Cancer Biology Data Curation at the Mouse Tumor Biology Database (MTB) (2009)
Debra M. Krupke, Dale A. Begley, Steven B. Neuhauser, Joel E. Richardson, John P. Sundberg, Carol J. Bult, ...
Many advances in the field of cancer biology have been made using mouse models of human cancer. The Mouse Tumor Biology (MTB,...
Evidence for Hox-specified positional identities in adult vasculature (2008)
Pruett, Nathanael D, Visconti, Richard P, Jacobs, Donna F, Scholz, Dimitri, McQuinn, Tim, Sundberg, John P, ...
Abstract Background The concept of specifying positional information in the adult cardiovascular system is largely unexplored. While the Hox transcriptional regulators have to be viewed as excellent...
Fantauzzo, Katherine A., Tadin-Strapps, Marija, You, Yun, Mentzer, Sarah E., Baumeister, Friedrich A.M., Cianfarani, Stefano, ...
Ambras syndrome (AS) is a rare form of congenital hypertrichosis with excessive hair on the shoulders, face and ears. Cytogenetic studies have previously implicated an association with rearrangements...
Jenson, A Bennett, Sundberg, John P, Ghim, Shin-Je
The papillomaviruses form a large group of species-specific pathogens that cause epithelial proliferations in a wide spectrum of animal hosts. Previous reports demonstrated a relatively high...
Ancient papillomavirus-host co-speciation in Felidae (2007)
Rector, Annabel, Lemey, Philippe, Tachezy, Ruth, Mostmans, Sara, Ghim, Shin-Je, Van Doorslaer, Koenraad, ...
Abstract Background Estimating evolutionary rates for slowly evolving viruses such as papillomaviruses (PVs) is not possible using fossil calibrations directly or sequences sampled over a time-scale...
Mouse Tumor Biology Database (MTB): status update and future directions (2007)
Begley, Dale A., Krupke, Debra M., Vincent, Matthew J., Sundberg, John P., Bult, Carol J., Eppig, Janan T.
The Mouse Tumor Biology (MTB) database provides access to data about endogenously arising tumors (both spontaneous and induced) in genetically defined mice (inbred, hybrid, mutant and genetically...
Van Doorslaer, Koenraad, Bertelsen, Mads, Barker, Ian K, Olberg, Rolf-Arne, ...
Partial sequences of a novel papillomavirus were amplified from a cutaneous lesion biopsy of a raccoon (Procyon lotor), by using PCR with degenerate papillomavirus-specific primers. The Procyon lotor...
Tachezy, Ruth, Van Doorslaer, Koenraad, MacNamara, Tracey, Burk, Robert D, Sundberg, John P, ...
The complete genome of a novel papillomavirus was isolated from a cutaneous papillomatous lesion of a North American porcupine (Erethizon dorsatum) using multiply primed rolling-circle amplification...
Bossart, Gregory D, Ghim, Shin-Je, Sundberg, John P, Jenson, A Bennett
By using an isothermal multiply primed rolling-circle amplification protocol, the complete genomic DNA of a novel papillomavirus was amplified from a skin lesion biopsy of a Florida manatee...
Delius, Hajo, Sundberg, John P, Jenson, A Bennett
Equus caballus papillomavirus type 1 (EcPV-1) was isolated from a cutaneous papilloma, the most common neoplasm in horses. The complete EcPV-1 nucleotide sequence and genomic organization were...
Proteotypic classification of spontaneous and transgenic mammary neoplasms (2004)
Mikaelian, Igor, Blades, Natalie, Churchill, Gary A, Fancher, Karen, Knowles, Barbara B, Eppig, Janan T, ...
Abstract Introduction Mammary tumors in mice are categorized by using morphologic and architectural criteria. Immunolabeling for terminal differentiation markers was compared among a variety of mouse...
Pathbase: a new reference resource and database for laboratory mouse pathology (2004)
Schofield, Paul N., Bard, Jonathan B. L., Boniver, Jacques, Covelli, Vincenzo, Delvenne, Philippe, Ellender, Michele, ...
Pathbase (http://www.pathbase.net) is a web accessible database of histopathological images of laboratory mice, developed as a resource for the coding and archiving of data derived from the analysis...
