John Yates

Scrapping over data: are the data scrapers' days numbered? (2009)

Jennings, Frank, Yates, John

Legal context ‘Data scraping’, the automated extraction of website content and its subsequent reuse of on third party websites, recently made the headlines when the UK airlines, Ryanair and...

Experimental philosophy and the MBI (2008)

Yates, Dr. John

Various facets of the MBI are discussed, and how it can be used in connection with experimental philosophy, experimental psychology and neuroscience. Brief historical references are given. The large...

Category theory applied to a radically new but logically essential description of time and space (2008)

Yates, Dr. John

McTaggart's ideas on the unreality of time as expressed in "The Nature of Existence" have retained great interest for many years for scholars, academics and other philosophers. In this essay, there...

The maintenance of human CD4+CD25+ regulatory T cell function: IL-2, IL-4, IL-7 and IL-15 preserve optimal suppressive potency in vitro (2007)

Yates, John, Rovis, Flavia, Mitchell, Peter, Afzali, Behdad, Tsang, JY-S, Garin, Marina, ...

CD4+CD25+ regulatory T cells (Tregs) have far-reaching immunotherapeutic applications, the realization of which will require a greater understanding of the factors influencing their function and...

Cytoskeletal Components of an Invasion Machine—The Apical Complex of Toxoplasma gondii (2006)

Ke Hu, Jeff Johnson, Laurence Florens, Martin Fraunholz, Sapna Suravajjala, Camille DiLullo, ...

The apical complex of Toxoplasma gondii is widely believed to serve essential functions in both invasion of its host cells (including human cells), and in replication of the parasite. The...

Dynamics of the peroxisomal import cycle of PpPex20p: ubiquitin-dependent localization and regulation (2006)

Léon, Sébastien, Zhang, Lan, McDonald, W Hayes, Yates, John, Cregg, James M, Subramani, Suresh

We characterize the peroxin PpPex20p from Pichia pastoris and show its requirement for translocation of PTS2 cargoes into peroxisomes. PpPex20p docks at the peroxisomal membrane and translocates into...

TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae (2004)

Reinke, Aaron, Anderson, Scott, McCaffery, J Michael, Yates, John, Aronova, Sofia, Chu, Stephanie, ...

The Tor1p and Tor2p kinases, targets of the therapeutically important antibiotic rapamycin, function as components of two distinct protein complexes in yeast, termed TOR complex 1 (TORC1) and TORC2....

CFD Simulations of Gas Fluidized Beds Using Alternative Eulerian-Eulerian Modelling Approaches (2002)

Lettieri, Paola, Cammarata, Luca, Micale, Giorgio D. M., Yates, John

A commercially available Computational Fluid-Dynamics code, CFX-4, has been chosen to carry out computer simulations of gas fluidized beds. In this study, the Eulerian-Eulerian granular kinetic...

CFD Simulations of Gas Fluidized Beds Using Alternative Eulerian-Eulerian Modelling Approaches (2002)

Lettieri, Paola, Cammarata, Luca, Micale, Giorgio D. M., Yates, John

A commercially available Computational Fluid-Dynamics code, CFX-4, has been chosen to carry out computer simulations of gas fluidized beds. In this study, the Eulerian-Eulerian granular kinetic...

CFD Simulations of Gas Fluidized Beds Using Alternative Eulerian-Eulerian Modelling Approaches (2002)

Lettieri, Paola, Cammarata, Luca, Micale, Giorgio D. M., Yates, John

A commercially available Computational Fluid-Dynamics code, CFX-4, has been chosen to carry out computer simulations of gas fluidized beds. In this study, the Eulerian-Eulerian granular kinetic...

CFD Simulations of Gas Fluidized Beds Using Alternative Eulerian-Eulerian Modelling Approaches (2002)

Lettieri, Paola, Cammarata, Luca, Micale, Giorgio D. M., Yates, John

A commercially available Computational Fluid-Dynamics code, CFX-4, has been chosen to carry out computer simulations of gas fluidized beds. In this study, the Eulerian-Eulerian granular kinetic...

