Cardiac and coronary function in the Langendorff-perfused mouse heart model (2008)
Reichelt, Melissa Elizabeth, Willems, Laura, Hack, Benjamin A., Peart, Jason Nigel John, Headrick, John Patrick
The Langendorff mouse heart model is widely employed in studies of myocardial function and responses to injury (e.g. ischaemia). Nonetheless, marked variability exists in its preparation and...
Peart, Jason Nigel John, Gross, Eric R., Reichelt, Melissa Elizabeth, Hsu, Anna, Headrick, John Patrick, Gross, Garrett J.
The temporal properties of kappa-opioid receptor (κ-OR) mediated cardioprotection are less well characterised than delta-opioid receptor (δ-OR) responses. This study was aimed at delineating the...
Cardiac and coronary function in the Langendorff-perfused mouse heart model (2008)
Reichelt, Melissa Elizabeth, Willems, Laura, Hack, Benjamin A., Peart, Jason Nigel John, Headrick, John Patrick
The Langendorff mouse heart model is widely employed in studies of myocardial function and responses to injury (e.g. ischaemia). Nonetheless, marked variability exists in its preparation and...
P2 purinoceptor-mediated cardioprotection in ischemic-reperfused mouse heart (2007)
Wee, Shirley, Peart, Jason Nigel John, Headrick, John Patrick
Reichelt, Melissa Elizabeth, Willems, Laura, Peart, Jason Nigel John, Ashton, Kevin John, Matherne, G. Paul, Blackburn, Michael R., ...
Ashton, Kevin John, Peart, Jason Nigel John, Morrison, R. Ray, Matherne, G. Paul, Blackburn, Michael R., Headrick, John Patrick
Myocardial Ischemia-Reperfusion Injury, Antioxidant Enzyme Systems, and Selenium: A Review (2007)
Venardos, Kylie M., Perkins, Anthony Vincent, Headrick, John Patrick, Kaye, David M.
Ashton, Kevin John, Willems, Laura, Holmgren, Kirsty, Ferreira, Linda Anne, Headrick, John Patrick
Aged hearts exhibit reduced tolerance to ischemia-reperfusion, together with altered structure and post-ischemic remodelling. The molecular bases of such changes are unclear. Using cDNA microarrays...
Adenosine receptor-mediated coronary vascular protection in post-ischemic mouse heart (2006)
Zatta, Amanda Jane, Matherne, G. Paul, Headrick, John Patrick
This study evaluated the ability of A1 and A3 adenosine receptor (AR) agonism, and A1, A2A, A2B and A3AR antagonism (revealing "intrinsic" responses), to modify post-ischemic coronary dysfunction in...
Willems, Laura, Reichelt, Melissa Elizabeth, Molina, Jose G, Sun, Chun-Xiao, Chunn, Janci L, Ashton, Kevin John, ...
OBJECTIVE: Adenosine deaminase (ADA) may be multifunctional, regulating adenosine levels and adenosine receptor (AR) agonism, and potentially modifying AR functionality. Herein we assess effects of...
Oxidant Stress and Damage in Post-Ischemic Mouse Hearts: Effects of Adenosine (2006)
Hack, Benjamin Daniel Noel, Witting, Paul K, Rayner, Benjamin S., Stocker, Roland, Headrick, John Patrick
Despite the general understanding that ischemia-reperfusion (I/R) promotes oxidant stress, specific contributions of oxidant stress or damage to myocardial I/R injury remain poorly defined. Moreover,...
Genetic deletion of the A1 adenosine receptor limits myocardial ischemic tolerance (2005)
Reichelt, Melissa Elizabeth, Willems, Laura, Molina, JG, Sun, CX, Noble, JC, Ashton, Kevin John, ...
Age-related changes in ischemic tolerance in male and female mouse hearts (2005)
Willems, Laura, Zatta, Amanda Jane, Holmgren, Kirsty, Ashton, Kevin John, Headrick, John Patrick
Willems, Laura, Headrick, John Patrick
1. By selectively modifying adenosine metabolism via adenosine deaminase or adenosine kinase inhibitors, it may be possible to enhance the receptor-mediated protective actions of adenosine in a site-...
