Jose Aramburu

Analysis of the transcriptional activity of endogenous NFAT5 in primary cells using transgenic NFAT-luciferase reporter mice (2008)

Morancho, Beatriz, Minguillón, Jordi, Molkentin, Jeffery D, López-Rodríguez, Cristina, Aramburu, Jose

Abstract Background The transcription factor NFAT5/TonEBP regulates the response of mammalian cells to hypertonicity. However, little is known about the physiopathologic tonicity thresholds that...

The Jak family tyrosine kinase Jak3 is required for IL-2 synthesis by naive/resting CD4+ T cells (1999)

Thomis, Daniel C., Aramburu, Jose, Berg, Leslie J.

The Jak family tyrosine kinase, Jak3, is involved in signaling through cytokine receptors using the common gamma-chain. Mice deficient in Jak3 have mature T cells, all of which have an...

Blockade of T-cell activation by dithiocarbamates involves novel mechanisms of inhibition of nuclear factor of activated T cells. (1997)

Martínez-Martínez, Sara, Gómez Del Arco, Pablo, Armesilla, Angel Luis, Aramburu, Jose, Luo, Chun, Rao, Anjana, ...

Dithiocarbamates (DTCs) have recently been reported as powerful inhibitors of NF-kappaB activation in a number of cell types. Given the role of this transcription factor in the regulation of gene...