Proteasomal Proteomics: Identification of Nucleotide-sensitive Proteasome-interacting Proteins by Mass Spectrometric Analysis of Affinity-purified Proteasomes (2000)

Verma, Rati, Chen, Stephen, Feldman, Renny, Schieltz, David, Yates, John, Dohmen, Juergen, ...

Ubiquitin-dependent proteolysis is catalyzed by the 26S proteasome, a dynamic complex of 32 different proteins whose mode of assembly and mechanism of action are poorly understood, in part due to the...

CYCLOPS SYSTEMS RESEARCH. (1998)

Marill,Thomas, Yates,John, Turner,Elisabeth

The Cyclops research project is aimed at developing computer-based systems that perform various processes on pictorial information, including enhancement and recognition. The work described in the...

FX!32: A profile-directed binary translator (1998)

Anton Chernoff, Mark Herdeg, Ray Hookway, Chris Reeve, Norman Rubin, Tony Tye, ...

A new innovation from Digital allows most x86 Windows applications to run on Alpha platforms with good performance.

A YAC contig in Xp21 containing the adrenal hypoplasia congenita and glycerol kinase deficiency genes (1992)

Walker, Ann P., Chelly, Jamel, Love, Donald R., Brush, Yumiko Ishikawa, Récan, Dominique, Chaussain, Jean-Louis, ...

The gene loci for adrenal hypoplasia congenita (AHC) and glycerol kinase deficiency (GK) map in Xp21 distal to Duchenne muscular dystrophy (DMD), and proximal to DXS28 (C7), by analysis of patient...

Onchocerca volvulus heat shock protein 70 is a major immunogen in amicrofilaremic individuals from a filariasis-endemic area (1989)

Rothstein, Neil M., Higashi, Gene, Yates, John, Rajan, Thiruchandurai V.

Infestation with organisms causing lymphatic filariasis (i.e. Wuchereria bancrofti and Brugia malayi) results in a variety of clinical presentations. It is possible that some of the variation is due...

Proteasomal Proteomics: Identification of Nucleotide-sensitive Proteasome-interacting Proteins by Mass Spectrometric Analysis of Affinity-purified Proteasomes

Verma, Rati, Chen, Stephen, Feldman, Renny, Schieltz, David, Yates, John, Dohmen, Juergen, ...

Ubiquitin-dependent proteolysis is catalyzed by the 26S proteasome, a dynamic complex of 32 different proteins whose mode of assembly and mechanism of action are poorly understood, in part due to the...

Active recycling of yeast Golgi mannosyltransferase complexes through the endoplasmic reticulum

Todorow, Zlatko, Spang, Anne, Carmack, Edwin, Yates, John, Schekman, Randy

Mnn9p is a component of two distinct multiprotein complexes in the Saccharomyces cerevisiae cis-Golgi that have both been shown to have α-1,6-mannosyltransferase activity in vitro. In one of these...

Cell Cycle-dependent Assembly of a Gin4-Septin Complex

Mortensen, Eric M., McDonald, Hayes, Yates, John, Kellogg, Douglas R.

Gin4, a Nim1-related kinase, is required in budding yeast for localization of the septins and for proper control of daughter cell growth during G2/M. Gin4 becomes hyperphosphorylated when cells enter...

Tor Kinases Are in Distinct Membrane-associated Protein Complexes in Saccharomyces cerevisiae

Wedaman, Karen P., Reinke, Aaron, Anderson, Scott, Yates, John, McCaffery, J. Michael, Powers, Ted

Tor1p and Tor2p kinases, targets of the immune-suppressive antibiotic rapamycin, are components of a highly conserved signaling network that couples nutrient availability and cell growth. To gain...

Was Rodney Ledward a statistical outlier? Retrospective analysis using routine hospital data to identify gynaecologists' performance

Harley, Mike, Mohammed, Mohammed A, Hussain, Shakir, Yates, John, Almasri, Abdullah

Objectives To investigate whether routinely collected data from hospital episode statistics could be used to identify the gynaecologist Rodney Ledward, who was suspended in 1966 and was the subject...

