Adrenal proteins bound by a reactive intermediate of mitotane (1997)
Cai, W., Sinsheimer, Joseph E., Schteingart, David E., Wotring, Linda L., Vaz, Alfin D. N., Counsell, Raymond E.
Purpose : Mitotane ( o,p ′-DDD), is the only adrenolytic agent available for the treatment of adrenocortical carcinoma. Previous studies have shown that mitotane covalently binds to adrenal...
Substituent effects on the genotoxicity of 4-nitrostilbene derivatives (1994)
Hooberman, Barry H., Brezzell, M. D., Das, S. K., You, Zhengqing, Sinsheimer, Joseph E.
4-Nitrostilbene and twelve of its derivatives (eleven E-stilbenes and two Z-stilbenes) were examined for possible quantitative structure-activity relationships of their in vitro and in vivo...
You, Zhengqing, Brezzell, M. D., Das, S. K., Hooberman, Barry H., Sinsheimer, Joseph E.
4-Amino-4'-substituted biphenyls and 4-aminostilbenes substituted in the 3' or 4' position were studied for their in vitro and in vivo genotoxicity. The in vitro mutagenicity of the biphenyls with...
Das, L., Das, S. K., Hooberman, Barry H., Chu, Ernest H. Y., Sinsheimer, Joseph E.
Mouse lymphocytes were exposed in vitro for 2 h or in vivo for 24 h to benzidine and related aromatic amines to test for chromosome aberrations (CA) and mitotic indices. Uninduced mouse S9 was used...
Wotring, Linda L., Sinsheimer, Joseph E., Counsell, Raymond E., Hines, Jennifer V., Benitez, Ricardo, Ruangwises, Nongluck, ...
Mitotane is an important adrenalytic drug for the treatment of adrenal cancer whose use is limited by toxicity. Reports from another laboratory indicated that a methylated homolog of Mitotane...
ortho-Substituent effects on the in vitro and in vivo genotoxicity of benzidine derivatives (1993)
You, Zhengqing, Brezzell, M. D., Das, S. K., Espadas-Torre, M. C., Hooberman, Barry H., Sinsheimer, Joseph E.
Benzidine and its 3,3'-diamino, 3,3'-dimethyl, 3,3'-dimethoxy, 3,3'-difluoro, 3,3'-dichloro, 3,3'-dibromo, 3,3'-dicarbomethoxy and 3,3'-dinitro derivatives together with 2-nitrobenzidine and...
Hooberman, Barry H., Chakraborty, Pulak K., Sinsheimer, Joseph E.
A quantitative structure-activity relationship approach was used to investigate the mutagenicity of a series of seventeen-monosubstituted propylene oxides in Salmonella typhimurium strains TA100 and...
Das, L., Das, S. K., Chu, Ernest H. Y., Sinsheimer, Joseph E.
Mouse lymphocytes in vivo or in vitro were exposed for 24 h to 4 aliphatic epoxides, glycidyl 1-naphthyl ether, glycidyl 4-nitrophenyl ether, 1-naphthylpropylene oxide and trichloropropylene oxide...
The genotoxicity of enantiomeric aliphatic epoxides (1993)
Sinsheimer, Joseph E., Chen, R., Das, S. K., Hooberman, Barry H., Osorio, S., You, Zhengqing
The (R)- and (S)-optical isomers of 9 epoxides, benzyloxymethyloxirane, epichlorohydrin, glycidol, glycidyl 3-nitrobenzenesulfonate, glycidyl 4-nitrobenzoate, glycidyl tosylate, styrene oxide,...
Enantioselective detoxication of optical isomers of glycidyl ethers (1993)
Chen, Ruth R., Nguyen, Phuong, You, Zhengqing, Sinsheimer, Joseph E.
The detoxication of the enantiomers of glycidyl 4-nitrophenyl ether (GNPE), (−)-(R)- and (+)-(S)-GNPE, and glycidyl 1-naphthyl ether (GNE), (−)-(R)- and (+)-(S)-GNE, by rat liver glutathione...
Sinsheimer, Joseph E., Hooberman, Barry H., Das, S. K., Brezzell, M. D., You, Zhengqing
Benzidine and 12 related aromatic amines have been studied for the effects of substituent groups and [pi] orbital conjugation on their genotoxicity as measured by their mutagenicity in vitro with...
Coene, J., Claereboudt, J., Borremans, F., Claeys, M., Esmans, E. L., ...
