William Valdar, Jonathan Flint, Richard Mott
It has been suggested that the collaborative cross, a large set of recombinant inbred strains derived from eight inbred mouse strains, would be a powerful resource for the dissection of complex...
High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissues (2009)
Huang, Guo-Jen, Shifman, Sagiv, Valdar, William, Johannesson, Martina, Yalcin, Binnaz, Taylor, Martin S., ...
A proportion of the genetic variants underlying complex phenotypes do so through their effects on gene expression, so an important challenge in complex trait analysis is to discover the genetic basis...
Johannesson, Martina, Lopez-Aumatell, Regina, Stridh, Pernilla, Diez, Margarita, Tuncel, Jonatan, Blázquez, Gloria, ...
The laboratory rat (Rattus norvegicus) is a key tool for the study of medicine and pharmacology for human health. A large database of phenotypes for integrated fields such as cardiovascular,...
William Valdar, Leah C. Solberg, Dominique Gauguier, William O. Cookson, Nicholas P. Rawlins, Richard Mott, ...
The interaction between genotype and environment is recognized as an important source of experimental variation when complex traits are measured in the mouse, but the magnitude of that interaction...
Martin Taylor, William Valdar, Ashish Kumar, Jonathan Flint, Richard Mott
Motivation: Advances in high-throughput genotyping have made it possible to carry out genome-wide association studies using very high densities of genetic markers. This has led to the problem of the...
Heterozygosity increases microsatellite mutation rate, linking it to demographic history (2008)
Amos, William, Flint, Jonathan, Xu, Xin
Abstract Background Biochemical experiments in yeast suggest a possible mechanism that would cause heterozygous sites to mutate faster than equivalent homozygous sites. If such a process operates, it...
Tom Price, Regina Regan, Richard Mott, Nicki Ventress, Lee Smith, Andy Greenfield, ...
by array comparative genome hybridization.
Marcus R. Munafò, Jonathan Flint
Meta-analysis, a statistical tool for combining results across studies, is becoming popular as a method for resolving discrepancies in genetic association studies. Persistent difficulties in...
Identifying the genetic determinants of emotionality in humans; insights from rodents
rearrangements associated with (2008)
Jonathan Flint, Samantha Knight
The use of telomere probes to investigate submicroscopic
The idea that some phenotypes bear a closer relationship to the biological processes that give rise to psychiatric illness than diagnostic categories has attracted considerable interest. Much effort...
A High-Resolution Single Nucleotide Polymorphism Genetic Map of the Mouse Genome (2008)
Sagiv Shifman, Jordana Tzenova Bell, Richard R. Copley, Martin S. Taylor, Robert W. Williams, Richard Mott, ...
High-resolution genetic maps are required for mapping complex traits and for the study of recombination. We report the highest density genetic map yet created for any organism, except humans. Using...
Sagiv Shifman, Martina Johannesson, Michal Bronstein, Sam X. Chen, David A. Collier, Nicholas J. Craddock, ...
Sex differences in schizophrenia are well known, but their genetic basis has not been identified. We performed a genome-wide association scan for schizophrenia in an Ashkenazi Jewish population using...
Neuregulin 1 Genotype and Schizophrenia (2008)
Munafò, Marcus R., Attwood, Angela S., Flint, Jonathan
The neuregulin 1 (NRG1) gene has been the subject of considerable excitement within the psychiatric genetics literature since it was originally identified as a potential susceptibility locus for...
Animal models of anxiety and their molecular dissection (2007)
Genetic approaches to psychiatric illness need appropriate animal models both for investigating how genetic variants give rise to behavioural disorder and for identifying genes that may be important...
Genetic e¡ects on an animal model of anxiety (2007)
Abstract Genetic e¡ects on behavioural measures thought to model anxiety have been reported on 15 mouse chromosomes. In general the individual e¡ect from each locus is small, contributing to 10%or...
Original Contributions Fine scale mapping of a genetic locus for conditioned fear (2007)
Christopher J. Talbot, Richard A. Radcliffe, Jan Fullerton, Robert Hitzemann, Jeanne M. Wehner, Jonathan Flint
Fear conditioning is one of a number of models for investigating the genetic basis of individual variation in emotion and learning. Genetic mapping using crosses between strains of laboratory mice...
