Mortensen, Stefan P, Dawson, Ellen A, Yoshiga, Chie C, Dalsgaard, Mads K, Damsgaard, Rasmus, Secher, Niels H, ...
Reductions in systemic and locomotor limb muscle blood flow and O2 delivery limit aerobic capacity in humans. To examine whether O2 delivery limits both aerobic power and capacity, we first measured...
Rosenmeier, Jaya B, Hansen, Jim, González-Alonso, José
Despite increases in muscle sympathetic vasoconstrictor activity, skeletal muscle blood flow and O2 delivery increase during exercise in humans in proportion to the local metabolic demand, a...
Brain and central haemodynamics and oxygenation during maximal exercise in humans
González-Alonso, José, Dalsgaard, Mads K, Osada, Takuya, Volianitis, Stefanos, Dawson, Ellen A, Yoshiga, Chie C, ...
During maximal exercise in humans, fatigue is preceded by reductions in systemic and skeletal muscle blood flow, O2 delivery and uptake. Here, we examined whether the uptake of O2 and substrates by...
Mortensen, Stefan P, Dawson, Ellen A, Yoshiga, Chie C, Dalsgaard, Mads K, Damsgaard, Rasmus, Secher, Niels H, ...
Reductions in systemic and locomotor limb muscle blood flow and O2 delivery limit aerobic capacity in humans. To examine whether O2 delivery limits both aerobic power and capacity, we first measured...
Rosenmeier, Jaya B, Hansen, Jim, González-Alonso, José
Despite increases in muscle sympathetic vasoconstrictor activity, skeletal muscle blood flow and O2 delivery increase during exercise in humans in proportion to the local metabolic demand, a...
Brain and central haemodynamics and oxygenation during maximal exercise in humans
González-Alonso, José, Dalsgaard, Mads K, Osada, Takuya, Volianitis, Stefanos, Dawson, Ellen A, Yoshiga, Chie C, ...
During maximal exercise in humans, fatigue is preceded by reductions in systemic and skeletal muscle blood flow, O2 delivery and uptake. Here, we examined whether the uptake of O2 and substrates by...
González-Alonso, José, Mortensen, Stefan P, Dawson, Ellen A, Secher, Niels H, Damsgaard, Rasmus
Blood flow to dynamically contracting myocytes is regulated to match O2 delivery to metabolic demand. The red blood cell (RBC) itself functions as an O2 sensor, contributing to the control of O2...
Muscle blood flow is reduced with dehydration during prolonged exercise in humans
González-Alonso, José, Calbet, José A L, Nielsen, Bodil
The present study examined whether the blood flow to exercising muscles becomes reduced when cardiac output and systemic vascular conductance decline with dehydration during prolonged exercise in the...
Yegutkin, Gennady G, Samburski, Sergei S, Mortensen, Stefan P, Jalkanen, Sirpa, González-Alonso, José
Extracellular ATP and ADP trigger vasodilatatory and prothrombotic signalling events in the vasculature. Here, we tested the hypothesis that nucleotide turnover is activated in the bloodstream of...
González-Alonso, José, Calbet, José A L, Nielsen, Bodil
The present study examined whether reductions in muscle blood flow with exercise-induced dehydration would reduce substrate delivery and metabolite and heat removal to and from active skeletal...
Heat production in human skeletal muscle at the onset of intense dynamic exercise
González-Alonso, José, Quistorff, Bjørn, Krustrup, Peter, Bangsbo, Jens, Saltin, Bengt
We hypothesised that heat production of human skeletal muscle at a given high power output would gradually increase as heat liberation per mole of ATP produced rises when energy is derived from...
González-Alonso, José, Richardson, Russell S, Saltin, Bengt
We hypothesised that reducing arterial oxyhaemoglobin (O2Hba) with carbon monoxide (CO) in both normoxia and hyperoxia, or acute hypoxia would cause similar compensatory increases in human skeletal...
Krustrup, Peter, González-Alonso, José, Quistorff, Bjørn, Bangsbo, Jens
The aim of the present study was to examine muscle heat production, oxygen uptake and anaerobic energy turnover throughout repeated intense exercise to test the hypotheses that (i) energy turnover is...
Gibala, Martin J, González-Alonso, José, Saltin, Bengt
It has been suggested that a decrease in the total concentration of tricarboxylic acid cycle intermediates (TCAIs) - secondary to a reduction in glycogen availability - compromises oxidative energy...
Hanada, Akiko, Sander, Mikael, González-Alonso, José
Acute systemic hypoxia causes significant increases in human skeletal muscle sympathetic nerve activity (MSNA), heart rate and ventilation. This phenomenon is thought to be primarily mediated by...
Mortensen, Stefan P, González-Alonso, José, Damsgaard, Rasmus, Saltin, Bengt, Hellsten, Ylva
Prostaglandins, nitric oxide (NO) and endothelial-derived hyperpolarizing factors (EDHFs) are substances that have been proposed to be involved in the regulation of skeletal muscle blood flow during...
The cardiovascular challenge of exercising in the heat
González-Alonso, José, Crandall, Craig G, Johnson, John M
Exercise in the heat can pose a severe challenge to human cardiovascular control, and thus the provision of oxygen to exercising muscles and vital organs, because of enhanced thermoregulatory demand...
Mortensen, Stefan P, Damsgaard, Rasmus, Dawson, Ellen A, Secher, Niels H, González-Alonso, José
Perfusion to exercising skeletal muscle is regulated to match O2 delivery to the O2 demand, but this regulation might be compromised during or approaching maximal whole-body exercise as muscle blood...
González-Alonso, José, Mortensen, Stefan P, Jeppesen, Tina D, Ali, Leena, Barker, Horace, Damsgaard, Rasmus, ...
The muscle pump and muscle vasodilatory mechanims are thought to play important roles in increasing and maintaining muscle perfusion and cardiac output during exercise, but their actual contributions...
Rosenmeier, Jaya B, Yegutkin, Gennady G, González-Alonso, José
Sympathetic vasoconstriction is blunted in the vascular beds of contracting skeletal muscle in humans, presumably due to the action of vasoactive metabolites (functional sympatholysis). Recently, we...