Daly, Christopher, Wong, Vivian, Burova, Elena, Wei, Yi, Zabski, Stephanie, Griffiths, Jennifer, ...
Despite genetic evidence establishing angiopoietin-1 (Ang-1) as an essential regulator of vascular development, the molecular mechanisms underlying Ang-1 function are almost completely...
VEGF-Trap: A VEGF blocker with potent antitumor effects
Holash, Jocelyn, Davis, Sam, Papadopoulos, Nick, Croll, Susan D., Ho, Lillian, Russell, Michelle, ...
Vascular endothelial growth factor (VEGF) plays a critical role during normal embryonic angiogenesis and also in the pathological angiogenesis that occurs in a number of diseases, including cancer....
Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma
Kim, Eugene S., Serur, Anna, Huang, Jianzhong, Manley, Christina A., McCrudden, Kimberly W., Frischer, Jason S., ...
Vascular endothelial growth factor (VEGF) plays a key role in human tumor angiogenesis. We compared the effects of inhibitors of VEGF with different specificities in a xenograft model of...
Huang, Jianzhong, Frischer, Jason S., Serur, Anna, Kadenhe, Angela, Yokoi, Akiko, McCrudden, Kimberly W., ...
Vascular endothelial growth factor (VEGF) is a critical promoter of blood vessel growth during embryonic development and tumorigenesis. To date, studies of VEGF antagonists have primarily focused on...
Daly, Christopher, Wong, Vivian, Burova, Elena, Wei, Yi, Zabski, Stephanie, Griffiths, Jennifer, ...
Despite genetic evidence establishing angiopoietin-1 (Ang-1) as an essential regulator of vascular development, the molecular mechanisms underlying Ang-1 function are almost completely...
VEGF-Trap: A VEGF blocker with potent antitumor effects
Holash, Jocelyn, Davis, Sam, Papadopoulos, Nick, Croll, Susan D., Ho, Lillian, Russell, Michelle, ...
Vascular endothelial growth factor (VEGF) plays a critical role during normal embryonic angiogenesis and also in the pathological angiogenesis that occurs in a number of diseases, including cancer....
Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma
Kim, Eugene S., Serur, Anna, Huang, Jianzhong, Manley, Christina A., McCrudden, Kimberly W., Frischer, Jason S., ...
Vascular endothelial growth factor (VEGF) plays a key role in human tumor angiogenesis. We compared the effects of inhibitors of VEGF with different specificities in a xenograft model of...
Huang, Jianzhong, Frischer, Jason S., Serur, Anna, Kadenhe, Angela, Yokoi, Akiko, McCrudden, Kimberly W., ...
Vascular endothelial growth factor (VEGF) is a critical promoter of blood vessel growth during embryonic development and tumorigenesis. To date, studies of VEGF antagonists have primarily focused on...
Daly, Christopher, Wong, Vivian, Burova, Elena, Wei, Yi, Zabski, Stephanie, Griffiths, Jennifer, ...
Despite genetic evidence establishing angiopoietin-1 (Ang-1) as an essential regulator of vascular development, the molecular mechanisms underlying Ang-1 function are almost completely...
Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells
Daly, Christopher, Pasnikowski, Elizabeth, Burova, Elena, Wong, Vivian, Aldrich, Thomas H., Griffiths, Jennifer, ...
Angiopoietin (Ang)-2, a context-dependent agonist/antagonist for the vascular-specific Tie2 receptor, is highly expressed by endothelial cells at sites of normal and pathologic angiogenesis. One...
Rudge, John S., Holash, Jocelyn, Hylton, Donna, Russell, Michelle, Jiang, Shelly, Leidich, Raymond, ...
VEGF is the best characterized mediator of tumor angiogenesis. Anti-VEGF agents have recently demonstrated impressive efficacy in human cancer trials, but the optimal dosing of such agents must still...