Macaca Mulatta, Zhi-yan Han, Nicolas Le Noveáre, Michele Zoli, Joseph A. Hill, Nicolas Champtiaux, ...
We present here a systematic mapping of nAChR subunit mRNAs in Macaca mulatta brain. A fragment, from the transmembrane segments MIII to MIV of Macaca neuronal nAChR subunits was cloned, and shown to...
lmmunocytochemical Localization of a Neuronal Nicotinic Receptor: The (2008)
Joseph A. Hill, Michele Zoli, Jean-pierre Bourgeois, Jean-pierre Changeux
We have characterized in adult rat the tissue-specific ex-
Spanel-Borowski, Katharina, Smith, Mark A., Simone, Cristiano, Simonsen, Anne, Simon, Hans-Uwe, ...
Research in autophagy continues to accelerate, and as a result many new scientists are entering the field. Accordingly, it is important to establish a standard set of criteria for monitoring...
Montgomery, Rusty L., Davis, Christopher A., Potthoff, Matthew J., Haberland, Michael, Fielitz, Jens, Qi, Xiaoxia, ...
Histone deacetylases (HDACs) tighten chromatin structure and repress gene expression through the removal of acetyl groups from histone tails. The class I HDACs, HDAC1 and HDAC2, are expressed...
Vander Perre, Sarah, Hill, Joseph A
BACKGROUND: A key factor in the pathogenesis of endometriosis is the endometrial-peritoneal adhesion. To study the pathogenesis of endometriosis, a quantitative in vitro assay (QIVA) was developed to...
Debrock, Sophie, De Strooper, Bart, Perre, Sarah Vander, Hill, Joseph A., DHooghe, Thomas M
BACKGROUND: A key factor in the pathogenesis of endometriosis is the endometrial–peritoneal adhesion. To study the pathogenesis of endometriosis, a quantitative in vitro assay (QIVA) was developed...
Wang, Zhigang C., Hill, Joseph A., Yunis, Edmond J., Xiao, Ling, Anderson, Deborah J.
BACKGROUND: Women with recurrent pregnancy loss (RPL) and T-helper (Th)1-type immunity to trophoblast antigens have an increased frequency of the IL1B-511*1 promoter variant. Since CD46 gene products...
Wang, Zhigang C., Hill, Joseph A., Yunis, Edmond J., Xiao, Ling, Anderson, Deborah J.
BACKGROUND: Women with recurrent pregnancy loss (RPL) and T-helper (Th)1-type immunity to trophoblast antigens have an increased frequency of the IL1B-511*1 promoter variant. Since CD46 gene products...
Debrock, Sophie, De Strooper, Bart, Vander Perre, Sarah, Hill, Joseph A., D’Hooghe, Thomas M
BACKGROUND: A key factor in the pathogenesis of endometriosis is the endometrial-peritoneal adhesion. To study the pathogenesis of endometriosis, a quantitative in vitro assay (QIVA) was developed to...
Endometriosis and subfertility: is the relationship resolved? (2003)
Hill, Joseph A, Meuleman, Christel
There are many arguments to support the hypothesis that there is a causal relationship between the presence of endometriosis and subfertility. These arguments are reviewed in this article and...
Future directions in endometriosis research (2003)
Meuleman, Christel, Hill, Joseph A, Mwenda, Jason M
Future research in endometriosis must focus on pathogenesis studies in the baboon model, the early interactions between endometrial and peritoneal cells in the pelvic cavity at the time of...
Patel, Radhika N., Quack, Katharina C., Hill, Joseph A., Schust, Danny J.
Recurrent pregnancy loss (RPL) has many known aetiologies. However, using current diagnostic testing, a large fraction of recurrent pregnancy losses remain unexplained. Many of these may have immune...
Vander Perre, Sarah, Meuleman, Christel, Hill, Joseph A
BACKGROUND: Endometrium can adhere to autologous peritoneum. This study was undertaken to determine the effect of the menstrual cycle phase and the presence and stage of endometriosis on in-vitro...
Debrock, Sophie, Vander Perre, Sarah, Meuleman, Christel, Moerman, Philippe, Hill, Joseph A., D'Hooghe, Thomas M.
BACKGROUND: Endometrium can adhere to autologous peritoneum. This study was undertaken to determine the effect of the menstrual cycle phase and the presence and stage of endometriosis on in-vitro...
Quack, Katharina C., Vassiliadou, Neratzoula, Pudney, Jeffrey, Anderson, Deborah J., Hill, Joseph A.
As part of our continuing programme to investigate immunological causes of unexplained recurrent pregnancy losses, we studied subpopulations of white blood cells and their activation status in...