Cytoskeletal Components of an Invasion Machine—The Apical Complex of Toxoplasma gondii

Hu, Ke, Johnson, Jeff, Florens, Laurence, Fraunholz, Martin, Suravajjala, Sapna, DiLullo, Camille, ...

The apical complex of Toxoplasma gondii is widely believed to serve essential functions in both invasion of its host cells (including human cells), and in replication of the parasite. The...

Metalloendoprotease cleavage triggers gelsolin amyloidogenesis

Page, Lesley J, Suk, Ji Young, Huff, Mary E, Lim, Hee-Jong, Venable, John, Yates, John, ...

Amyloid diseases like Alzheimer's disease and familial amyloidosis of Finnish type (FAF) stem from endoproteolytic cleavage of a precursor protein to generate amyloidogenic peptides that accumulate...

Proteasomal Proteomics: Identification of Nucleotide-sensitive Proteasome-interacting Proteins by Mass Spectrometric Analysis of Affinity-purified Proteasomes

Verma, Rati, Chen, Stephen, Feldman, Renny, Schieltz, David, Yates, John, Dohmen, Juergen, ...

Ubiquitin-dependent proteolysis is catalyzed by the 26S proteasome, a dynamic complex of 32 different proteins whose mode of assembly and mechanism of action are poorly understood, in part due to the...

Active recycling of yeast Golgi mannosyltransferase complexes through the endoplasmic reticulum

Todorow, Zlatko, Spang, Anne, Carmack, Edwin, Yates, John, Schekman, Randy

Mnn9p is a component of two distinct multiprotein complexes in the Saccharomyces cerevisiae cis-Golgi that have both been shown to have α-1,6-mannosyltransferase activity in vitro. In one of these...

Cell Cycle-dependent Assembly of a Gin4-Septin Complex

Mortensen, Eric M., McDonald, Hayes, Yates, John, Kellogg, Douglas R.

Gin4, a Nim1-related kinase, is required in budding yeast for localization of the septins and for proper control of daughter cell growth during G2/M. Gin4 becomes hyperphosphorylated when cells enter...

Tor Kinases Are in Distinct Membrane-associated Protein Complexes in Saccharomyces cerevisiae

Wedaman, Karen P., Reinke, Aaron, Anderson, Scott, Yates, John, McCaffery, J. Michael, Powers, Ted

Tor1p and Tor2p kinases, targets of the immune-suppressive antibiotic rapamycin, are components of a highly conserved signaling network that couples nutrient availability and cell growth. To gain...

Was Rodney Ledward a statistical outlier? Retrospective analysis using routine hospital data to identify gynaecologists' performance

Harley, Mike, Mohammed, Mohammed A, Hussain, Shakir, Yates, John, Almasri, Abdullah

Objectives To investigate whether routinely collected data from hospital episode statistics could be used to identify the gynaecologist Rodney Ledward, who was suspended in 1966 and was the subject...

Metalloendoprotease cleavage triggers gelsolin amyloidogenesis

Page, Lesley J, Suk, Ji Young, Huff, Mary E, Lim, Hee-Jong, Venable, John, Yates, John, ...

Amyloid diseases like Alzheimer's disease and familial amyloidosis of Finnish type (FAF) stem from endoproteolytic cleavage of a precursor protein to generate amyloidogenic peptides that accumulate...

Cytoskeletal Components of an Invasion Machine—The Apical Complex of Toxoplasma gondii

Hu, Ke, Johnson, Jeff, Florens, Laurence, Fraunholz, Martin, Suravajjala, Sapna, DiLullo, Camille, ...

The apical complex of Toxoplasma gondii is widely believed to serve essential functions in both invasion of its host cells (including human cells), and in replication of the parasite. The...

