It is well known that genotyping errors lead to loss of power in gene-mapping studies and underestimation of the strength of correlations between trait- and marker-locus genotypes. In two-point...
Hennah, William, Tomppo, Liisa, Hiekkalinna, Tero, Palo, Outi M., Kilpinen, Helena, Ekelund, Jesper, ...
We have previously reported a robust association between an allelic haplotype of ‘Disrupted in Schizophrenia 1’ (DISC1) and schizophrenia in a nationwide collection of Finnish schizophrenia...
Li, Zhe, Szabolcs, Matthias, Terwilliger, Joseph D., Efstratiadis, Argiris
NEU (ERBB2) and other members of the epidermal growth factor receptor (EGFR) family have been implicated in human prostate cancer (CAP) development and progression to an androgen-independent state,...
Li, Zhe, Szabolcs, Matthias, Terwilliger, Joseph D., Efstratiadis, Argiris
NEU (ERBB2) and other members of the epidermal growth factor receptor (EGFR) family have been implicated in human prostate cancer (CAP) development and progression to an androgen-independent state,...
Hennah, William, Tomppo, Liisa, Hiekkalinna, Tero, Palo, Outi M, Kilpinen, Helena, Ekelund, Jesper, ...
We have previously reported a robust association between an allelic haplotype of DISC1 and schizophrenia in a nationwide collection of Finnish schizophrenia families. This specific DISC1 allele was...
Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones (2004)
Tadashi Imanishi, Takeshi Itoh, Yutaka Suzuki, Claire O'Donovan, Satoshi Fukuchi, Kanako O. Koyanagi, ...
An international team has systematically validated and annotated just over 21,000 human genes using full-length cDNA, thereby providing a valuable new resource for the human genetics community.
Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones (2004)
Tadashi Imanishi, Takeshi Itoh, Yutaka Suzuki, Claire O'Donovan, Satoshi Fukuchi, Kanako O. Koyanagi, ...
The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this...
There is a lot of confusion in the literature about the “differences ” between “model-based ” and “model-free” methods and about which approach is better suited for detection of the genes...
Linkage is a phenomenon that correlates the genotypes of loci, rather than the phenotypes of one locus to the genotypes of another. It is therefore necessary to convert the observed trait phenotypes...
In linkage and linkage disequilibrium (LD) analysis of complex multifactorial phenotypes, various types of errors can greatly reduce the chance of successful gene localization. The power of such...
Ekelund, Jesper, Lichtermann, Dirk, Hovatta, Iiris, Ellonen, Pekka, Suvisaari, Jaana, Terwilliger, Joseph D., ...
We report the results of a four-stage genome-wide scan in a schizophrenia study sample consisting of 134 affected sib-pairs collected in Finland. In stage I we genotyped 370 markers from the Weber 6...
New polymorphic microsatellite markers place the haemochromatosis gene telomeric to D6S105 (1995)
Raha-Chowdhury, Ruma, Bowen, Derrick J., Stone, Caroline, Pointon, Jennifer J., Terwilliger, Joseph D., Shearman, Jeremy D., ...
The haemochromatosis gene (HFE) is linked to both HLA-A and D6S105 on the short arm of chromosome 6 but these markers are separated by ∼2 Mb of DNA. Most chromosomes carrying HFE have a common...
Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones
Imanishi, Tadashi, Itoh, Takeshi, Suzuki, Yutaka, O'Donovan, Claire, Fukuchi, Satoshi, Koyanagi, Kanako O, ...
The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this...
Large Upward Bias in Estimation of Locus-Specific Effects from Genomewide Scans
Göring, Harald H. H., Terwilliger, Joseph D., Blangero, John
The primary goal of a genomewide scan is to estimate the genomic locations of genes influencing a trait of interest. It is sometimes said that a secondary goal is to estimate the phenotypic effects...
Pajukanta, Päivi, Cargill, Michele, Viitanen, Laura, Nuotio, Ilpo, Kareinen, Anu, Perola, Markus, ...
Coronary heart disease (CHD) is a complex disorder constituting a major health problem in Western societies. To assess the genetic background of CHD, we performed a genomewide linkage scan in two...
Moses, Eric K., Lade, Jennifer A., Guo, Guanglan, Wilton, Alan N., Grehan, Madonna, Freed, Katy, ...
Epidemiological studies have shown that genetic factors contribute to the etiology of the common and serious pregnancy-specific disorder pre-eclampsia (PE)/eclampsia (E). Candidate-gene studies have...
Göring, Harald H. H., Terwilliger, Joseph D.
Linkage is a phenomenon that correlates the genotypes of loci, rather than the phenotypes of one locus to the genotypes of another. It is therefore necessary to convert the observed trait phenotypes...
Göring, Harald H. H., Terwilliger, Joseph D.
