Trivedi, Hariprasad, Xiang, Qun, Klein, John P.
Background. The risks of major cardiac events in patients initiating long-term dialysis related to prior coronary disease and various other factors are not well known. Methods. We used United States...
Xu Zhang, Fausto R. Loberiza, John P. Klein, Mei-jie Zhang, Xu Zhang
Abstract. Often in biomedical research the aim of a study is to compare the outcomes of several treatment arms while adjusting for multiple clinical prognostic factors. In this paper we focus on...
MODELING MULTISTATE SURVIVAL ILLUSTRATED IN (2007)
Ph. D, Bone Marrow Transplantation, Bone Marrow Transplantation, John P. Klein, John P. Klein, Chunlin Qian
In many applications of survival analysis techniques there are intermediate events whose occurrence may effect a patient's prognosis. The occurrence of these intermediate events can be modeled...
Per Kragh Andersen, Per Kragh Andersen, Mary M. Horowitz, Mary M. Horowitz, John P. Klein, John P. Klein, ...
A study of long term survival of 1,487 patients given an allogenic bone marrow transplant for acute myelogenous leukemia and 729 patients given a transplant for severe aplastic anemia was conducted...
A SAS Macro For The Positive Stable Frailty Model (2007)
: A SAS macro to extend the Cox proportional hazards regression model to allow for positive stable frailties is presented. This macro computes, using a modied EM algorithm, estimates of the model...
Often when comparing the survival rates of individuals given either of two treatments the analysis stops with a test of the hypothesis of no treatment di erence and perhaps a plot of the two survival...
A SAS MACRO FOR THE ADDITIVE HAZARDS REGRESSION MODEL (2007)
Alicia M. Howell, John P. Klein
Regression models for survival data have traditionally been based on a proportional hazards model. The effect of the covariates on survival is to act multiplicatively on some unknown baseline hazard...
Many applications in biostatistics involve the modeling of lifetime data. In these applications the outcome of interest is the time T,until some event occurs. This eventmay be death, the appearance...
Confidence Regions For The Equality Of Two Survival Curves (2007)
Ph. D, John P. Klein, John P. Klein, Mei-jie Zhang
Often when comparing the survival rates of individuals given either of two treatments the analysis stops with a test of the hypothesis of no treatment difference and perhaps a plot of the two...
Analysis of Survival Data: A Comparison of Three Major Statistical Packages (SAS, SPSS, BMDP) (2007)
INTRODUCTION The application of survival models to data is valid when the endpoint of interest is the "time to the occurrence of a particular event." Survival models may be applied to a...
Additive hazards Markov regression models illustrated with bone marrow transplant data (2005)
When there are covariate effects to be considered, multi-state survival analysis is dominated either by parametric Markov regression models or by semiparametric Markov regression models using Cox's...
Andersen, Per Kragh, Klein, John P., Rosthøj, Susanne
In multi‐state models regression analysis typically involves the modelling of each transition intensity separately. Each probability of interest, namely the probability that a subject will be...
Bone marrow transplantation from HLA-identical siblings as treatment for myelodysplasia (2002)
Pérez, Waleska S, Rozman, Ciril, Carreras, Enric, Klein, John P, Rizzo, J Douglas, ...
Allogeneic hematopoietic stem cell transplantation is the only curative therapy for myelodysplasia (MDS). To identify factors influencing transplantation outcome, we studied 452 recipients of...
Berry, Donald A., Broadwater, Gloria, Klein, John P., Antman, Karen, Aisner, Joseph, Bitran, Jacob, ...
PURPOSE: To assess survival of patients with metastatic breast cancer treated with high-dose chemotherapy (HDC) versus standard-dose chemotherapy (SDC). PATIENTS AND METHODS: SDC in four Cancer and...
Accelerated Life Tests under Competing Weibull Causes of Failure. (2002)
Accelerated life testing of a product under more severe than normal condition is commonly used to reduce test time and cost. Data collected at such accelerated conditions is used to obtain estimates...
Weibull Accelerated Life Tests When There Are Competing Causes of Failure. (2002)
Accelerated life testing of a product under more severe than normal conditions is commonly used to reduce test time and costs. Data collected at such accelerated conditions are used to obtain...
Accelerated Life Testing Under Competing Exponential Failure Distributions. (2002)
Accelerated life testing of a product is commonly used to estimate parameters of devices with extremely long lifelines. The problem of analyzing accelerated life tests when the product can fail from...
Moeschberger,Melvin L., Klein,John P.
