Jason M. Johnson, Elizabeth M. Meiering, Joel E. Wright, Jorge Pardo, Andre Rosowsky, Gerhard Wagner
: The antitumor compound PT523 [N R -(4-amino-4-deoxypteroyl)-N # -hemiphthaloyl-L-ornithine] was found to have an inhibition constant (K i ) of 0.35 ( 0.10 pM against human dihydrofolate reductase...
Systematic identification of regulatory proteins critical for T-cell activation (2003)
Chu, Peter, Pardo, Jorge, Zhao, Haoran, Li, Connie C, Pali, Erlina, Shen, Mary M, ...
Abstract Background The activation of T cells, mediated by the T-cell receptor (TCR), activates a battery of specific membrane-associated, cytosolic and nuclear proteins. Identifying the signaling...
Systematic identification of regulatory proteins critical for T-cell activation
Chu, Peter, Pardo, Jorge, Zhao, Haoran, Li, Connie C, Pali, Erlina, Shen, Mary M, ...
Systematic identification of regulatory proteins critical for T-cell activation
Chu, Peter, Pardo, Jorge, Zhao, Haoran, Li, Connie C, Pali, Erlina, Shen, Mary M, ...
Holland, Sacha J., Liao, X. Charlene, Mendenhall, Marcy K., Zhou, Xiulan, Pardo, Jorge, Chu, Peter, ...
In an effort to identify novel therapeutic targets for autoimmunity and transplant rejection, we developed and performed a large-scale retroviral-based functional screen to select for proteins that...