It is well known that genotyping errors lead to loss of power in gene-mapping studies and underestimation of the strength of correlations between trait- and marker-locus genotypes. In two-point...
Linkage Analysis in the Presence of Errors III: Marker Loci and Their Map as Nuisance Parameters
Göring, Harald H. H., Terwilliger, Joseph D.
In linkage and linkage disequilibrium (LD) analysis of complex multifactorial phenotypes, various types of errors can greatly reduce the chance of successful gene localization. The power of such...
Göring, Harald H. H., Terwilliger, Joseph D.
There is a lot of confusion in the literature about the “differences” between “model-based” and “model-free” methods and about which approach is better suited for detection of the genes...
Leppävuori, Jenni, Kujala, Urho, Kinnunen, Jaakko, Kaprio, Jaakko, Nissilä, Martti, Heliövaara, Markku, ...
The genetic contribution to common forms of osteoarthritis (OA) is well established but poorly understood. We performed a genome scan, using 302 markers for loci predisposing to distal...
Hovatta, Iiris, Varilo, Teppo, Suvisaari, Jaana, Terwilliger, Joseph D., Ollikainen, Vesa, Arajärvi, Ritva, ...
Schizophrenia is a severe mental disorder affecting ∼1% of the world's population. Here, we report the results from a three-stage genomewide screen performed in a study sample from an internal...
Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones
Imanishi, Tadashi, Itoh, Takeshi, Suzuki, Yutaka, O'Donovan, Claire, Fukuchi, Satoshi, Koyanagi, Kanako O, ...
The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this...
A Genomewide Screen of 345 Families for Autism-Susceptibility Loci
Yonan, Amanda L., Alarcón, Maricela, Cheng, Rong, Magnusson, Patrik K. E., Spence, Sarah J., Palmer, Abraham A., ...
We previously reported a genomewide scan to identify autism-susceptibility loci in 110 multiplex families, showing suggestive evidence (P < .01) for linkage to autism-spectrum disorders (ASD) on...
Large Upward Bias in Estimation of Locus-Specific Effects from Genomewide Scans
Göring, Harald H. H., Terwilliger, Joseph D., Blangero, John
The primary goal of a genomewide scan is to estimate the genomic locations of genes influencing a trait of interest. It is sometimes said that a secondary goal is to estimate the phenotypic effects...
Pajukanta, Päivi, Cargill, Michele, Viitanen, Laura, Nuotio, Ilpo, Kareinen, Anu, Perola, Markus, ...
Coronary heart disease (CHD) is a complex disorder constituting a major health problem in Western societies. To assess the genetic background of CHD, we performed a genomewide linkage scan in two...
Moses, Eric K., Lade, Jennifer A., Guo, Guanglan, Wilton, Alan N., Grehan, Madonna, Freed, Katy, ...
Epidemiological studies have shown that genetic factors contribute to the etiology of the common and serious pregnancy-specific disorder pre-eclampsia (PE)/eclampsia (E). Candidate-gene studies have...
Göring, Harald H. H., Terwilliger, Joseph D.
Linkage is a phenomenon that correlates the genotypes of loci, rather than the phenotypes of one locus to the genotypes of another. It is therefore necessary to convert the observed trait phenotypes...
Göring, Harald H. H., Terwilliger, Joseph D.
It is well known that genotyping errors lead to loss of power in gene-mapping studies and underestimation of the strength of correlations between trait- and marker-locus genotypes. In two-point...
Linkage Analysis in the Presence of Errors III: Marker Loci and Their Map as Nuisance Parameters
Göring, Harald H. H., Terwilliger, Joseph D.
In linkage and linkage disequilibrium (LD) analysis of complex multifactorial phenotypes, various types of errors can greatly reduce the chance of successful gene localization. The power of such...
Göring, Harald H. H., Terwilliger, Joseph D.
There is a lot of confusion in the literature about the “differences” between “model-based” and “model-free” methods and about which approach is better suited for detection of the genes...
Leppävuori, Jenni, Kujala, Urho, Kinnunen, Jaakko, Kaprio, Jaakko, Nissilä, Martti, Heliövaara, Markku, ...
The genetic contribution to common forms of osteoarthritis (OA) is well established but poorly understood. We performed a genome scan, using 302 markers for loci predisposing to distal...
Hovatta, Iiris, Varilo, Teppo, Suvisaari, Jaana, Terwilliger, Joseph D., Ollikainen, Vesa, Arajärvi, Ritva, ...
Schizophrenia is a severe mental disorder affecting ∼1% of the world's population. Here, we report the results from a three-stage genomewide screen performed in a study sample from an internal...
ForSim: a tool for exploring the genetic architecture of complex traits with controlled truth
Lambert, Brian W., Terwilliger, Joseph D., Weiss, Kenneth M.
Many important problems in biology involve complex traits affected by multiple coding or regulatory parts of the genome. How well the underlying genetic architecture can be inferred by statistical...