Regulation of hyaluronan expression during cervical ripening (2005)
Straach, Kelly J., Shelton, John M., Richardson, James A., Hascall, Vincent C., Mahendroo, Mala S.
In preparation for birth, the uterine cervix undergoes a remarkable transformation from a closed, rigid structure to a distensible, remodeled configuration that stretches to allow passage of a fetus....
Regulation of hyaluronan expression during cervical ripening (2004)
Grabbe, Kelly J., Shelton, John M., Richardson, James A., Hascall, Vincent C., Mahendroo, Mala S.
The uterine cervix, in preparation for birth, undergoes a remarkable transformation from a closed, rigid structure to a distensible, remodeled configuration that stretches to allow passage of a...
Regulation of hyaluronan expression during cervical ripening (2004)
Grabbe, Kelly J., Shelton, John M., Richardson, James A., Hascall, Vincent C., Mahendroo, Mala S.
The uterine cervix, in preparation for birth, undergoes a remarkable transformation from a closed, rigid structure to a distensible, remodeled configuration that stretches to allow passage of a...
A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type (1998)
Chin, Eva R., Olson, Eric N., Richardson, James A., Yang, Quan, Humphries, Caroline, Shelton, John M., ...
A thesis on congestive fever / (1840)
Thesis (M.D.)--Medical College of the State of South Carolina, 1840.
Cyclosporine A-induced hypertension involves synapsin in renal sensory nerve endings
Zhang, Weiguo, Li, Jia-Ling, Hosaka, Masahiro, Janz, Roger, Shelton, John M., Albright, George M., ...
The calcineurin inhibitor cyclosporine A (CsA) has emerged as a major cause of secondary hypertension in humans, but the underlying pathogenetic mechanisms have remained enigmatic. Synapsins are a...
Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo
Rothermel, Beverly A., McKinsey, Timothy A., Vega, Rick B., Nicol, Rebekka L., Mammen, Pradeep, Yang, John, ...
Signaling events controlled by calcineurin promote cardiac hypertrophy, but the degree to which such pathways are required to transduce the effects of various hypertrophic stimuli remains uncertain....
Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout mice
Gupta, Praveena, Soyombo, Abigail A., Atashband, Armita, Wisniewski, Krystyna E., Shelton, John M., Richardson, James A., ...
PPT1 and PPT2 encode two lysosomal thioesterases that catalyze the hydrolysis of long chain fatty acyl CoAs. In addition to this function, PPT1 (palmitoyl-protein thioesterase 1) hydrolyzes fatty...
Activated glycogen synthase-3β suppresses cardiac hypertrophy in vivo
Antos, Christopher L., McKinsey, Timothy A., Frey, Norbert, Kutschke, William, McAnally, John, Shelton, John M., ...
The adult myocardium responds to a variety of pathologic stimuli by hypertrophic growth that frequently progresses to heart failure. The calcium/calmodulin-dependent protein phosphatase calcineurin...
Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway
Wu, Hai, Rothermel, Beverly, Kanatous, Shane, Rosenberg, Paul, Naya, Francisco J., Shelton, John M., ...
Gene expression in skeletal muscles of adult vertebrates is altered profoundly by changing patterns of contractile work. Here we observed that the functional activity of MEF2 transcription factors is...
Disruption of PPT2 in mice causes an unusual lysosomal storage disorder with neurovisceral features
Gupta, Praveena, Soyombo, Abigail A., Shelton, John M., Wilkofsky, Ian G., Wisniewski, Krystyna E., Richardson, James A., ...
The palmitoyl protein thioesterase-2 (PPT2) gene encodes a lysosomal thioesterase homologous to PPT1, which is the enzyme defective in the human disorder called infantile neuronal ceroid...
Essential Role of STAT3 in Body Weight and Glucose Homeostasis
Cui, Yunxia, Huang, Lu, Elefteriou, Florent, Yang, Guoqing, Shelton, John M., Giles, Jerald E., ...
STAT3 is a ubiquitous transcription factor that is indispensable during early embryogenesis. To study the functions of STAT3 postnatally, we generated conditional STAT3-deficient mice. To that end,...
MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type
Wu, Hai, Naya, Francisco J., McKinsey, Timothy A., Mercer, Brian, Shelton, John M., Chin, Eva R., ...
Different patterns of motor nerve activity drive distinctive programs of gene transcription in skeletal muscles, thereby establishing a high degree of metabolic and physiological specialization among...
A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type
Chin, Eva R., Olson, Eric N., Richardson, James A., Yang, Quan, Humphries, Caroline, Shelton, John M., ...
Slow- and fast-twitch myofibers of adult skeletal muscles express unique sets of muscle-specific genes, and these distinctive programs of gene expression are controlled by variations in motor neuron...
Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression
López-Rodríguez, Cristina, Antos, Christopher L., Shelton, John M., Richardson, James A., Lin, Fangming, Novobrantseva, Tatiana I., ...
The transcription factor NFAT5/TonEBP, a member of the NFAT/Rel family of transcription factors, has been implicated in diverse cellular responses, including the response to osmotic stress,...
Marschang, Peter, Brich, Jochen, Weeber, Edwin J., Sweatt, J. David, Shelton, John M., Richardson, James A., ...
LRP1b and the closely related LRP1 are large members of the low-density lipoprotein receptor family. At the protein level LRP1b is 55% identical to LRP1, a multifunctional and developmentally...
TRPC3 channels confer cellular memory of recent neuromuscular activity
Rosenberg, Paul, Hawkins, April, Stiber, Jonathan, Shelton, John M., Hutcheson, Kelley, Bassel-Duby, Rhonda, ...
Skeletal muscle adapts to different patterns of motor nerve activity by alterations in gene expression that match specialized properties of contraction, metabolism, and muscle mass to changing work...
Tamura, Naohisa, Doolittle, Lynda K., Hammer, Robert E., Shelton, John M., Richardson, James A., Garbers, David L.
Guanylyl cyclase B is the receptor for a small peptide (C-type natriuretic peptide) produced locally in many different tissues. To unravel the functions of the receptor, we generated mice lacking...
Calcineurin Is Necessary for the Maintenance but Not Embryonic Development of Slow Muscle Fibers
Oh, Misook, Rybkin, Igor I., Copeland, Victoria, Czubryt, Michael P., Shelton, John M., Van Rooij, Eva, ...
Skeletal muscles are a mosaic of slow and fast twitch myofibers. During embryogenesis, patterns of fiber type composition are initiated that change postnatally to meet physiological demand. To...
Nakagawa, Osamu, Arnold, Michael, Nakagawa, Masayo, Hamada, Hideaki, Shelton, John M., Kusano, Hajime, ...
Myocyte enhancer factor 2 (MEF2) plays essential roles in transcriptional control of muscle development. However, signaling pathways acting downstream of MEF2 are largely unknown. Here, we performed...
Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
Inagaki, Takeshi, Moschetta, Antonio, Lee, Youn-Kyoung, Peng, Li, Zhao, Guixiang, Downes, Michael, ...
Obstruction of bile flow results in bacterial proliferation and mucosal injury in the small intestine that can lead to the translocation of bacteria across the epithelial barrier and systemic...
Cyclosporine A-induced hypertension involves synapsin in renal sensory nerve endings
Zhang, Weiguo, Li, Jia-Ling, Hosaka, Masahiro, Janz, Roger, Shelton, John M., Albright, George M., ...
The calcineurin inhibitor cyclosporine A (CsA) has emerged as a major cause of secondary hypertension in humans, but the underlying pathogenetic mechanisms have remained enigmatic. Synapsins are a...
Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo
Rothermel, Beverly A., McKinsey, Timothy A., Vega, Rick B., Nicol, Rebekka L., Mammen, Pradeep, Yang, John, ...
Signaling events controlled by calcineurin promote cardiac hypertrophy, but the degree to which such pathways are required to transduce the effects of various hypertrophic stimuli remains uncertain....
Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout mice
Gupta, Praveena, Soyombo, Abigail A., Atashband, Armita, Wisniewski, Krystyna E., Shelton, John M., Richardson, James A., ...