Genetic Mapping of Variation in Spatial Learning in the Mouse (2007)
Daniela Steinberger, David S. Reynolds, Pushpindar Ferris, Rachael Lincoln, Susmita Datta, Joanna Stanley, ...
Inbred strains of mice are known to differ in their performance in the Morris water maze task, a test of spatial discrimination and place navigation in rodents, but the genetic basis of individual...
INVITED REVIEW The genetic basis of cognition (2007)
The molecular characterization of single-gene disorders or chromosomal abnormalities that restfit in a cognitive abnormality (predominantly mental retardation) and of the genetic variants responsible...
Specific behavioral patterns associated with chromosomal and genetic disorders are being recognized more frequently. The hope is that the demonstration of a behavioral phenotype with a particular...
Psychiatric genetics: A frightful chromosome (2007)
inherited in a non-Mendelian fashion, has been found to be strongly associated with phobic disorders. This unusual genetic mechanism may partly explain the heritability of phobias and other complex...
Raúl Aguilar, Luis Gil, Jonathan Flint, Jeffrey A. Gray, Gerard R. Dawson, Peter Driscoll, ...
Learned fear, emotional reactivity and fear of heights: A factor analytic map from a large F 2 intercross of
Jonathan Flint, Cristina Tufarelli, Rachael J. Daniels, Ross Hardison, Webb Miller, Sjaak Philipsen, ...
genome analysis delimits a chromosomal domain and identifies key regulatory elements in the globin cluster
Maria Grazia Turri, Christopher J. Talbot, Richard A. Radcliffe, Jeanne M. Wehner, Jonathan Flint
High-resolution mapping of quantitative trait loci for emotionality in selected strains of mice
An Optimized Set of Human Telomere Clones for Studying Telomere Integrity and Architecture (2007)
Christa M. Lese, Kathrin S. Precht, Julie Kuc, Yi Ning, Sarah Lucas, ...
Telomere-specific clones are a valuable resource for the characterization of chromosomal rearrangements. We previously reported a first-generation set of human telomere probes consisting of 34...
Gray has drawn upon genetic evidence to argue for the existence of rodent emotionality, a model of human neuroticism. With the advent of molecular mapping techniques it has become possible to test...
Maria Grazia Turri, John C. Defries, Norman D. Henderson, Jonathan Flint
The number and mode of action of quantitative trait loci (QTL) that contribute to behavioral variation in rodents is still largely unknown. On theoretical grounds, multivariate techniques are...
Keays, David A, Francis, Fiona, Saillour, Yoann, Bahi, Nadia, Manouvrier, Sylvie, ...
We have recently reported a missense mutation in exon 4 of the tubulin alpha 1A (Tuba1a) gene in a hyperactive N-ethyl-N-nitrosourea (ENU) induced mouse mutant with abnormal lamination of the...
Management, presentation and interpretation of genome scans using GSCANDB (2007)
Taylor, Martin, Valdar, William, Kumar, Ashish, Flint, Jonathan, Mott, Richard
Motivation: Advances in high-throughput genotyping have made it possible to carry out genome-wide association studies using very high densities of genetic markers. This has led to the problem of the...
Evidence of a Large-Scale Functional Organization of Mammalian Chromosomes: Authors' Reply (2007)
Sagiv Shifman, Jordana Tzenova Bell, Richard R. Copley, Martin S. Taylor, Richard Mott, Jonathan Flint, ...
A High-Resolution Single Nucleotide Polymorphism Genetic Map of the Mouse Genome (2006)
Sagiv Shifman, Jordana Tzenova Bell, Richard R. Copley, Martin S. Taylor, Robert W. Williams, Richard Mott, ...
High-resolution genetic maps are required for mapping complex traits and for the study of recombination. We report the highest density genetic map yet created for any organism, except humans. Using...
So You Want Your Child to Be a Genius? (2006)
Geneticist Jonathan Flint reviews David Plotz's book The Genius Factory: The Curious History of the Nobel Prize Sperm Bank.
