysis using CGHAnalyzer, a software suite, designed specifically...

Region-specific detection of neuroblastoma loss of heterozygosity at multiple loci simultaneously using a SNP-based tag-array platform

Maris, John M., Hii, George, Gelfand, Craig A., Varde, Shobha, White, Peter S., Rappaport, Eric, ...

Many cancers are characterized by chromosomal aberrations that may be predictive of disease outcome. Human neuroblastomas are characterized by somatically acquired copy number changes, including loss...

The ETV6-NTRK3 chimeric tyrosine kinase suppresses TGF-β signaling by inactivating the TGF-β type II receptor

Jin, Wook, Kim, Byung-Chul, Tognon, Cristina, Lee, Ho-Jae, Patel, Sejal, Lannon, Chris L., ...

An emerging theme in cancer biology is that although some malignancies occur through the sequential acquisition of different genetic alterations, certain dominantly acting oncoproteins such as those...

Region-specific detection of neuroblastoma loss of heterozygosity at multiple loci simultaneously using a SNP-based tag-array platform

Maris, John M., Hii, George, Gelfand, Craig A., Varde, Shobha, White, Peter S., Rappaport, Eric, ...

Many cancers are characterized by chromosomal aberrations that may be predictive of disease outcome. Human neuroblastomas are characterized by somatically acquired copy number changes, including loss...

The ETV6-NTRK3 chimeric tyrosine kinase suppresses TGF-β signaling by inactivating the TGF-β type II receptor

Jin, Wook, Kim, Byung-Chul, Tognon, Cristina, Lee, Ho-Jae, Patel, Sejal, Lannon, Chris L., ...

An emerging theme in cancer biology is that although some malignancies occur through the sequential acquisition of different genetic alterations, certain dominantly acting oncoproteins such as those...

STAC: A method for testing the significance of DNA copy number aberrations across multiple array-CGH experiments

Diskin, Sharon J., Eck, Thomas, Greshock, Joel, Mosse, Yael P., Naylor, Tara, Stoeckert, Christian J., ...

Regions of gain and loss of genomic DNA occur in many cancers and can drive the genesis and progression of disease. These copy number aberrations (CNAs) can be detected at high resolution by using...

Rapamycin improves lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome (ALPS)

Teachey, David T., Obzut, Dana A., Axsom, Kelly, Choi, John K., Goldsmith, Kelly C., Hall, Junior, ...

Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of abnormal lymphocyte survival caused by defective Fas-mediated apoptosis, leading to lymphadenopathy, hepatosplenomegaly, and an...

Evaluation of semi-quantitative scoring system for metaiodobenzylguanidine (mIBG) scans in patients with relapsed neuroblastoma

Messina, Julia A., Cheng, Su-Chun, Franc, Benjamin L., Charron, Martin, Shulkin, Barry, To, Bao, ...

Background The purpose of this study was to determine the accuracy of two semi-quantitative scoring systems to assess response to 131 I-metaiodobenzylguanidine (mIBG) therapy in recurrent...

The kinesin KIF1Bβ acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor

Schlisio, Susanne, Kenchappa, Rajappa S., Vredeveld, Liesbeth C.W., George, Rani E., Stewart, Rodney, Greulich, Heidi, ...

VHL, NF-1, c-Ret, and Succinate Dehydrogenase Subunits B and D act on a developmental apoptotic pathway that is activated when nerve growth factor (NGF) becomes limiting for neuronal progenitor cells...

Adjustment of genomic waves in signal intensities from whole-genome SNP genotyping platforms

Diskin, Sharon J., Li, Mingyao, Hou, Cuiping, Yang, Shuzhang, Glessner, Joseph, Hakonarson, Hakon, ...

Whole-genome microarrays with large-insert clones designed to determine DNA copy number often show variation in hybridization intensity that is related to the genomic position of the clones. We found...

High Myc pathway activity and low stage of neuronal differentiation associate with poor outcome in neuroblastoma

Fredlund, Erik, Ringnér, Markus, Maris, John M., Påhlman, Sven

The childhood cancer neuroblastoma arises in the developing sympathetic nervous system and is a genotypically and phenotypically heterogeneous disease. Prognostic markers of poor survival probability...

Effect of sleep stage on breathing in children with central hypoventilation

Huang, Jingtao, Colrain, Ian M., Panitch, Howard B., Tapia, Ignacio E., Schwartz, Michael S., Samuel, John, ...

The early literature suggests that hypoventilation in infants with congenital central hypoventilation syndrome (CHS) is less severe during rapid eye movement (REM) than during non-REM (NREM) sleep....

Genomic copy number determination in cancer cells from single nucleotide polymorphism microarrays based on quantitative genotyping corrected for aneuploidy

Attiyeh, Edward F., Diskin, Sharon J., Attiyeh, Marc A., Mossé, Yaël P., Hou, Cuiping, Jackson, Eric M., ...

Microarrays are frequently used to profile genome-wide copy number (CN) aberrations. While generally robust for detecting CN variants in germline DNA, the methods used to derive CN from signal...

Cortical Processing of Respiratory Occlusion Stimuli in Children with Central Hypoventilation Syndrome

Huang, Jingtao, Marcus, Carole L., Bandla, Preetam, Schwartz, Michael S., Pepe, Michelle E., Samuel, John M., ...

Rationale: The ability of patients with central hypoventilation syndrome (CHS) to produce and process mechanoreceptor signals is unknown.