2D NMR Metabonomic Analysis: A Novel Method for Automated Peak Alignment (2008)
Ming Zheng, Peng Lu, Yanzhou Liu, Joseph Pease, Jonathan Usuka, Guochun Liao, ...
Motivation: Comparative metabolic profiling by nuclear magnetic resonance (NMR) is showing increasing promise for identifying interindividual differences to drug response. Two dimensional (2D) 1 H-...
2D NMR metabonomic analysis: a novel method for automated peak alignment (2007)
Zheng, Ming, Lu, Peng, Liu, Yanzhou, Pease, Joseph, Usuka, Jonathan, Liao, Guochun, ...
Motivation: Comparative metabolic profiling by nuclear magnetic resonance (NMR) is showing increasing promise for identifying inter-individual differences to drug response. Two dimensional (2D) 1H...
Optimal spliced alignment of homologous cDNA to a genomic DNA template (2000)
Usuka, Jonathan, Zhu, Wei, Brendel, Volker
*To whom correspondence should be addressed. Motivation: Supplementary cDNA or EST evidence is often decisive for discriminating between alternative gene predictions derived from computational...
Pharmacogenomics and Drug Development
Guo, Yingying, Shafer, Steven, Weller, Paul, Usuka, Jonathan, Peltz, Gary
It is generally anticipated that pharmacogenomic information will have a large impact on drug development and will facilitate individualized drug treatment. However, there has been relatively little...
In silico and in vitro pharmacogenetic analysis in mice
Guo, Yingying, Lu, Peng, Farrell, Erin, Zhang, Xun, Weller, Paul, Monshouwer, Mario, ...
Combining the experimental efficiency of a murine hepatic in vitro drug biotransformation system with in silico genetic analysis produces a model system that can rapidly analyze interindividual...
Plasminogen Alleles Influence Susceptibility to Invasive Aspergillosis
Zaas, Aimee K., Liao, Guochun, Chien, Jason W., Weinberg, Clarice, Shore, David, Giles, Steven S., ...
Invasive aspergillosis (IA) is a common and life-threatening infection in immunocompromised individuals. A number of environmental and epidemiologic risk factors for developing IA have been...
Understanding Our Drugs and Our Diseases
Guo, Yingying, Weller, Paul, Allard, John, Usuka, Jonathan, Masjedizadeh, Mohammad, Wu, Shao-Yong, ...
Analysis of mouse genetic models of human disease–associated traits has provided important insight into the pathogenesis of human disease. As one example, analysis of a murine genetic model of...