Best, Craig L., Pudney, Jeffrey, Welch, William R., Burger, Natalie, Hill, Joseph A.
The purpose of this investigation was to localize and characterize white blood cell populations in the human ovary through its physiological life cycle. Ovaries from 30 women of reproductive age and...
Michele Zoli, Nicolas Le Novkre, Joseph A. Hill, Jean-pierre Changeux
In the present study we have investigated the anatomical distribution pattern of nAChR (~3, 0~4, p2, and f34 subunit mRNAs during prenatal and perinatal development of the rat CNS and PNS. Three main...
Best, Craig L., Hill, Joseph A.
This study was designed to test the hypothesis that inter-leukin-1α (IL-1α) and β directly affect progesterone, and oestradiol production in cultures of purified human granulosa cells. Luteinized...
Pregnancy: Seminal white blood cells and recurrent abortion (1994)
Hill, Joseph A., Anderson, Deborah J., Polgar, Katalin, Abbott, Amy F., Politch, Joseph A.
The incidence of leukocytospermia (>1 million white blood cells/ml semen) and concentrations of white blood cell populations in semen from men whose partners experience unexplained recurrent...
Activated glycogen synthase-3β suppresses cardiac hypertrophy in vivo
Antos, Christopher L., McKinsey, Timothy A., Frey, Norbert, Kutschke, William, McAnally, John, Shelton, John M., ...
The adult myocardium responds to a variety of pathologic stimuli by hypertrophic growth that frequently progresses to heart failure. The calcium/calmodulin-dependent protein phosphatase calcineurin...
Chang, Shurong, McKinsey, Timothy A., Zhang, Chun Li, Richardson, James A., Hill, Joseph A., Olson, Eric N.
The adult heart responds to stress signals by hypertrophic growth, which is often accompanied by activation of a fetal cardiac gene program and eventual cardiac demise. We showed previously that...
Calcineurin Is Necessary for the Maintenance but Not Embryonic Development of Slow Muscle Fibers
Oh, Misook, Rybkin, Igor I., Copeland, Victoria, Czubryt, Michael P., Shelton, John M., Van Rooij, Eva, ...
Skeletal muscles are a mosaic of slow and fast twitch myofibers. During embryogenesis, patterns of fiber type composition are initiated that change postnatally to meet physiological demand. To...
TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling
Kuwahara, Koichiro, Wang, Yanggan, McAnally, John, Richardson, James A., Bassel-Duby, Rhonda, Hill, Joseph A., ...
The heart responds to injury and chronic pressure overload by pathologic growth and remodeling, which frequently result in heart failure and sudden death. Calcium-dependent signaling pathways promote...
Activated glycogen synthase-3β suppresses cardiac hypertrophy in vivo
Antos, Christopher L., McKinsey, Timothy A., Frey, Norbert, Kutschke, William, McAnally, John, Shelton, John M., ...
The adult myocardium responds to a variety of pathologic stimuli by hypertrophic growth that frequently progresses to heart failure. The calcium/calmodulin-dependent protein phosphatase calcineurin...
Chang, Shurong, McKinsey, Timothy A., Zhang, Chun Li, Richardson, James A., Hill, Joseph A., Olson, Eric N.
The adult heart responds to stress signals by hypertrophic growth, which is often accompanied by activation of a fetal cardiac gene program and eventual cardiac demise. We showed previously that...
Calcineurin Is Necessary for the Maintenance but Not Embryonic Development of Slow Muscle Fibers
Oh, Misook, Rybkin, Igor I., Copeland, Victoria, Czubryt, Michael P., Shelton, John M., Van Rooij, Eva, ...
Skeletal muscles are a mosaic of slow and fast twitch myofibers. During embryogenesis, patterns of fiber type composition are initiated that change postnatally to meet physiological demand. To...
TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling
Kuwahara, Koichiro, Wang, Yanggan, McAnally, John, Richardson, James A., Bassel-Duby, Rhonda, Hill, Joseph A., ...
The heart responds to injury and chronic pressure overload by pathologic growth and remodeling, which frequently result in heart failure and sudden death. Calcium-dependent signaling pathways promote...
Modulation of adverse cardiac remodeling by STARS, a mediator of MEF2 signaling and SRF activity
Kuwahara, Koichiro, Pipes, Gordon C. Teg, McAnally, John, Richardson, James A., Hill, Joseph A., Bassel-Duby, Rhonda, ...
