Cheryl A. Nechamen, Richard M. Thomas, Brian D. Cohen, Giselles Acevedo, Poulikos I. Poulikakos, Joseph R. Testa, ...
Selection of a dominant follicle that will ovulate likely occurs by activation of cell survival pathways and suppression of death-promoting pathways in a mechanism involving FSH and its cognate...
Balsara, Binaifer R., Pei, Jianming, Mitsuuchi, Yasuhiro, Page, Robert, Klein-Szanto, Andres, Wang, Hao, ...
AKT is frequently activated in various cancers, but its involvement in lung tumor development and progression is not well established. We examined AKT activity by immunohistochemistry (IHC) in 110...
Balsara, Binaifer R., Pei, Jianming, Mitsuuchi, Yasuhiro, Page, Robert, Klein-Szanto, Andres, Wang, Hao, ...
AKT is frequently activated in various cancers, but its involvement in lung tumor development and progression is not well established. We examined AKT activity by immunohistochemistry in 110...
Godwin, Andrew K., Testa, Joseph R., Handel, Laura M., Liu, Zemin, Vanderveer, Lisa A., Tracey, Pamela A., ...
Background: Ovarian surface epithelial cells undergo several rounds of division to repair the wound created by follicular rupture at the time of ovulation. This cyclical requirement for cell...
Xiao, Guang-Hui, Jeffers, Michael, Bellacosa, Alfonso, Mitsuuchi, Yasuhiro, Vande Woude, George F., Testa, Joseph R.
Hepatocyte growth factor (HGF) is a ligand of the receptor tyrosine kinase encoded by the c-Met protooncogene. HGF/Met signaling has multifunctional effects on various cell types. We sought to...
Bocchetta, Maurizio, Di Resta, Ilaria, Powers, Amy, Fresco, Raoul, Tosolini, Alessandra, Testa, Joseph R., ...
Mesothelioma, a malignancy associated with asbestos, has been recently linked to simian virus 40 (SV40). We found that infection of human mesothelial cells by SV40 is very different from the...
Cell Cycle Withdrawal Promotes Myogenic Induction of Akt, a Positive Modulator of Myocyte Survival
Fujio, Yasushi, Guo, Kun, Mano, Toshiaki, Mitsuuchi, Yasuhiro, Testa, Joseph R., Walsh, Kenneth
During myogenesis, proliferating myoblasts withdraw from the cell cycle, acquire an apoptosis-resistant phenotype, and differentiate into myotubes. Previous studies indicate that myogenic induction...
Khazak, Vladimir, Estojak, Joanne, Cho, Helen, Majors, Jenifer, Sonoda, Gonosuke, Testa, Joseph R., ...
Under conditions of environmental stress, prokaryotes and lower eukaryotes such as the yeast Saccharomyces cerevisiae selectively utilize particular subunits of RNA polymerase II (pol II) to alter...
p53 Differentially Inhibits Cell Growth Depending on the Mechanism of Telomere Maintenance
Razak, Zaineb R. Abdul, Varkonyi, Robert J., Kulp-McEliece, Michelle, Caslini, Corrado, Testa, Joseph R., Murphy, Maureen E., ...
Telomere stabilization is critical for tumorigenesis. A number of tumors and cell lines use a recombination-based mechanism, alternative lengthening of telomeres (ALT), to maintain telomere repeat...
Xiao, Guang-Hui, Gallagher, Ryan, Shetler, Justin, Skele, Kristine, Altomare, Deborah A., Pestell, Richard G., ...
Inactivation of the NF2 tumor suppressor gene has been observed in certain benign and malignant tumors. Recent studies have demonstrated that merlin, the product of the NF2 gene, is regulated by...
Wei, Bangdong L., Arora, Vivek K., Raney, Alexa, Kuo, Lillian S., Xiao, Guang-Hui, O'Neill, Eduardo, ...
The accessory human immunodeficiency virus type 1 (HIV-1) protein Nef activates the autophosphorylation activity of p21-activated kinase 2 (PAK2). Merlin, a cellular substrate of PAK2, is homologous...
Xiao, Guang-Hui, Jeffers, Michael, Bellacosa, Alfonso, Mitsuuchi, Yasuhiro, Vande Woude, George F., Testa, Joseph R.
Hepatocyte growth factor (HGF) is a ligand of the receptor tyrosine kinase encoded by the c-Met protooncogene. HGF/Met signaling has multifunctional effects on various cell types. We sought to...
Bocchetta, Maurizio, Di Resta, Ilaria, Powers, Amy, Fresco, Raoul, Tosolini, Alessandra, Testa, Joseph R., ...
Mesothelioma, a malignancy associated with asbestos, has been recently linked to simian virus 40 (SV40). We found that infection of human mesothelial cells by SV40 is very different from the...
Cell Cycle Withdrawal Promotes Myogenic Induction of Akt, a Positive Modulator of Myocyte Survival
Fujio, Yasushi, Guo, Kun, Mano, Toshiaki, Mitsuuchi, Yasuhiro, Testa, Joseph R., Walsh, Kenneth
During myogenesis, proliferating myoblasts withdraw from the cell cycle, acquire an apoptosis-resistant phenotype, and differentiate into myotubes. Previous studies indicate that myogenic induction...