A3 adenosine receptor-mediated protection of the ischemic heart (2005)
Headrick, John Patrick, Peart, Jason Nigel John
The A3 adenosine receptor (A3AR) is attributed with multiple beneficial actions in ischemic–reperfused myocardium, including modulation of oncotic and apoptotic cell death and enhancement of...
Kin, Hajime, Zatta, Amanda J., Lofye, Mark T., Amerson, Bradley S., Halkos, Michael E., Kerendi, Faraz, ...
Objective This study tested the hypothesis that brief cycles of iterative ischemia–reperfusion at onset of reperfusion (termed “postconditioning”, post-con) delays washout of intravascular...
Effects of dietary selenium on post-ischemic expression of antioxidant mRNA (2005)
Venardos, Kylie, Ashton, Kevin John, Headrick, John Patrick, Perkins, Anthony Vincent
The role of adenosine-related genes variants in susceptibility to essential hypertension (2004)
Wright, Kirsty, Tajouri, Lotfi, Lea, Rodney Arthur, Ovcaric, Micky, Heuy, Stephanie, Morin, Fabien, ...
Selenium supplementation and ischemia-reperfusion injury in rats (2004)
Venardos, Kylie, Harrison, Glenn, Headrick, John Patrick, Perkins, Anthony Vincent
Venardos, Kylie, Harrison, Glenn, Headrick, John Patrick, Perkins, Anthony Vincent
Glutathione peroxidase and thioredoxin reductase are selenocysteine-dependent enzymes that protect against oxidative injury. This study examined the effects of dietary selenium on the activity of...
Venardos, Kylie, Ashton, Kevin John, Harrison, Glenn, Headrick, John Patrick, Perkins, Anthony Vincent
Effects of aging and ischemia on adenosine receptor transcription in mouse myocardium (2003)
Ashton, Kevin John, Nilsson, Ulrika, Willems, Laura, Holmgren, Kirsty, Headrick, John Patrick
Effects of A1 adenosine receptor overexpression on normoxic and post-ischemic gene expression (2003)
Ashton, Kevin John, Holmgren, Kirsty, Peart, Jason Nigel John, Lankford, Amy R., Matherne, G. Paul, Grimmond, Sean, ...
Objectives: To identify potential molecular genetic determinants of cardiovascular ischemic tolerance in wild-type and transgenic hearts overexpressing A1 adenosine receptors (A1ARs). Methods: cDNA...
Pyruvate-dependent preconditioning and cardioprotection in murine myocardium (2003)
Zatta, Amanda Jane, Hack, Benjamin Daniel Noel, Headrick, John Patrick
1. Whether pyruvate inhibits or can actually initiate myocardial preconditioning is unclear and whether pyruvate provides protection via its action as a 'cosubstrate' with glucose or via alternative...
Receptor and non-receptor-dependent mechanisms of cardioprotection with adenosine (2003)
Peart, Jason Nigel John, Willems, Laura, Headrick, John Patrick
Adenosine Receptor Subtypes Mediating Coronary Vasodilation in Rat Hearts (2003)
Hinschen, Andrea, Rose'Meyer, Roselyn, Headrick, John Patrick
Headrick, John Patrick, Willems, Laura, Ashton, Kevin John, Holmgren, Kirsty, Peart, Jason Nigel John, Matherne, G. Paul
The genesis of the ischaemia intolerant phenotype in aged myocardium is poorly understood. We tested the hypothesis that impaired adenosine-mediated protection contributes to ischaemic intolerance,...
Peart, Jason Nigel John, Headrick, John Patrick
Objective: ±1-Adrenergic receptors (ARs) are known mediators of a positive inotropy in the heart, which may play even more important roles in heart disease. Due to a lack of sufficiently selective...