The overall objective of this proposal is to investigate the robustness to departures from independence of methods currently in use in reliability studies when competing failure modes or competing...
Moeschberger,Melvin L., Klein,John P.
The overall objective of this proposal is to investigate the robustness to departures from independence of methods currently in use in reliability studies when competing failure modes or competing...
Moeschberger, Melvin L., Klein, John P.
The overall objective of this proposal is to develop improved estimation techniques for us in reliability studies when there are competing failure modes or competing causes of failure associated with...
Niels Keiding, Per Kragh Andersen, John P. Klein
INTRODUCTION Statistical modelling of heterogeneity may be based on strati#cation according to factors, regression on covariates, or by assuming a probability distribution of the interindividual...
Mei-jie Zhang, Per Kragh Andersen, Per Kragh Andersen, John P. Klein, John P. Klein, Mie-jie Zhang
The problem of testing for a center effect following a proportional hazards regression is considered. Two approaches...
Statistical Challenges In Comparing Chemotherapy And (1996)
Bone Marrow Transplantation, John P. Klein, Mei-jie Zhang
Introduction Both chronic and acute leukemias are treated by one of two treatment modalities: intensive chemotherapy or bone marrow transplantation. Both treatment regimes have shown varying e#cacies...
Graphical models for panel studies, illustrated on data from the Framingham heart study (1995)
John P. Klein, John P. Klein, Niels Keiding, Niels Keiding, Svend Kreiner, Svend Kreiner
Recursive graphical models allow description of the simultaneous development of several (discrete) characteristics such as are recorded in a panel study. Irreversible events (death, irreversible...
Estimates of marginal survival for dependent competing risks based on an assumed copula (1995)
When time to death and time to censoring are associated one may be appreciably misled when the marginal survival functions are estimated using the product-limit estimators, which assume independent...
Yi-Hwei Li, John P. Klein, M. L. Moeschberger
The results of a Monte Carlo study of the size and power of parametric and semiparametric approaches to inference on covariate effects in survival (time-to-events) models in the presence of model...
Cahn, Jean-Yves, Klein, John P., Lee, Stephanie J., Milpied, Noël, Blaise, Didier, Antin, Joseph H., ...
The most commonly used grading system for acute graft-versus-host disease (aGVHD) was introduced 30 years ago by Glucksberg; a revised system was developed by the International Bone Marrow Transplant...
Schmitz, Norbert, Eapen, Mary, Horowitz, Mary M., Zhang, Mei-Jie, Klein, John P., Rizzo, J. Douglas, ...
We previously compared outcomes after allogeneic peripheral-blood stem cell (PBSC) and bone marrow (BM) transplantation in 706 patients with leukemia. We obtained long-term follow up on 413 of 491...
PER K. ANDERSEN, JOHN P. KLEIN
Typically, regression analysis for multistate models has been based on regression models for the transition intensities. These models lead to highly nonlinear and very complex models for the effects...
Champlin, Richard E., Perez, Waleska S., Passweg, Jakob R., Klein, John P., Camitta, Bruce M., Gluckman, Eliane, ...
The addition of antithymocyte globulin (ATG) to a regimen of high-dose cyclophosphamide has been advocated to enhance engraftment after allogeneic bone marrow transplantation (BMT) for severe...
Miller, Jeffery S., Cooley, Sarah, Parham, Peter, Farag, Sherif S., Verneris, Michael R., McQueen, Karina L., ...
Natural killer (NK) cells can alter the outcome of hematopoietic cell transplantation (HCT) if donor alloreactivity targets the recipient. Since most NK cells express inhibitory killer-immunoglobulin...
Schrezenmeier, Hubert, Passweg, Jakob R., Marsh, Judith C. W., Bacigalupo, Andrea, Bredeson, Christopher N., Bullorsky, Eduardo, ...
We analyzed the outcome of 692 patients with severe aplastic anemia (SAA) receiving transplants from HLA-matched siblings. A total of 134 grafts were peripheral blood progenitor cell (PBPC) grafts,...
Additive hazards Markov regression models illustrated with bone marrow transplant data
When there are covariate effects to be considered, multi-state survival analysis is dominated either by parametric Markov regression models or by semiparametric Markov regression models using Cox's...
Pulsipher, Michael A., Chitphakdithai, Pintip, Miller, John P., Logan, Brent R., King, Roberta J., Rizzo, J. Douglas, ...
Limited data are available describing donor adverse events (AEs) associated with filgrastim mobilized peripheral blood stem cell (PBSC) collections in unrelated volunteers. We report results in 2408...