Saccharomyces cerevisiae Ime2 phosphorylates Sic1 at multiple PXS/T sites but is insufficient to trigger Sic1 degradation

Sedgwick, Chantelle, Rawluk, Matthew, Decesare, James, Raithatha, Sheetal, Wohlschlegel, James, Semchuk, Paul, ...

The initiation of DNA replication in Saccharomyces cerevisiae depends upon the destruction of the Clb–Cdc28 inhibitor Sic1. In proliferating cells Cln–Cdc28 complexes phosphorylate Sic1, which...

An Animal Model for Human EBV-Associated Hemophagocytic Syndrome : Herpesvirus Papio Frequently Induces Fatal Lymphoproliferative Disorders with Hemophagocytic Syndrome in Rabbits

Hayashi, Kazuhiko, Ohara, Nobuya, Teramoto, Norihiro, Onoda, Sachiyo, Chen, Hong-Li, Oka, Takashi, ...

Epstein-Barr virus-associated hemophagocytic syndrome (EBV-AHS) is often associated with fatal infectious mononucleosis. However, the animal model for EBV-AHS has not been developed. We reported the...

Probing the Membrane Environment of the TOR Kinases Reveals Functional Interactions between TORC1, Actin, and Membrane Trafficking in Saccharomyces cerevisiae

Aronova, Sofia, Wedaman, Karen, Anderson, Scott, Yates, John, Powers, Ted

The TOR kinases are regulators of growth in eukaryotic cells that assemble into two distinct protein complexes, TORC1 and TORC2, where TORC1 is inhibited by the antibiotic rapamycin. Present models...

Dynamics of the peroxisomal import cycle of PpPex20p: ubiquitin-dependent localization and regulation

Léon, Sébastien, Zhang, Lan, McDonald, W. Hayes, Yates, John, Cregg, James M., Subramani, Suresh

We characterize the peroxin PpPex20p from Pichia pastoris and show its requirement for translocation of PTS2 cargoes into peroxisomes. PpPex20p docks at the peroxisomal membrane and translocates into...

The Role of GRASP55 in Golgi Fragmentation and Entry of Cells into Mitosis

Duran, Juan Manuel, Kinseth, Matt, Bossard, Carine, Rose, David W., Polishchuk, Roman, Wu, Christine C., ...

GRASP55 is a Golgi-associated protein, but its function at the Golgi remains unclear. Addition of full-length GRASP55, GRASP55-specific peptides, or an anti-GRASP55 antibody inhibited Golgi...

Large-Scale Differential Proteome Analysis in Plasmodium falciparum under Drug Treatment

Prieto, Judith Helena, Koncarevic, Sasa, Park, Sung Kyu, Yates, John, Becker, Katja

Proteome studies contribute markedly to our understanding of parasite biology, host-parasite interactions, and mechanisms of drug action. For most antimalarial drugs neither mode of action nor...

Effect of Pioglitazone on Cardiovascular Outcome in Diabetes and Chronic Kidney Disease

Schneider, Christian A., Ferrannini, Ele, DeFronzo, Ralph, Schernthaner, Guntram, Yates, John, Erdmann, Erland

Patients with diabetes and chronic kidney disease (CKD) are at particularly high risk for cardiovascular disease (CVD). This post hoc analysis from the PROspective pioglitAzone Clinical Trial In...

Molecular Architecture of the Centriole Proteome: The Conserved WD40 Domain Protein POC1 Is Required for Centriole Duplication and Length Control

Keller, Lani C., Geimer, Stefan, Romijn, Edwin, Yates, John, Zamora, Ivan, Marshall, Wallace F.

Centrioles are intriguing cylindrical organelles composed of triplet microtubules. Proteomic data suggest that a large number of proteins besides tubulin are necessary for the formation and...

Polar hydrocarbon technologies: future developments

Yates, John, Cunningham, Paul, Smith, Denis

This paper addresses the physical and technological difficulties inherent in the extraction of marine hydrocarbons in the polar regions. The factors are then analysed to assess the potential for the...