Jonathan A. Meulbroek

Reversal of oncogene transformation and suppression of tumor growth by the novel IGF1R kinase inhibitor A-928605 (2009)

Pappano, William N, Jung, Paul M, Meulbroek, Jonathan A, Wang, Yi-Chun, Hubbard, Robert D, Zhang, Qian, ...

Abstract Background The insulin-like growth factor (IGF) axis is an important signaling pathway in the growth and survival of many cell and tissue types. This pathway has also been implicated in many...

Polyphosphoinositides suppress the adhesion of Haemophilus influenzaeto pharyngeal cells (2004)

Liu, Jim-Wen R, Anderson, Steve N, Meulbroek, Jonathan A, Hwang, Shie-Ming, Mukerji, Pradip, Huang, Yung-Sheng

Abstract Background One of the primary causes of otitis media (OM), an inflammation of the middle ear, is the bacterium Haemophilus influenzae (HI). OM often occurs to young children, and is mostly...

Correlation of tumor growth suppression and methionine aminopetidase-2 activity blockade using an orally active inhibitor

Wang, Jieyi, Tucker, Lora A., Stavropoulos, Jason, Zhang, Qian, Wang, Yi-Chun, Bukofzer, Gail, ...

This laboratory and others have shown that agents that inhibit the in vitro catalytic activity of methionine aminopeptidase-2 (MetAP2) are effective in blocking angiogenesis and tumor growth in...