Leah C. Solberg, William Valdar, Dominique Gauguier, Graciela Nunez, Amy Taylor, Stephanie Burnett, ...
in mice
William Valdar, Leah C. Solberg, Dominique Gauguier, William O. Cookson, J. Nicholas, P. Rawlins, ...
The interaction between genotype and environment is recognized as an important source of experimental variation when complex traits are measured in the mouse, but the magnitude of that interaction...
Price, Thomas S., Regan, Regina, Mott, Richard, Hedman, Åsa, Honey, Ben, Daniels, Rachael J., ...
Comparative genome hybridization (CGH) to DNA microarrays (array CGH) is a technique capable of detecting deletions and duplications in genomes at high resolution. However, array CGH studies of the...
Plenum Publishing Corporation 267 (2004)
Behavior Genetics Vol, Norman D. Henderson, Maria Grazia Turri, John C. Defries, Jonathan Flint
this report we explore the consequences of the combination and choice of phenotypes for genetic mapping. In accompanying papers we investigate multivariate approaches to genetic mapping and the...
Little epistasis for anxiety-related measures in the DeFries (2004)
Strains Of Laboratory, Jonathan Flint, John C. Defries, Norman D. Henderson
Recent advances in methodologies for testing epistatic interactions, combined with several successes in demonstrating genetic interaction effects in animal and human genetics, have rekindled interest...
The nature and identification of quantitative trait loci: a community’s view (2003)
Rosemann, Michael, Pomp, Daniel, Peirce, Jeremy L., Palmer, Abraham A., Paigen, Beverly, Osadchuk, Alexander V., ...
This white paper by eighty members of the Complex Trait Consortium presents a community’s view on the approaches and statistical analyses that are needed for the identification of genetic loci that...
Analysis of quantitative trait loci that influence animal behavior (2003)
ABSTRACT: Behavioral differences between inbred strains of mice and rats have a genetic basis that can now be dissected using quantitative trait locus (QTL) analysis. Over the last 10 years, a large...
Jan Fullerton, Matthew Cubin, Hemant Tiwari, Chenxi Wang, Amarjit Bomhra, Stuart Davidson, ...
Several theoretical studies have suggested that large samples of randomly ascertained siblings can be used to ascertain phenotypically extreme individuals and thereby increase power to detect genetic...
quantitative trait locus influencing anxiety in the laboratory rat. Genome Res 2002;12:618–26 (2002)
Alberto Fernández-teruel, Rosa M. Escorihuela, Jeffrey A. Gray, Raúl Aguilar, Luis Gil, Lydia Giménez-llort, ...
A critical test for a gene that influences susceptibility to fear in animals is that it should have a consistent pattern of effects across a broad range of conditioned and unconditioned models of...
A Quantitative Trait Locus Influencing Anxiety in the Laboratory Rat (2002)
Fernández-Teruel, Alberto, Escorihuela, Rosa M., Gray, Jeffrey A., Aguilar, Raúl, Gil, Luis, Giménez-Llort, Lydia, ...
Daniels, Rachael J., Peden, John F., Lloyd, Christine, Horsley, Sharon W., Clark, Kevin, Tufarelli, Cristina, ...
We have sequenced 1949 kb from the terminal Giemsa light band of human chromosome 16p, enabling us to fully annotate the region extending from the telomeric repeats to the previously published...
Flint, Jonathan, Tufarelli, Cristina, Peden, John, Clark, Kevin, Daniels, Rachael J., Hardison, Ross, ...
We have cloned, sequenced and annotated segments of DNA spanning the mouse, chicken and pufferfish α globin gene clusters and compared them with the corresponding region in man. This has defined a...
The genetic basis of cognition (1999)
The molecular characterization of single-gene disorders or chromosomal abnormalities that result in a cognitive abnormality (predominantly mental retardation) and of the genetic variants responsible...
Characterization of Short Tandem Repeats from Thirty-One Human Telomeres (1997)
Rosenberg, Marjorie, Hui, Lester, Ma, Junli, Nusbaum, Harris C., Clark, Kevin, Robinson, Louise, ...
The genetics of mental retardation (1996)
Flint, Jonathan, Wilkie, Andrew O M
We review the advances that have been achieved using molecular genetic techniques to characterise the genetic basis of mental retardation in recognised syndromes and in discovering new genetic...