2'-Deoxycitidine (dCyd) and 2'-deoxyguanosine (dGuo) were subjected to reaction with phenylglycidyl ether (PGE) in methanol in order to study the formation of the corresponding 2'-deoxynucleoside...
DNA strand breaks in liver for four aliphatic epoxides in mice (1990)
Giri, A. K., Messerly, E. A., Chakraborty, Pulak K., Hooberman, Barry H., Sinsheimer, Joseph E.
Four aliphatic epoxides, 1-naphthyl glycidyl ether (NGE), 1-naphthylpropylene oxide (NPO), 4-nitrophenyl glycidyl ether (NPGE), 3,3,3-trichloropropylene oxide (TCPO) and two of their precursors,...
De Bruyn, A., Pepermans, H., Esmans, E. L., Vryens, I., Claereboudt, J., ...
Thymidine 2'-deoxyadenosine were reacted with phenyl glycidyl ether in order to study the formation of the corresponding 2'-deoxynucleoside adducts. Separation methods were elaborated using either...
Mutagenicity of oxaspiro compounds with Salmonella (1989)
Sinsheimer, Joseph E., Chakraborty, Pulak K., Messerly, E. A., Gaddamidi, V.
The spiro attachment of an epoxide group to a tetrahydropyran ring in the trichothecene mycotoxins has prompted this study of the mutagenicity and alkylation rates of the trichothecene, anguidine,...
Sister-chromatid exchange and chromosome aberrations for 4 aliphatic epoxides in mice (1989)
Giri, A. K., Messerly, E. A., Sinsheimer, Joseph E.
Sister-chromatid exchange (SCE) and chromosome aberrations (CA) in bone marrow cells were analyzed after in vivo exposure in mice to 4 aliphatic epoxides, namely 1-naphthyl glycidyl ether (NGE),...
Mutagenicity of aromatic glycidyl ethers with Salmonella (1988)
Rosman, L. B., Chakraborty, Pulak K., Messerly, E. A., Sinsheimer, Joseph E.
6 aromatic glycidyl ethers containing naphthyl, biphenyl or benzylphenyl substituents were synthesized. These epoxides together with the commercially available compounds 2-biphenylyl glycidyl ether...
Mutagenicity of aryl propylene and butylene oxides with Salmonella (1987)
Rosman, L. B., Gaddamidi, V., Sinsheimer, Joseph E.
10 aryl propylene oxides and 6 aryl butylene oxides were synthesized. Dose-mutagenicity relationships were studied for these compounds and for 1,2-epoxybutane, using both the preincubation and plate...
Detoxication of aliphatic epoxides by diol formation and glutathione conjugation (1987)
Sinsheimer, Joseph E., Hooberman, Barry H., Beylin, Vladimir G.
The Ames procedure with Salmonella typhimurium strain TA100 was used to follow the detoxication by rat liver fractions of two series of aliphatic epoxides. The epoxides employed were 3-chloro-,...
Mutagenicity of para-substituted [alpha]-methylstyrene oxide derivatives with Salmonella (1986)
Rosman, L. B., Beylin, Vladimir G., Gaddamidi, V., Hooberman, Barry H., Sinsheimer, Joseph E.
A series of 5 para-substituted [alpha]-methylstyrene oxide derivatives have been synthesized and together with [alpha]-methylstyrene oxide as well as styrene oxide have been studied as to their...
Mutagenicity in Salmonella assays of cyclohexane epoxide derivatives (1985)
Frantz, Stephen W., Sinsheimer, Joseph E., Yoshihara, M., Koreeda, Masato
15 Cyclohexane epoxide derivatives were synthesized and compared for direct mutagenicity an bacterial toxicity using Salmonella typhimurium strain TA100 in the liquid suspension and spot-test version...
De Moerloose, P., Sinsheimer, Joseph E.
A simple, rapid and sensitive high-performance thin-layer chromatographic assay for the determination of epoxide hydrolase activity in rat liver homogenates is described. It is extended to the...
Mitotane (o,p'-DDD) emulsion and tablet analysis by high-performance liquid chromatography (1985)
Musial, S.P., Freeman, C.J., Sinsheimer, Joseph E.
Peer Reviewed
Djuric, Zora, Sinsheimer, Joseph E.
Thymidine was reacted in methanol with four epoxides of varying mutagenicities: propylene oxide, glycidol, epichlorohydrin and trichloropropylene oxide. A single product was detected with each...
