Maternal Licorice Consumption and Detrimental Cognitive and Psychiatric Outcomes in Children (2009)
Räikkönen, Katri, Pesonen, Anu-Katriina, Heinonen, Kati, Lahti, Jari, Komsi, Niina, Eriksson, Johan G., ...
Overexposure to glucocorticoids may link prenatal adversity with detrimental outcomes in later life. Glycyrrhiza, a natural constituent of licorice, inhibits placental 11-beta-hydroxysteroid...
Association between umbilical cord glucocorticoids and blood pressure at age 3 years (2008)
Huh, Susanna Y, Andrew, Ruth, Rich-Edwards, Janet W, Kleinman, Ken P, Seckl, Jonathan R, Gillman, Matthew W
Abstract Background Animal data show that decreased activity of placental 11-beta-hydroxysteroid dehydrogenase type 2 (11β-HSD2), which potently inactivates glucocorticoids (e.g. cortisol) to inert...
Peripheral Mechanisms Contributing to the Glucocorticoid Hypersensitivity in (2007)
Michailidou, Zoi, Coll, Anthony P, Kenyon, Christopher J, Morton, Nicholas M, O'Rahilly, Stephen, Seckl, Jonathan R, ...
Proopiomelanocortin (POMC) deficiency causes severe obesity through hyperphagia of hypothalamic origin. However, low glucocorticoid levels caused by adrenal insufficiency mitigate against insulin...
Mineralocorticoid receptor expression and increased survival following neuronal injury. (2003)
Macleod, Malcolm R, Johansson, Inga-Maj, Söderström, Ingegerd, Lai, Maggie, Gidö, Gunilla, Wieloch, Tadeusz, ...
Abstract is not available
Magnetic resonance spectroscopy and cognitive function in healthy elderly men (2002)
Ferguson, Karen J., MacLullich, Alasdair M. J., Marshall, Ian, Deary, Ian J., Starr, John M., Seckl, Jonathan R., ...
Subtle cognitive decrements in older people are important in terms of the associated morbidity and as a risk factor for dementia. However, their pathophysiological basis is poorly understood. Proton...
Coughlan, Christine M., Seckl, Jonathan R., Fox, David J., Unsworth, Robin, Breen, Kieran C.
In this study we have examined the effects of corticosteroids on both the total sialyltransferase (sialyl-T) activity and on two individual isozymes in neural, hepatic, and renal tissues using an in...
NEUROHYPOPHYSEAL PEPTIDE FUNCTION DURING EARLY POSTOPERATIVE DIABETES INSIPIDUS (1987)
SECKL, JONATHAN R., DUNGER, DAVID B., LIGHTMAN, STAFFORD L.
Neurohypophyseal function has been investigated in 11 children undergoing pituitary or suprasellar surgery. All had corticosteroid and thyroxine replacement; 9 developed diabetes insipidus (DI)...
Kotelevtsev, Yuri, Holmes, Megan C., Burchell, Ann, Houston, Pamela M., Schmoll, Dieter, Jamieson, Pauline, ...
Glucocorticoid hormones, acting via nuclear receptors, regulate many metabolic processes, including hepatic gluconeogenesis. It recently has been recognized that intracellular glucocorticoid...
Yau, Joyce L. W., Noble, June, Kenyon, Christopher J., Hibberd, Carina, Kotelevtsev, Yuri, Mullins, John J., ...
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) intracellularly regenerates active corticosterone from circulating inert 11-dehydrocorticosterone (11-DHC) in specific tissues. The hippocampus...
Masuzaki, Hiroaki, Yamamoto, Hiroshi, Kenyon, Christopher J., Elmquist, Joel K., Morton, Nicholas M., Paterson, Janice M., ...
Obesity is closely associated with the metabolic syndrome, a combination of disorders including insulin resistance, diabetes, dyslipidemia, and hypertension. A role for local glucocorticoid...
Sandeep, Thekkepat C., Yau, Joyce L. W., MacLullich, Alasdair M. J., Noble, June, Deary, Ian J., Walker, Brian R., ...
In aging humans and rodents, inter-individual differences in cognitive function have been ascribed to variations in long-term glucocorticoid exposure. 11β-Hydroxysteroid dehydrogenase type 1...
Paterson, Janice M., Morton, Nicholas M., Fievet, Catherine, Kenyon, Christopher J., Holmes, Megan C., Staels, Bart, ...
In obese humans and rodents there is increased expression of the key glucocorticoid (GC) regenerating enzyme, 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), in adipose tissue. This increased...
Hypertension in mice lacking 11β-hydroxysteroid dehydrogenase type 2
Kotelevtsev, Yuri, Brown, Roger W., Fleming, Stewart, Kenyon, Christopher, Edwards, Christopher R.W., Seckl, Jonathan R., ...
Deficiency of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) in humans leads to the syndrome of apparent mineralocorticoid excess (SAME), in which cortisol illicitly occupies mineralocorticoid...
Glucocorticoids suppress beta-cell development and induce hepatic metaplasia in embryonic pancreas.
Shen, Chia-Ning, Seckl, Jonathan R, Slack, Jonathan M W, Tosh, David
Elevated glucocorticoids are associated with low birth weight and fetal 'programming' of hypertension and glucose intolerance. In the present paper, we show that treatment of fetal rats with...
Glucocorticoids and the ageing hippocampus
HIBBERD, CARINA, YAU, JOYCE L. W., SECKL, JONATHAN R.
Approximately 30% of human and mammalian populations develop cognitive impairments with ageing. Many of these impairments have been linked to dysfunction of the hippocampus, a well studied area of...
Kotelevtsev, Yuri, Holmes, Megan C., Burchell, Ann, Houston, Pamela M., Schmoll, Dieter, Jamieson, Pauline, ...
