Chromatin conformation signatures of cellular differentiation (2009)
Fraser, James, Rousseau, Mathieu, Shenker, Solomon, Ferraiuolo, Maria A, Hayashizaki, Yoshihide, Blanchette, Mathieu, ...
Abstract One of the major genomics challenges is to better understand how correct gene expression is orchestrated. Recent studies have shown how spatial chromatin organization is critical in the...
Dostie, Josée, Richmond, Todd A., Arnaout, Ramy A., Selzer, Rebecca R., Lee, William L., Honan, Tracey A., ...
Physical interactions between genetic elements located throughout the genome play important roles in gene regulation and can be identified with the Chromosome Conformation Capture (3C) methodology....
Dostie, Josée, Richmond, Todd A., Arnaout, Ramy A., Selzer, Rebecca R., Lee, William L., Honan, Tracey A., ...
Physical interactions between genetic elements located throughout the genome play important roles in gene regulation and can be identified with the Chromosome Conformation Capture (3C) methodology....
Gemins modulate the expression and activity of the SMN complex (2005)
Feng, Wenqin, Gubitz, Amelie K., Wan, Lili, Battle, Daniel J., Dostie, Josée, Golembe, Tracey J., ...
Reduction in the expression of the survival of motor neurons (SMN) protein results in spinal muscular atrophy (SMA), a common motor neuron degenerative disease. SMN is part of a large macromolecular...
Dostie, Josée, Ferraiuolo, Maria, Pause, Arnim, Adam, Stephen A., Sonenberg, Nahum
The eukaryotic translation initiation factor 4E (eIF4E) plays an important role in the control of cell growth. eIF4E binds to the mRNA 5′ cap structure m7GpppN (where N is any nucleotide), and...
miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs
Mourelatos, Zissimos, Dostie, Josée, Paushkin, Sergey, Sharma, Anup, Charroux, Bernard, Abel, Linda, ...
Gemin3 is a DEAD-box RNA helicase that binds to the Survival of Motor Neurons (SMN) protein and is a component of the SMN complex, which also comprises SMN, Gemin2, Gemin4, Gemin5, and Gemin6....
Suppression of cap-dependent translation in mitosis
Pyronnet, Stéphane, Dostie, Josée, Sonenberg, Nahum
Cap-dependent translation is mediated by eIF4F, a protein complex composed of three subunits as follows: eIF4E, which recognizes the mRNA 5′ cap structure; eIF4A, an RNA-helicase; and eIF4G, a...
miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs
Mourelatos, Zissimos, Dostie, Josée, Paushkin, Sergey, Sharma, Anup, Charroux, Bernard, Abel, Linda, ...
Gemin3 is a DEAD-box RNA helicase that binds to the Survival of Motor Neurons (SMN) protein and is a component of the SMN complex, which also comprises SMN, Gemin2, Gemin4, Gemin5, and Gemin6....
Dostie, Josée, Ferraiuolo, Maria, Pause, Arnim, Adam, Stephen A., Sonenberg, Nahum
The eukaryotic translation initiation factor 4E (eIF4E) plays an important role in the control of cell growth. eIF4E binds to the mRNA 5′ cap structure m7GpppN (where N is any nucleotide), and...
Suppression of cap-dependent translation in mitosis
Pyronnet, Stéphane, Dostie, Josée, Sonenberg, Nahum
Cap-dependent translation is mediated by eIF4F, a protein complex composed of three subunits as follows: eIF4E, which recognizes the mRNA 5′ cap structure; eIF4A, an RNA-helicase; and eIF4G, a...
Koritzinsky, Marianne, Magagnin, Michaël G, Van Den Beucken, Twan, Seigneuric, Renaud, Savelkouls, Kim, Dostie, Josée, ...
Hypoxia has recently been shown to activate the endoplasmic reticulum kinase PERK, leading to phosphorylation of eIF2α and inhibition of mRNA translation initiation. Using a quantitative assay, we...
Dostie, Josée, Richmond, Todd A., Arnaout, Ramy A., Selzer, Rebecca R., Lee, William L., Honan, Tracey A., ...
Physical interactions between genetic elements located throughout the genome play important roles in gene regulation and can be identified with the Chromosome Conformation Capture (3C) methodology....
Nuclear Eukaryotic Initiation Factor 4e (Eif4e) Colocalizes with Splicing Factors in Speckles
Dostie, Josée, Lejbkowicz, Flavio, Sonenberg, Nahum
The eukaryotic initiation factor 4E (eIF4E) plays a pivotal role in the control of protein synthesis. eIF4E binds to the mRNA 5′ cap structure, m7GpppN (where N is any nucleotide) and promotes...
Chromatin conformation signatures of cellular differentiation
Fraser, James, Rousseau, Mathieu, Shenker, Solomon, Ferraiuolo, Maria A, Hayashizaki, Yoshihide, Blanchette, Mathieu, ...
A suite of computer programs to identify genome-wide chromatin conformation signatures with 5C technology is reported.
D'haene, Barbara, Attanasio, Catia, Beysen, Diane, Dostie, Josée, Lemire, Edmond, Bouchard, Philippe, ...
To date, the contribution of disrupted potentially cis-regulatory conserved non-coding sequences (CNCs) to human disease is most likely underestimated, as no systematic screens for putative...