Attomole Detection of in Vivo Protein Targets (2008)
Of Benzene In, Katherine E. Williams, Tonya A. Carver, Jj L. Mir, Antti Kautiainen, John S. Vogel, ...
This paper is available on line at http://www.mcponline.org Accelerator mass spectrometry (AMS) provides an extremely sensitive method for the detection of low level modifications of proteins (30)....
Evaluation Of Microdosing Strategies For Studies In Preclinical Drug (2008)
Development Demonstration Of, Punam S, John S. Vogel, Mark J. Rose, Esther A. Ubick, Janice E. Brunner, ...
The technique of accelerator mass spectrometry (AMS) was validated successfully and used to study the pharmacokinetics and disposition in dogs of a preclinical drug candidate (7-deaza-2-Cmethyl...
Dose-response studies of MeIQx in rat liver and liver DNA at low doses (1995)
Frantz, Christopher E., Bangerter, Christy, Fultz, Ester, Mayer, Kathryn M., Vogel, John S., Turteltaub, Kenneth W.
2-Amino-3,8-dimethylimidazo [4,5-f]quinoxaline (MeIQx) is a heterocyclic amine mutagen found in cooked meats and is carcinogenic in mice and rats at high doses (mg/kg body wt). Humans, however,...
Isotope-labeled immunoassays without radiation waste
Shan, Guomin, Huang, Wei, Gee, Shirley J., Buchholz, Bruce A., Vogel, John S., Hammock, Bruce D.
The practice of immunoassay has experienced a widespread transition from radioisotopic labeling to nonisotopic labeling over the last two decades. Radioisotope labels have drawbacks that hamper their...
Attomole level protein sequencing by Edman degradation coupled with accelerator mass spectrometry
Miyashita, Masahiro, Presley, Jack M., Buchholz, Bruce A., Lam, Kit S., Lee, Young Moo, Vogel, John S., ...
Edman degradation remains the primary method for determining the sequence of proteins. In this study, accelerator mass spectrometry was used to determine the N-terminal sequence of glutathione...
Protein binding of isofluorophate in vivo after coexposure to multiple chemicals.
Vogel, John S, Keating, Garrett A, Buchholz, Bruce A
Full toxicologic profiles of chemical mixtures, including dose-response extrapolations to realistic exposures, is a prohibitive analytical problem, even for a restricted class of chemicals. We...
Isotope-labeled immunoassays without radiation waste
Shan, Guomin, Huang, Wei, Gee, Shirley J., Buchholz, Bruce A., Vogel, John S., Hammock, Bruce D.
The practice of immunoassay has experienced a widespread transition from radioisotopic labeling to nonisotopic labeling over the last two decades. Radioisotope labels have drawbacks that hamper their...
Attomole level protein sequencing by Edman degradation coupled with accelerator mass spectrometry
Miyashita, Masahiro, Presley, Jack M., Buchholz, Bruce A., Lam, Kit S., Lee, Young Moo, Vogel, John S., ...
Edman degradation remains the primary method for determining the sequence of proteins. In this study, accelerator mass spectrometry was used to determine the N-terminal sequence of glutathione...
Protein binding of isofluorophate in vivo after coexposure to multiple chemicals.
Vogel, John S, Keating, Garrett A, Buchholz, Bruce A
Full toxicologic profiles of chemical mixtures, including dose-response extrapolations to realistic exposures, is a prohibitive analytical problem, even for a restricted class of chemicals. We...