Pathbase: a database of mutant mouse pathology (2004)
Schofield, Paul N., Bard, Jonathan B. L., Booth, Catherine, Boniver, Jacques, Covelli, Vincenzo, Delvenne, Philippe, ...
Pathbase is a database that stores images of the abnormal histology associated with spontaneous and induced mutations of both embryonic and adult mice including those produced by transgenesis,...
Ikeda, Sakae, Cunningham, Leslie A., Boggess, Dawnalyn, Hobson, Craig D., Sundberg, John P., Naggert, Jürgen K., ...
Cloning and genomic characterization of Felis domesticus papillomavirus type 1 (2002)
Duson, Griet, Jenson, A Bennett, Sundberg, John P
A novel papillomavirus was cloned from hyperkeratotic cutaneous lesions of a Persian domestic cat. The Felis domesticus papillomavirus (FdPV-1) genome counts 8300 bp and has a typical genome...
Tachezy, Ruth, Rector, Annabel, Havelkova, Marta, Wollants, Elke, Fiten, Pierre, Opdenakker, Ghislain, ...
Abstract Background An avian papillomavirus genome has been cloned from a cutaneous exophytic papilloma from an African grey parrot ( Psittacus erithacus ). The nucleotide sequence, genome...
Havelkova, Marta, ...
BACKGROUND: An avian papillomavirus genome has been cloned from a cutaneous exophytic papilloma from an African grey parrot (Psittacus erithacus). The nucleotide sequence, genome organization, and...
DEVELOPMENT AND DISEASE (2002)
Liang Ma, Jian Liu, Tobey Wu, Maksim Plikus, Ting-xin Jiang, Qun Bi, ...
doi:10.1242/dev.00201
Web-based access to mouse models of human cancers: the Mouse Tumor Biology (MTB) Database (2001)
Bult, Carol J., Krupke, Debra M., Näf, Dieter, Sundberg, John P., Eppig, Janan T.
The Mouse Tumor Biology (MTB) Database serves as a curated, integrated resource for information about tumor genetics and pathology in genetically defined strains of mice (i.e., inbred, transgenic and...
Notch signaling is essential for vascular morphogenesis in mice (2000)
Krebs, Luke T., Xue, Yingzi, Norton, Christine R., Shutter, John R., Maguire, Maureen, Sundberg, John P., ...
Mouse Tumor Biology Database (MTB): enhancements and current status (2000)
Bult, Carol J., Krupke, Debra M., Sundberg, John P., Eppig, Janan T.
The Mouse Tumor Biology Database (MTB) is a Web-based resource that provides access to information on tumor frequency and latency, genetics and pathology in genetically defined mice (transgenics,...
Dieter Näf, Debra M. Krupke, John P. Sundberg, Carol J. Bult
Developing genetic mouse models for cancer research has been recognized as an “exceptional opportunity ” by the National Cancer Institute. The establishment of bioinformatics resources to...
Web-based access to mouse models of human cancers: the Mouse Tumor Biology (MTB) Database
Bult, Carol J., Krupke, Debra M., Näf, Dieter, Sundberg, John P., Eppig, Janan T.
The Mouse Tumor Biology (MTB) Database serves as a curated, integrated resource for information about tumor genetics and pathology in genetically defined strains of mice (i.e., inbred, transgenic and...
A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice
Farmer, Mark A., Sundberg, John P., Bristol, Ian J., Churchill, Gary A., Li, Renhua, Elson, Charles O., ...
Colitic lesions are much more severe in C3H/HeJBir (C3H) than C57BL/6J (B6) mice after 10 backcrosses of a disrupted interleukin-10 (Il10) gene. This study identified cytokine deficiency-induced...
Mouse Tumor Biology Database (MTB): enhancements and current status
Bult, Carol J., Krupke, Debra M., Sundberg, John P., Eppig, Janan T.
The Mouse Tumor Biology Database (MTB) is a Web-based resource that provides access to information on tumor frequency and latency, genetics and pathology in genetically defined mice (transgenics,...