PPT1 and PPT2 encode two lysosomal thioesterases that catalyze the hydrolysis of long chain fatty acyl CoAs. In addition to this function, PPT1 (palmitoyl-protein thioesterase 1) hydrolyzes fatty...
Activated glycogen synthase-3β suppresses cardiac hypertrophy in vivo
Antos, Christopher L., McKinsey, Timothy A., Frey, Norbert, Kutschke, William, McAnally, John, Shelton, John M., ...
The adult myocardium responds to a variety of pathologic stimuli by hypertrophic growth that frequently progresses to heart failure. The calcium/calmodulin-dependent protein phosphatase calcineurin...
Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway
Wu, Hai, Rothermel, Beverly, Kanatous, Shane, Rosenberg, Paul, Naya, Francisco J., Shelton, John M., ...
Gene expression in skeletal muscles of adult vertebrates is altered profoundly by changing patterns of contractile work. Here we observed that the functional activity of MEF2 transcription factors is...
Disruption of PPT2 in mice causes an unusual lysosomal storage disorder with neurovisceral features
Gupta, Praveena, Soyombo, Abigail A., Shelton, John M., Wilkofsky, Ian G., Wisniewski, Krystyna E., Richardson, James A., ...
The palmitoyl protein thioesterase-2 (PPT2) gene encodes a lysosomal thioesterase homologous to PPT1, which is the enzyme defective in the human disorder called infantile neuronal ceroid...
Essential Role of STAT3 in Body Weight and Glucose Homeostasis
Cui, Yunxia, Huang, Lu, Elefteriou, Florent, Yang, Guoqing, Shelton, John M., Giles, Jerald E., ...
STAT3 is a ubiquitous transcription factor that is indispensable during early embryogenesis. To study the functions of STAT3 postnatally, we generated conditional STAT3-deficient mice. To that end,...
MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type
Wu, Hai, Naya, Francisco J., McKinsey, Timothy A., Mercer, Brian, Shelton, John M., Chin, Eva R., ...
Different patterns of motor nerve activity drive distinctive programs of gene transcription in skeletal muscles, thereby establishing a high degree of metabolic and physiological specialization among...
A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type
Chin, Eva R., Olson, Eric N., Richardson, James A., Yang, Quan, Humphries, Caroline, Shelton, John M., ...
Slow- and fast-twitch myofibers of adult skeletal muscles express unique sets of muscle-specific genes, and these distinctive programs of gene expression are controlled by variations in motor neuron...
Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression
López-Rodríguez, Cristina, Antos, Christopher L., Shelton, John M., Richardson, James A., Lin, Fangming, Novobrantseva, Tatiana I., ...
The transcription factor NFAT5/TonEBP, a member of the NFAT/Rel family of transcription factors, has been implicated in diverse cellular responses, including the response to osmotic stress,...
Marschang, Peter, Brich, Jochen, Weeber, Edwin J., Sweatt, J. David, Shelton, John M., Richardson, James A., ...
LRP1b and the closely related LRP1 are large members of the low-density lipoprotein receptor family. At the protein level LRP1b is 55% identical to LRP1, a multifunctional and developmentally...
TRPC3 channels confer cellular memory of recent neuromuscular activity
Rosenberg, Paul, Hawkins, April, Stiber, Jonathan, Shelton, John M., Hutcheson, Kelley, Bassel-Duby, Rhonda, ...
Skeletal muscle adapts to different patterns of motor nerve activity by alterations in gene expression that match specialized properties of contraction, metabolism, and muscle mass to changing work...
Tamura, Naohisa, Doolittle, Lynda K., Hammer, Robert E., Shelton, John M., Richardson, James A., Garbers, David L.
Guanylyl cyclase B is the receptor for a small peptide (C-type natriuretic peptide) produced locally in many different tissues. To unravel the functions of the receptor, we generated mice lacking...
Calcineurin Is Necessary for the Maintenance but Not Embryonic Development of Slow Muscle Fibers
Oh, Misook, Rybkin, Igor I., Copeland, Victoria, Czubryt, Michael P., Shelton, John M., Van Rooij, Eva, ...