Cytoskeletal proteins have been implicated in the pathogenesis of cardiomyopathy, but how the cytoskeleton influences the transcriptional alterations associated with adverse cardiac remodeling...
Cardiac autophagy is a maladaptive response to hemodynamic stress
Zhu, Hongxin, Tannous, Paul, Johnstone, Janet L., Kong, Yongli, Shelton, John M., Richardson, James A., ...
Cardiac hypertrophy is a major predictor of heart failure and a prevalent disorder with high mortality. Little is known, however, regarding mechanisms governing the transition from stable cardiac...
Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility
Montgomery, Rusty L., Davis, Christopher A., Potthoff, Matthew J., Haberland, Michael, Fielitz, Jens, Qi, Xiaoxia, ...
Histone deacetylases (HDACs) tighten chromatin structure and repress gene expression through the removal of acetyl groups from histone tails. The class I HDACs, HDAC1 and HDAC2, are expressed...
The MEF2D transcription factor mediates stress-dependent cardiac remodeling in mice
Kim, Yuri, Phan, Dillon, Van Rooij, Eva, Wang, Da-Zhi, McAnally, John, Qi, Xiaoxia, ...
The adult heart responds to excessive neurohumoral signaling and workload by a pathological growth response characterized by hypertrophy of cardiomyocytes and activation of a fetal program of cardiac...
The transient outward current in mice lacking the potassium channel gene Kv1.4
London, Barry, Wang, Dao W, Hill, Joseph A, Bennett, Paul B
The transient outward current (Ito) plays a prominent role in the repolarization phase of the cardiac action potential. Several K+ channel genes, including Kv1.4, are expressed in the heart, produce...
Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein
Rybkin, Igor I., Kim, Mi-Sung, Bezprozvannaya, Svetlana, Qi, Xiaoxia, Richardson, James A., Plato, Craig F., ...
Atrial cardiomyocytes, neurons, and endocrine tissues secrete neurotransmitters and peptide hormones via large dense-core vesicles (LDCVs). We describe a new member of the Ras family of G-proteins,...
Ni, Yan G., Wang, Na, Cao, Dian J., Sachan, Nita, Morris, David J., Gerard, Robert D., ...
Insulin resistance and metabolic syndrome are rapidly expanding public health problems. Acting through the PI3K/Akt pathway, insulin and insulin-like growth factor-1 (IGF-1) inactivate FoxO...
Shen, Chengcheng, Lin, Mei-Jung, Yaradanakul, Alp, Lariccia, Vincenzo, Hill, Joseph A, Hilgemann, Donald W
We describe a new assay to determine the fraction of cardiac Na+–Ca2+ exchangers (NCX1) in the surface membrane of cells (Fsurf). An extracellular NCX1 disulphide bond is rapidly reduced by...
Requirement of protein kinase D1 for pathological cardiac remodeling
Fielitz, Jens, Kim, Mi-Sung, Shelton, John M., Qi, Xiaoxia, Hill, Joseph A., Richardson, James A., ...
The adult heart responds to biomechanical stress and neurohormonal signaling by hypertrophic growth, accompanied by fibrosis, diminished pump function, and activation of a fetal gene program. Class...
Autophagy is an adaptive response in desmin-related cardiomyopathy
Tannous, Paul, Zhu, Hongxin, Johnstone, Janet L., Shelton, John M., Rajasekaran, Namakkal S., Benjamin, Ivor J., ...
A missense mutation in the αB-crystallin (CryAB) gene triggers a severe form of desmin-related cardiomyopathy (DRCM) characterized by accumulation of misfolded proteins. We hypothesized that...
Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis
Van Rooij, Eva, Sutherland, Lillian B., Thatcher, Jeffrey E., DiMaio, J. Michael, Naseem, R. Haris, Marshall, William S., ...
Acute myocardial infarction (MI) due to coronary artery occlusion is accompanied by a pathological remodeling response that includes hypertrophic cardiac growth and fibrosis, which impair cardiac...
Backs, Johannes, Backs, Thea, Neef, Stefan, Kreusser, Michael M., Lehmann, Lorenz H., Patrick, David M., ...
Acute and chronic injuries to the heart result in perturbation of intracellular calcium signaling, which leads to pathological cardiac hypertrophy and remodeling. Calcium/calmodulin-dependent protein...
Wang, Yanggan, Tandan, Samvit, Cheng, Jun, Yang, Chunmei, Nguyen, Lan, Sugianto, Jessica, ...
Ca2+/calmodulin-dependent protein kinase II (CaMKII) activity is increased in heart failure (HF), a syndrome characterized by markedly increased risk of arrhythmia. Activation of CaMKII increases...