Aging-related changes in myocardial purine metabolism and ischemic tolerance (2003)
Willems, Laura, Garnham, Bronwyn Gaye, Headrick, John Patrick
Impaired tolerance to ischemia-reperfusion in older hearts may stem in part from alterations in purine catabolism, impacting on maintenance of energy state and protective signaling via extracellular...
Enhanced adenosine A2B mediated coronary response in reserpinised rat heart. (2003)
Rose'Meyer, Roselyn, Harrison, Glenn, Headrick, John Patrick
Adenosine mediated cardioprotection in ischemic reperfused mouse heart. (2002)
Peart, Jason Nigel John, Zatta, Amanda Jane, Linden, Joel, Matherne, G. Paul, Headrick, John Patrick
Cerniway, Racheel J., Morrison, Ray R., Byford, Anne M., Lankford, Amy R., Headrick, John Patrick, ...
Zatta, Amanda Jane, Willems, Laura, Headrick, John Patrick
Objectives: To assess the impact of ischemia-reperfusion (I/R) on coronary function, and the role of endogenous adenosine in modifying post-ischemic vascular function in asanguinous hearts. Methods:...
Lankford, Amy R., Byford, Anne M., Ashton, Kevin John, French, Brett A., Lee, J.K., Headrick, John Patrick, ...
Harden, Fiona Anne, Brown, Lindsay, Quinn, Ronald J, Harrison, Glenn, Headrick, John Patrick, Rose'Meyer, Roselyn, ...
Harrison, Glenn, Cerniway, Rachael J, Peart, Jason Nigel John, Berr, Stuart S, Ashton, Kevin John, Regan, Sara, ...
Objectives: To characterize effects of A3 adenosine receptor (A3AR) activation and gene knock-out on responses to ischemia-reperfusion in mouse heart. Methods: Perfused hearts from wild-type and A3AR...
Age-related changes in adenosine-mediated dilation of coronary and aortic smooth muscle (2001)
Hinschen, Andrea, Rose'Meyer, Roselyn, Headrick, John Patrick
Cardioprotection with adenosine metabolism inhibitors in ischemic-reperfused mouse heart (2001)
Peart, Jason Nigel John, Matherne, Paul, Cerniway, Rachel, Headrick, John Patrick
Objectives: To characterize the anti-ischemic' effects of adenosine metabolism inhibition in ischemic reperfused myocardium. Methods: Perfused C57/B16 mouse hearts were subjected to 20 min ischemia...
Headrick, John Patrick, Peart, Jason Nigel John, Hack, Benjamin Daniel Noel, Garnham, Bronwyn Gaye, Matherne, G Paul
We examined myocardial 52-adenosine monophosphate (52-AMP) catabolism, adenosine salvage and adenosine responses in perfused guinea pig, rat and mouse heart. MV2 increased from 71±8 ¼l O2/min per g...
Headrick, John Patrick, Peart, Jason Nigel John, Hack, Benjamin Daniel Noel, Zatta, Amanda Jane, Matherne, G Paul
Rose'Meyer, Roselyn, Headrick, John Patrick, Peart, Jason Nigel John, Harrison, Glenn, Garnham, Bronwyn Gaye, Willis, Roger
1. The effect of acute (50 ¼mol/L) and chronic (0.06% in drinking water for 14 days) caffeine on the response to ischaemia reperfusion was studied in Wistar rat isolated perfused hearts. 2. Neither...
Age-related changes in A1 adenosine receptor mediated bradycardia (2000)
Hinschen, Andrea, Rose'Meyer, Roselyn, Headrick, John Patrick
Transgenic overexpression of cardiac A1 adenosine receptors mimics ischemic preconditioning (2000)
Peart, Jason Nigel John, Headrick, John Patrick, Morrison, RR, Jones, R, Byford, AM, Stell, AR.
Headrick, John Patrick, Gauthier, NS, Morrison, RR, Matherne, GP
1. Chronotropic and vasodilatory effects of adenosine receptor activation with 2-chloroadenosine (2-ClAdo) and ²-adrenoceptor activation with isoproterenol were studied in wild-type murine hearts...