Tachezy, Ruth, Rector, Annabel, Havelkova, Marta, Wollants, Elke, Fiten, Pierre, Opdenakker, Ghislain, ...
Pathbase: a database of mutant mouse pathology
Schofield, Paul N., Bard, Jonathan B. L., Booth, Catherine, Boniver, Jacques, Covelli, Vincenzo, Delvenne, Philippe, ...
Pathbase is a database that stores images of the abnormal histology associated with spontaneous and induced mutations of both embryonic and adult mice including those produced by transgenesis,...
Notch signaling is essential for vascular morphogenesis in mice
Krebs, Luke T., Xue, Yingzi, Norton, Christine R., Shutter, John R., Maguire, Maureen, Sundberg, John P., ...
The Notch gene family encodes large transmembrane receptors that are components of an evolutionarily conserved intercellular signaling mechanism. To assess the role of the Notch4 gene, we generated...
Rector, Annabel, Bossart, Gregory D., Ghim, Shin-Je, Sundberg, John P., Jenson, A. Bennett, Van Ranst, Marc
By using an isothermal multiply primed rolling-circle amplification protocol, the complete genomic DNA of a novel papillomavirus was amplified from a skin lesion biopsy of a Florida manatee...
Proteotypic classification of spontaneous and transgenic mammary neoplasms
Mikaelian, Igor, Blades, Natalie, Churchill, Gary A, Fancher, Karen, Knowles, Barbara B, Eppig, Janan T, ...
Targeted Ablation of the Abcc6 Gene Results in Ectopic Mineralization of Connective Tissues
Klement, John F., Matsuzaki, Yasushi, Jiang, Qiu-Jie, Terlizzi, Joseph, Choi, Hae Young, Fujimoto, Norihiro, ...
Pseudoxanthoma elasticum (PXE), characterized by connective tissue mineralization of the skin, eyes, and cardiovascular system, is caused by mutations in the ABCC6 gene. ABCC6 encodes multidrug...
Web-based access to mouse models of human cancers: the Mouse Tumor Biology (MTB) Database
Bult, Carol J., Krupke, Debra M., Näf, Dieter, Sundberg, John P., Eppig, Janan T.
The Mouse Tumor Biology (MTB) Database serves as a curated, integrated resource for information about tumor genetics and pathology in genetically defined strains of mice (i.e., inbred, transgenic and...
A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice
Farmer, Mark A., Sundberg, John P., Bristol, Ian J., Churchill, Gary A., Li, Renhua, Elson, Charles O., ...
Colitic lesions are much more severe in C3H/HeJBir (C3H) than C57BL/6J (B6) mice after 10 backcrosses of a disrupted interleukin-10 (Il10) gene. This study identified cytokine deficiency-induced...
Mouse Tumor Biology Database (MTB): enhancements and current status
Bult, Carol J., Krupke, Debra M., Sundberg, John P., Eppig, Janan T.
The Mouse Tumor Biology Database (MTB) is a Web-based resource that provides access to information on tumor frequency and latency, genetics and pathology in genetically defined mice (transgenics,...
Tachezy, Ruth, Rector, Annabel, Havelkova, Marta, Wollants, Elke, Fiten, Pierre, Opdenakker, Ghislain, ...
Pathbase: a database of mutant mouse pathology
Schofield, Paul N., Bard, Jonathan B. L., Booth, Catherine, Boniver, Jacques, Covelli, Vincenzo, Delvenne, Philippe, ...
Pathbase is a database that stores images of the abnormal histology associated with spontaneous and induced mutations of both embryonic and adult mice including those produced by transgenesis,...
Notch signaling is essential for vascular morphogenesis in mice
Krebs, Luke T., Xue, Yingzi, Norton, Christine R., Shutter, John R., Maguire, Maureen, Sundberg, John P., ...
The Notch gene family encodes large transmembrane receptors that are components of an evolutionarily conserved intercellular signaling mechanism. To assess the role of the Notch4 gene, we generated...
Rector, Annabel, Bossart, Gregory D., Ghim, Shin-Je, Sundberg, John P., Jenson, A. Bennett, Van Ranst, Marc
By using an isothermal multiply primed rolling-circle amplification protocol, the complete genomic DNA of a novel papillomavirus was amplified from a skin lesion biopsy of a Florida manatee...