Khazak, Vladimir, Estojak, Joanne, Cho, Helen, Majors, Jenifer, Sonoda, Gonosuke, Testa, Joseph R., ...
Under conditions of environmental stress, prokaryotes and lower eukaryotes such as the yeast Saccharomyces cerevisiae selectively utilize particular subunits of RNA polymerase II (pol II) to alter...
p53 Differentially Inhibits Cell Growth Depending on the Mechanism of Telomere Maintenance
Razak, Zaineb R. Abdul, Varkonyi, Robert J., Kulp-McEliece, Michelle, Caslini, Corrado, Testa, Joseph R., Murphy, Maureen E., ...
Telomere stabilization is critical for tumorigenesis. A number of tumors and cell lines use a recombination-based mechanism, alternative lengthening of telomeres (ALT), to maintain telomere repeat...
Xiao, Guang-Hui, Gallagher, Ryan, Shetler, Justin, Skele, Kristine, Altomare, Deborah A., Pestell, Richard G., ...
Inactivation of the NF2 tumor suppressor gene has been observed in certain benign and malignant tumors. Recent studies have demonstrated that merlin, the product of the NF2 gene, is regulated by...
Wei, Bangdong L., Arora, Vivek K., Raney, Alexa, Kuo, Lillian S., Xiao, Guang-Hui, O'Neill, Eduardo, ...
The accessory human immunodeficiency virus type 1 (HIV-1) protein Nef activates the autophosphorylation activity of p21-activated kinase 2 (PAK2). Merlin, a cellular substrate of PAK2, is homologous...
Yang, Haining, Bocchetta, Maurizio, Kroczynska, Barbara, Elmishad, Amira G., Chen, Yuanbin, Liu, Zemin, ...
Asbestos is the main cause of human malignant mesothelioma (MM). In vivo, macrophages phagocytize asbestos and, in response, release TNF-α and other cytokines that contribute to carcinogenesis...
GIPC Is Recruited by APPL to Peripheral TrkA Endosomes and Regulates TrkA Trafficking and Signaling▿
Varsano, Tal, Dong, Meng-Qiu, Niesman, Ingrid, Gacula, Hyacynth, Lou, Xiaojing, Ma, Tianlin, ...
GIPC is a PDZ protein located on peripheral endosomes that binds to the juxtamembrane region of the TrkA nerve growth factor (NGF) receptor and has been implicated in NGF signaling. We establish here...
Lin, Dan C., Quevedo, Celia, Brewer, Natalie E., Bell, Alex, Testa, Joseph R., Grimes, Mark L., ...
The neurotrophin receptor TrkA plays critical roles in the nervous system by recruiting signaling molecules that activate pathways required for the growth and survival of neurons. Here, we report...
Feng, Sheau-Line Y., Guo, Yan, Factor, Valentina M., Thorgeirsson, Snorri S., Bell, Daphne W., Testa, Joseph R., ...
Polypeptide growth factors stimulate mammalian cell proliferation by binding to specific cell surface receptors. This interaction triggers numerous biochemical responses including the activation of...
Lee, Hansoo, Kim, Donghwa, Dan, Han C., Wu, Eric L., Gritsko, Tatiana M., Cao, Chuanhai, ...
Mutations of the neurofibromatosis 2 (NF2) tumor suppressor gene have frequently been detected not only in schwannomas and other central nervous system tumors of NF2 patients but also in their...
Gonzalez, Alfonso Dueñas, Kaya, Mitsunori, Shi, Wen, Song, Howard, Testa, Joseph R., Penn, Linda Z., ...
OCI-5/GPC3 is a member of the glypican family. Glypicans are heparan sulfate proteoglycans that are bound to the cell surface through a glycosyl-phosphatidylinositol anchor. It has recently been...
Tarn, Chi, Rink, Lori, Merkel, Erin, Flieder, Douglas, Pathak, Harsh, Koumbi, Daphne, ...
A subset of gastrointestinal stromal tumors (GISTs) lack gain-of-function mutations in c-KIT and PDGFRα. These so-called wild-type (WT) GISTs tend to be less responsive to imatinib-based therapies...
HGF Mediates Cell Proliferation of Human Mesothelioma Cells through a PI3K/MEK5/Fra-1 Pathway
Ramos-Nino, Maria E., Blumen, Steven R., Sabo-Attwood, Tara, Pass, Harvey, Carbone, Michele, Testa, Joseph R., ...
The ligand hepatocyte growth factor/scatter factor (HGF) and its receptor tyrosine kinase, c-Met, are highly expressed in most human malignant mesotheliomas (MMs) and may contribute to their...
Altomare, Deborah A., Menges, Craig W., Pei, Jianming, Zhang, Lili, Skele-Stump, Kristine L., Carbone, Michele, ...
The human CDKN2A locus encodes 2 distinct proteins, p16(INK4A) and p14(ARF) [mouse p19(Arf)], designated INK4A (inhibitor of cyclin dependent kinase 4) and ARF (alternative reading frame) here, that...