Skeletal muscles are a mosaic of slow and fast twitch myofibers. During embryogenesis, patterns of fiber type composition are initiated that change postnatally to meet physiological demand. To...
Nakagawa, Osamu, Arnold, Michael, Nakagawa, Masayo, Hamada, Hideaki, Shelton, John M., Kusano, Hajime, ...
Myocyte enhancer factor 2 (MEF2) plays essential roles in transcriptional control of muscle development. However, signaling pathways acting downstream of MEF2 are largely unknown. Here, we performed...
Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
Inagaki, Takeshi, Moschetta, Antonio, Lee, Youn-Kyoung, Peng, Li, Zhao, Guixiang, Downes, Michael, ...
Obstruction of bile flow results in bacterial proliferation and mucosal injury in the small intestine that can lead to the translocation of bacteria across the epithelial barrier and systemic...
Cardiac autophagy is a maladaptive response to hemodynamic stress
Zhu, Hongxin, Tannous, Paul, Johnstone, Janet L., Kong, Yongli, Shelton, John M., Richardson, James A., ...
Cardiac hypertrophy is a major predictor of heart failure and a prevalent disorder with high mortality. Little is known, however, regarding mechanisms governing the transition from stable cardiac...
Histone deacetylase degradation andMEF2 activation promote the formation of slow-twitch myofibers
Potthoff, Matthew J., Wu, Hai, Arnold, Michael A., Shelton, John M., Backs, Johannes, McAnally, John, ...
Skeletal muscle is composed of heterogeneous myofibers with distinctive rates of contraction, metabolic properties, and susceptibility to fatigue. We show that class II histone deacetylase (HDAC)...
Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3
Fielitz, Jens, Kim, Mi-Sung, Shelton, John M., Latif, Shuaib, Spencer, Jeffrey A., Glass, David J., ...
Maintenance of skeletal and cardiac muscle structure and function requires precise control of the synthesis, assembly, and turnover of contractile proteins of the sarcomere. Abnormalities in...
Fielitz, Jens, Van Rooij, Eva, Spencer, Jeffrey A., Shelton, John M., Latif, Shuaib, Van Der Nagel, Roel, ...
RING-finger proteins commonly function as ubiquitin ligases that mediate protein degradation by the ubiquitin-proteasome pathway. Muscle-specific RING-finger (MuRF) proteins are striated...
Requirement of protein kinase D1 for pathological cardiac remodeling
Fielitz, Jens, Kim, Mi-Sung, Shelton, John M., Qi, Xiaoxia, Hill, Joseph A., Richardson, James A., ...
The adult heart responds to biomechanical stress and neurohormonal signaling by hypertrophic growth, accompanied by fibrosis, diminished pump function, and activation of a fetal gene program. Class...
Protein Kinase D1 Stimulates MEF2 Activity in Skeletal Muscle and Enhances Muscle Performance▿
Kim, Mi-Sung, Fielitz, Jens, McAnally, John, Shelton, John M., Lemon, Douglas D., McKinsey, Timothy A., ...
Skeletal muscle consists of type I and type II myofibers, which exhibit different metabolic and contractile properties. Type I fibers display an oxidative metabolism and are resistant to fatigue,...
Autophagy is an adaptive response in desmin-related cardiomyopathy
Tannous, Paul, Zhu, Hongxin, Johnstone, Janet L., Shelton, John M., Rajasekaran, Namakkal S., Benjamin, Ivor J., ...
A missense mutation in the αB-crystallin (CryAB) gene triggers a severe form of desmin-related cardiomyopathy (DRCM) characterized by accumulation of misfolded proteins. We hypothesized that...
Lavery, Gareth G., Walker, Elizabeth A., Turan, Nil, Rogoff, Daniela, Ryder, Jeffery W., Shelton, John M., ...
Hexose-6-phosphate dehydrogenase (H6PD) is the initial component of a pentose phosphate pathway inside the endoplasmic reticulum (ER) that generates NADPH for ER enzymes. In liver H6PD is required...