Quantitative Analysis of the Voltage-dependent Gating of Mouse Parotid ClC-2 Chloride Channel
De Santiago, Jose Antonio, Nehrke, Keith, Arreola, Jorge
Various ClC-type voltage-gated chloride channel isoforms display a double barrel topology, and their gating mechanisms are thought to be similar. However, we demonstrate in this work that the nearly...
Giovannucci, David R, Bruce, Jason I. E, Straub, Stephen V, Arreola, Jorge, Sneyd, James, Shuttleworth, Trevor J, ...
The dynamics of Ca2+ release and Ca2+-activated Cl− currents in two related, but functionally distinct exocrine cells, were studied to gain insight into how the molecular specialization of Ca2+...
Arreola, Jorge, Begenisich, Ted, Melvin, James E
We have investigated the gating properties of the inward rectifier chloride channel (Clir) from mouse parotid acinar cells by external protons (Ho+) using the whole-cell patch-clamp technique....
Arreola, Jorge, Begenisich, Ted, Nehrke, Keith, Nguyen, Ha-Van, Park, Keerang, Richardson, Linda, ...
Salivary gland acinar cells shrink when Cl− currents are activated following cell swelling induced by exposure to a hypotonic solution or in response to calcium-mobilizing agonists. The molecular...
Nonindependent K+ Movement through the Pore in IRK1 Potassium Channels
Stampe, Per, Arreola, Jorge, Pérez-Cornejo, Patricia, Begenisich, Ted
We measured unidirectional K+ in- and efflux through an inward rectifier K channel (IRK1) expressed in Xenopus oocytes. The ratio of these unidirectional fluxes differed significantly from...
A novel chloride conductance activated by extracellular ATP in mouse parotid acinar cells
Arreola, Jorge, Melvin, James E
Salivary gland fluid secretion is driven by transepithelial Cl− movement involving an apical Cl− channel whose molecular identity remains unknown. Extracellular ATP (ATPo) has been shown to...
Kaba, Nubia K., Schultz, Joanne, Law, Foon-Yee, Lefort, Craig T., Martel-Gallegos, Guadalupe, Kim, Minsoo, ...
Ischemia-reperfusion injury is a common pathological occurrence causing tissue damage in heart attack and stroke. Entrapment of neutrophils in the vasculature during ischemic events has been...