Joost J. Neijssen

Puromycin-sensitive aminopeptidase limits MHC class I presentation in dendritic cells but does not affect CD8 T cell responses during viral infections (2008)

Towne, Charles Fenton, York, Ian A., Neijssen, Joost J., Karow, Margaret L., Murphy, Andrew J., Valenzuela, David M., ...

Previous experiments using enzyme inhibitors, cell lysates, and purified enzyme have suggested that puromycin-sensitive aminopeptidase (PSA) plays a role in creating and destroying MHC class...

Leucine aminopeptidase is not essential for trimming peptides in the cytosol or generating epitopes for MHC class I antigen presentation (2005)

Towne, Charles Fenton, York, Ian A., Neijssen, Joost J., Karow, Margaret L., Murphy, Andrew J., Valenzuela, David M., ...

To detect viral infections and tumors, CD8+ T lymphocytes monitor cells for the presence of antigenic peptides bound to MHC class I molecules. The majority of MHC class I-presented peptides are...