Reactivity of propylene oxides towards deoxycytidine and identification of reaction products (1984)
Djuric, Zora, Sinsheimer, Joseph E.
Deoxycytidine was reacted with four epoxides of varying alkylating rates: propylene oxide, glycidol, epichlorohydrin and trichloropropylene oxide. Deoxycytidine was chosen to compare the reactivities...
Substituent effects on the mutagenicity of phenyl glycidyl ethers in Salmonella typhimurium (1982)
Neau, Steven H., Hooberman, Barry H., Frantz, Stephen W., Sinsheimer, Joseph E.
Phenyl glycidyl ether and 6 para-substituted derivatives, the methoxy, tert-butyl, methyl, chloro, bromo and nitro compounds, were tested in the Ames' test for mutagenicity. With the exception of the...
Isomerization of trans-diethylstilbestrol to pseudo-diethylstilbestrol (1981)
Airy, Subhash C., Sinsheimer, Joseph E.
This study reports the formation and isolation of a diethyl-stilbestrol-dimethylsulfoxide (DES-DMSO) adjunct and Z-3, 4-di(p-hydroxyphenyl)-2-hexene ([psi]-DES) from -DES. The presence of [psi]-DES...
Bacterial mutagenicity and toxicity of cycloaliphatic epoxides (1981)
Frantz, Stephen W., Sinsheimer, Joseph E.
The mutagenicity of 12 cycloaliphatic epoxides was investigated using the Ames Salmonella assay without the addition of liver homogenate fractions. Base-pair substitution mutagenic activity was...
A highly sensitive fluorimetric procedure based on alkylation of nicotinamide is described for the determination of aliphatic epoxides. Subsequent reaction of the resulting N-alkylni-cotinamides with...
Ishidate, Kozo, Drach, John C., Sinsheimer, Joseph E., Burckhalter, Joseph H.
Peer Reviewed
Mutagenicity of aliphatic epoxides (1978)
Wade, D. R., Airy, Subhash C., Sinsheimer, Joseph E.
The mutagenicity of 17 aliphatic epoxides was determined using the specially constructed mutants of Salmonella typhimurium developed by Ames. The activity of these epoxides together with those...
Mechanisms for the biodehalogenation of iodocompounds (1978)
Sinsheimer, Joseph E., Wang, T., Roder, S., Shum, Y. Y.
The deiodination of [125I]-4-iodobiphenyl, [125I]-4-iodonitrobenzene and [125I]-4-iodoaniline was investigated. No deiodination was detected in rat thyroid homogenates. However, at least three...
Pulmonary O-methyl transferases (1975)
Law, Francis C. P., Drach, John C., Sinsheimer, Joseph E.
An investigation in vitro of pulmonary O-methyl transferases revealed the presence of microsomal phenol-O-methyl transferase and soluble and microsomal catechol-O-methyl transferases in guineapig...
Fluorescein isothiocyanates: Improved synthesis and purity : Spectral studies (1974)
Sinsheimer, Joseph E., Jagodic, Vjekoslav, Burckhalter, Joseph H.
Modification of the methods of synthesis by direct reaction of the isomeric aminofluoresceins with a limited excess of thiophosgene in the presence of calcium carbonate has yielded the 5- and...
Isolation and antiviral activity of the gymnemic acids (1968)
Sinsheimer, Joseph E., Subba Rao, G., McIlhenny, H. M., Smith, R. V., Maassab, Hunein F., Cochran, Kenneth W.
Aus den Blättern von Gymnema sylvestre wurden 4 Gymneasäuren (A, B, C und D) isoliert. Die Antivirusaktivität der Säuren A und B wurde geprüft.
Species differences in the metabolism of norephedrine in man, rabbit and rat
Sinsheimer, Joseph E., Dring, L. Graham, Williams, R. Tecwyn
1. (±)-2-Amino-1-phenyl[1-14C]propan-1-ol ([14C]norephedrine) was administered orally to man, rat and rabbit and the metabolites excreted in the urine were identified and measured. Pronounced...
Species differences in the metabolism of norephedrine in man, rabbit and rat
Sinsheimer, Joseph E., Dring, L. Graham, Williams, R. Tecwyn
1. (±)-2-Amino-1-phenyl[1-14C]propan-1-ol ([14C]norephedrine) was administered orally to man, rat and rabbit and the metabolites excreted in the urine were identified and measured. Pronounced...