A method for fine mapping quantitative trait loci in outbred animal stocks
Mott, Richard, Talbot, Christopher J., Turri, Maria G., Collins, Allan C., Flint, Jonathan
High-resolution mapping of quantitative trait loci (QTL) in animals has proved to be difficult because the large effect sizes detected in crosses between inbred strains are often caused by numerous...
A Quantitative Trait Locus Influencing Anxiety in the Laboratory Rat
Fernández-Teruel, Alberto, Escorihuela, Rosa M., Gray, Jeffrey A., Aguilar, Raúl, Gil, Luis, Giménez-Llort, Lydia, ...
A critical test for a gene that influences susceptibility to fear in animals is that it should have a consistent pattern of effects across a broad range of conditioned and unconditioned models of...
Characterization of Short Tandem Repeats from Thirty-One Human Telomeres
Rosenberg, Marjorie, Hui, Lester, Ma, Junli, Nusbaum, Harris C., Clark, Kevin, Robinson, Louise, ...
Completion of genetic and physical maps requires markers from the ends (telomeres) of every human chromosome. We have searched for short tandem repeats (microsatellites) in cosmid and P1 clones and...
An Optimized Set of Human Telomere Clones for Studying Telomere Integrity and Architecture
Knight, Samantha J. L., Lese, Christa M., Precht, Kathrin S., Kuc, Julie, Ning, Yi, Lucas, Sarah, ...
Telomere-specific clones are a valuable resource for the characterization of chromosomal rearrangements. We previously reported a first-generation set of human telomere probes consisting of 34...
Price, Thomas S., Regan, Regina, Mott, Richard, Hedman, Åsa, Honey, Ben, Daniels, Rachael J., ...
Comparative genome hybridization (CGH) to DNA microarrays (array CGH) is a technique capable of detecting deletions and duplications in genomes at high resolution. However, array CGH studies of the...
So You Want Your Child to Be a Genius?
Geneticist Jonathan Flint reviews David Plotz's book The Genius Factory: The Curious History of the Nobel Prize Sperm Bank.
Valdar, William, Flint, Jonathan, Mott, Richard
It has been suggested that the collaborative cross, a large set of recombinant inbred strains derived from eight inbred mouse strains, would be a powerful resource for the dissection of complex...
Mott, Richard, Flint, Jonathan
We describe a method to simultaneously detect and fine map quantitative trait loci (QTL) that is especially suited to the mapping of modifier loci in mouse mutant models. The method exploits the high...
A method for fine mapping quantitative trait loci in outbred animal stocks
Mott, Richard, Talbot, Christopher J., Turri, Maria G., Collins, Allan C., Flint, Jonathan
High-resolution mapping of quantitative trait loci (QTL) in animals has proved to be difficult because the large effect sizes detected in crosses between inbred strains are often caused by numerous...
A Quantitative Trait Locus Influencing Anxiety in the Laboratory Rat
Fernández-Teruel, Alberto, Escorihuela, Rosa M., Gray, Jeffrey A., Aguilar, Raúl, Gil, Luis, Giménez-Llort, Lydia, ...
A critical test for a gene that influences susceptibility to fear in animals is that it should have a consistent pattern of effects across a broad range of conditioned and unconditioned models of...
Characterization of Short Tandem Repeats from Thirty-One Human Telomeres
Rosenberg, Marjorie, Hui, Lester, Ma, Junli, Nusbaum, Harris C., Clark, Kevin, Robinson, Louise, ...
Completion of genetic and physical maps requires markers from the ends (telomeres) of every human chromosome. We have searched for short tandem repeats (microsatellites) in cosmid and P1 clones and...
Price, Thomas S., Regan, Regina, Mott, Richard, Hedman, Åsa, Honey, Ben, Daniels, Rachael J., ...
Comparative genome hybridization (CGH) to DNA microarrays (array CGH) is a technique capable of detecting deletions and duplications in genomes at high resolution. However, array CGH studies of the...
Fullerton, Jan, Cubin, Matthew, Tiwari, Hemant, Wang, Chenxi, Bomhra, Amarjit, Davidson, Stuart, ...