Proteotypic classification of spontaneous and transgenic mammary neoplasms
Mikaelian, Igor, Blades, Natalie, Churchill, Gary A, Fancher, Karen, Knowles, Barbara B, Eppig, Janan T, ...
Targeted Ablation of the Abcc6 Gene Results in Ectopic Mineralization of Connective Tissues
Klement, John F., Matsuzaki, Yasushi, Jiang, Qiu-Jie, Terlizzi, Joseph, Choi, Hae Young, Fujimoto, Norihiro, ...
Pseudoxanthoma elasticum (PXE), characterized by connective tissue mineralization of the skin, eyes, and cardiovascular system, is caused by mutations in the ABCC6 gene. ABCC6 encodes multidrug...
Mouse Tumor Biology Database (MTB): status update and future directions
Begley, Dale A., Krupke, Debra M., Vincent, Matthew J., Sundberg, John P., Bult, Carol J., Eppig, Janan T.
The Mouse Tumor Biology (MTB) database provides access to data about endogenously arising tumors (both spontaneous and induced) in genetically defined mice (inbred, hybrid, mutant and genetically...
Asebia-2J (Scd1ab2J): A New Allele and a Model for Scarring Alopecia
Sundberg, John P., Boggess, Dawnalyn, Sundberg, Beth A., Eilertsen, Ken, Parimoo, Satish, Filippi, Mario, ...
A spontaneous, autosomal, recessive mouse mutation exhibiting mild scaly skin, progressive scarring alopecia, slightly runted growth, and photophobia arose at The Jackson Laboratory in 1993 in the...
The Role of the Hairless (hr) Gene in the Regulation of Hair Follicle Catagen Transformation
Panteleyev, Andrei A., Botchkareva, Natalia V., Sundberg, John P., Christiano, Angela M., Paus, Ralf
Mice that carry a mutation at the hairless (hr) locus develop seemingly normal hair follicles (HF) but shed their hairs completely soon after birth. Histologically, their HFs degenerate into...
Ancient papillomavirus-host co-speciation in Felidae
Rector, Annabel, Lemey, Philippe, Tachezy, Ruth, Mostmans, Sara, Ghim, Shin-Je, Van Doorslaer, Koenraad, ...
The evolutionary rate of feline papillomaviruses is inferred from the phylogenetic analysis of their hosts, providing evidence for long-term virus-host co-speciation
Restricted MHC–peptide repertoire predisposes to autoimmunity
Logunova, Nadezda N., Viret, Christophe, Pobezinsky, Leonid A., Miller, Sara A., Kazansky, Dmitri B., Sundberg, John P., ...
MHC molecules associated with autoimmunity possess known structural features that limit the repertoire of peptides that they can present. Such limitation gives a selective advantage to TCRs that rely...
Cong, Yingzi, Brandwein, Steven L., McCabe, Robert P., Lazenby, A., Birkenmeier, Edward H., Sundberg, John P., ...
C3H/HeJBir mice are a new substrain that spontaneously develop colitis early in life. This study was done to determine the T cell reactivity of C3H/HeJBir mice to candidate antigens that might be...
Evidence for Hox-specified positional identities in adult vasculature
Pruett, Nathanael D, Visconti, Richard P, Jacobs, Donna F, Scholz, Dimitri, McQuinn, Tim, Sundberg, John P, ...
Utility of AntiPax5 in the Diagnosis of Lymphoproliferative Disorders and Neoplasia in Mice
Rehg, Jerold E, Sundberg, John P
CD45R/B220 antigen (B220) is a common mouse panB-cell marker used for paraffin-embedded tissues. However, antiB220 has limited specificity in diagnostic pathology because the B220 antigen is...
Fantauzzo, Katherine A., Tadin-Strapps, Marija, You, Yun, Mentzer, Sarah E., Baumeister, Friedrich A.M., Cianfarani, Stefano, ...
Ambras syndrome (AS) is a rare form of congenital hypertrichosis with excessive hair on the shoulders, face and ears. Cytogenetic studies have previously implicated an association with rearrangements...