Ligand-specific Conformational Changes in the {alpha}1 Glycine Receptor Ligand-binding Domain (2009)
Gilbert, Daniel, Wilson, John C., Nink, Virginia, Lynch, Joseph W., Osborne, Geoffrey W.
Flow cytometry is an important drug discovery tool because it permits high-content multiparameter analysis of individual cells. A new method dramatically enhanced screening throughput by multiplexing...
Pless, Stephan A., Millen, Kat S., Hanek, Ariele P., Lynch, Joseph W., Lester, Henry A., Lummis, Sarah C. R., ...
Cys-loop receptor binding sites characteristically contain many aromatic amino acids. In nicotinic ACh and 5-HT3 receptors, a Trp residue forms a cation-{pi} interaction with the agonist, whereas in...
Illuminating the structure and function of Cys-loop receptors (2008)
Pless, Stephan A, Lynch, Joseph W
Cys-loop receptors are an important class of ligand-gated ion channels. They mediate fast synaptic neurotransmission, are implicated in various 'channelopathies' and are important pharmacological...
Lynch, Joseph W., Chen, Xuebin
Bilobalide, a major bioactive component of Ginkgo biloba herbal extracts, exhibits neuroprotective and anti-ischaemic activity. However, its therapeutic potential is limited because of its...
Pless, Stephan A., Millen, Kat S., Hanek, Ariele P., Lynch, Joseph W., Lester, Henry A., Lummis, Sarah C. R., ...
Subunit-specific modulation of glycine receptors by cannabinoids and N-arachidonyl-glycine (2008)
Yang, Zhe, Aubrey, Karin R., Alroy, Iris, Harvey, Robert J., Vandenberg, Robert J., Lynch, Joseph W.
Pless, Stephan A., Dibas, Mohammed I., Lester, Henry A., Lynch, Joseph W.
Models describing the structural changes mediating cys-loop receptor activation generally give little attention to the possibility that different agonists may promote activation via distinct M2...
Kruger, Wade, Gilbert, Daniel, Hawthorne, Rebecca, Hryciw, Deanne H., Frings, Stephan, Poronnik, Philip, ...
There is a significant clinical need to identify novel ligands with high selectivity and potency for GABA(A), GABA(C) and glycine receptor Cl- channels. Two recently developed, yellow fluorescent...
A picrotoxin-specific conformational change in the glycine receptor M2-M3 domain. (2005)
Hawthorne, Rebecca L., Lynch, Joseph W.
The external loop linking the M2 and M3 transmembrane domains is crucial for coupling agonist binding to channel gating in the glycine receptor chloride channel (GlyR). A substituted cysteine...
Kruger, Wade, Gilbert, Daniel, Hawthorne, Rebecca, Hryciw, Deanne H., Frings, Stephan, Poronnik, Philip, ...
There is a significant clinical need to identify novel ligands with high selectivity and potency for GABA(A), GABA(C) and glycine receptor Cl- channels. Two recently developed, yellow fluorescent...
A picrotoxin-specific conformational change in the glycine receptor M2-M3 loop. (2005)
Hawthorne, Rebecca L., Lynch, Joseph W.
The external loop linking the M2 and M3 transmembrane domains is crucial for coupling agonist binding to channel gating in the glycine receptor chloride channel (GlyR). A substituted cysteine...
Han, Nian-Lin R., Haddrill, Justine L., Lynch, Joseph W.
The beta -amino acid, taurine, is a full agonist of the human glycine receptor al subunit when recombinantly expressed in a mammalian (HEK293) cell line, but a partial agonist of the same receptor...