Glucocorticoid hormones, acting via nuclear receptors, regulate many metabolic processes, including hepatic gluconeogenesis. It recently has been recognized that intracellular glucocorticoid...
Yau, Joyce L. W., Noble, June, Kenyon, Christopher J., Hibberd, Carina, Kotelevtsev, Yuri, Mullins, John J., ...
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) intracellularly regenerates active corticosterone from circulating inert 11-dehydrocorticosterone (11-DHC) in specific tissues. The hippocampus...
Masuzaki, Hiroaki, Yamamoto, Hiroshi, Kenyon, Christopher J., Elmquist, Joel K., Morton, Nicholas M., Paterson, Janice M., ...
Obesity is closely associated with the metabolic syndrome, a combination of disorders including insulin resistance, diabetes, dyslipidemia, and hypertension. A role for local glucocorticoid...
Sandeep, Thekkepat C., Yau, Joyce L. W., MacLullich, Alasdair M. J., Noble, June, Deary, Ian J., Walker, Brian R., ...
In aging humans and rodents, inter-individual differences in cognitive function have been ascribed to variations in long-term glucocorticoid exposure. 11β-Hydroxysteroid dehydrogenase type 1...
Paterson, Janice M., Morton, Nicholas M., Fievet, Catherine, Kenyon, Christopher J., Holmes, Megan C., Staels, Bart, ...
In obese humans and rodents there is increased expression of the key glucocorticoid (GC) regenerating enzyme, 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), in adipose tissue. This increased...
Hypertension in mice lacking 11β-hydroxysteroid dehydrogenase type 2
Kotelevtsev, Yuri, Brown, Roger W., Fleming, Stewart, Kenyon, Christopher, Edwards, Christopher R.W., Seckl, Jonathan R., ...
Deficiency of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) in humans leads to the syndrome of apparent mineralocorticoid excess (SAME), in which cortisol illicitly occupies mineralocorticoid...
Glucocorticoids suppress beta-cell development and induce hepatic metaplasia in embryonic pancreas.
Shen, Chia-Ning, Seckl, Jonathan R, Slack, Jonathan M W, Tosh, David
Elevated glucocorticoids are associated with low birth weight and fetal 'programming' of hypertension and glucose intolerance. In the present paper, we show that treatment of fetal rats with...
Glucocorticoids and the ageing hippocampus
HIBBERD, CARINA, YAU, JOYCE L. W., SECKL, JONATHAN R.
Approximately 30% of human and mammalian populations develop cognitive impairments with ageing. Many of these impairments have been linked to dysfunction of the hippocampus, a well studied area of...
De Vries, Annick, Holmes, Megan C., Heijnis, Areke, Seier, Jürgen V., Heerden, Joritha, Louw, Johan, ...
Prenatal stress or glucocorticoid administration has persisting “programming” effects on offspring in rodents and other model species. Multiple doses of glucocorticoids are in widespread use in...
Changes in protein expression in the rat medial vestibular nuclei during vestibular compensation
Paterson, Janet M, Short, Duncan, Flatman, Peter W, Seckl, Jonathan R, Aitken, Alastair, Dutia, Mayank B
The molecular mechanisms of neural and synaptic plasticity in the vestibular nuclei during ‘vestibular compensation’, the behavioural recovery that follows deafferentation of one inner ear, are...
Michailidou, Zoi, Coll, Anthony P, Kenyon, Christopher J, Morton, Nicholas M, O'Rahilly, Stephen, Seckl, Jonathan R, ...
Proopiomelanocortin (POMC) deficiency causes severe obesity through hyperphagia of hypothalamic origin. However, low glucocorticoid levels caused by adrenal insufficiency mitigate against insulin...
Ye, Ping, Kenyon, Christopher J, MacKenzie, Scott M, Nichol, Katherine, Seckl, Jonathan R, Fraser, Robert, ...
Using a highly sensitive quantitative RT-PCR method for the measurement of CYP11B1 (11β-hydroxylase) and CYP11B2 (aldosterone synthase) mRNAs, we previously demonstrated that CYP11B2 expression in...
Prenatal dexamethasone ‘programmes’ hypotension, but stress-induced hypertension in adult offspring
O'Regan, David, Kenyon, Christopher J, Seckl, Jonathan R, Holmes, Megan C
Low birth weight in humans is predictive of hypertension in adult life. Although the mechanisms underlying this link remain unknown, fetal overexposure to glucocorticoids has been implicated. We...
Johnston, Alex R, Seckl, Jonathan R, Dutia, Mayank B
We investigated the role of the cerebellar flocculus in mediating the adaptive changes that occur in the intrinsic properties of brainstem medial vestibular nucleus (MVN) neurons during vestibular...
Association between umbilical cord glucocorticoids and blood pressure at age 3 years
Huh, Susanna Y, Andrew, Ruth, Rich-Edwards, Janet W, Kleinman, Ken P, Seckl, Jonathan R, Gillman, Matthew W
A Switch in the Mechanism of Hypertension in the Syndrome of Apparent Mineralocorticoid Excess
Bailey, Matthew A., Paterson, Janice M., Hadoke, Patrick W.F., Wrobel, Nicola, Bellamy, Christopher O.C., Brownstein, David G., ...
The syndrome of apparent mineralocorticoid excess arises from nonfunctional mutations in 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2), an enzyme that inactivates cortisol and confers...
Prenatal Stress, Glucocorticoids and the Programming of Adult Disease
Cottrell, Elizabeth C., Seckl, Jonathan R.
Numerous clinical studies associate an adverse prenatal environment with the development of cardio-metabolic disorders and neuroendocrine dysfunction, as well as an increased risk of psychiatric...