Several theoretical studies have suggested that large samples of randomly ascertained siblings can be used to ascertain phenotypically extreme individuals and thereby increase power to detect genetic...
An Optimized Set of Human Telomere Clones for Studying Telomere Integrity and Architecture
Knight, Samantha J. L., Lese, Christa M., Precht, Kathrin S., Kuc, Julie, Ning, Yi, Lucas, Sarah, ...
Telomere-specific clones are a valuable resource for the characterization of chromosomal rearrangements. We previously reported a first-generation set of human telomere probes consisting of 34...
Valdar, William, Flint, Jonathan, Mott, Richard
It has been suggested that the collaborative cross, a large set of recombinant inbred strains derived from eight inbred mouse strains, would be a powerful resource for the dissection of complex...
So You Want Your Child to Be a Genius?
Geneticist Jonathan Flint reviews David Plotz's book The Genius Factory: The Curious History of the Nobel Prize Sperm Bank.
Mott, Richard, Flint, Jonathan
We describe a method to simultaneously detect and fine map quantitative trait loci (QTL) that is especially suited to the mapping of modifier loci in mouse mutant models. The method exploits the high...
Genetic and Environmental Effects on Complex Traits in Mice
Valdar, William, Solberg, Leah C., Gauguier, Dominique, Cookson, William O., Rawlins, J. Nicholas P., Mott, Richard, ...
The interaction between genotype and environment is recognized as an important source of experimental variation when complex traits are measured in the mouse, but the magnitude of that interaction...
A High-Resolution Single Nucleotide Polymorphism Genetic Map of the Mouse Genome
Shifman, Sagiv, Bell, Jordana Tzenova, Copley, Richard R, Taylor, Martin S, Williams, Robert W, Mott, Richard, ...
High-resolution genetic maps are required for mapping complex traits and for the study of recombination. We report the highest density genetic map yet created for any organism, except humans. Using...
Evidence of a Large-Scale Functional Organization of Mammalian Chromosomes: Authors' Reply
Shifman, Sagiv, Bell, Jordana Tzenova, Copley, Richard R, Taylor, Martin S, Mott, Richard, Flint, Jonathan, ...
Mutations in α-Tubulin Cause Abnormal Neuronal Migration in Mice and Lissencephaly in Humans
Keays, David A., Tian, Guoling, Poirier, Karine, Huang, Guo-Jen, Siebold, Christian, Cleak, James, ...
The development of the mammalian brain is dependent on extensive neuronal migration. Mutations in mice and humans that affect neuronal migration result in abnormal lamination of brain structures with...
Shifman, Sagiv, Johannesson, Martina, Bronstein, Michal, Chen, Sam X, Collier, David A, Craddock, Nicholas J, ...
Sex differences in schizophrenia are well known, but their genetic basis has not been identified. We performed a genome-wide association scan for schizophrenia in an Ashkenazi Jewish population using...
Neuregulin 1 Genotype and Schizophrenia
Munafò, Marcus R., Attwood, Angela S., Flint, Jonathan
The neuregulin 1 (NRG1) gene has been the subject of considerable excitement within the psychiatric genetics literature since it was originally identified as a potential susceptibility locus for...
Johannesson, Martina, Lopez-Aumatell, Regina, Stridh, Pernilla, Diez, Margarita, Tuncel, Jonatan, Blázquez, Gloria, ...
The laboratory rat (Rattus norvegicus) is a key tool for the study of medicine and pharmacology for human health. A large database of phenotypes for integrated fields such as cardiovascular,...
Mapping in Structured Populations by Resample Model Averaging
Valdar, William, Holmes, Christopher C., Mott, Richard, Flint, Jonathan
Highly recombinant populations derived from inbred lines, such as advanced intercross lines and heterogeneous stocks, can be used to map loci far more accurately than is possible with standard...
A New Standard Genetic Map for the Laboratory Mouse
Cox, Allison, Ackert-Bicknell, Cheryl L., Dumont, Beth L., Ding, Yueming, Bell, Jordana Tzenova, Brockmann, Gudrun A., ...
Genetic maps provide a means to estimate the probability of the co-inheritance of linked loci as they are transmitted across generations in both experimental and natural populations. However, in the...